메뉴 건너뛰기




Volumn 56, Issue 5, 2015, Pages 3242-3252

Lipofuscin redistribution and loss accompanied by cytoskeletal stress in retinal pigment epithelium of eyes with age-related macular degeneration

Author keywords

AMD; Autofluorescence; Granule; Lipofuscin; Melanolipofuscin

Indexed keywords

LIPOFUSCIN; VISUAL PIGMENT;

EID: 84939796366     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.14-16274     Document Type: Article
Times cited : (140)

References (89)
  • 3
    • 0344830731 scopus 로고    scopus 로고
    • Fundus autofluorescence in age-related macular disease imaged with a laser scanning ophthalmoscope
    • von Ruckmann A, Fitzke FW, Bird AC. Fundus autofluorescence in age-related macular disease imaged with a laser scanning ophthalmoscope. Invest Ophthalmol Vis Sci. 1997; 38:478-486.
    • (1997) Invest Ophthalmol Vis Sci , vol.38 , pp. 478-486
    • Von Ruckmann, A.1    Fitzke, F.W.2    Bird, A.C.3
  • 4
    • 77958531621 scopus 로고    scopus 로고
    • Drusen characterization with multimodal imaging
    • Spaide RF, Curcio CA. Drusen characterization with multimodal imaging. Retina. 2010;30:1441-1454.
    • (2010) Retina , vol.30 , pp. 1441-1454
    • Spaide, R.F.1    Curcio, C.A.2
  • 6
    • 79951809103 scopus 로고    scopus 로고
    • Optical coherence tomography and autofluorescence findings in areas with geographic atrophy due to age-related macular degeneration
    • Schmitz-Valckenberg S, Fleckenstein M, Gobel AP, Hohman TC, Holz FG. Optical coherence tomography and autofluorescence findings in areas with geographic atrophy due to age-related macular degeneration. Invest Ophthalmol Vis Sci. 2011;52:1-6.
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , pp. 1-6
    • Schmitz-Valckenberg, S.1    Fleckenstein, M.2    Gobel, A.P.3    Hohman, T.C.4    Holz, F.G.5
  • 7
    • 0037316832 scopus 로고    scopus 로고
    • Fundus autofluorescence and age-related macular degeneration
    • Spaide R. Fundus autofluorescence and age-related macular degeneration. Ophthalmology. 2003;110:392-399.
    • (2003) Ophthalmology , vol.110 , pp. 392-399
    • Spaide, R.1
  • 8
    • 0017078404 scopus 로고
    • Ageing and degeneration in the macular region: A clinico-pathological study
    • Sarks SH. Ageing and degeneration in the macular region: a clinico-pathological study. Br J Ophthalmol. 1976;60:324-341.
    • (1976) Br J Ophthalmol , vol.60 , pp. 324-341
    • Sarks, S.H.1
  • 9
    • 0033040280 scopus 로고    scopus 로고
    • Early drusen formation in the normal and aging eye and their relation to age related maculopathy: A clinicopathological study
    • Sarks SH, Arnold JJ, Killingsworth MC, Sarks JP. Early drusen formation in the normal and aging eye and their relation to age related maculopathy: a clinicopathological study. Br J Ophthalmol. 1999;83:358-368.
    • (1999) Br J Ophthalmol , vol.83 , pp. 358-368
    • Sarks, S.H.1    Arnold, J.J.2    Killingsworth, M.C.3    Sarks, J.P.4
  • 10
    • 84905690180 scopus 로고    scopus 로고
    • Quantitative autofluorescence and cell density maps of the human retinal pigment epithelium
    • Ach T, Huisingh C, McGwin G Jr, et al. Quantitative autofluorescence and cell density maps of the human retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2014;55: 4832-4841.
    • (2014) Invest Ophthalmol Vis Sci , vol.55 , pp. 4832-4841
    • Ach, T.1    Huisingh, C.2    McGwin, G.3
  • 11
    • 0017897377 scopus 로고
    • The topography and age relationship of lipofuscin concentration in the retinal pigment epithelium
    • Wing GL, Blanchard GC, Weiter JJ. The topography and age relationship of lipofuscin concentration in the retinal pigment epithelium. Invest Ophthalmol Vis Sci. 1978;17:601-607.
    • (1978) Invest Ophthalmol Vis Sci , vol.17 , pp. 601-607
    • Wing, G.L.1    Blanchard, G.C.2    Weiter, J.J.3
  • 12
    • 84875734739 scopus 로고    scopus 로고
    • Histologic basis of variations in retinal pigment epithelium autofluorescence in eyes with geographic atrophy
    • Rudolf M, Vogt SD, Curcio CA, et al. Histologic basis of variations in retinal pigment epithelium autofluorescence in eyes with geographic atrophy. Ophthalmology. 2013;120:821-828.
    • (2013) Ophthalmology , vol.120 , pp. 821-828
    • Rudolf, M.1    Vogt, S.D.2    Curcio, C.A.3
  • 14
    • 82255164373 scopus 로고    scopus 로고
    • Noninvasive imaging of the human rod photoreceptor mosaic using a confocal adaptive optics scanning ophthalmoscope
    • Dubra A, Sulai Y, Norris JL, et al. Noninvasive imaging of the human rod photoreceptor mosaic using a confocal adaptive optics scanning ophthalmoscope. Biomed Opt Express. 2011; 2:1864-1876.
    • (2011) Biomed Opt Express , vol.2 , pp. 1864-1876
    • Dubra, A.1    Sulai, Y.2    Norris, J.L.3
  • 15
    • 0001795352 scopus 로고
    • Lipofuscin in aged and AMD eyes
    • Hollyfield J, Anderson R, LaVail M, eds., New York: Springer
    • Dorey CK, Staurenghi G, Delori F. Lipofuscin in aged and AMD eyes. In: Hollyfield J, Anderson R, LaVail M, eds. Retinal Degeneration. New York: Springer; 1993:3-14.
    • (1993) Retinal Degeneration , pp. 3-14
    • Dorey, C.K.1    Staurenghi, G.2    Delori, F.3
  • 16
    • 84899711378 scopus 로고    scopus 로고
    • Quantitative fundus autofluorescence in recessive Stargardt disease
    • Burke TR, Duncker T, Woods RL, et al. Quantitative fundus autofluorescence in recessive Stargardt disease. Invest Ophthalmol Vis Sci. 2014;55:2841-2852.
    • (2014) Invest Ophthalmol Vis Sci , vol.55 , pp. 2841-2852
    • Burke, T.R.1    Duncker, T.2    Woods, R.L.3
  • 18
    • 84862833106 scopus 로고    scopus 로고
    • Quantitative measurements of autofluorescence with the scanning laser ophthalmoscope
    • Delori F, Greenberg JP, Woods RL, et al. Quantitative measurements of autofluorescence with the scanning laser ophthalmoscope. Invest Ophthalmol Vis Sci. 2011;52:9379-9390.
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , pp. 9379-9390
    • Delori, F.1    Greenberg, J.P.2    Woods, R.L.3
  • 19
    • 0034940622 scopus 로고    scopus 로고
    • Age-related accumulation and spatial distribution of lipofuscin in RPE of normal subjects
    • Delori FC, Goger DG, Dorey CK. Age-related accumulation and spatial distribution of lipofuscin in RPE of normal subjects. Invest Ophthalmol Vis Sci. 2001;42:1855-1866.
    • (2001) Invest Ophthalmol Vis Sci , vol.42 , pp. 1855-1866
    • Delori, F.C.1    Goger, D.G.2    Dorey, C.K.3
  • 20
    • 0017843940 scopus 로고
    • Lipofuscin and melanin of human retinal pigment epithelium. Fluorescence, enzyme cytochemical, and ultrastructural studies
    • Feeney L. Lipofuscin and melanin of human retinal pigment epithelium. Fluorescence, enzyme cytochemical, and ultrastructural studies. Invest Ophthalmol Vis Sci. 1978;17:583-600.
    • (1978) Invest Ophthalmol Vis Sci , vol.17 , pp. 583-600
    • Feeney, L.1
  • 21
    • 0031806880 scopus 로고    scopus 로고
    • The Alabama Age-Related Macular Degeneration Grading System for donor eyes
    • Curcio CA, Medeiros NE, Millican CL. The Alabama Age-Related Macular Degeneration Grading System for donor eyes. Invest Ophthalmol Vis Sci. 1998;39:1085-1096.
    • (1998) Invest Ophthalmol Vis Sci , vol.39 , pp. 1085-1096
    • Curcio, C.A.1    Medeiros, N.E.2    Millican, C.L.3
  • 22
    • 84939793399 scopus 로고    scopus 로고
    • The Project MACULA retinal pigment epithelium grading system for histology and optical coherence tomography in age-related macular degeneration
    • Zanzottera EC, Messinger JD, Ach T, Smith RT, Freund KB, Curcio CA. The Project MACULA retinal pigment epithelium grading system for histology and optical coherence tomography in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2015;56:3253-3268.
    • (2015) Invest Ophthalmol Vis Sci , vol.56 , pp. 3253-3268
    • Zanzottera, E.C.1    Messinger, J.D.2    Ach, T.3    Smith, R.T.4    Freund, K.B.5    Curcio, C.A.6
  • 23
    • 84939811874 scopus 로고    scopus 로고
    • Subducted and melanotic cells in advanced age-related macular degeneration are derived from retinal pigment epithelium
    • Zanzottera EC, Messinger JD, Ach T, Smith RT, Curcio CA. Subducted and melanotic cells in advanced age-related macular degeneration are derived from retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2015;56:3269-3278.
    • (2015) Invest Ophthalmol Vis Sci , vol.56 , pp. 3269-3278
    • Zanzottera, E.C.1    Messinger, J.D.2    Ach, T.3    Smith, R.T.4    Curcio, C.A.5
  • 24
    • 0037332052 scopus 로고    scopus 로고
    • Apolipoprotein B in cholesterol-containing drusen and basal deposits of human eyes with age-related maculopathy
    • Malek G, Li CM, Guidry C, Medeiros NE, Curcio CA. Apolipoprotein B in cholesterol-containing drusen and basal deposits of human eyes with age-related maculopathy. Am J Pathol. 2003;162:413-425.
    • (2003) Am J Pathol , vol.162 , pp. 413-425
    • Malek, G.1    Li, C.M.2    Guidry, C.3    Medeiros, N.E.4    Curcio, C.A.5
  • 25
    • 28444468904 scopus 로고    scopus 로고
    • Esterified and unesterified cholesterol in drusen and basal deposits of eyes with age-related maculopathy
    • Curcio CA, Presley JB, Malek G, Medeiros NE, Avery DV, Kruth HS. Esterified and unesterified cholesterol in drusen and basal deposits of eyes with age-related maculopathy. Exp Eye Res. 2005;81:731-741.
    • (2005) Exp Eye Res , vol.81 , pp. 731-741
    • Curcio, C.A.1    Presley, J.B.2    Malek, G.3    Medeiros, N.E.4    Avery, D.V.5    Kruth, H.S.6
  • 27
    • 0000916906 scopus 로고
    • Beiträge zur theorie des mikroskops und der mikroskopischen wahrnehmung
    • Abbe E. Beiträge zur theorie des mikroskops und der mikroskopischen wahrnehmung. Archiv für mikroskopische Anatomie. 1873;9:6.
    • (1873) Archiv für Mikroskopische Anatomie , vol.9 , pp. 6
    • Abbe, E.1
  • 28
    • 84864860464 scopus 로고    scopus 로고
    • Autofluorescence imaging of human RPE cell granules using structured illumination microscopy
    • Ach T, Best G, Rossberger S, Heintzmann R, Cremer C, Dithmar S. Autofluorescence imaging of human RPE cell granules using structured illumination microscopy. Br J Ophthalmol. 2012; 96:1141-1144.
    • (2012) Br J Ophthalmol , vol.96 , pp. 1141-1144
    • Ach, T.1    Best, G.2    Rossberger, S.3    Heintzmann, R.4    Cremer, C.5    Dithmar, S.6
  • 29
    • 0033174543 scopus 로고    scopus 로고
    • Current understanding on the role of retinal pigment epithelium and its pigmentation
    • Schraermeyer U, Heimann K. Current understanding on the role of retinal pigment epithelium and its pigmentation. Pigment Cell Res. 1999;12:219-236.
    • (1999) Pigment Cell Res , vol.12 , pp. 219-236
    • Schraermeyer, U.1    Heimann, K.2
  • 30
    • 0029081168 scopus 로고
    • Melanosomes are specialized members of the lysosomal lineage of organelles
    • Orlow SJ. Melanosomes are specialized members of the lysosomal lineage of organelles. J Invest Dermatol. 1995; 105:3-7.
    • (1995) J Invest Dermatol , vol.105 , pp. 3-7
    • Orlow, S.J.1
  • 31
    • 0021323978 scopus 로고
    • Aging human RPE: Morphometric analysis of macular, equatorial, and peripheral cells
    • Feeney-Burns L, Hilderbrand ES, Eldridge S. Aging human RPE: morphometric analysis of macular, equatorial, and peripheral cells. Invest Ophthalmol Vis Sci. 1984;25:195-200.
    • (1984) Invest Ophthalmol Vis Sci , vol.25 , pp. 195-200
    • Feeney-Burns, L.1    Hilderbrand, E.S.2    Eldridge, S.3
  • 32
    • 84855931309 scopus 로고    scopus 로고
    • A novel melano-lysosome in the retinal epithelium of rhesus monkeys
    • Gouras P, Brown K, Ivert L, Neuringer M. A novel melano-lysosome in the retinal epithelium of rhesus monkeys. Exp Eye Res. 2011;93:937-946.
    • (2011) Exp Eye Res , vol.93 , pp. 937-946
    • Gouras, P.1    Brown, K.2    Ivert, L.3    Neuringer, M.4
  • 34
    • 80052661270 scopus 로고    scopus 로고
    • Defective photore-ceptor phagocytosis in a mouse model of enhanced S-cone syndrome causes progressive retinal degeneration
    • Mustafi D, Kevany BM, Genoud C, et al. Defective photore-ceptor phagocytosis in a mouse model of enhanced S-cone syndrome causes progressive retinal degeneration. FASEB J. 2011;25:3157-3176.
    • (2011) FASEB J , vol.25 , pp. 3157-3176
    • Mustafi, D.1    Kevany, B.M.2    Genoud, C.3
  • 36
    • 42749092828 scopus 로고    scopus 로고
    • Itinerant exosomes: Emerging roles in cell and tissue polarity
    • Lakkaraju A, Rodriguez-Boulan E. Itinerant exosomes: emerging roles in cell and tissue polarity. Trends Cell Biol. 2008;18: 199-209.
    • (2008) Trends Cell Biol , vol.18 , pp. 199-209
    • Lakkaraju, A.1    Rodriguez-Boulan, E.2
  • 37
    • 58349109733 scopus 로고    scopus 로고
    • Autophagy and exosomes in the aged retinal pigment epithelium: Possible relevance to drusen formation and age-related macular degeneration
    • Wang AL, Lukas TJ, Yuan M, Du N, Tso MO, Neufeld AH. Autophagy and exosomes in the aged retinal pigment epithelium: possible relevance to drusen formation and age-related macular degeneration. PLoS One. 2009;4:e4160.
    • (2009) Plos One , vol.4
    • Wang, A.L.1    Lukas, T.J.2    Yuan, M.3    Du, N.4    Tso, M.O.5    Neufeld, A.H.6
  • 38
    • 78149428751 scopus 로고    scopus 로고
    • Alpha B crystallin is apically secreted within exosomes by polarized human retinal pigment epithelium and provides neuroprotection to adjacent cells
    • Sreekumar PG, Kannan R, Kitamura M, et al. alpha B crystallin is apically secreted within exosomes by polarized human retinal pigment epithelium and provides neuroprotection to adjacent cells. PLoS One. 2010;5:e12578.
    • (2010) Plos One , vol.5
    • Sreekumar, P.G.1    Kannan, R.2    Kitamura, M.3
  • 39
    • 79952802009 scopus 로고    scopus 로고
    • Alpha B-crystallin is found in detergent-resistant membrane microdomains and is secreted via exosomes from human retinal pigment epithelial cells
    • Gangalum RK, Atanasov IC, Zhou ZH, Bhat SP. Alpha B-crystallin is found in detergent-resistant membrane microdomains and is secreted via exosomes from human retinal pigment epithelial cells. J Biol Chem. 2011;286:3261-3269.
    • (2011) J Biol Chem , vol.286 , pp. 3261-3269
    • Gangalum, R.K.1    Atanasov, I.C.2    Zhou, Z.H.3    Bhat, S.P.4
  • 40
    • 84875177162 scopus 로고    scopus 로고
    • High-resolution imaging of autofluorescent particles within drusen using structured illumination microscopy
    • Rossberger S, Ach T, Best G, Cremer C, Heintzmann R, Dithmar S. High-resolution imaging of autofluorescent particles within drusen using structured illumination microscopy. Br J Ophthalmol. 2013;97:518-523.
    • (2013) Br J Ophthalmol , vol.97 , pp. 518-523
    • Rossberger, S.1    Ach, T.2    Best, G.3    Cremer, C.4    Heintzmann, R.5    Dithmar, S.6
  • 41
    • 84939986310 scopus 로고    scopus 로고
    • Essential versus accessory aspects of cell death: Recommendations of the NCCD 2015
    • Galluzzi L, JM Bravo-San Pedro, Vitale I, et al. Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death Differ. 2015;22:58-73.
    • (2015) Cell Death Differ , vol.22 , pp. 58-73
    • Galluzzi, L.1    Bravo-San Pedro, J.M.2    Vitale, I.3
  • 42
    • 0015383455 scopus 로고
    • Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
    • Kerr JF, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer. 1972;26:239-257.
    • (1972) Br J Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.1    Wyllie, A.H.2    Currie, A.R.3
  • 43
    • 0033791650 scopus 로고    scopus 로고
    • Autophagy, cytoplasm-to-vacuole targeting pathway, and pexophagy in yeast and mammalian cells
    • Kim J, Klionsky DJ. Autophagy, cytoplasm-to-vacuole targeting pathway, and pexophagy in yeast and mammalian cells. Annu Rev Biochem. 2000;69:303-342.
    • (2000) Annu Rev Biochem , vol.69 , pp. 303-342
    • Kim, J.1    Klionsky, D.J.2
  • 44
    • 0036741098 scopus 로고    scopus 로고
    • A role for local inflammation in the formation of drusen in the aging eye
    • Anderson DH, Mullins RF, Hageman GS, Johnson LV. A role for local inflammation in the formation of drusen in the aging eye. Am J Ophthalmol. 2002;134:411-431.
    • (2002) Am J Ophthalmol , vol.134 , pp. 411-431
    • Anderson, D.H.1    Mullins, R.F.2    Hageman, G.S.3    Johnson, L.V.4
  • 45
    • 80055052597 scopus 로고    scopus 로고
    • Retinal pigment epithelial expression of complement regulator CD46 is altered early in the course of geographic atrophy
    • Vogt SD, Curcio CA, Wang L, et al. Retinal pigment epithelial expression of complement regulator CD46 is altered early in the course of geographic atrophy. Exp Eye Res. 2011;93:413-423.
    • (2011) Exp Eye Res , vol.93 , pp. 413-423
    • Vogt, S.D.1    Curcio, C.A.2    Wang, L.3
  • 46
    • 53149090950 scopus 로고    scopus 로고
    • High-resolution spectral domain-OCT imaging in geographic atrophy associated with age-related macular degeneration
    • Fleckenstein M, Charbel Issa P, Helb HM, et al. High-resolution spectral domain-OCT imaging in geographic atrophy associated with age-related macular degeneration. Invest Ophthalmol Vis Sci. 2008;49:4137-4144.
    • (2008) Invest Ophthalmol Vis Sci , vol.49 , pp. 4137-4144
    • Fleckenstein, M.1    Charbel Issa, P.2    Helb, H.M.3
  • 47
    • 0023183681 scopus 로고
    • Lysosomal enzyme cytochemistry of human RPE, Bruch's membrane and drusen
    • Feeney-Burns L, Gao CL, Tidwell M. Lysosomal enzyme cytochemistry of human RPE, Bruch's membrane and drusen. Invest Ophthalmol Vis Sci. 1987;28:1138-1147.
    • (1987) Invest Ophthalmol Vis Sci , vol.28 , pp. 1138-1147
    • Feeney-Burns, L.1    Gao, C.L.2    Tidwell, M.3
  • 48
    • 0022412567 scopus 로고
    • Age-related changes in the ultrastructure of Bruch's membrane
    • Feeney-Burns L, Ellersieck MR. Age-related changes in the ultrastructure of Bruch's membrane. Am J Ophthalmol. 1985; 100:686-697.
    • (1985) Am J Ophthalmol , vol.100 , pp. 686-697
    • Feeney-Burns, L.1    Ellersieck, M.R.2
  • 49
    • 84860883878 scopus 로고    scopus 로고
    • DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88
    • Tarallo V, Hirano Y, Gelfand BD, et al. DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88. Cell. 2012;149:847-859.
    • (2012) Cell , vol.149 , pp. 847-859
    • Tarallo, V.1    Hirano, Y.2    Gelfand, B.D.3
  • 50
    • 0033924382 scopus 로고    scopus 로고
    • Spare the rods, save the cones in aging and age-related maculopathy
    • Curcio CA, Owsley C, Jackson GR. Spare the rods, save the cones in aging and age-related maculopathy. Invest Ophthalmol Vis Sci. 2000;41:2015-2018.
    • (2000) Invest Ophthalmol Vis Sci , vol.41 , pp. 2015-2018
    • Curcio, C.A.1    Owsley, C.2    Jackson, G.R.3
  • 51
    • 55949107533 scopus 로고    scopus 로고
    • Physiology of cell volume regulation in vertebrates
    • Hoffmann EK, Lambert IH, Pedersen SF. Physiology of cell volume regulation in vertebrates. Physiol Rev. 2009;89:193-277.
    • (2009) Physiol Rev , vol.89 , pp. 193-277
    • Hoffmann, E.K.1    Lambert, I.H.2    Pedersen, S.F.3
  • 54
    • 33344469599 scopus 로고    scopus 로고
    • You say lipofuscin, we say ceroid: Defining autofluorescent storage material
    • Seehafer SS, Pearce DA. You say lipofuscin, we say ceroid: defining autofluorescent storage material. Neurobiol Aging. 2006;27:576-588.
    • (2006) Neurobiol Aging , vol.27 , pp. 576-588
    • Seehafer, S.S.1    Pearce, D.A.2
  • 55
    • 44749093044 scopus 로고    scopus 로고
    • The comparative biology of neuromelanin and lipofuscin in the human brain
    • Double KL, Dedov VN, Fedorow H, et al. The comparative biology of neuromelanin and lipofuscin in the human brain. J Cell Mol Life Sci. 2008;65:1669-1682.
    • (2008) J Cell Mol Life Sci , vol.65 , pp. 1669-1682
    • Double, K.L.1    Dedov, V.N.2    Fedorow, H.3
  • 56
    • 45449093259 scopus 로고    scopus 로고
    • Neuronal pigmented autophagic vacuoles: Lipofuscin, neuro-melanin, and ceroid as macroautophagic responses during, aging and disease
    • Sulzer D, Mosharov E, Talloczy Z, Zucca FA, Simon JD, Zecca L. Neuronal pigmented autophagic vacuoles: lipofuscin, neuro-melanin, and ceroid as macroautophagic responses during, aging and disease. J Neurochem. 2008;106:24-36.
    • (2008) J Neurochem , vol.106 , pp. 24-36
    • Sulzer, D.1    Mosharov, E.2    Talloczy, Z.3    Zucca, F.A.4    Simon, J.D.5    Zecca, L.6
  • 57
    • 0036124957 scopus 로고    scopus 로고
    • What is lipofuscin? Defining characteristics and differentiation from other autofluorescent lyso13 somal storage bodies
    • Katz ML, Robison WG. What is lipofuscin? Defining characteristics and differentiation from other autofluorescent lyso13 somal storage bodies. Arch Gerontol Geriatr. 2002;34:169-184.
    • (2002) Arch Gerontol Geriatr , vol.34 , pp. 169-184
    • Katz, M.L.1    Robison, W.G.2
  • 58
    • 0036139916 scopus 로고    scopus 로고
    • Phenotypic variation of retinal pigment epithelium in age-related macular degenera: Tion
    • Guidry C, Medeiros NE, Curcio CA. Phenotypic variation of retinal pigment epithelium in age-related macular degenera: tion. Invest Ophthalmol Vis Sci. 2002;43:267-273.
    • (2002) Invest Ophthalmol Vis Sci , vol.43 , pp. 267-273
    • Guidry, C.1    Medeiros, N.E.2    Curcio, C.A.3
  • 59
    • 38949185692 scopus 로고    scopus 로고
    • Oxidative L damage-induced inflammation initiates age-related macular) degeneration
    • Hollyfield JG, Bonilha VL, Rayborn ME, et al. Oxidative L damage-induced inflammation initiates age-related macular degeneration. Nat Med. 2008;14:194-198.
    • (2008) Nat Med , vol.14 , pp. 194-198
    • Hollyfield, J.G.1    Bonilha, V.L.2    Rayborn, M.E.3
  • 60
    • 79961159284 scopus 로고    scopus 로고
    • Dysregulation in retinal para! inflammation and age-related retinal degeneration in CCL2 or CCR2 deficient mice
    • Chen M, Forrester JV, Xu H. Dysregulation in retinal para! inflammation and age-related retinal degeneration in CCL2 or CCR2 deficient mice. PLoS One. 2011;6:e22818.
    • (2011) Plos One , vol.6
    • Chen, M.1    Forrester, J.V.2    Xu, H.3
  • 61
    • 84886420285 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor deficiency causes dysregulated cellular matrix metabolism and age-related macular degeneration-like pathology
    • Hu P, Herrmann R, Bednar A, et al. Aryl hydrocarbon receptor deficiency causes dysregulated cellular matrix metabolism and age-related macular degeneration-like pathology. Proc Natl Acad Sci USA. 2013;110:E4069-E4078.
    • (2013) Proc Natl Acad Sci USA , vol.110
    • Hu, P.1    Herrmann, R.2    Bednar, A.3
  • 62
    • 4644293303 scopus 로고    scopus 로고
    • Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration
    • Hahn P, Qian Y, Dentchev T, et al. Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration. Proc Natl Acad Sci USA. 2004;101:13850-13855.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 13850-13855
    • Hahn, P.1    Qian, Y.2    Dentchev, T.3
  • 63
    • 78650928867 scopus 로고    scopus 로고
    • MTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photorecep-tor degeneration in mice
    • Zhao C, Yasumura D, Li X, et al. mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photorecep-tor degeneration in mice. J Clin Invest. 2011;121:369-383.
    • (2011) J Clin Invest , vol.121 , pp. 369-383
    • Zhao, C.1    Yasumura, D.2    Li, X.3
  • 64
    • 79958255071 scopus 로고    scopus 로고
    • Adenovirus-mediated delivery of CD46 attenuates the alternative complement pathway on RPE: Implications for age-related macular degeneration
    • Sweigard JH, Cashman SM, Kumar-Singh R. Adenovirus-mediated delivery of CD46 attenuates the alternative complement pathway on RPE: implications for age-related macular degeneration. Gene Ther. 2011;18:613-621.
    • (2011) Gene Ther , vol.18 , pp. 613-621
    • Sweigard, J.H.1    Cashman, S.M.2    Kumar-Singh, R.3
  • 65
    • 23844463473 scopus 로고    scopus 로고
    • Apolipoprotein E allele-dependent pathogenesis: A model for age-related retinal degeneration
    • Malek G, Johnson LV, Mace BE, et al. Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration. Proc Natl Acad Sci USA. 2005;102:11900-11905.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 11900-11905
    • Malek, G.1    Johnson, L.V.2    Mace, B.E.3
  • 66
    • 79955765832 scopus 로고    scopus 로고
    • Age-related retinopathy in NRF2-deficient mice
    • Zhao Z, Chen Y, Wang J, et al. Age-related retinopathy in NRF2-deficient mice. PLoS One. 2011;6:e19456.
    • (2011) Plos One , vol.6
    • Zhao, Z.1    Chen, Y.2    Wang, J.3
  • 67
    • 0344676389 scopus 로고    scopus 로고
    • An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice
    • Ambati J, Anand A, Fernandez S, et al. An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice. Nat Med. 2003;9:1390-1397.
    • (2003) Nat Med , vol.9 , pp. 1390-1397
    • Ambati, J.1    Anand, A.2    Fernandez, S.3
  • 68
    • 84860239954 scopus 로고    scopus 로고
    • Evidence for baseline retinal pigment epithelium pathology in the Trp1-Cre mouse
    • Thanos A, Morizane Y, Murakami Y, et al. Evidence for baseline retinal pigment epithelium pathology in the Trp1-Cre mouse. Am J Pathol. 2012;180:1917-1927.
    • (2012) Am J Pathol , vol.180 , pp. 1917-1927
    • Thanos, A.1    Morizane, Y.2    Murakami, Y.3
  • 69
    • 84901044356 scopus 로고    scopus 로고
    • Age- and gene-dosage-dependent cre-induced abnormalities in the retinal pigment epithelium
    • He L, Marioutina M, Dunaief JL, Marneros AG. Age- and gene-dosage-dependent cre-induced abnormalities in the retinal pigment epithelium. Am J Pathol. 2014;184:1660-1667.
    • (2014) Am J Pathol , vol.184 , pp. 1660-1667
    • He, L.1    Marioutina, M.2    Dunaief, J.L.3    Marneros, A.G.4
  • 70
    • 84905041061 scopus 로고    scopus 로고
    • Mitochondrial oxidative stress in the retinal pigment epithelium leads to localized retinal degeneration
    • Mao H, Seo SJ, Biswal MR, et al. Mitochondrial oxidative stress in the retinal pigment epithelium leads to localized retinal degeneration. Invest Ophthalmol Vis Sci. 2014;55:4613-4627.
    • (2014) Invest Ophthalmol Vis Sci , vol.55 , pp. 4613-4627
    • Mao, H.1    Seo, S.J.2    Biswal, M.R.3
  • 71
    • 33746628449 scopus 로고    scopus 로고
    • Drusen, choroidal neovascularization, and retinal pigment epithelium dysfunction in SOD1-deficient mice: A model of age-related macular degeneration
    • Imamura Y, Noda S, Hashizume K, et al. Drusen, choroidal neovascularization, and retinal pigment epithelium dysfunction in SOD1-deficient mice: a model of age-related macular degeneration. Proc Natl Acad Sci USA. 2006;103:11282-11287.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 11282-11287
    • Imamura, Y.1    Noda, S.2    Hashizume, K.3
  • 72
    • 84876339803 scopus 로고    scopus 로고
    • Age-and light-dependent development of localised retinal atrophy in CCL2-/-CX3CR1GFP/GFP mice
    • Chen M, Hombrebueno JR, Luo C, et al. Age-and light-dependent development of localised retinal atrophy in CCL2-/-CX3CR1GFP/GFP mice. PLoS One. 2013;8:e61381.
    • (2013) Plos One , vol.8
    • Chen, M.1    Hombrebueno, J.R.2    Luo, C.3
  • 73
    • 21744445111 scopus 로고    scopus 로고
    • The actin cytoskeleton: A key regulator of apoptosis and ageing?
    • Gourlay CW, Ayscough KR. The actin cytoskeleton: a key regulator of apoptosis and ageing? Nat Rev Mol Cell Biol. 2005;6:583-589.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 583-589
    • Gourlay, C.W.1    Ayscough, K.R.2
  • 74
    • 36248969983 scopus 로고    scopus 로고
    • Actin stress fibres
    • Pellegrin S, Mellor H. Actin stress fibres. J Cell Sci. 2007;120: 3491-3499.
    • (2007) J Cell Sci , vol.120 , pp. 3491-3499
    • Pellegrin, S.1    Mellor, H.2
  • 75
    • 84863113109 scopus 로고    scopus 로고
    • Actin stress fibers -assembly, dynamics and biological roles
    • Tojkander S, Gateva G, Lappalainen P. Actin stress fibers -assembly, dynamics and biological roles. JCell Sci. 2012;125:1855-1864.
    • (2012) Jcell Sci , vol.125 , pp. 1855-1864
    • Tojkander, S.1    Gateva, G.2    Lappalainen, P.3
  • 76
    • 33344463910 scopus 로고    scopus 로고
    • Pigment epithelium-derived factor protects retinal pigment epithelium from oxidant-mediated barrier dysfunction
    • Ho T-C, Yang Y-C, Cheng H-C, Wu A-C, Chen S-L, Tsao Y-P. Pigment epithelium-derived factor protects retinal pigment epithelium from oxidant-mediated barrier dysfunction. Bio-chem Biophys Res Commun. 2006;342:372-378.
    • (2006) Bio-Chem Biophys Res Commun , vol.342 , pp. 372-378
    • Ho, T.-C.1    Yang, Y.-C.2    Cheng, H.-C.3    Wu, A.-C.4    Chen, S.-L.5    Tsao, Y.-P.6
  • 77
    • 0024366679 scopus 로고
    • Cytoskeletal organization of migrating retinal pigment epithelial cells during wound healing in organ culture
    • Hergott GJ, Sandig M, Kalnins VI. Cytoskeletal organization of migrating retinal pigment epithelial cells during wound healing in organ culture. Cell Motil Cytoskeleton. 1989;13:83-93.
    • (1989) Cell Motil Cytoskeleton , vol.13 , pp. 83-93
    • Hergott, G.J.1    Sandig, M.2    Kalnins, V.I.3
  • 78
    • 78651419444 scopus 로고    scopus 로고
    • The regulation of traction force in relation to cell shape and focal adhesions
    • Rape AD, Guo WH, Wang YL. The regulation of traction force in relation to cell shape and focal adhesions. Biomaterials. 2011;32:2043-2051.
    • (2011) Biomaterials , vol.32 , pp. 2043-2051
    • Rape, A.D.1    Guo, W.H.2    Wang, Y.L.3
  • 79
    • 79961005068 scopus 로고    scopus 로고
    • Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration
    • Ding JD, Johnson LV, Herrmann R, et al. Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration. Proc Natl Acad Sci U S A. 2011;108:E279-E287.
    • (2011) Proc Natl Acad Sci U S A , vol.108
    • Ding, J.D.1    Johnson, L.V.2    Herrmann, R.3
  • 80
    • 63549133336 scopus 로고    scopus 로고
    • Amyloid-ß (1-42) alters structure and function of retinal pigmented epithelial cells
    • Bruban J, Glotin A-L, Dinet V, et al. Amyloid-ß (1-42) alters structure and function of retinal pigmented epithelial cells. Aging Cell. 2009;8:162-177.
    • (2009) Aging Cell , vol.8 , pp. 162-177
    • Bruban, J.1    Glotin, A.-L.2    Dinet, V.3
  • 81
    • 84909609625 scopus 로고    scopus 로고
    • DICER1/Alu RNA dysmetab-olism induces Caspase-8-mediated cell death in age-related macular degeneration
    • Kim Y, Tarallo V, Kerur N, et al. DICER1/Alu RNA dysmetab-olism induces Caspase-8-mediated cell death in age-related macular degeneration. Proc Natl Acad Sci U S A. 2014;111: 16082-16087.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 16082-16087
    • Kim, Y.1    Tarallo, V.2    Kerur, N.3
  • 83
    • 84884877310 scopus 로고    scopus 로고
    • Band-limit and appropriate sampling in microscopy
    • Celis JE, ed., Waltham, MA: Elsevier Academic Press
    • Heintzmann R. Band-limit and appropriate sampling in microscopy. In: Celis JE, ed. Cell Biology: A Laboratory Handbook. Waltham, MA: Elsevier Academic Press; 2006:29-36.
    • (2006) Cell Biology: A Laboratory Handbook , pp. 29-36
    • Heintzmann, R.1
  • 84
    • 84883361410 scopus 로고    scopus 로고
    • In vivo dark-field imaging of the retinal pigment epithelium cell mosaic
    • Scoles D, Sulai YN, Dubra A. In vivo dark-field imaging of the retinal pigment epithelium cell mosaic. Biomed Opt Express. 2013;4:1710-1723.
    • (2013) Biomed Opt Express , vol.4 , pp. 1710-1723
    • Scoles, D.1    Sulai, Y.N.2    Dubra, A.3
  • 85
    • 0024378477 scopus 로고
    • Cell loss in the aging retina. Relationship to lipofuscin accumulation and macular degeneration
    • Dorey CK, Wu G, Ebenstein D, Garsd A, Weiter JJ. Cell loss in the aging retina. Relationship to lipofuscin accumulation and macular degeneration. Invest Ophthalmol Vis Sci. 1989;30: 1691-1699.
    • (1989) Invest Ophthalmol Vis Sci , vol.30 , pp. 1691-1699
    • Dorey, C.K.1    Wu, G.2    Ebenstein, D.3    Garsd, A.4    Weiter, J.J.5
  • 86
    • 84905698800 scopus 로고    scopus 로고
    • Mosaicism of the retinal pigment epitheliums
    • Burke JM, Hjelmeland LM. Mosaicism of the retinal pigment epitheliums. Mol Interv. 2005;5:9.
    • (2005) Mol Interv , vol.5 , pp. 9
    • Burke, J.M.1    Hjelmeland, L.M.2
  • 87
    • 84866910223 scopus 로고    scopus 로고
    • Spatial correlation between hyperpigmentary changes on color fundus photography and hyperreflective foci on SDOCT in intermediate AMD
    • Folgar FA, Chow JH, Farsiu S, et al. Spatial correlation between hyperpigmentary changes on color fundus photography and hyperreflective foci on SDOCT in intermediate AMD. Invest Ophthalmol Vis Sci. 2012;53:4626-4633.
    • (2012) Invest Ophthalmol Vis Sci , vol.53 , pp. 4626-4633
    • Folgar, F.A.1    Chow, J.H.2    Farsiu, S.3
  • 88
    • 84872037771 scopus 로고    scopus 로고
    • Spectral-domain optical coherence tomography characteristics of intermediate age-related macular degeneration
    • Leuschen JN, Schuman SG, Winter KP, et al. Spectral-domain optical coherence tomography characteristics of intermediate age-related macular degeneration. Ophthalmology. 2013;120:140-150.
    • (2013) Ophthalmology , vol.120 , pp. 140-150
    • Leuschen, J.N.1    Schuman, S.G.2    Winter, K.P.3
  • 89


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.