Sympathoexcitatory response to peripheral chemoreflex activation is enhanced in juvenile rats exposed to chronic intermittent hypoxia

Experimental Physiology

Volumn 91, Issue 6, 2006, Pages 1025-1031

  Braga, Valdir A ^a   Soriano, Renato N ^a   Machado, Benedito H ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

POTASSIUM CYANIDE;

ANIMAL EXPERIMENT; ARTICLE; BRAIN STEM; CHEMORECEPTOR REFLEX; CONTROLLED STUDY; HEART; HEART RATE; HYPOTHESIS; HYPOXIA; NERVE POTENTIAL; NONHUMAN; PHRENIC NERVE; RAT; RESPIRATORY FUNCTION; SYMPATHETIC INNERVATION; SYMPATHETIC NERVE;

EID: 33750628249     PISSN: 09580670     EISSN: 1469445X     Source Type: Journal    
DOI: 10.1113/expphysiol.2006.034868     Document Type: Article

References (26)

1. Antunes VR, Braga VA & Machado BH (2005). Autonomic and respiratory responses to microinjection of ATP into the intermediate or caudal nucleus tractus solitarius in the working heart-brainstem preparation of the rat. Clin Exp Pharmacol Physiol 32, 467-472.
2. Baker TL & Mitchell GS (2000). Episodic but not continuous hypoxia elicits long-term facilitation of phrenic motor output in rats. J Physiol 529, 215-219.
3. Bisgard GE, Olson EB Jr, Wang ZY, Bavis RW, Fuller DD & Mitchell GS (2003). Adult carotid chemoafferent responses to hypoxia after 1, 2, and 4 wk of postnatal hyperoxia. J Appl Physiol 95, 946-952.
4. Braga VA, Antunes VR & Machado BH (2006). Autonomic and respiratory responses to microinjection of L-glutamate into the commissural subnucleus of the NTS in the working heart-brainstem preparation of the rat. Brain Res 1093, 150-160.
5. Braga VA & Machado BH (2006). Chemoreflex sympathoexcitation is not altered by the antagonism of glutamate receptors in the commissural NTS in the working heart-brainstem preparation of rat. Exp Physiol 91, 551-559.
6. Dumas S, Pequignot JM, Ghilini G, Mallet J & Denavit-Saubre M (1996). Plasticity of tyrosine hydroxylase gene expression in the rat nucleus tractus solitarius after ventilatory acclimatization to hypoxia. Mol Brain Res 40, 188-194.
7. Fletcher EC (2001). Invited review: Physiological consequences of intermittent hypoxia: systemic blood pressure. J Appl Physiol 90, 1600-1605.
8. Fletcher EC, Lesske J, Behm R, Miller CC, Stauss H & Unger T (1992a). Carotid chemoreceptors, systemic blood pressure and chronic episodic hypoxia mimicking sleep apnea. J Appl Physiol 72, 1978-1984.
9. Fletcher EC, Lesske J, Qian W, Miller CC & Unger T (1992b). Repetitive episodic hypoxia causes diurnal elevation of systemic blood pressure in rats. Hypertension 19, 555-561.
10. Franchini KG & Krieger EM (1993). Cardiovascular responses of conscious rats to carotid body chemoreceptor stimulation by intravenous KCN. J Auton Nerv Syst 42, 63-69.
11. Greenberg HE, Sica A, Batson D & Scharf SM (1999). Chronic intermittent hypoxia increases sympathetic responsiveness to hypoxia and hypercapnia. J Appl Physiol 86, 298-305.
12. Jacono FJ, Peng YJ, Kumar GK & Prabhakar NR (2005). Modulation of the hypoxic sensory response of the carotid body by 5-hydroxytryptamine: role of the 5-HT2 receptor. Respir Physiol Neurobiol 145, 135-142.
13. Ling L, Fuller DD, Bach KB, Kinkead R, Olson EB Jr & Mitchell GS (2001). Chronic intermittent hypoxia elicits serotonin-dependent plasticity in the central neural control of breathing. J Neurosci 21, 5381-5388.
14. McGuire M & Ling L (2005). Ventilatory long-term facilitation is greater in 1- vs. 2-mo-old awake rats. J Appl Physiol 98, 1195-1201.
15. McGuire M, Zhang Y, White DP & Ling L (2003). Chronic intermittent hypoxia enhances ventilatory long-term facilitation in awake rats. J Appl Physiol 95, 1499-1508.
16. Machado BH (2001). Neurotransmission of the cardiovascular reflexes in the nucleus tractus solitarii of awake rats. Ann N Y Acad Sci 940, 179-196.
17. Machado BH (2004). Chemoreflex and sympathoexcitation. In Neural Mechanisms of Cardiovascular Regulation, ed. Dun NJ, Machado BH & Pilowsky PM, pp. 31-58. Kluwer Academic Publishers, Norwell, MA, USA.
18. Paton JFR (1996). A working heart-brainstem preparation of the mouse. J Neurosci Meth 65, 63-68.
19. Paton JFR, de Paula PM, Spyer KM, Machado BH & Boscan P (2002). Sensory afferent selective role of P2 receptors in the nucleus tractus solitarii for mediating the cardiac component of the peripheral chemoreceptor reflex. J Physiol 543, 995-1005.
20. Paton JFR, Li YW, Schwaber JS & Kasparov S (1999). Reflex response and convergence of pharyngoesophageal and peripheral chemoreceptors in the nucleus of the solitary tract. Neurosc 95, 141-153.
21. Peng YJ, Overholt JL, Kline D, Kumar GK & Prabhakar NR (2003). Induction of sensory long-term facilitation in the carotid body by intermittent hypoxia: implications for recurrent apneas. Proc Natl Acad Sci 100, 10073-10078.
22. Prabhakar NR & Peng YJ (2003). Peripheral chemoreceptors in health and disease. J Appl Physiol 96, 359-366.
23. Prabhakar NR, Peng YJ, Jacono FJ, Kumar GK & Dick TE (2005). Cardiovascular alterations by chronic intermittent hypoxia: importance of carotid body chemoreflexes. Clin Exp Pharmacol Physiol 32, 447-449.
24. Reeves SR, Guo SZ, Brittian KR, Row BW & Gozal D (2006). Anatomical changes in selected cardio-respiratory brainstem nuclei following early post-natal chronic intermittent hypoxia. Neurosc Lett 402, 233-237.
25. Reis D, Golanov E, Ruggiero D & Sun MK (1994). Sympatho-excitatory neurons of the rostral ventrolateral medulla are oxygen sensors and essential elements in the tonic and reflex control of the systemic and central circulation. J Hypertens 12, S159-S180.
26. Soukhova-O'Hare GK, Cheng ZJ, Roberts AM & Gozal D (2006). Postnatal intermittent hypoxia alters baroreflex function in adult rats. Am J Physiol Heart Circ Physiol 290, H1157-H1164.