Cysteine proteases bleomycin hydrolase and cathepsin Z mediate N-terminal proteolysis and toxicity of mutant huntingtin

Journal of Biological Chemistry

Volumn 286, Issue 14, 2011, Pages 12578-12589

  Ratovitski, Tamara ^a   Chighladze, Ekaterine ^a   Waldron, Elaine ^a   Hirschhorn, Ricky R ^a,b   Ross, Christopher A ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HOOD COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCINS; CELL LINES; CLEAVAGE SITES; COLOCALIZATION; CYSTEINE PROTEASE; HEK293 CELLS; HUNTINGTIN; IN-CELL; IN-VIVO; LATE ENDOSOMES; MUTANT HUNTINGTIN; N-TERMINALS; NEURODEGENERATION; OVER-EXPRESSION; PRIMARY SCREEN; PROTEOLYTIC ENZYME; WESTERN BLOTTING; WIDE SCREEN;

AMINO ACIDS; CATALYSTS; CELL CULTURE; ENZYMES; MASS SPECTROMETRY; PEPTIDES; RNA; TOXICITY;

HYDROLASES;

BLEOMYCIN HYDROLASE; CATHEPSIN X; HUNTINGTIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOPLASM; GENE MUTATION; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; MOUSE; MUTAGENESIS; NONHUMAN; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN LOCALIZATION;

BLOTTING, WESTERN; CASPASE 3; CATHEPSIN Z; CELL LINE; CYSTEINE ENDOPEPTIDASES; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; RNA, SMALL INTERFERING;

EID: 79953325705     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.185348     Document Type: Article

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