-
1
-
-
0034640011
-
Fourteen and counting: Unraveling trinucleotide repeat diseases
-
Cummings, C.J. and Zoghbi, H.Y. (2000) Fourteen and counting: unraveling trinucleotide repeat diseases. Hum. Mol. Genet., 9, 909-916.
-
(2000)
Hum. Mol. Genet.
, vol.9
, pp. 909-916
-
-
Cummings, C.J.1
Zoghbi, H.Y.2
-
2
-
-
16044373842
-
Exon 1 of the ED gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice
-
Mangiarini, L., Sathasivam, K., Seller, M., Cozens, B., Harper, A., Hetherington, C., Lawton, M., Trottier, Y., Lehrach, H., Davies, S.W. et al. (1996) Exon 1 of the ED gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell, 87, 493-506.
-
(1996)
Cell
, vol.87
, pp. 493-506
-
-
Mangiarini, L.1
Sathasivam, K.2
Seller, M.3
Cozens, B.4
Harper, A.5
Hetherington, C.6
Lawton, M.7
Trottier, Y.8
Lehrach, H.9
Davies, S.W.10
-
3
-
-
0037107191
-
Early motor dysfunction and striosomal distribution of huntingtin microaggregates in Huntington's disease knock-in mice
-
Menalled, L.B., Sison, J.D., Wu, Y., Olivieri, M., Li, X.J., Li, H., Zeitlin, S. and Chesselet, M.Y. (2002) Early motor dysfunction and striosomal distribution of huntingtin microaggregates in Huntington's disease knock-in mice. J. Neurosci., 22, 8266-8276.
-
(2002)
J. Neurosci.
, vol.22
, pp. 8266-8276
-
-
Menalled, L.B.1
Sison, J.D.2
Wu, Y.3
Olivieri, M.4
Li, X.J.5
Li, H.6
Zeitlin, S.7
Chesselet, M.Y.8
-
4
-
-
0035862896
-
Neurological abnormalities in a knock-in mouse model of Huntington's disease
-
Lin, C.H., Tallaksen-Greene, S., Chien, W.M., Cearley, J.A., Jackson, W.S., Crouse, A.B., Ren, S., Li, X.J., Albin, R.L. and Detloff, P.J. (2001) Neurological abnormalities in a knock-in mouse model of Huntington's disease. Hum. Mol. Genet., 10, 137-144.
-
(2001)
Hum. Mol. Genet.
, vol.10
, pp. 137-144
-
-
Lin, C.H.1
Tallaksen-Greene, S.2
Chien, W.M.3
Cearley, J.A.4
Jackson, W.S.5
Crouse, A.B.6
Ren, S.7
Li, X.J.8
Albin, R.L.9
Detloff, P.J.10
-
5
-
-
0037087771
-
Early phenotypes tat presage late-onset neurodegenerative disease allow testing of modifiers in Hdh CAG knock-in mice
-
Wheeler, V.C., Gutekunst, C.A., Vrbanac, V., Lebel, L.A., Schilling, G., Hersch, S., Friedlander, R.M., Gusella, J.F., Vonsattel, J.P., Borchelt, D.R. et al. (2002) Early phenotypes tat presage late-onset neurodegenerative disease allow testing of modifiers in Hdh CAG knock-in mice. Hum. Mol. Genet., 11, 633-640.
-
(2002)
Hum. Mol. Genet.
, vol.11
, pp. 633-640
-
-
Wheeler, V.C.1
Gutekunst, C.A.2
Vrbanac, V.3
Lebel, L.A.4
Schilling, G.5
Hersch, S.6
Friedlander, R.M.7
Gusella, J.F.8
Vonsattel, J.P.9
Borchelt, D.R.10
-
6
-
-
0032949459
-
A Huntington's disease CAG expansion at the marine Hdh locus is unstable and associated with behavioural abnormalities in mice
-
Shelbourne, P.F., Killeen, N., Hevner, R.F., Jobnston, H.M., Tecott, L., Lewandoski, M., Ennis, M., Ramirez, L., Li, Z., Iannicola, C. et al. (1999) A Huntington's disease CAG expansion at the marine Hdh locus is unstable and associated with behavioural abnormalities in mice. Hum. Mol. Genet., 8, 763-774.
-
(1999)
Hum. Mol. Genet.
, vol.8
, pp. 763-774
-
-
Shelbourne, P.F.1
Killeen, N.2
Hevner, R.F.3
Jobnston, H.M.4
Tecott, L.5
Lewandoski, M.6
Ennis, M.7
Ramirez, L.8
Li, Z.9
Iannicola, C.10
-
7
-
-
0033136692
-
A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration
-
Hodgson, J.G., Agopyan, N., Gutekunst, C.A., Leavilt, B.R., LePiane, F., Singaraja, R., Smith, D.J., Bissada, N., McCutcheon, K., Nasir, J. et al. (1999) A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration. Neuron, 23, 181-192.
-
(1999)
Neuron
, vol.23
, pp. 181-192
-
-
Hodgson, J.G.1
Agopyan, N.2
Gutekunst, C.A.3
Leavilt, B.R.4
LePiane, F.5
Singaraja, R.6
Smith, D.J.7
Bissada, N.8
McCutcheon, K.9
Nasir, J.10
-
8
-
-
0030752709
-
Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain
-
DiFiglia, M., Sapp, E., Chase, K.O., Davies, S.W., Bates, G.P., Vonsattel, J.P. and Aronin, N. (1997) Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. Science, 277, 1990-1993.
-
(1997)
Science
, vol.277
, pp. 1990-1993
-
-
DiFiglia, M.1
Sapp, E.2
Chase, K.O.3
Davies, S.W.4
Bates, G.P.5
Vonsattel, J.P.6
Aronin, N.7
-
9
-
-
0029152808
-
Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodies
-
Gutekunst, C.A., Levey, A.I., Heilman, C.J., Whaley, W.L., Yi, H., Nash, N.R., Rees, H.D., Madden, J.J. and Hersch, S.M. (1995) Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodies. Proc. Natl Acad. Sci. USA, 92, 8710-8714.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 8710-8714
-
-
Gutekunst, C.A.1
Levey, A.I.2
Heilman, C.J.3
Whaley, W.L.4
Yi, H.5
Nash, N.R.6
Rees, H.D.7
Madden, J.J.8
Hersch, S.M.9
-
10
-
-
7144253143
-
Truncated N-terminal fragments of huntingtin with expanded glutamine repeats form nuclear and cytoplasmic aggregates in cell culture
-
Cooper, J.K., Schilling, G., Peters, M.F., Herring, W.J., Sharp, A.H., Kaminsky, Z., Masone, J., Khan, F.A., Delanoy, M., Borchelt, D.R. et al. (1998) Truncated N-terminal fragments of huntingtin with expanded glutamine repeats form nuclear and cytoplasmic aggregates in cell culture. Hum. Mol. Genet., 7, 783-790.
-
(1998)
Hum. Mol. Genet.
, vol.7
, pp. 783-790
-
-
Cooper, J.K.1
Schilling, G.2
Peters, M.F.3
Herring, W.J.4
Sharp, A.H.5
Kaminsky, Z.6
Masone, J.7
Khan, F.A.8
Delanoy, M.9
Borchelt, D.R.10
-
11
-
-
0032475931
-
Huntinglin acts in the nucleus to induce apoptosis but death does not correlate with die formation of intranuclear inclusions
-
Saudou, F., Finkbeiner, S., Devys, D. and Greenberg, M.E. (1998) Huntinglin acts in the nucleus to induce apoptosis but death does not correlate with die formation of intranuclear inclusions. Cell, 95, 55-66.
-
(1998)
Cell
, vol.95
, pp. 55-66
-
-
Saudou, F.1
Finkbeiner, S.2
Devys, D.3
Greenberg, M.E.4
-
12
-
-
0032590053
-
Huntington aggregates may not predict neuronal death in Huntington's disease
-
Kuemmerle, S., Gutekunst, C.A., Klein, A.M., Li, X.J., Li, S.H., Beal, M.F., Hersch, S.M. and Ferrante, R.J. (1999) Huntington aggregates may not predict neuronal death in Huntington's disease. Ann. Neurol., 46, 842-849.
-
(1999)
Ann. Neurol.
, vol.46
, pp. 842-849
-
-
Kuemmerle, S.1
Gutekunst, C.A.2
Klein, A.M.3
Li, X.J.4
Li, S.H.5
Beal, M.F.6
Hersch, S.M.7
Ferrante, R.J.8
-
13
-
-
0029816724
-
Subcellular localization of the Huntington's disease gene product in cell lines by immunofluorescence and biochemical subcellular fractionation
-
De Rooij, K.E., Dorsman, J.C., Smoor, M.A., Den Dunnen, J.T. and Van Ommen, G.J. (1996) Subcellular localization of the Huntington's disease gene product in cell lines by immunofluorescence and biochemical subcellular fractionation. Hum. Mol. Genet., 5, 1093-1099.
-
(1996)
Hum. Mol. Genet.
, vol.5
, pp. 1093-1099
-
-
De Rooij, K.E.1
Dorsman, J.C.2
Smoor, M.A.3
Den Dunnen, J.T.4
Van Ommen, G.J.5
-
14
-
-
0034703860
-
Huntingtin: An iron-regulated protein essential for normal nuclear and perinuclear organelles
-
Hilditch-Maguire, P., Trettel, F., Passani, L.A., Auerbach, A., Persichetti, F. and MacDonald, M.E. (2000) Huntingtin: an iron-regulated protein essential for normal nuclear and perinuclear organelles. Hum. Mol. Genet., 9, 2789-2797.
-
(2000)
Hum. Mol. Genet.
, vol.9
, pp. 2789-2797
-
-
Hilditch-Maguire, P.1
Trettel, F.2
Passani, L.A.3
Auerbach, A.4
Persichetti, F.5
MacDonald, M.E.6
-
15
-
-
0034971846
-
Nuclear relocation of normal huntingtin
-
Tao, T. and Tartakoff, A.M. (2001) Nuclear relocation of normal huntingtin. Traffic, 2, 385-394.
-
(2001)
Traffic
, vol.2
, pp. 385-394
-
-
Tao, T.1
Tartakoff, A.M.2
-
16
-
-
18544368523
-
Huntingtin is present in the nucleus, interacts with the transcriptional corepressor C-terminal binding protein, and represses transcription
-
Kegel, K.B., Meloni, A.R., Yi, Y., Kim, Y.J., Doyle, E., Cuiffo, B.G., Sapp, E., Wang, Y., Qin, Z.H., Chen, J.D. et al. (2001) Huntingtin is present in the nucleus, interacts with the transcriptional corepressor C-terminal binding protein, and represses transcription. J. Biol. Chem., 277, 7466-7476.
-
(2001)
J. Biol. Chem.
, vol.277
, pp. 7466-7476
-
-
Kegel, K.B.1
Meloni, A.R.2
Yi, Y.3
Kim, Y.J.4
Doyle, E.5
Cuiffo, B.G.6
Sapp, E.7
Wang, Y.8
Qin, Z.H.9
Chen, J.D.10
-
17
-
-
0031446233
-
Intranuclear neuronal inclusions: A common pathogenic mechanism for glutamine-repeat neurodegenerative diseases?
-
Ross, CA. (1997) intranuclear neuronal inclusions: a common pathogenic mechanism for glutamine-repeat neurodegenerative diseases? Neuron, 19, 1147-1150.
-
(1997)
Neuron
, vol.19
, pp. 1147-1150
-
-
Ross, C.A.1
-
18
-
-
0033037919
-
Huntington's disease intranuclear inclusions contain truncated, ubiquitinated huntingtin protein
-
Sieradzan, K.A., Mechan, A.O., Jones, L., Wanker, E.E., Nukina, N. and Mann, D.M. (1999) Huntington's disease intranuclear inclusions contain truncated, ubiquitinated huntingtin protein. Exp. Neurol., 156, 92-99.
-
(1999)
Exp. Neurol.
, vol.156
, pp. 92-99
-
-
Sieradzan, K.A.1
Mechan, A.O.2
Jones, L.3
Wanker, E.E.4
Nukina, N.5
Mann, D.M.6
-
19
-
-
0032847708
-
Nuclear targeting of mutant Huntingtin increases toxicity
-
Peters, M.F., Nucifora, F.C. Jr, Kushi, J., Seaman, H.C., Cooper, J.K., Herring, W.J., Dawson, V.L., Dawson, T.M. and Ross, C.A. (1999) Nuclear targeting of mutant Huntingtin increases toxicity Mol. Cell. Neurosci., 14, 121-128.
-
(1999)
Mol. Cell. Neurosci.
, vol.14
, pp. 121-128
-
-
Peters, M.F.1
Nucifora F.C., Jr.2
Kushi, J.3
Seaman, H.C.4
Cooper, J.K.5
Herring, W.J.6
Dawson, V.L.7
Dawson, T.M.8
Ross, C.A.9
-
20
-
-
0033119123
-
Nuclear and neuropil a gregates in Huntington's disease: Relationship to neuropathology
-
Gutekunst, C.A., Li, S.H., Yi, H., Mulroy, J.S., Kuemmerle, S., Jones, R., Rye, D., Ferrante, R.J., Hersch, S.M. and Li, X.J. (1999) Nuclear and neuropil a gregates in Huntington's disease: relationship to neuropathology. J. Neurosci., 19, 2522-2534.
-
(1999)
J. Neurosci.
, vol.19
, pp. 2522-2534
-
-
Gutekunst, C.A.1
Li, S.H.2
Yi, H.3
Mulroy, J.S.4
Kuemmerle, S.5
Jones, R.6
Rye, D.7
Ferrante, R.J.8
Hersch, S.M.9
Li, X.J.10
-
21
-
-
0032475941
-
Ataxin-1 nuclear localization and aggregation: Role in polyglutamine-induced disease in SCA1 transgenic mice
-
Klement, I.A., Skinner, P.J., Kaytor, M.D., Yi, H., Hersch, S.M., Clark, H.B., Zoghbi, H.Y. and Orr, H.T. (1998) Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice. Cell, 95, 41-53.
-
(1998)
Cell
, vol.95
, pp. 41-53
-
-
Klement, I.A.1
Skinner, P.J.2
Kaytor, M.D.3
Yi, H.4
Hersch, S.M.5
Clark, H.B.6
Zoghbi, H.Y.7
Orr, H.T.8
-
22
-
-
0032101287
-
The influence of huntingtin protein size on nuclear localization and cellular toxicity
-
Hackam, A.S., Singaraja, R., Wellington, C.L., Metzler, M., McCutcheon, K., Zhang, T., Kalchman, M. and Hayden, M.R. (1998) The influence of huntingtin protein size on nuclear localization and cellular toxicity. J. Cell. Biol., 141, 1097-1105.
-
(1998)
J. Cell. Biol.
, vol.141
, pp. 1097-1105
-
-
Hackam, A.S.1
Singaraja, R.2
Wellington, C.L.3
Metzler, M.4
McCutcheon, K.5
Zhang, T.6
Kalchman, M.7
Hayden, M.R.8
-
23
-
-
0029085920
-
The identification of a functional nuclear localization signal in the Huntington disease protein
-
Bessert, D.A., Gutridge, K.L., Dunbar, J.C. and Carlock, L.R. (1995) The identification of a functional nuclear localization signal in the Huntington disease protein. Brain Res. Mol. Brain Res., 33, 165-173.
-
(1995)
Brain Res. Mol. Brain Res.
, vol.33
, pp. 165-173
-
-
Bessert, D.A.1
Gutridge, K.L.2
Dunbar, J.C.3
Carlock, L.R.4
-
24
-
-
0033614768
-
Evidence for a recruitment and sequestration mechanism in Huntington's disease
-
Preisinger, F., Jordan, B.M., Kazantsev, A. and Housman, D. (1999) Evidence for a recruitment and sequestration mechanism in Huntington's disease. Phil. Trans. R. Soc. Lond B. Biol. Sci., 354, 1029-1034.
-
(1999)
Phil. Trans. R. Soc. Lond. B. Biol. Sci.
, vol.354
, pp. 1029-1034
-
-
Preisinger, F.1
Jordan, B.M.2
Kazantsev, A.3
Housman, D.4
-
25
-
-
0034703869
-
Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells
-
Trettel, F., Rigamonti, D., Hilditch-Maguire, P., Wheeler, V.C., Sharp, A.H., Persichetti, F., Cattaneo, F. and MacDonald, M.E. (2000) Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells, Hum. Mol. Genet., 9, 2799-2809.
-
(2000)
Hum. Mol. Genet.
, vol.9
, pp. 2799-2809
-
-
Trettel, F.1
Rigamonti, D.2
Hilditch-Maguire, P.3
Wheeler, V.C.4
Sharp, A.H.5
Persichetti, F.6
Cattaneo, F.7
MacDonald, M.E.8
-
26
-
-
0032936125
-
Mapping of nuclear localization signals by simultaneous fusion to green fluorescent protein and to beta-galactosidase
-
Sorg, G. and Stamminger, T. (1999) Mapping of nuclear localization signals by simultaneous fusion to green fluorescent protein and to beta-galactosidase. Biotechniques, 26, 858-862.
-
(1999)
Biotechniques
, vol.26
, pp. 858-862
-
-
Sorg, G.1
Stamminger, T.2
-
27
-
-
0031887250
-
Identification and functional characterization of a novel nuclear localization signal present in the yeast Nab2 poly(A) + RNA binding protein
-
Truant, R., Fridell, R.A., Benson, R.E., Bogerd, H. and Cullen, B.R. (1998) Identification and functional characterization of a novel nuclear localization signal present in the yeast Nab2 poly(A) + RNA binding protein. Mol. Cell. Biol., 18, 1449-1458.
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 1449-1458
-
-
Truant, R.1
Fridell, R.A.2
Benson, R.E.3
Bogerd, H.4
Cullen, B.R.5
-
28
-
-
0033527576
-
The human tap nuclear RNA export factor contains a novel transportin-dependent nuclear localization signal that lacks nuclear export signal function
-
Truant, R., Kang, Y. and Cullen, B.R. (1999) The human tap nuclear RNA export factor contains a novel transportin-dependent nuclear localization signal that lacks nuclear export signal function. J. Biol. Chem., 274, 32167-32171.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 32167-32171
-
-
Truant, R.1
Kang, Y.2
Cullen, B.R.3
-
29
-
-
0029894726
-
Protein sequence requirements for function of the human T-cell leukemia virus type 1 Rex nuclear export signal delineated by a novel in vivo randomization-selection assay
-
Bogerd, H.P., Fridell, R.A., Benson, RE., Hua, J. and Cullen, B.R. (1996) Protein sequence requirements for function of the human T-cell leukemia virus type 1 Rex nuclear export signal delineated by a novel in vivo randomization-selection assay. Mol. Cell. Biol., 16, 4207-4214.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 4207-4214
-
-
Bogerd, H.P.1
Fridell, R.A.2
Benson, R.E.3
Hua, J.4
Cullen, B.R.5
-
30
-
-
0035059898
-
Nuclear pore complex architecture and functional dynamics
-
Fahrenkrog, B., Stoffler, D. and Aebi, U. (2001) Nuclear pore complex architecture and functional dynamics. Curr. Top. Microbiol. Immunol., 259, 95-117.
-
(2001)
Curr. Top. Microbiol. Immunol.
, vol.259
, pp. 95-117
-
-
Fahrenkrog, B.1
Stoffler, D.2
Aebi, U.3
-
31
-
-
0032911885
-
The arginine-rich domains present in human immunodeficiency virus type 1 Tat and Rev function as direct importin beta-dependent nuclear localization signals
-
Truant, R. and Cullen, B.R. (1999) The arginine-rich domains present in human immunodeficiency virus type 1 Tat and Rev function as direct importin beta-dependent nuclear localization signals. Mol. Cell. Biol., 19, 1210-1217.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 1210-1217
-
-
Truant, R.1
Cullen, B.R.2
-
32
-
-
0030595342
-
A novel receptor-mediated nuclear protein import pathway
-
Pollard, V.W., Michael, W.M., Nakielny, S., Siomi, M.C., Wang, F. and Dreyfuss, G. (1996) A novel receptor-mediated nuclear protein import pathway. Cell, 86, 985-994.
-
(1996)
Cell
, vol.86
, pp. 985-994
-
-
Pollard, V.W.1
Michael, W.M.2
Nakielny, S.3
Siomi, M.C.4
Wang, F.5
Dreyfuss, G.6
-
33
-
-
0026319596
-
New possibilities for bacterial cytochemistry: Light microscopical demonstration ofbeta-galactosidase in unfixed immobilized bacteria
-
Barer, M.R. (1991) New possibilities for bacterial cytochemistry: light microscopical demonstration ofbeta-galactosidase in unfixed immobilized bacteria. Histochem. J., 23, 529-533.
-
(1991)
Histochem. J.
, vol.23
, pp. 529-533
-
-
Barer, M.R.1
-
34
-
-
0031662269
-
Huntingtin interacts with a family of WW domain proteins
-
Faber, P.W., Barnes, G.T., Srinidhi, J., Chen, I, Gusella, J.F. and MacDonald, M.E. (1998) Huntingtin interacts with a family of WW domain proteins. Hum. Mol. Genet., 7, 1463-1474.
-
(1998)
Hum. Mol. Genet.
, vol.7
, pp. 1463-1474
-
-
Faber, P.W.1
Barnes, G.T.2
Srinidhi, J.3
Chen, I.4
Gusella, J.F.5
MacDonald, M.E.6
-
35
-
-
0033540067
-
A novel nuclear, export activity in HIV-1 matrix protein required for viral replication
-
Dupont, S., Sharova, N., DeHoratius, C., Virbasius, C.M., Zhu, K., Bukrinskaya, A.G., Stevenson, M. and Green, MY. (1999) A novel nuclear, export activity in HIV-1 matrix protein required for viral replication. Nature, 402, 681-685.
-
(1999)
Nature
, vol.402
, pp. 681-685
-
-
Dupont, S.1
Sharova, N.2
DeHoratius, C.3
Virbasius, C.M.4
Zhu, K.5
Bukrinskaya, A.G.6
Stevenson, M.7
Green, M.Y.8
-
36
-
-
0029130169
-
The HIV-I Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs
-
Fischer, U., Huber, J., Boelens, W.C., Mattaj, I.W. and Luhrmann, R. (1995) The HIV-I Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs. Cell, 82, 475-483.
-
(1995)
Cell
, vol.82
, pp. 475-483
-
-
Fischer, U.1
Huber, J.2
Boelens, W.C.3
Mattaj, I.W.4
Luhrmann, R.5
-
37
-
-
0026661059
-
Stable expression of transdominant Rev protein in human T cells inhibits human immunodeficiency virus replication
-
Malim, M.H., Freimuth, W.W., Liu, J., Boyle, T.J., Lyerly, H.K., Cullen, B.R. and Nabel, G.J. (1992) Stable expression of transdominant Rev protein in human T cells inhibits human immunodeficiency virus replication. J. Exp. Med., 176, 1197-1201.
-
(1992)
J. Exp. Med.
, vol.176
, pp. 1197-1201
-
-
Malim, M.H.1
Freimuth, W.W.2
Liu, J.3
Boyle, T.J.4
Lyerly, H.K.5
Cullen, B.R.6
Nabel, G.J.7
-
38
-
-
0030913267
-
How proteins are transported from cytoplasm to the nucleus
-
Yoneda, Y. (1997) How proteins are transported from cytoplasm to the nucleus. J. Biochem. (Tokyo), 121, 811-847.
-
(1997)
J. Biochem. (Tokyo)
, vol.121
, pp. 811-847
-
-
Yoneda, Y.1
-
39
-
-
0031079648
-
LeptomycinB is an inhibitor of nuclear export: Inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type I (HIV-1) Rev protein and Rev-dependent mRNA
-
Wolff, B., Sanglier, J.J. and Wang, Y. (1997) LeptomycinB is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type I (HIV-1) Rev protein and Rev-dependent mRNA. Chem. Biol., 4, 139-147.
-
(1997)
Chem. Biol.
, vol.4
, pp. 139-147
-
-
Wolff, B.1
Sanglier, J.J.2
Wang, Y.3
-
40
-
-
0030924190
-
CRMI is an export receptor for leucine-rich nuclear export signals
-
Fornerod, M., Ohno, M., Yoshida, M. and Mattaj, J.W. (1997) CRMI is an export receptor for leucine-rich nuclear export signals. Cell, 90, 1051-1060.
-
(1997)
Cell
, vol.90
, pp. 1051-1060
-
-
Fornerod, M.1
Ohno, M.2
Yoshida, M.3
Mattaj, J.W.4
-
41
-
-
0032146749
-
Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1
-
Kudo, N., Wolff, B., Sekimoto, T., Schreiner, E.P., Yoneda, Y., Yanagida, M., Horinouchi, S. and Yoshida, M. (1998) Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1. Exp. Cell. Res., 242, 540-547.
-
(1998)
Exp. Cell. Res.
, vol.242
, pp. 540-547
-
-
Kudo, N.1
Wolff, B.2
Sekimoto, T.3
Schreiner, E.P.4
Yoneda, Y.5
Yanagida, M.6
Horinouchi, S.7
Yoshida, M.8
-
42
-
-
0027024350
-
Nuclear protein import using digitonin-permeabilized cells
-
Adam, S.A., Sterne-Marr, R. and Gerace, L. (1992) Nuclear protein import using digitonin-permeabilized cells. Meth. Enzymol., 219, 97-110.
-
(1992)
Meth. Enzymol.
, vol.219
, pp. 97-110
-
-
Adam, S.A.1
Sterne-Marr, R.2
Gerace, L.3
-
43
-
-
0030780220
-
Identification of novel homologues of mouse importin alpha, the alpha subunit of the nuclear pore-targeting complex, and their tissue-specific expression
-
Tsuji, L., Takumi, T., Inamoto, N. and Yoneda, Y. (1997) Identification of novel homologues of mouse importin alpha, the alpha subunit of the nuclear pore-targeting complex, and their tissue-specific expression. FEBS Lett., 416, 30-34.
-
(1997)
FEBS Lett.
, vol.416
, pp. 30-34
-
-
Tsuji, L.1
Takumi, T.2
Inamoto, N.3
Yoneda, Y.4
-
44
-
-
0037335074
-
Specific progressive cAMP reduction implicates energy deficit in presymptomatic Huntington's disease knock-in mice
-
Gines, S., Seong, I.S., Fossale, E., Ivanova, F., Trettel, F., Gusella, J.F., Wheeler, V.C., Persichetti, F. and MacDonald, M.E. (2003) Specific progressive cAMP reduction implicates energy deficit in presymptomatic Huntington's disease knock-in mice. Hum. Mol. Genet., 12, 497-508.
-
(2003)
Hum. Mol. Genet.
, vol.12
, pp. 497-508
-
-
Gines, S.1
Seong, I.S.2
Fossale, E.3
Ivanova, F.4
Trettel, F.5
Gusella, J.F.6
Wheeler, V.C.7
Persichetti, F.8
MacDonald, M.E.9
-
45
-
-
0028077159
-
Basal components of the transcription apparatus (RNA polymerase II, TATA-binding protein) contain activation domains: Is the repetitive C-terminal domain (CTD) of RNA polymerase II a 'portable enhancer domain'?
-
Seipel, K., Georgiev, O., Gerber, H.P. and Schaffher, W. (1994) Basal components of the transcription apparatus (RNA polymerase II, TATA-binding protein) contain activation domains: is the repetitive C-terminal domain (CTD) of RNA polymerase II a 'portable enhancer domain'? Mol. Reprod Dev., 39, 215-225.
-
(1994)
Mol. Reprod. Dev.
, vol.39
, pp. 215-225
-
-
Seipel, K.1
Georgiev, O.2
Gerber, H.P.3
Schaffher, W.4
-
46
-
-
0035031779
-
Polyglutamine and CBP: Fatal attraction?
-
McCampbell, A. and Fischbeck, K.H. (2001) Polyglutamine and CBP: fatal attraction? Nat. Med., 7, 528-530.
-
(2001)
Nat. Med.
, vol.7
, pp. 528-530
-
-
McCampbell, A.1
Fischbeck, K.H.2
-
47
-
-
0032538797
-
Signal transduction in hypoxic cells: Inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1 alpha
-
Kalijo, P.J., Okamoto, K., O'Brien, S., Carrero, P., Makino, Y., Tanaka, H. and Poellinger, L. (1998) Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1 alpha. EMBO J., 17, 6573-6586.
-
(1998)
EMBO J.
, vol.17
, pp. 6573-6586
-
-
Kalijo, P.J.1
Okamoto, K.2
O'Brien, S.3
Carrero, P.4
Makino, Y.5
Tanaka, H.6
Poellinger, L.7
-
48
-
-
0033612576
-
Nuclear import of the TATA-binding protein: Mediation by the karyopherin Kapil14p and a possible mechanism for intranuclear targeting
-
Pemberton, L.F., Rosenblum, J.S. and Bobel, G. (1999) Nuclear import of the TATA-binding protein: mediation by the karyopherin Kapil14p and a possible mechanism for intranuclear targeting. J. Cell Biol., 145, 1407-1417.
-
(1999)
J. Cell Biol.
, vol.145
, pp. 1407-1417
-
-
Pemberton, L.F.1
Rosenblum, J.S.2
Bobel, G.3
-
49
-
-
0035852687
-
The Gln-Ala repeat transcriptional activator CA 150 interacts with huntingtin: Neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis
-
Holbert, S., Denghien, I., Kiechle, T., Rosenblatt, A., Wellington, C., Hayden. M.R., Margolis, R.L., Ross, C.A., Dausset, J., Ferrante, R.J. et al. (2001) The Gln-Ala repeat transcriptional activator CA 150 interacts with huntingtin: neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis. Proc. Natl Acad. Sci. USA, 98, 1811-1816.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 1811-1816
-
-
Holbert, S.1
Denghien, I.2
Kiechle, T.3
Rosenblatt, A.4
Wellington, C.5
Hayden, M.R.6
Margolis, R.L.7
Ross, C.A.8
Dausset, J.9
Ferrante, R.J.10
-
50
-
-
0032450856
-
Amyloid formation by mutant huntingtin: Threshold, progressivity and recruitment of normal polyglutamine proteins
-
Huang, C.C., Faber, P.W., Persichetti, F., Mittal, V., Vonsattel, J.P., MacDonald, M.E. and Gusella, J.F. (1998) Amyloid formation by mutant huntingtin: threshold, progressivity and recruitment of normal polyglutamine proteins. Somat. Cell Mol. Genet., 24, 217-233.
-
(1998)
Somat. Cell Mol. Genet.
, vol.24
, pp. 217-233
-
-
Huang, C.C.1
Faber, P.W.2
Persichetti, F.3
Mittal, V.4
Vonsattel, J.P.5
MacDonald, M.E.6
Gusella, J.F.7
-
51
-
-
0034284565
-
Huntingtin's WW domain partners in Huntington's disease post-mortem brain fulfill genetic criteria for direct involvement in Huntington's disease pathogenesis
-
Passani, L.A., Bedford, M.T., Faber, P.W., McGinnis, K.M., Sharp, A.H., Gusella, J.F., Vonsattel, J.P. and MacDonald, M.E. (2000) Huntingtin's WW domain partners in Huntington's disease post-mortem brain fulfill genetic criteria for direct involvement in Huntington's disease pathogenesis. Hum. Mol. Genet., 9, 2175-2182.
-
(2000)
Hum. Mol. Genet.
, vol.9
, pp. 2175-2182
-
-
Passani, L.A.1
Bedford, M.T.2
Faber, P.W.3
McGinnis, K.M.4
Sharp, A.H.5
Gusella, J.F.6
Vonsattel, J.P.7
MacDonald, M.E.8
-
52
-
-
0032728305
-
Mutant huntingtin forms in vivo complexes with distinct context-dependent conformations of the polyglutainine segment
-
Persichetti, F., Trettel, F., Huang, C.C., Fraefel, C., Timmers, H.T., Gusella, J.F. and MacDonald, M.E. (1999) Mutant huntingtin forms in vivo complexes with distinct context-dependent conformations of the polyglutainine segment. Neurobiol. Dis., 6, 364-375.
-
(1999)
Neurobiol. Dis.
, vol.6
, pp. 364-375
-
-
Persichetti, F.1
Trettel, F.2
Huang, C.C.3
Fraefel, C.4
Timmers, H.T.5
Gusella, J.F.6
MacDonald, M.E.7
-
53
-
-
0029392854
-
HEAT repeats in the Huntington's disease protein
-
Andrade, M.A. and Bork, P. (1995) HEAT repeats in the Huntington's disease protein. Nat. Genet., 11, 115-116.
-
(1995)
Nat. Genet.
, vol.11
, pp. 115-116
-
-
Andrade, M.A.1
Bork, P.2
-
54
-
-
0035897405
-
Identities of sequestered proteins in aggregates from cells with induced polyglutamine expression
-
Suhr, S.T., Senut, M.C., Whitelegge, J.P., Faull, K.F., Cuizon, D.B. and Gage, F.H. (2001) Identities of sequestered proteins in aggregates from cells with induced polyglutamine expression. J. Cell Biol., 153, 283-294.
-
(2001)
J. Cell Biol.
, vol.153
, pp. 283-294
-
-
Suhr, S.T.1
Senut, M.C.2
Whitelegge, J.P.3
Faull, K.F.4
Cuizon, D.B.5
Gage, F.H.6
-
55
-
-
0037459085
-
Regulating access to the genome: Nucleocytoplasmic transport throughout the cell cycle
-
Weis, K. (2003) Regulating access to the genome: nucleocytoplasmic transport throughout the cell cycle. Cell, 112, 441-451.
-
(2003)
Cell
, vol.112
, pp. 441-451
-
-
Weis, K.1
-
56
-
-
0034649661
-
FIP-2, a coiled-coil protein, links Huntingtin to Rab8 and modulates cellular morphogenesis
-
Hattula, K. and Peranen, J. (2000) FIP-2, a coiled-coil protein, links Huntingtin to Rab8 and modulates cellular morphogenesis. Curr. Biol., 10, 1603-1606.
-
(2000)
Curr. Biol.
, vol.10
, pp. 1603-1606
-
-
Hattula, K.1
Peranen, J.2
-
57
-
-
0036500862
-
Perinuclear localization of huntingtin as a consequence of its binding to microtubules through an interaction with beta-tubulin: Relevance to Huntington's disease
-
Hoffner, G., Kahiem, P. and Djian, P. (2002) Perinuclear localization of huntingtin as a consequence of its binding to microtubules through an interaction with beta-tubulin: relevance to Huntington's disease. J. Cell Sci., 115, 941-948.
-
(2002)
J. Cell Sci.
, vol.115
, pp. 941-948
-
-
Hoffner, G.1
Kahiem, P.2
Djian, P.3
-
58
-
-
0032103078
-
Huntingtin: A single bait hooks many species
-
Gusella, J.F. and MacDonald, M.E. (1998) Huntingtin: a single bait hooks many species. Curr. Opin. Neurobiol., 8, 425-430.
-
(1998)
Curr. Opin. Neurobiol.
, vol.8
, pp. 425-430
-
-
Gusella, J.F.1
MacDonald, M.E.2
-
59
-
-
0034960907
-
Postrepression activation of NF-kappaB requires the amino-terminal nuclear export signal specific to IkappaBalpha
-
Huang, T.T. and Miyamoto, S. (2001) Postrepression activation of NF-kappaB requires the amino-terminal nuclear export signal specific to IkappaBalpha. Mol. Cell. Biol., 21, 4737-4747.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 4737-4747
-
-
Huang, T.T.1
Miyamoto, S.2
-
60
-
-
0033486033
-
An N-terminal nuclear export signal is required for the nucleocytoplasmic shuttling of IkappaBalpha
-
Johnson, C., Van Antwerp, D. and Hope, T.J. (1999) An N-terminal nuclear export signal is required for the nucleocytoplasmic shuttling of IkappaBalpha. EMBO J., 18, 6682-6693.
-
(1999)
EMBO J.
, vol.18
, pp. 6682-6693
-
-
Johnson, C.1
Van Antwerp, D.2
Hope, T.J.3
-
61
-
-
0034917123
-
Identification of the full-length huntingtin-interacting protein p23IHBP/HYPB as a DNA-binding factor
-
Rega, S., Stiewe, T., Chang, D.I., Pollmeier, B., Esche, H., Bardenheuer, W., Marquitan, G. and Putzer, B.M. (2001) Identification of the full-length huntingtin-interacting protein p23IHBP/HYPB as a DNA-binding factor. Mol. Cell. Neurosci., 18, 68-79.
-
(2001)
Mol. Cell. Neurosci.
, vol.18
, pp. 68-79
-
-
Rega, S.1
Stiewe, T.2
Chang, D.I.3
Pollmeier, B.4
Esche, H.5
Bardenheuer, W.6
Marquitan, G.7
Putzer, B.M.8
-
62
-
-
0034710914
-
Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm
-
Neufeld, K.L., Nix, D.A., Bogerd, H., Kang, Y., Beckerle, M.C., Cullen, B.R. and White, R.L. (2000) Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm. Proc. Natl Acad. Sci. USA, 97, 12085-12090.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 12085-12090
-
-
Neufeld, K.L.1
Nix, D.A.2
Bogerd, H.3
Kang, Y.4
Beckerle, M.C.5
Cullen, B.R.6
White, R.L.7
-
63
-
-
0034282097
-
Nuclear-cytoplasmic shuttling of APC regulates beta-catenin subcellular localization and turnover
-
Hendeson, B.R. (2000) Nuclear-cytoplasmic shuttling of APC regulates beta-catenin subcellular localization and turnover. Nat. Cell Biol., 2, 653-660.
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 653-660
-
-
Hendeson, B.R.1
-
64
-
-
0031056478
-
HIP-I: A huntingtjn interacting protein isolated by the yeast two-hybrid system
-
Wanker, E.E., Rovira, C., Scherzinger, E., Hasenbank, R., Walter, S., Tait, D., Colicelli, I and Lehrach, H. (1997) HIP-I: a huntingtjn interacting protein isolated by the yeast two-hybrid system. Hum. Mol. Genet., 6, 487-495.
-
(1997)
Hum. Mol. Genet.
, vol.6
, pp. 487-495
-
-
Wanker, E.E.1
Rovira, C.2
Scherzinger, E.3
Hasenbank, R.4
Walter, S.5
Tait, D.6
Colicelli, I.7
Lehrach, H.8
-
65
-
-
0033457373
-
Movement and localization of RNA in the cell nucleus
-
Pederson, T. (1999) Movement and localization of RNA in the cell nucleus. FASEB J., 13 (Suppl. 2), S238-242.
-
(1999)
FASEB J.
, vol.13
, Issue.SUPPL. 2
-
-
Pederson, T.1
-
66
-
-
0035503231
-
The Fragile X mental retardation protein
-
Bardoni, B., Schenck, A. and Mandel, J.L. (2001) The Fragile X mental retardation protein. Brain Res. Bull., 56, 375-382.
-
(2001)
Brain Res. Bull.
, vol.56
, pp. 375-382
-
-
Bardoni, B.1
Schenck, A.2
Mandel, J.L.3
-
67
-
-
18044379515
-
Microarray Identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in Fragile X syndrome
-
Brown, V., Jin, P., Ceman, S., Darnell, J.C., O'Donnell, W.T., Tenenbaum, S.A., Jin, X., Feng, Y., Wilkinson, K.D., Keene, J.D. et al. (2001) Microarray Identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in Fragile X syndrome. Cell, 107, 477-487.
-
(2001)
Cell
, vol.107
, pp. 477-487
-
-
Brown, V.1
Jin, P.2
Ceman, S.3
Darnell, J.C.4
O'Donnell, W.T.5
Tenenbaum, S.A.6
Jin, X.7
Feng, Y.8
Wilkinson, K.D.9
Keene, J.D.10
-
68
-
-
0029818460
-
A nuclear role for the Fragile X mental retardation protein
-
Fridell, R.A., Benson, R.E., Hua, J., Bogerd, H.P. and Cullen, W.R. (1996) A nuclear role for the Fragile X mental retardation protein. EMBO J., 15, 5408-5414.
-
(1996)
EMBO J.
, vol.15
, pp. 5408-5414
-
-
Fridell, R.A.1
Benson, R.E.2
Hua, J.3
Bogerd, H.P.4
Cullen, W.R.5
-
69
-
-
0035869544
-
Tissue-specific proteolysis of Huntingtin (htt) in human brain: Evidence of enhanced levels of N- and C-terminal hU fragments in Huntington's disease striatum
-
Mende-Mueller, L.M., Toneff, T., Hwang, S.R., Chesselet, M.F. and Hook, V.Y. (2001) Tissue-specific proteolysis of Huntingtin (htt) in human brain: evidence of enhanced levels of N- and C-terminal hU fragments in Huntington's disease striatum. J. Neurosci., 21, 1830-1837.
-
(2001)
J. Neurosci.
, vol.21
, pp. 1830-1837
-
-
Mende-Mueller, L.M.1
Toneff, T.2
Hwang, S.R.3
Chesselet, M.F.4
Hook, V.Y.5
-
70
-
-
0032502715
-
Caspase cleavage of gene products associated wit triplet expansion disorders generates truncated fragments containing the polyglutamine tract
-
Wellington, C.L., Ellerby, L.M., Hackam, A.S., Margolis, R.L., Trifiro, M.A., Singaraja, R., McCutcheon, K., Salvesen, G.S., Propp, S.S., Bromm, M. et al. (1998) Caspase cleavage of gene products associated wit triplet expansion disorders generates truncated fragments containing the polyglutamine tract. J. Biol. Chem., 273, 9158-9167.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 9158-9167
-
-
Wellington, C.L.1
Ellerby, L.M.2
Hackam, A.S.3
Margolis, R.L.4
Trifiro, M.A.5
Singaraja, R.6
McCutcheon, K.7
Salvesen, G.S.8
Propp, S.S.9
Bromm, M.10
-
71
-
-
0034426013
-
Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity
-
Li, H., Li, S.H. Johnston, H., Shelbourne, P.F. and Li, X.J. (2000) Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity. Nat. Genet., 25, 385-389.
-
(2000)
Nat. Genet.
, vol.25
, pp. 385-389
-
-
Li, H.1
Li, S.H.2
Johnston, H.3
Shelbourne, P.F.4
Li, X.J.5
-
72
-
-
0036797242
-
Polyglutamine protein aggregates are dynamic
-
Kim, S., Nollen, E.A., Kitagawa, K., Bindokas, V.P. and Morimoto, R.I. (2002) Polyglutamine protein aggregates are dynamic. Nat. Cell Biol., 4, 826-831.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 826-831
-
-
Kim, S.1
Nollen, E.A.2
Kitagawa, K.3
Bindokas, V.P.4
Morimoto, R.I.5
-
73
-
-
0037047123
-
Live-cell imaging reveals divergent intracellular dynamics of polyglutamine disease proteins and supports a sequestration model of pathogenesis
-
Chai, Y., Shao, J., Miller, V.M., Williams, A. and Paulson, H.L. (2002) Live-cell imaging reveals divergent intracellular dynamics of polyglutamine disease proteins and supports a sequestration model of pathogenesis. Proc. Natl Acad. Sci. USA, 99, 9310-9315.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 9310-9315
-
-
Chai, Y.1
Shao, J.2
Miller, V.M.3
Williams, A.4
Paulson, H.L.5
|