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Volumn 93, Issue 5, 2015, Pages 473-480

Hypoxia-inducible factors and hypertension: lessons from sleep apnea syndrome

Author keywords

Carotid body; NADPH oxidase; Oxidative stress; Sensory long term facilitation; Superoxide dismutase

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA;

EID: 84939960430     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-015-1274-2     Document Type: Review
Times cited : (42)

References (79)
  • 2
    • 0034711753 scopus 로고    scopus 로고
    • Essential hypertension. Part I: definition and etiology
    • COI: 1:STN:280:DC%2BD3c7ht1OgsQ%3D%3D, PID: 10645931
    • Carretero OA, Oparil S (2000) Essential hypertension. Part I: definition and etiology. Circulation 101:329–335
    • (2000) Circulation , vol.101 , pp. 329-335
    • Carretero, O.A.1    Oparil, S.2
  • 7
    • 0027462562 scopus 로고
    • The occurrence of sleep-disordered breathing among middle-aged adults
    • COI: 1:STN:280:DyaK3s3hvVKlug%3D%3D, PID: 8464434
    • Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S (1993) The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med 328:1230–1235
    • (1993) N Engl J Med , vol.328 , pp. 1230-1235
    • Young, T.1    Palta, M.2    Dempsey, J.3    Skatrud, J.4    Weber, S.5    Badr, S.6
  • 8
    • 0034636477 scopus 로고    scopus 로고
    • Prospective study of the association between sleep-disordered breathing and hypertension
    • COI: 1:STN:280:DC%2BD3c3kvVyhuw%3D%3D, PID: 10805822
    • Peppard PE, Young T, Palta M, Skatrud J (2000) Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med 342:1378–1384
    • (2000) N Engl J Med , vol.342 , pp. 1378-1384
    • Peppard, P.E.1    Young, T.2    Palta, M.3    Skatrud, J.4
  • 9
    • 0029069298 scopus 로고
    • An animal model of the relationship between systemic hypertension and repetitive episodic hypoxia as seen in sleep apnoea
    • PID: 10607178
    • Fletcher EC (1995) An animal model of the relationship between systemic hypertension and repetitive episodic hypoxia as seen in sleep apnoea. J Sleep Res 4:71–77
    • (1995) J Sleep Res , vol.4 , pp. 71-77
    • Fletcher, E.C.1
  • 10
    • 33746847626 scopus 로고    scopus 로고
    • Chronic intermittent hypoxia induces hypoxia-evoked catecholamine efflux in adult rat adrenal medulla via oxidative stress
    • COI: 1:CAS:528:DC%2BD28Xpslaitb0%3D, PID: 16777938
    • Kumar GK, Rai V, Sharma SD, Ramakrishnan DP, Peng YJ, Souvannakitti D, Prabhakar NR (2006) Chronic intermittent hypoxia induces hypoxia-evoked catecholamine efflux in adult rat adrenal medulla via oxidative stress. J Physiol 575:229–239
    • (2006) J Physiol , vol.575 , pp. 229-239
    • Kumar, G.K.1    Rai, V.2    Sharma, S.D.3    Ramakrishnan, D.P.4    Peng, Y.J.5    Souvannakitti, D.6    Prabhakar, N.R.7
  • 12
    • 84864131464 scopus 로고    scopus 로고
    • Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2
    • COI: 1:CAS:528:DC%2BC38Xht1KmtbvF, PID: 22811423
    • Prabhakar NR, Semenza GL (2012) Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2. Physiol Rev 92:967–1003
    • (2012) Physiol Rev , vol.92 , pp. 967-1003
    • Prabhakar, N.R.1    Semenza, G.L.2
  • 13
    • 84897019542 scopus 로고    scopus 로고
    • Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology
    • COI: 1:CAS:528:DC%2BC2cXlt1emsb8%3D, PID: 23937437
    • Semenza GL (2014) Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology. Annu Rev Pathol 9:47–71
    • (2014) Annu Rev Pathol , vol.9 , pp. 47-71
    • Semenza, G.L.1
  • 14
    • 0031461027 scopus 로고    scopus 로고
    • The sympathetic nervous system and obstructive sleep apnea: implications for hypertension
    • COI: 1:STN:280:DyaK1c7kslGgtA%3D%3D, PID: 9488212
    • Narkiewicz K, Somers VK (1997) The sympathetic nervous system and obstructive sleep apnea: implications for hypertension. J Hypertens 15:1613–1619
    • (1997) J Hypertens , vol.15 , pp. 1613-1619
    • Narkiewicz, K.1    Somers, V.K.2
  • 15
    • 0027238259 scopus 로고
    • Augmented resting sympathetic activity in awake patients with obstructive sleep apnea
    • COI: 1:STN:280:DyaK2c%2FgvVShtQ%3D%3D, PID: 8404098
    • Carlson JT, Hedner J, Elam M, Ejnell H, Sellgren J, Wallin BG (1993) Augmented resting sympathetic activity in awake patients with obstructive sleep apnea. Chest 103:1763–1768
    • (1993) Chest , vol.103 , pp. 1763-1768
    • Carlson, J.T.1    Hedner, J.2    Elam, M.3    Ejnell, H.4    Sellgren, J.5    Wallin, B.G.6
  • 16
    • 0023519461 scopus 로고
    • Urinary catecholamines before and after tracheostomy in patients with obstructive sleep apnea and hypertension
    • COI: 1:STN:280:DyaL2s7nslertQ%3D%3D, PID: 3563246
    • Fletcher EC, Miller J, Schaaf JW, Fletcher JG (1987) Urinary catecholamines before and after tracheostomy in patients with obstructive sleep apnea and hypertension. Sleep 10:35–44
    • (1987) Sleep , vol.10 , pp. 35-44
    • Fletcher, E.C.1    Miller, J.2    Schaaf, J.W.3    Fletcher, J.G.4
  • 17
    • 0027513328 scopus 로고
    • Catecholamines and blood pressure in obstructive sleep apnea syndrome
    • COI: 1:STN:280:DyaK3s7ptlCquw%3D%3D, PID: 8449058
    • Marrone O, Riccobono L, Salvaggio A, Mirabella A, Bonanno A, Bonsignore MR (1993) Catecholamines and blood pressure in obstructive sleep apnea syndrome. Chest 103:722–727
    • (1993) Chest , vol.103 , pp. 722-727
    • Marrone, O.1    Riccobono, L.2    Salvaggio, A.3    Mirabella, A.4    Bonanno, A.5    Bonsignore, M.R.6
  • 18
    • 0028841211 scopus 로고
    • Sympathetic neural mechanisms in obstructive sleep apnea
    • COI: 1:CAS:528:DyaK2MXosFyhtrc%3D, PID: 7560081
    • Somers VK, Dyken ME, Clary MP, Abboud FM (1995) Sympathetic neural mechanisms in obstructive sleep apnea. J Clin Invest 96:1897–1904
    • (1995) J Clin Invest , vol.96 , pp. 1897-1904
    • Somers, V.K.1    Dyken, M.E.2    Clary, M.P.3    Abboud, F.M.4
  • 19
    • 0037422591 scopus 로고    scopus 로고
    • Effect of nasal continuous positive airway pressure treatment on blood pressure in patients with obstructive sleep apnea
    • PID: 12515745
    • Becker HF, Jerrentrup A, Ploch T, Grote L, Penzel T, Sullivan CE, Peter JH (2003) Effect of nasal continuous positive airway pressure treatment on blood pressure in patients with obstructive sleep apnea. Circulation 107:68–73
    • (2003) Circulation , vol.107 , pp. 68-73
    • Becker, H.F.1    Jerrentrup, A.2    Ploch, T.3    Grote, L.4    Penzel, T.5    Sullivan, C.E.6    Peter, J.H.7
  • 20
    • 34248578612 scopus 로고    scopus 로고
    • Sympathetic chemoreflex responses in obstructive sleep apnea and effects of continuous positive airway pressure therapy
    • PID: 17494791
    • Imadojemu VA, Mawji Z, Kunselman A, Gray KS, Hogeman CS, Leuenberger UA (2007) Sympathetic chemoreflex responses in obstructive sleep apnea and effects of continuous positive airway pressure therapy. Chest 131:1406–1413
    • (2007) Chest , vol.131 , pp. 1406-1413
    • Imadojemu, V.A.1    Mawji, Z.2    Kunselman, A.3    Gray, K.S.4    Hogeman, C.S.5    Leuenberger, U.A.6
  • 21
    • 0032911907 scopus 로고    scopus 로고
    • Chronic intermittent hypoxia increases sympathetic responsiveness to hypoxia and hypercapnia
    • COI: 1:STN:280:DyaK1M7gsVaisQ%3D%3D, PID: 9887143
    • Greenberg HE, Sica A, Batson D, Scharf SM (1999) Chronic intermittent hypoxia increases sympathetic responsiveness to hypoxia and hypercapnia. J Appl Physiol 86:298–305
    • (1999) J Appl Physiol , vol.86 , pp. 298-305
    • Greenberg, H.E.1    Sica, A.2    Batson, D.3    Scharf, S.M.4
  • 22
    • 63649091223 scopus 로고    scopus 로고
    • Sympathetic response to chemostimulation in conscious rats exposed to chronic intermittent hypoxia
    • COI: 1:CAS:528:DC%2BD1MXktFaltLY%3D, PID: 19429526
    • Huang J, Lusina S, Xie T, Ji E, Xiang S, Liu Y, Weiss JW (2009) Sympathetic response to chemostimulation in conscious rats exposed to chronic intermittent hypoxia. Respir Physiol Neurobiol 166:102–106
    • (2009) Respir Physiol Neurobiol , vol.166 , pp. 102-106
    • Huang, J.1    Lusina, S.2    Xie, T.3    Ji, E.4    Xiang, S.5    Liu, Y.6    Weiss, J.W.7
  • 23
    • 33846235510 scopus 로고    scopus 로고
    • Acute intermittent hypoxia increases both phrenic and sympathetic nerve activities in the rat
    • PID: 17138622
    • Dick TE, Hsieh YH, Wang N, Prabhakar N (2007) Acute intermittent hypoxia increases both phrenic and sympathetic nerve activities in the rat. Exp Physiol 92:87–97
    • (2007) Exp Physiol , vol.92 , pp. 87-97
    • Dick, T.E.1    Hsieh, Y.H.2    Wang, N.3    Prabhakar, N.4
  • 24
    • 77949571119 scopus 로고    scopus 로고
    • Chronic intermittent hypoxia augments chemoreflex control of sympathetic activity: role of the angiotensin II type 1 receptor
    • COI: 1:CAS:528:DC%2BC3cXjvFCiu7w%3D, PID: 20153844
    • Marcus NJ, Li YL, Bird CE, Schultz HD, Morgan BJ (2010) Chronic intermittent hypoxia augments chemoreflex control of sympathetic activity: role of the angiotensin II type 1 receptor. Respir Physiol Neurobiol 171:36–45
    • (2010) Respir Physiol Neurobiol , vol.171 , pp. 36-45
    • Marcus, N.J.1    Li, Y.L.2    Bird, C.E.3    Schultz, H.D.4    Morgan, B.J.5
  • 25
    • 47249118848 scopus 로고    scopus 로고
    • Increased sympathetic outflow in juvenile rats submitted to chronic intermittent hypoxia correlates with enhanced expiratory activity
    • COI: 1:CAS:528:DC%2BD1cXovVSmtro%3D, PID: 18450774
    • Zoccal DB, Simms AE, Bonagamba LG, Braga VA, Pickering AE, Paton JF, Machado BH (2008) Increased sympathetic outflow in juvenile rats submitted to chronic intermittent hypoxia correlates with enhanced expiratory activity. J Physiol 586:3253–3265
    • (2008) J Physiol , vol.586 , pp. 3253-3265
    • Zoccal, D.B.1    Simms, A.E.2    Bonagamba, L.G.3    Braga, V.A.4    Pickering, A.E.5    Paton, J.F.6    Machado, B.H.7
  • 26
    • 0026781962 scopus 로고
    • Sympathetic denervation blocks blood pressure elevation in episodic hypoxia
    • COI: 1:STN:280:DyaK3s%2Flt1Oitw%3D%3D, PID: 1428112
    • Fletcher EC, Lesske J, Culman J, Miller CC, Unger T (1992) Sympathetic denervation blocks blood pressure elevation in episodic hypoxia. Hypertension 20:612–619
    • (1992) Hypertension , vol.20 , pp. 612-619
    • Fletcher, E.C.1    Lesske, J.2    Culman, J.3    Miller, C.C.4    Unger, T.5
  • 27
    • 84862002022 scopus 로고    scopus 로고
    • Peripheral chemoreceptors: function and plasticity of the carotid body
    • Kumar P, Prabhakar NR (2012) Peripheral chemoreceptors: function and plasticity of the carotid body. Comprehensive Physiol 2:141–219
    • (2012) Comprehensive Physiol , vol.2 , pp. 141-219
    • Kumar, P.1    Prabhakar, N.R.2
  • 28
    • 0026490421 scopus 로고
    • A specific and potent pressor effect of hypoxia in patients with sleep apnea
    • COI: 1:STN:280:DyaK3s%2Fntlagug%3D%3D, PID: 1443878
    • Hedner JA, Wilcox I, Laks L, Grunstein RR, Sullivan CE (1992) A specific and potent pressor effect of hypoxia in patients with sleep apnea. Am Rev Respir Dis 146:1240–1245
    • (1992) Am Rev Respir Dis , vol.146 , pp. 1240-1245
    • Hedner, J.A.1    Wilcox, I.2    Laks, L.3    Grunstein, R.R.4    Sullivan, C.E.5
  • 29
    • 0037342849 scopus 로고    scopus 로고
    • Chemoreflexes—physiology and clinical implications
    • COI: 1:CAS:528:DC%2BD3sXitlOru7o%3D, PID: 12609009
    • Kara T, Narkiewicz K, Somers VK (2003) Chemoreflexes—physiology and clinical implications. Acta Physiol Scand 177:377–384
    • (2003) Acta Physiol Scand , vol.177 , pp. 377-384
    • Kara, T.1    Narkiewicz, K.2    Somers, V.K.3
  • 30
    • 0033537701 scopus 로고    scopus 로고
    • Selective potentiation of peripheral chemoreflex sensitivity in obstructive sleep apnea
    • COI: 1:STN:280:DyaK1M7mvFSnsQ%3D%3D, PID: 10069786
    • Narkiewicz K, van de Borne PJ, Pesek CA, Dyken ME, Montano N, Somers VK (1999) Selective potentiation of peripheral chemoreflex sensitivity in obstructive sleep apnea. Circulation 99:1183–1189
    • (1999) Circulation , vol.99 , pp. 1183-1189
    • Narkiewicz, K.1    van de Borne, P.J.2    Pesek, C.A.3    Dyken, M.E.4    Montano, N.5    Somers, V.K.6
  • 31
    • 0025852437 scopus 로고
    • Peripheral chemoreceptor reflex in obstructive sleep apnea patients; a relationship between ventilatory response to hypoxia and nocturnal bradycardia during apnea events
    • PID: 1866415
    • Tafil-Klawe M, Thiele AE, Raschke F, Mayer J, Peter JH, von Wichert W (1991) Peripheral chemoreceptor reflex in obstructive sleep apnea patients; a relationship between ventilatory response to hypoxia and nocturnal bradycardia during apnea events. Pneumologie 45(Suppl 1):309–311
    • (1991) Pneumologie , vol.45 , pp. 309-311
    • Tafil-Klawe, M.1    Thiele, A.E.2    Raschke, F.3    Mayer, J.4    Peter, J.H.5    von Wichert, W.6
  • 32
    • 7444220066 scopus 로고    scopus 로고
    • Chronic intermittent hypoxia enhances cat chemosensory and ventilatory responses to hypoxia
    • COI: 1:CAS:528:DC%2BD2cXpslKlurc%3D, PID: 15319419
    • Rey S, Del Rio R, Alcayaga J, Iturriaga R (2004) Chronic intermittent hypoxia enhances cat chemosensory and ventilatory responses to hypoxia. J Physiol 560:577–586
    • (2004) J Physiol , vol.560 , pp. 577-586
    • Rey, S.1    Del Rio, R.2    Alcayaga, J.3    Iturriaga, R.4
  • 33
    • 33751329032 scopus 로고    scopus 로고
    • Heterozygous HIF-1alpha deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia
    • COI: 1:CAS:528:DC%2BD2sXjslSr, PID: 16973705
    • Peng YJ, Yuan G, Ramakrishnan D, Sharma SD, Bosch-Marce M, Kumar GK, Semenza GL, Prabhakar NR (2006) Heterozygous HIF-1alpha deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia. J Physiol 577:705–716
    • (2006) J Physiol , vol.577 , pp. 705-716
    • Peng, Y.J.1    Yuan, G.2    Ramakrishnan, D.3    Sharma, S.D.4    Bosch-Marce, M.5    Kumar, G.K.6    Semenza, G.L.7    Prabhakar, N.R.8
  • 34
    • 33750628249 scopus 로고    scopus 로고
    • Sympathoexcitatory response to peripheral chemoreflex activation is enhanced in juvenile rats exposed to chronic intermittent hypoxia
    • PID: 16959820
    • Braga VA, Soriano RN, Machado BH (2006) Sympathoexcitatory response to peripheral chemoreflex activation is enhanced in juvenile rats exposed to chronic intermittent hypoxia. Exp Physiol 91:1025–1031
    • (2006) Exp Physiol , vol.91 , pp. 1025-1031
    • Braga, V.A.1    Soriano, R.N.2    Machado, B.H.3
  • 35
    • 0022242581 scopus 로고
    • Role of carotid chemoreceptors in control of breathing at rest and in exercise: studies on human subjects with bilateral carotid body resection
    • COI: 1:STN:280:DyaL28%2FmtlCgsA%3D%3D, PID: 3906209
    • Honda Y (1985) Role of carotid chemoreceptors in control of breathing at rest and in exercise: studies on human subjects with bilateral carotid body resection. Jpn J Physiol 35:535–544
    • (1985) Jpn J Physiol , vol.35 , pp. 535-544
    • Honda, Y.1
  • 36
    • 0027754005 scopus 로고
    • Chemoreflexes—responses, interactions and implications for sleep apnea
    • COI: 1:STN:280:DyaK2c3jtlagug%3D%3D, PID: 8178019, discussion S33-34
    • Somers VK, Abboud FM (1993) Chemoreflexes—responses, interactions and implications for sleep apnea. Sleep 16:S30–S33, discussion S33-34
    • (1993) Sleep , vol.16 , pp. 30-33
    • Somers, V.K.1    Abboud, F.M.2
  • 37
    • 0026656461 scopus 로고
    • Carotid chemoreceptors, systemic blood pressure, and chronic episodic hypoxia mimicking sleep apnea
    • COI: 1:CAS:528:DyaK38XksVGksLk%3D, PID: 1601808
    • Fletcher EC, Lesske J, Behm R, Miller CC 3rd, Stauss H, Unger T (1992) Carotid chemoreceptors, systemic blood pressure, and chronic episodic hypoxia mimicking sleep apnea. J Appl Physiol 72:1978–1984
    • (1992) J Appl Physiol , vol.72 , pp. 1978-1984
    • Fletcher, E.C.1    Lesske, J.2    Behm, R.3    Miller, C.C.4    Stauss, H.5    Unger, T.6
  • 38
    • 1342283025 scopus 로고    scopus 로고
    • Effect of two paradigms of chronic intermittent hypoxia on carotid body sensory activity
    • PID: 14660510, discussion 1196
    • Peng YJ, Prabhakar NR (2004) Effect of two paradigms of chronic intermittent hypoxia on carotid body sensory activity. J Appl Physiol 96:1236–1242, discussion 1196
    • (2004) J Appl Physiol , vol.96 , pp. 1236-1242
    • Peng, Y.J.1    Prabhakar, N.R.2
  • 39
    • 0042691713 scopus 로고    scopus 로고
    • Induction of sensory long-term facilitation in the carotid body by intermittent hypoxia: implications for recurrent apneas
    • COI: 1:CAS:528:DC%2BD3sXmvVeis7g%3D, PID: 12907705
    • Peng YJ, Overholt JL, Kline D, Kumar GK, Prabhakar NR (2003) Induction of sensory long-term facilitation in the carotid body by intermittent hypoxia: implications for recurrent apneas. Proc Natl Acad Sci U S A 100:10073–10078
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 10073-10078
    • Peng, Y.J.1    Overholt, J.L.2    Kline, D.3    Kumar, G.K.4    Prabhakar, N.R.5
  • 40
    • 80055118538 scopus 로고    scopus 로고
    • Chronic intermittent hypoxia-induced vascular enlargement and VEGF upregulation in the rat carotid body is not prevented by antioxidant treatment
    • PID: 21821731
    • Del Rio R, Munoz C, Arias P, Court FA, Moya EA, Iturriaga R (2011) Chronic intermittent hypoxia-induced vascular enlargement and VEGF upregulation in the rat carotid body is not prevented by antioxidant treatment. Am J Physiol Lung Cell Mol Physiol 301:L702–L711
    • (2011) Am J Physiol Lung Cell Mol Physiol , vol.301 , pp. 702-711
    • Del Rio, R.1    Munoz, C.2    Arias, P.3    Court, F.A.4    Moya, E.A.5    Iturriaga, R.6
  • 41
    • 0031035439 scopus 로고    scopus 로고
    • Obstructive sleep apnea as a cause of systemic hypertension. Evidence from a canine model
    • COI: 1:CAS:528:DyaK2sXjvFOmtg%3D%3D, PID: 9011563
    • Brooks D, Horner RL, Kozar LF, Render-Teixeira CL, Phillipson EA (1997) Obstructive sleep apnea as a cause of systemic hypertension. Evidence from a canine model. J Clin Invest 99:106–109
    • (1997) J Clin Invest , vol.99 , pp. 106-109
    • Brooks, D.1    Horner, R.L.2    Kozar, L.F.3    Render-Teixeira, C.L.4    Phillipson, E.A.5
  • 42
    • 79251540222 scopus 로고    scopus 로고
    • 14 nights of intermittent hypoxia elevate daytime blood pressure and sympathetic activity in healthy humans
    • COI: 1:STN:280:DC%2BC3M%2Foslygsg%3D%3D, PID: 20525723
    • Tamisier R, Pepin JL, Remy J, Baguet JP, Taylor JA, Weiss JW, Levy P (2011) 14 nights of intermittent hypoxia elevate daytime blood pressure and sympathetic activity in healthy humans. Eur Respir J 37:119–128
    • (2011) Eur Respir J , vol.37 , pp. 119-128
    • Tamisier, R.1    Pepin, J.L.2    Remy, J.3    Baguet, J.P.4    Taylor, J.A.5    Weiss, J.W.6    Levy, P.7
  • 43
    • 84877000835 scopus 로고    scopus 로고
    • Sensing hypoxia: physiology, genetics and epigenetics
    • COI: 1:CAS:528:DC%2BC3sXos1Kgur8%3D, PID: 23459758
    • Prabhakar NR (2013) Sensing hypoxia: physiology, genetics and epigenetics. J Physiol 591:2245–2257
    • (2013) J Physiol , vol.591 , pp. 2245-2257
    • Prabhakar, N.R.1
  • 44
    • 34247523363 scopus 로고    scopus 로고
    • Adaptive depression in synaptic transmission in the nucleus of the solitary tract after in vivo chronic intermittent hypoxia: evidence for homeostatic plasticity
    • COI: 1:CAS:528:DC%2BD2sXltF2jurc%3D, PID: 17460079
    • Kline DD, Ramirez-Navarro A, Kunze DL (2007) Adaptive depression in synaptic transmission in the nucleus of the solitary tract after in vivo chronic intermittent hypoxia: evidence for homeostatic plasticity. J Neurosci 27:4663–4673
    • (2007) J Neurosci , vol.27 , pp. 4663-4673
    • Kline, D.D.1    Ramirez-Navarro, A.2    Kunze, D.L.3
  • 45
    • 0033841946 scopus 로고    scopus 로고
    • Chronic-intermittent hypoxia: a model of sympathetic activation in the rat
    • COI: 1:STN:280:DC%2BD3cvosVeltQ%3D%3D, PID: 10963773
    • Sica AL, Greenberg HE, Ruggiero DA, Scharf SM (2000) Chronic-intermittent hypoxia: a model of sympathetic activation in the rat. Respir Physiol 121:173–184
    • (2000) Respir Physiol , vol.121 , pp. 173-184
    • Sica, A.L.1    Greenberg, H.E.2    Ruggiero, D.A.3    Scharf, S.M.4
  • 46
    • 79952581618 scopus 로고    scopus 로고
    • Altered sympathetic reflexes and vascular reactivity in rats after exposure to chronic intermittent hypoxia
    • COI: 1:CAS:528:DC%2BC3MXksFOrsLk%3D, PID: 21242253
    • Silva AQ, Schreihofer AM (2011) Altered sympathetic reflexes and vascular reactivity in rats after exposure to chronic intermittent hypoxia. J Physiol 589:1463–1476
    • (2011) J Physiol , vol.589 , pp. 1463-1476
    • Silva, A.Q.1    Schreihofer, A.M.2
  • 47
    • 0030738644 scopus 로고    scopus 로고
    • Blood pressure response to chronic episodic hypoxia: role of the sympathetic nervous system
    • COI: 1:STN:280:DyaK2szmtFGhuw%3D%3D, PID: 9216950
    • Bao G, Metreveli N, Li R, Taylor A, Fletcher EC (1997) Blood pressure response to chronic episodic hypoxia: role of the sympathetic nervous system. J Appl Physiol 83:95–101
    • (1997) J Appl Physiol , vol.83 , pp. 95-101
    • Bao, G.1    Metreveli, N.2    Li, R.3    Taylor, A.4    Fletcher, E.C.5
  • 48
    • 22044436344 scopus 로고    scopus 로고
    • Developmental changes in HIF transcription factor in carotid body: relevance for O2 sensing by chemoreceptors
    • COI: 1:CAS:528:DC%2BD2MXlsVyjsbs%3D, PID: 15879294
    • Roux JC, Brismar H, Aperia A, Lagercrantz H (2005) Developmental changes in HIF transcription factor in carotid body: relevance for O2 sensing by chemoreceptors. Pediatr Res 58:53–57
    • (2005) Pediatr Res , vol.58 , pp. 53-57
    • Roux, J.C.1    Brismar, H.2    Aperia, A.3    Lagercrantz, H.4
  • 49
    • 84863989372 scopus 로고    scopus 로고
    • Differential expressions and roles of hypoxia-inducible factor-1alpha, -2alpha and -3alpha in the rat carotid body during chronic and intermittent hypoxia
    • COI: 1:CAS:528:DC%2BD1cXhtVKgtL0%3D, PID: 18072084
    • Lam SY, Tipoe GL, Liong EC, Fung ML (2008) Differential expressions and roles of hypoxia-inducible factor-1alpha, -2alpha and -3alpha in the rat carotid body during chronic and intermittent hypoxia. Histol Histopathol 23:271–280
    • (2008) Histol Histopathol , vol.23 , pp. 271-280
    • Lam, S.Y.1    Tipoe, G.L.2    Liong, E.C.3    Fung, M.L.4
  • 50
    • 84934438351 scopus 로고    scopus 로고
    • Hypoxia-inducible factor (HIF)-1alpha and endothelin-1 expression in the rat carotid body during intermittent hypoxia
    • COI: 1:CAS:528:DC%2BC3cXltVWjtw%3D%3D, PID: 16683693, discussion 351-359
    • Lam SY, Tipoe GL, Liong EC, Fung ML (2006) Hypoxia-inducible factor (HIF)-1alpha and endothelin-1 expression in the rat carotid body during intermittent hypoxia. Adv Exp Med Biol 580:21–27, discussion 351-359
    • (2006) Adv Exp Med Biol , vol.580 , pp. 21-27
    • Lam, S.Y.1    Tipoe, G.L.2    Liong, E.C.3    Fung, M.L.4
  • 51
    • 59049086571 scopus 로고    scopus 로고
    • Intermittent hypoxia degrades HIF-2alpha via calpains resulting in oxidative stress: implications for recurrent apnea-induced morbidities
    • COI: 1:CAS:528:DC%2BD1MXhsFyisro%3D, PID: 19147445
    • Nanduri J, Wang N, Yuan G, Khan SA, Souvannakitti D, Peng YJ, Kumar GK, Garcia JA, Prabhakar NR (2009) Intermittent hypoxia degrades HIF-2alpha via calpains resulting in oxidative stress: implications for recurrent apnea-induced morbidities. Proc Natl Acad Sci U S A 106:1199–1204
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 1199-1204
    • Nanduri, J.1    Wang, N.2    Yuan, G.3    Khan, S.A.4    Souvannakitti, D.5    Peng, Y.J.6    Kumar, G.K.7    Garcia, J.A.8    Prabhakar, N.R.9
  • 52
    • 0024259862 scopus 로고
    • Measurement of carotid body blood flow in cats by use of radioactive microspheres
    • Barnett S, Mulligan E, Wagerle LC, Lahiri S (1988) Measurement of carotid body blood flow in cats by use of radioactive microspheres. J Appl Physiol 65:2484–2489
    • (1988) J Appl Physiol , vol.65 , pp. 2484-2489
    • Barnett, S.1    Mulligan, E.2    Wagerle, L.C.3    Lahiri, S.4
  • 53
    • 84939665835 scopus 로고
    • Dimensions and volume of the carotid body in the adult cat, and their relation to the specific blood flow through the organ. A histological and morphometric study
    • COI: 1:STN:280:DyaL283pt1Smtw%3D%3D
    • Clarke JA, de Burgh DM, Ead HW (1986) Dimensions and volume of the carotid body in the adult cat, and their relation to the specific blood flow through the organ. A histological and morphometric study. Acta Anat (Basel) 126:84–86
    • (1986) Acta Anat (Basel) , vol.126 , pp. 84-86
    • Clarke, J.A.1    de Burgh, D.M.2    Ead, H.W.3
  • 54
    • 84944496909 scopus 로고
    • Observations on the volume of blood flow and oxygen utilization of the carotid body in the cat
    • de Burgh Daly DM, Lambertsen CJ, Schweitzer A (1954) Observations on the volume of blood flow and oxygen utilization of the carotid body in the cat. J Physiol 125:67–89
    • (1954) J Physiol , vol.125 , pp. 67-89
    • de Burgh Daly, D.M.1    Lambertsen, C.J.2    Schweitzer, A.3
  • 55
    • 84885058064 scopus 로고    scopus 로고
    • Xanthine oxidase mediates hypoxia-inducible factor-2alpha degradation by intermittent hypoxia
    • COI: 1:CAS:528:DC%2BC3sXhsF2rsrvM, PID: 24124516
    • Nanduri J, Vaddi DR, Khan SA, Wang N, Makerenko V, Prabhakar NR (2013) Xanthine oxidase mediates hypoxia-inducible factor-2alpha degradation by intermittent hypoxia. PLoS One 8:e75838
    • (2013) PLoS One , vol.8 , pp. 75838
    • Nanduri, J.1    Vaddi, D.R.2    Khan, S.A.3    Wang, N.4    Makerenko, V.5    Prabhakar, N.R.6
  • 56
    • 54049088213 scopus 로고    scopus 로고
    • Induction of HIF-1alpha expression by intermittent hypoxia: involvement of NADPH oxidase, Ca2+ signaling, prolyl hydroxylases, and mTOR
    • COI: 1:CAS:528:DC%2BD1cXhtlOqt73E, PID: 18651560
    • Yuan G, Nanduri J, Khan S, Semenza GL, Prabhakar NR (2008) Induction of HIF-1alpha expression by intermittent hypoxia: involvement of NADPH oxidase, Ca2+ signaling, prolyl hydroxylases, and mTOR. J Cell Physiol 217:674–685
    • (2008) J Cell Physiol , vol.217 , pp. 674-685
    • Yuan, G.1    Nanduri, J.2    Khan, S.3    Semenza, G.L.4    Prabhakar, N.R.5
  • 57
    • 84928923228 scopus 로고    scopus 로고
    • HIF-1α activation by intermittent hypoxia requires NADPH oxidase stimulation by xanthine oxidase
    • Nanduri J, Vaddi D, Khan S, Wang N, Makarenko V, Semenza G, Prabhakar NR (2015) HIF-1α activation by intermittent hypoxia requires NADPH oxidase stimulation by xanthine oxidase. PLos One: 10:e0119762
    • (2015) PLos One , vol.e0119762 , pp. 10
    • Nanduri, J.1    Vaddi, D.2    Khan, S.3    Wang, N.4    Makarenko, V.5    Semenza, G.6    Prabhakar, N.R.7
  • 58
    • 14244256421 scopus 로고    scopus 로고
    • Ca2+/calmodulin kinase-dependent activation of hypoxia inducible factor 1 transcriptional activity in cells subjected to intermittent hypoxia
    • COI: 1:CAS:528:DC%2BD2MXhtVynu7Y%3D, PID: 15569687
    • Yuan G, Nanduri J, Bhasker CR, Semenza GL, Prabhakar NR (2005) Ca2+/calmodulin kinase-dependent activation of hypoxia inducible factor 1 transcriptional activity in cells subjected to intermittent hypoxia. J Biol Chem 280:4321–4328
    • (2005) J Biol Chem , vol.280 , pp. 4321-4328
    • Yuan, G.1    Nanduri, J.2    Bhasker, C.R.3    Semenza, G.L.4    Prabhakar, N.R.5
  • 59
    • 79960697192 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 mediates increased expression of NADPH oxidase-2 in response to intermittent hypoxia
    • COI: 1:CAS:528:DC%2BC3MXhtVKksrvO, PID: 21302291
    • Yuan G, Khan SA, Luo W, Nanduri J, Semenza GL, Prabhakar NR (2011) Hypoxia-inducible factor 1 mediates increased expression of NADPH oxidase-2 in response to intermittent hypoxia. J Cell Physiol 226:2925–2933
    • (2011) J Cell Physiol , vol.226 , pp. 2925-2933
    • Yuan, G.1    Khan, S.A.2    Luo, W.3    Nanduri, J.4    Semenza, G.L.5    Prabhakar, N.R.6
  • 60
    • 0031028005 scopus 로고    scopus 로고
    • Developmental loss of hypoxic chemosensitivity in rat adrenomedullary chromaffin cells
    • COI: 1:CAS:528:DyaK2sXhtFClsLY%3D, PID: 9032697
    • Thompson RJ, Jackson A, Nurse CA (1997) Developmental loss of hypoxic chemosensitivity in rat adrenomedullary chromaffin cells. J Physiol 498(Pt 2):503–510
    • (1997) J Physiol , vol.498 , pp. 503-510
    • Thompson, R.J.1    Jackson, A.2    Nurse, C.A.3
  • 64
    • 79952609061 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 2alpha (HIF-2alpha) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension
    • COI: 1:CAS:528:DC%2BC3MXisVaku7g%3D, PID: 21288809
    • Peng YJ, Nanduri J, Khan SA, Yuan G, Wang N, Kinsman B, Vaddi DR, Kumar GK, Garcia JA, Semenza GL et al (2011) Hypoxia-inducible factor 2alpha (HIF-2alpha) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension. Proc Natl Acad Sci U S A 108:3065–3070
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 3065-3070
    • Peng, Y.J.1    Nanduri, J.2    Khan, S.A.3    Yuan, G.4    Wang, N.5    Kinsman, B.6    Vaddi, D.R.7    Kumar, G.K.8    Garcia, J.A.9    Semenza, G.L.10
  • 66
    • 0035061344 scopus 로고    scopus 로고
    • Oxygen sensing during intermittent hypoxia: cellular and molecular mechanisms
    • COI: 1:CAS:528:DC%2BD3MXjsFertLw%3D, PID: 11299293
    • Prabhakar NR (2001) Oxygen sensing during intermittent hypoxia: cellular and molecular mechanisms. J Appl Physiol 90:1986–1994
    • (2001) J Appl Physiol , vol.90 , pp. 1986-1994
    • Prabhakar, N.R.1
  • 67
    • 0036528981 scopus 로고    scopus 로고
    • Increased adhesion molecules expression and production of reactive oxygen species in leukocytes of sleep apnea patients
    • PID: 11934717
    • Dyugovskaya L, Lavie P, Lavie L (2002) Increased adhesion molecules expression and production of reactive oxygen species in leukocytes of sleep apnea patients. Am J Respir Crit Care Med 165:934–939
    • (2002) Am J Respir Crit Care Med , vol.165 , pp. 934-939
    • Dyugovskaya, L.1    Lavie, P.2    Lavie, L.3
  • 68
    • 34547889942 scopus 로고    scopus 로고
    • ROS signaling in systemic and cellular responses to chronic intermittent hypoxia
    • COI: 1:CAS:528:DC%2BD2sXosVyku7o%3D, PID: 17627465
    • Prabhakar NR, Kumar GK, Nanduri J, Semenza GL (2007) ROS signaling in systemic and cellular responses to chronic intermittent hypoxia. Antioxid Redox Signal 9:1397–1403
    • (2007) Antioxid Redox Signal , vol.9 , pp. 1397-1403
    • Prabhakar, N.R.1    Kumar, G.K.2    Nanduri, J.3    Semenza, G.L.4
  • 70
    • 0036121191 scopus 로고    scopus 로고
    • Aconitase: sensitive target and measure of superoxide
    • COI: 1:CAS:528:DC%2BD38XjsFajt7w%3D, PID: 11912933
    • Gardner PR (2002) Aconitase: sensitive target and measure of superoxide. Methods Enzymol 349:9–23
    • (2002) Methods Enzymol , vol.349 , pp. 9-23
    • Gardner, P.R.1
  • 71
    • 84885952533 scopus 로고    scopus 로고
    • Role of oxidative stress-induced endothelin-converting enzyme activity in the alteration of carotid body function by chronic intermittent hypoxia
    • COI: 1:CAS:528:DC%2BC3sXhs1Oku7bE, PID: 23913764
    • Peng YJ, Nanduri J, Raghuraman G, Wang N, Kumar GK, Prabhakar NR (2013) Role of oxidative stress-induced endothelin-converting enzyme activity in the alteration of carotid body function by chronic intermittent hypoxia. Exp Physiol 98:1620–1630
    • (2013) Exp Physiol , vol.98 , pp. 1620-1630
    • Peng, Y.J.1    Nanduri, J.2    Raghuraman, G.3    Wang, N.4    Kumar, G.K.5    Prabhakar, N.R.6
  • 72
    • 65549160457 scopus 로고    scopus 로고
    • NADPH oxidase is required for the sensory plasticity of the carotid body by chronic intermittent hypoxia
    • COI: 1:CAS:528:DC%2BD1MXltFShsL0%3D, PID: 19369559
    • Peng YJ, Nanduri J, Yuan G, Wang N, Deneris E, Pendyala S, Natarajan V, Kumar GK, Prabhakar NR (2009) NADPH oxidase is required for the sensory plasticity of the carotid body by chronic intermittent hypoxia. J Neurosci 29:4903–4910
    • (2009) J Neurosci , vol.29 , pp. 4903-4910
    • Peng, Y.J.1    Nanduri, J.2    Yuan, G.3    Wang, N.4    Deneris, E.5    Pendyala, S.6    Natarajan, V.7    Kumar, G.K.8    Prabhakar, N.R.9
  • 73
    • 84870439505 scopus 로고    scopus 로고
    • Contribution of TASK-like potassium channels to the enhanced rat carotid body responsiveness to hypoxia
    • COI: 1:CAS:528:DC%2BC2MXitVaitLo%3D, PID: 23080184
    • Ortiz FC, Del Rio R, Varas R, Iturriaga R (2012) Contribution of TASK-like potassium channels to the enhanced rat carotid body responsiveness to hypoxia. Adv Exp Med Biol 758:365–371
    • (2012) Adv Exp Med Biol , vol.758 , pp. 365-371
    • Ortiz, F.C.1    Del Rio, R.2    Varas, R.3    Iturriaga, R.4
  • 74
    • 77956202249 scopus 로고    scopus 로고
    • NADPH oxidase-dependent regulation of T-type Ca2+ channels and ryanodine receptors mediate the augmented exocytosis of catecholamines from intermittent hypoxia-treated neonatal rat chromaffin cells
    • COI: 1:CAS:528:DC%2BC3cXhtVOhsbrN, PID: 20705601
    • Souvannakitti D, Nanduri J, Yuan G, Kumar GK, Fox AP, Prabhakar NR (2010) NADPH oxidase-dependent regulation of T-type Ca2+ channels and ryanodine receptors mediate the augmented exocytosis of catecholamines from intermittent hypoxia-treated neonatal rat chromaffin cells. J Neurosci 30:10763–10772
    • (2010) J Neurosci , vol.30 , pp. 10763-10772
    • Souvannakitti, D.1    Nanduri, J.2    Yuan, G.3    Kumar, G.K.4    Fox, A.P.5    Prabhakar, N.R.6
  • 75
    • 64149093520 scopus 로고    scopus 로고
    • Reactive oxygen species-dependent endothelin signaling is required for augmented hypoxic sensory response of the neonatal carotid body by intermittent hypoxia
    • COI: 1:CAS:528:DC%2BD1MXjtFGktbc%3D, PID: 19109370
    • Pawar A, Nanduri J, Yuan G, Khan SA, Wang N, Kumar GK, Prabhakar NR (2009) Reactive oxygen species-dependent endothelin signaling is required for augmented hypoxic sensory response of the neonatal carotid body by intermittent hypoxia. Am J Physiol Regul Integr Comp Physiol 296:R735–R742
    • (2009) Am J Physiol Regul Integr Comp Physiol , vol.296 , pp. 735-742
    • Pawar, A.1    Nanduri, J.2    Yuan, G.3    Khan, S.A.4    Wang, N.5    Kumar, G.K.6    Prabhakar, N.R.7
  • 76
    • 33846794822 scopus 로고    scopus 로고
    • The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology
    • COI: 1:CAS:528:DC%2BD2sXitVagsr4%3D, PID: 17237347
    • Bedard K, Krause KH (2007) The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev 87:245–313
    • (2007) Physiol Rev , vol.87 , pp. 245-313
    • Bedard, K.1    Krause, K.H.2
  • 77
    • 0027181186 scopus 로고
    • Evidence that mitochondrial respiration is a source of potentially toxic oxygen free radicals in intact rabbit hearts subjected to ischemia and reflow
    • COI: 1:CAS:528:DyaK3sXlslylsrY%3D, PID: 8395507
    • Ambrosio G, Zweier JL, Duilio C, Kuppusamy P, Santoro G, Elia PP, Tritto I, Cirillo P, Condorelli M, Chiariello M (1993) Evidence that mitochondrial respiration is a source of potentially toxic oxygen free radicals in intact rabbit hearts subjected to ischemia and reflow. J Biol Chem 268:18532–18541
    • (1993) J Biol Chem , vol.268 , pp. 18532-18541
    • Ambrosio, G.1    Zweier, J.L.2    Duilio, C.3    Kuppusamy, P.4    Santoro, G.5    Elia, P.P.6    Tritto, I.7    Cirillo, P.8    Condorelli, M.9    Chiariello, M.10
  • 78
    • 79251546780 scopus 로고    scopus 로고
    • NADPH oxidase 2 mediates intermittent hypoxia-induced mitochondrial complex I inhibition: relevance to blood pressure changes in rats
    • COI: 1:CAS:528:DC%2BC3MXlsFOjsA%3D%3D, PID: 20618070
    • Khan SA, Nanduri J, Yuan G, Kinsman B, Kumar GK, Joseph J, Kalyanaraman B, Prabhakar NR (2011) NADPH oxidase 2 mediates intermittent hypoxia-induced mitochondrial complex I inhibition: relevance to blood pressure changes in rats. Antioxid Redox Signal 14:533–542
    • (2011) Antioxid Redox Signal , vol.14 , pp. 533-542
    • Khan, S.A.1    Nanduri, J.2    Yuan, G.3    Kinsman, B.4    Kumar, G.K.5    Joseph, J.6    Kalyanaraman, B.7    Prabhakar, N.R.8
  • 79
    • 84901236200 scopus 로고    scopus 로고
    • HIF and pulmonary vascular responses to hypoxia
    • COI: 1:CAS:528:DC%2BC2cXpsFCgtLw%3D, PID: 24336881
    • Shimoda LA, Laurie SS (2014) HIF and pulmonary vascular responses to hypoxia. J Appl Physiol 116:867–874
    • (2014) J Appl Physiol , vol.116 , pp. 867-874
    • Shimoda, L.A.1    Laurie, S.S.2


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