Caspase-6 activity in a BACHD mouse modulates steady-state levels of mutant huntingtin protein but is not necessary for production of a 586 amino acid proteolytic fragment

Journal of Neuroscience

Volumn 32, Issue 22, 2012, Pages 7454-7465

  Gafni, Juliette ^a   Papanikolaou, Theodora ^a   Degiacomo, Francesco ^a   Holcomb, Jennifer ^a   Chen, Sylvia ^a   Menalled, Liliana ^b   Kudwa, Andrea ^b   Fitzpatrick, Jon ^b   Miller, Sam ^b   Ramboz, Sylvie ^b   Tuunanen, Pasi I ^c   Lehtimäki, Kimmo K ^c   Yang, X William ^d   Park, Larry ^e   Kwak, Seung ^e   Howland, David ^e   Park, Hyunsun ^e   Ellerby, Lisa M ^a  

^a BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^b PSYCHOGENICS INC   (United States)

^c Cerebricon Limited   (Finland)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e CHDI MANAGEMENT CHDI FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 12; CASPASE 2; CASPASE 3; CASPASE 6; CASPASE 7; CASPASE 8; CASPASE 9; HUNTINGTIN; PROCASPASE; PROCASPASE 3; PROCASPASE 7; PROTEIN P62; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; CORPUS STRIATUM; EMBRYO; FEMALE; HUNTINGTON CHOREA; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; MOUSE MUTANT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OPEN FIELD BEHAVIOR; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ROTAROD TEST; TRANSGENIC MOUSE; UBIQUITINATION; WESTERN BLOTTING;

AGE FACTORS; AMINO ACIDS; ANIMALS; ASPARTIC ACID; BODY WEIGHT; BRAIN; CASPASE 6; CELLS, CULTURED; CORPUS STRIATUM; DISEASE MODELS, ANIMAL; EMBRYO, MAMMALIAN; EXPLORATORY BEHAVIOR; FEMALE; GENE EXPRESSION REGULATION; HUNTINGTON DISEASE; MAGNETIC RESONANCE IMAGING; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, MUTANT STRAINS; MOTOR ACTIVITY; NERVE TISSUE PROTEINS; NEURONS; PROTEOLYSIS; RNA, SMALL INTERFERING; ROTAROD PERFORMANCE TEST; TRINUCLEOTIDE REPEAT EXPANSION; UBIQUITINATION;

EID: 84861630493     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.6379-11.2012     Document Type: Article

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