Chronic intermittent hypoxia increases sympathetic responsiveness to hypoxia and hypercapnia

Journal of Applied Physiology

Volumn 86, Issue 1, 1999, Pages 298-305

  Greenberg, Harly E ^a   Sica, Anthony ^a   Batson, Deirdre ^a   Scharf, Steven M ^a  

^a LONG ISLAND JEWISH MEDICAL CENTER   (United States)

Author keywords

Chemoreflex; Intermittent hypoxia; Sleep apnea; Sympathetic nervous system

Indexed keywords

CARBON DIOXIDE; URETHAN;

ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMORECEPTOR REFLEX; CIRCADIAN RHYTHM; CONTROLLED STUDY; HYPERCAPNIA; HYPOXIA; LONG TERM EXPOSURE; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PREGANGLIONIC NERVE CELL; PRIORITY JOURNAL; RAT; SLEEP APNEA SYNDROME; SYMPATHETIC REFLEX;

EID: 0032911907     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1999.86.1.298     Document Type: Article

References (37)

1. Angel, A., and J. Unwin. The effect of urethane on transmission along the dorsal column sensory pathway in the rat. J. Physiol. (Lond.) 208: 32p-33p, 1970.
2. Carlson, J. T., J. Hedner, M. Elam, H. Ejnell, J. Sellgren, and B. G. Wallin. Augmented resting sympathetic activity in awake patients with obstructive sleep apnea. Chest 103: 1763-1768, 1993.
3. 2 tension. J. Neurophysiol. 31: 142-165, 1968.
4. Cross, B. A., and R. G. Dyer. Unit activity in rat diencephalic islands - the effect of anesthesia. J. Physiol. (Lond.) 212: 467-481, 1971.
5. Cross, B. A., and I. A. Silver. Unit activity in the hypothalamus and the sympathetic response to hypoxia and hypercapnia. Exp. Neurol. 7: 375-393, 1963.
6. Czyzyk, M. F., L. Fedorko, and A. Trzebski. Pattern of the respiratory modulation of the sympathetic activity is species dependent: synchronization of the sympathetic outflow over the respiratory cycle in the rat. In: Organization of the Autonomic Nervous System, Central and Peripheral Mechanisms, edited by J. Ciriello, F. R. Calaresu, L. P. Renaud, and C. Polosa. New York: Liss, 1987, p. 143-152.
7. Czyzyk-Krzeska, M. F., and A. Trzebski. Respiratory related discharge pattern of sympathetic nerve activity in the spontaneously hypertensive rat. J. Physiol. (Lond.) 426: 355-368, 1990.
8. Dumas, S., J. M. Pequignot, G. Ghilini, J. Mallet, and M. Denavit-Saubre. Plasticity of tyrosine hydroxylase gene expression in the rat nucleus tractus solitarius after ventilatory acclimatization to hypoxia. Mol. Brain Res. 40: 188-194, 1996.
9. Eckberg, D. L., C. H. Nerhed, and G. Wallin. Respiratory modulation of the muscle sympathetic and vagal cardiac outflow in man. J. Physiol. (Lond.) 365: 181-196, 1985.
10. Fakuda, Y., A. Sata, A. Suzuki, and A. Trzebski. Autonomic nerve and cardiovascular responses to changing blood oxygen and carbon dioxide levels in the rat. J. Auton. Nerv. Syst. 28: 61-74, 1989.
11. Fletcher, E., J. Lesske, R. Behm, C. Miller III, H. Staus, and T. Unger. Carotid chemoreceptors, systemic blood pressure and chronic episodic hypoxia mimicking sleep apnea. J. Appl. Physiol. 72: 1978-1984, 1992.
12. Fletcher, E., J. Miller, W. Schaaf, and J. Fletcher. Urinary catecholamines before and after tracheostomy in patients with obstructive sleep apnea and hypertension. Sleep 10: 35-44, 1987.
13. Fletcher, E. C., J. Lesske, J. Culman, C. C. Miller, and T. Unger. Sympathetic denervation blocks blood pressure elevation in episodic hypoxia. Hypertension 20: 612-619, 1992.
14. Fletcher, E. C., J. Lesske, W. Qian, C. C. Miller, and T. Unger. Repetitive episodic hypoxia causes diurnal elevations of systemic blood pressure in rats. Hypertension 19: 555-561, 1992.
15. Haselton, J. R., and P. G. Guyenet. Central respiratory modulation of medullary sympathoexcitatory neurons in the rat. Am. J. Physiol. 256 (Regulatory Integrative Comp. Physiol. 25): R739-R750, 1989.
16. Hedner, J., H. Ejnell, T. Sleegren, and G. Wallin. Is high fluctuating muscle nerve sympathetic activity in the sleep apnea syndrome of pathogenic importance for the development of hypertension? J. Hypertens. 6: S529-S531, 1988.
17. Hedner, J., I. Wilcox, L. Laks, R. Grunstein, and C. Sullivan. A specific and potent pressor effect of hypoxia in patients with sleep apnea. Am. Rev. Respir. Dis. 146: 1240-1245, 1992.
18. Hla, K., T. Young, M. Bidwell, M. Palta, J. Skatrud, and J. Dempsey. Sleep apnea and hypertension. A population based study. Ann. Intern. Med. 120: 382-388, 1994.
19. Hung, J., E. Whitford, R. Parsons, and D. Hillmean. Association of sleep apnea with myocardial infarction in men. Lancet 336: 261-264, 1990.
20. Koskenvuo, M., J. Kaprio, M. Partinen, H. Langinvaio, S. Sarna, and K. Heikkila. Snoring as a risk factor for hypertension and angina pectoris. Lancet 1: 89-95, 1985.
21. Johnson, T. S., J. B. Young, and L. Landsberg. Sympathoadrenal responses to acute and chronic hypoxia in the rat. J. Clin. Invest. 71: 1263-1272, 1983.
22. Maggie, C. A., and A. Mali. Suitability of urethane anesthesia for physiopharmacological investigations in various systems. Part I: general considerations. Experientia 42: 109-210, 1986.
23. Mark, A. Regulation of sympathetic nerve activity in mild human hypertension. J. Hypertens. 8, Suppl. 1: S67-S75, 1990.
24. Palomaki, H., M. Partinen, T. Erkinjuntti, and M. Kaste. Snoring, sleep apnea syndrome and stroke. Neurology 42, Suppl. 6: 75-82, 1992.
25. Przybylski, J., A. Trzebski, T. Czyzewski, and J. Jodkowski. Responses to hyperoxia, hypoxia, hypercapnia and almitrine in spontaneously hypertensive rats. Bull. Eur. Physiopath. Respir. 18. Suppl. 4: 154-54, 1982.
26. Rao, R., H. Greenberg, A. Sica, and S. M. Scharf. γ-Aminobutyric acid contributes to modulation of cardiorespiratory control after chronic ventilatory loading. Respir. Physiol. 108: 35-44, 1997.
27. Reis, D., E. Golanov, D. Ruggiero, and M. K. Sun. Sympathoexcitatory neurons of the rostral ventrolateral medullar are oxygen sensors and essential elements in the tonic and reflex control of the systemic and cerebral circulations. J. Hypertens. 12, Suppl. 10: S159-S180, 1994.
28. Rose, C. E., Jr., J. A. Althaus, D. L. Kaiser, E. D. Miller, and R. M. Carey. Acute hypoxemia and hypercapnia: increase in plasma catecholamines in conscious dogs. Am. J. Physiol. 246 (Heart Circ. Physiol. 15): H924-H929, 1984.
29. Shepard, J. W. Gas exchange and hemodynamics during sleep. Med. Clin. North Am. 69: 1243-1264, 1985.
30. Sommers, V., A. Mark, and F. M. Abboud. Interaction of baroreceptor and chemoreceptor reflex control of sympathetic nerve activity in normal humans. J. Clin. Invest. 87: 1953-1957, 1991.
31. Sommers, V. K., M. E. Dyken, M. Clary, and M. Abboud. Sympathetic neural mechanisms in obstructive sleep apnea. J. Clin. Invest. 96: 1897-1904, 1995.
32. Sun, M. K., and D. Reis. Hypoxia selectively excites vasomotor neurons of rostral ventrolateral medulla in rats. Am. J. Physiol. 266 (Regulatory Integrative Comp. Physiol. 35): R245-R256, 1994.
33. Sylvester, J. T., S. M. Scharf, R. D. Gilbert, R. S. Fitzgerald, and R. J. Traystman. Hypoxic and CO hypoxia in dogs. Hemodynamics, carotid reflexes, and catecholamines. Am. J. Physiol. 236 (Heart Circ. Physiol. 5): H22-H28, 1979.
34. Trzebski, A., M. Tafil, M. Zoltowski, and J. Przybylski. Increased sensitivity of the arterial chemoreceptor drive in young men with mild hypertension. Cardiovasc. Res. 16: 163-172, 1982.
35. Watanabe, T., T. Mano, S. Iwase, Y. Sugiyama, H. Okada, and S. Takaeuchi. Enhanced muscle sympathetic nerve activity during sleep apnea in the elderly. J. Auton. Nerv. Syst. 37: 223-226, 1992.
36. Xie, P. L., T. S. McDowell, M. W. Chapleau, G. Hajduczok, and F. M. Abboud. Rapid baroreceptor resetting in chronic hypertension. Implications for normalization of arterial pressure. Hypertension 17: 72-79, 1991.
37. Young, T., M. Palta, J. Dempsey, J. Skatrud, S. Weber, and S. Badir. The occurrence of sleep disordered breathing among middle aged adults. N. Engl. J. Med. 328: 1230-1235, 1993.