Actin stress fibers - Assembly, dynamics and biological roles

Journal of Cell Science

Volumn 125, Issue 8, 2012, Pages 1855-1864

  Tojkander, Sari ^a   Gateva, Gergana ^a   Lappalainen, Pekka ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Actin; Adhesion; Assembly; Mechanotransduction; Stress fibers

Indexed keywords

ACTIN; ALPHA ACTININ; MYOSIN ADENOSINE TRIPHOSPHATASE; MYOSIN LIGHT CHAIN; MYOSIN LIGHT CHAIN PHOSPHATASE;

ACTIN FILAMENT; ACTIN STRESS FIBER; ANIMAL CELL; ARTICLE; CELL ADHESION; CELL INTERACTION; CELL MIGRATION; CELL NUCLEUS; CELL STRUCTURE; FOCAL ADHESION; HUMAN; LAMELLAR BODY; MECHANOTRANSDUCTION; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; STRESS FIBER;

ACTINS; ANIMALS; CELL ADHESION; CELL MOVEMENT; HUMANS; MECHANOTRANSDUCTION, CELLULAR; STRESS FIBERS;

ANIMALIA;

EID: 84863113109     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.098087     Document Type: Article

References (154)

1. Adams, J. C. (1995). Formation of stable microspikes containing actin and the 55 kDa actin bundling protein, fascin, is a consequence of cell adhesion to thrombospondin-1: implications for the anti-adhesive activities of thrombospondin-1. J. Cell Sci. 108, 1977-1990.
2. Amano, M., Ito, M., Kimura, K., Fukata, Y., Chihara, K., Nakano, T., Matsuura, Y. and Kaibuchi, K. (1996). Phosphorylation and activation of myosin by Rhoassociated kinase (Rho-kinase) J. Biol. Chem. 271, 20246-20249.
3. Anderson, T. W., Vaughan, A. N. and Cramer, L. P. (2008). Retrograde flow and myosin II activity within the leading cell edge deliver F-actin to the lamella to seed the formation of graded polarity actomyosin II filament bundles in migrating fibroblasts. Mol. Biol. Cell. 19, 5006-5018
4. Assinder, S. J., Stanton, J. A. and Prasad, P. D. (2009). Transgelin: an actin-binding protein and tumour suppressor. Int. J. Biochem. Cell Biol. 41, 482-486.
5. Balaban, N. Q., Schwarz, U. S., Riveline, D., Goichberg, P., Tzur, G., Sabanay, I., Mahalu, D., Safran, S., Bershadsky, A., Addadi, L. and Geiger, B. (2001). Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates. Nat. Cell Biol. 3, 466-472.
6. Bao, J., Jana, S. S. and Adelstein, R. S. (2005). Vertebrate nonmuscle myosin II isoforms rescue small interfering RNA-induced defects in COS-7 cell cytokinesis. J. Biol. Chem. 280, 19594-19599.
7. Bershadsky, A. D., Ballestrem, C., Carramusa, L., Zilberman, Y., Gilquin, B., Khochbin, S., Alexandrova, A. Y., Verkhovsky, A. B., Shemesh, T. and Kozlov, M. M. (2006). Assembly and mechanosensory function of focal adhesions: experiments and models. Eur. J. Cell Biol. 85, 165-173.
8. Boukhelifa, M., Parast, M. M., Bear, J. E., Gertler, F. B. and Otey. C A. (2004). Palladin is a novel binding partner for Ena/VASP family members. Cell Motil. Cytoskeleton. 58, 17-29.
9. Boukhelifa, M., Moza, M., Johansson, T., Rachlin, A., Parast, M., Huttelmaier, S., Roy, P., Jockusch, B. M., Carpen, O., Karlsson, R. et al. (2006). The proline-rich protein palladin is a binding partner for profilin. FEBS J. 273, 26-33.
10. Broschat, K. O. (1990). Tropomyosin prevents depolymerization of actin filaments from the pointed end. J. Biol. Chem. 265, 21323-21329.
11. Brotschi, E. A., Hartwig, J. H. and Stossel, T. P. (1978). The gelation of actin by actinbinding protein. J. Biol. Chem. 253, 8988-8993.
12. Bugyi, B. and Carlier, M. F. (2010). Control of actin filament treadmilling in cell motility. Annu. Rev. Biophys. 39, 449-470.
13. Burnette, D. T., Manley, S., Sengupta, P., Sougrat, R., Davidson, M. W., Kachar, B. and Lippincott-Schwartz, J. (2011). A role for actin arcs in the leading-edge advance of migrating cells. Nat. Cell Biol. 13, 371-381.
14. Burridge, K., Fath, K., Kelly, T., Nuckolls, G. and Turner, C. (1988). Focal adhesions: transmembrane junctions between the extracellular matrix and the cytoskeleton. Annu. Rev. Cell Biol. 4, 487-525.
15. Castella, L. F., Buscemi, L., Godbout, C., Meister, J. J. and Hinz, B. (2010). A new lock-step mechanism of matrix remodelling based on subcellular contractile events..J. Cell Sci. 123, 1751-1760.
16. Castellino, F., Ono, S., Matsumura, F. and Luini, A. (1995). Essential role of caldesmon in the actin filament reorganization induced by glucocorticoids. J. Cell Biol. 131, 1223-1230.
17. Chen, W. T. (1981). Mechanism of retraction of the trailing edge during fibroblast movement. J. Cell Biol. 90, 187-200.
18. Chrzanowska-Wodnicka, M. and Burridge, K. (1996). Rho-stimulated contractility drives the formation of stress fibers and focal adhesions. J. Cell Biol. 133, 1403-1415.
19. Clayton, J. E., Sammons, M. R., Stark, B. C., Hodges, A. R. and Lord, M. (2010). Differential regulation of unconventional fission yeast myosins via the actin track. Curr. Biol. 20, 1423-1431.
20. Colombelli, J., Besser, A., Kress, H., Reynaud, E. G., Girard, P., Caussinus, E., Haselmann, U., Small, J. V., Schwarz, U. S. and Stelzer, E. H. K. (2009). Mechanosensing in actin stress fibers revealed by a close correlation between force and protein localization. J. Cell Sci. 122, 1665-1679.
21. Cramer, L. P., Siebert, M. and Mitchison, T. J. (1997). Identification of novel graded polarity actin filament bundles in locomoting heart fibroblasts: implications for the generation of motile force. J. Cell Biol. 136, 1287-1305.
22. Danninger, C. and Gimona, M. (2000). Live dynamics of GFP-calponin: isoformspecific modulation of the actin cytoskeleton and autoregulation by C-terminal sequences. J. Cell Sci. 21, 3725-3736.
23. del Rio, A., Perez-Jimenez, R., Liu, R., Roca-Cusachs, P., Fernandez, J. M. and Sheetz, S. M. P. (2009). Stretching single talin rod molecules activates vinculin binding. Science 323, 638-641.
24. DesMarais, V., Ichetovkin, I., Condeelis, J. and Hitchcock-DeGregori, S. E. (2002). Spatial regulation of actin dynamics: a tropomyosin-free, actin-rich compartment at the leading edge. J. Cell Sci. 115, 4649-4660.
25. Discher, D. E., Janmey, P. and Wang, Y.-L. (2005). Tissue cells feel and respond to the stiffness of their substrate. Science 310, 1139-1143.
26. Dixon, R. D., Arneman, D. K., Rachlin, A. S., Sundaresan, N. R., Costello, M. J., Campbell, S. L. and Otey, C. A. (2008). Palladin is an actin cross-linking protein that uses immunoglobulin-like domains to bind filamentous actin. J. Biol. Chem. 283, 6222-6231.
27. Draeger, A., Gimona, M., Stuckert, A., Celis, J. E. and Small, J. V. (1991). Calponin. Developmental isoforms and a low molecular weight variant. FEBS Lett. 291, 24-28.
28. Ehrlicher, A. J., Nakamura, F., Hartwig, J. H., Weitz, D. A. and Stossel, T. P. (2011). Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A. Nature. 478, 260-263.
29. Endlich, N., Schordan, E., Cohen, C. D., Kretzler, M., Lewko, B., Welsch, T., Kriz, W., Otey, C. A. and Endlich K. (2009). Palladin is a dynamic actin-associated protein in podocytes. Kidney Int. 75, 214-226.
30. Engler, A. J., Sen, S., Sweeney, H. L. and Discher, D. E. (2006). Matrix elasticity directs stem cell lineage specification. Cell 126, 677-689.
31. Fan, L., Pellegrin, S., Scott, A. and Mellor, H. (2010). The small GTPase Rif is an alternative trigger for the formation of actin stress fibers in epithelial cells. J. Cell Sci. 123, 1247-1252.
32. Fischer, R. S., Gardel, M., Ma, X., Adelstein, R. S. and Waterman, C. M. (2009). Local Cortical Tension by Myosin II Guides 3D Endothelial Cell Branching. Curr. Biol. 19, 260-265.
33. Gardel, M. L., Sabass, B., Ji, L., Danuser, G., Schwarz, U. S. and Waterman, C. M. (2008). Traction stress in focal adhesions correlates biphasically with actin retrograde flow speed. J. Cell Biol. 183, 999-1005.
34. Geiger, B., Spatz, J. P. and Bershadsky, A. D. (2009). Environmental sensing through focal adhesions. Nat. Rev. Mol. Cell Biol. 10, 21-33.
35. Gilbert, S. F. (2003). Developmental Biology, 7th edn.Sunderland, MA: Sinauer
36. Gingras, A. R., Vogel, K.-P., Steinhoff, H.-J., Ziegler, W. H., Patel, B., Emsley, J., Critchley, D. R., Roberts, G. C. K. and Barsukov, I. L. (2006). Structural and dynamic characterization of a vinculin binding site in the talin. Biochemistry 45, 1805-1817.
37. Goicoechea, S. M., Arneman, D. and Otey, C. A. (2008). The role of palladin in actin organization and cell motility. Eur. J. Cell Biol. 87, 517-525.
38. Gunning, P. (2008). Emerging issues for tropomyosin structure, regulation, function and pathology. Adv. Exp. Med. Biol. 644, 293-298.
39. Gupton, S. L., Anderson, K. L., Kole, T. P., Fischer, R. S., Ponti, A., Hitchcock-DeGregori, S. E., Danuser, G., Fowler, V. M., Wirtz, D., Hanein, D. et al. (2005). Cell migration without a lamellipodium: translation of actin dynamics into cell movement mediated by tropomyosin. J. Cell Biol. 168, 619-631.
40. Handel, S. E., Greaser, M. L., Schultz, E., Wang, S. M., Bulinski, J. C., Lin, J. J. and Lessard, J. L. (1991). Chicken cardiac myofibrillogenesis studied with antibodies specific for titin and the muscle and nonmuscle isoforms of actin and tropomyosin. Cell Tissue Res. 263, 419-430.
41. Hashimoto, Y., Kim, D. J. and Adams, J. C. (2011). The roles of fascins in health and disease. J. Pathol. 224, 289-300.
42. Hayakawa, K., Tatsumi, H. and Sokabe, M. (2008). Actin stress fibers transmit and focus force to activate mechanosensitive channels. J. Cell Sci. 121, 496-503.
43. Heasman, S. J. and Ridley, A. J. (2008). Mammalian Rho GTPases: new insights into their functions from in vivo studies. Nat. Rev. Mol. Cell Biol. 9, 690-701.
44. Heath, J. P. (1983). Behaviour and structure of the leading lamella in moving fibroblasts. I. Occurrence and centripetal movement of arc-shaped microfilament bundles beneath the dorsal cell surface. J. Cell Sci. 60, 331-354.
45. Helfman, D. M., Levy, E. T., Berthier, C., Shtutman, M., Riveline, D., Grosheva, I., Lachish-Zalait, A., Elbaum, M. and Bershadsky, A. D. (1999). Caldesmon inhibits nonmuscle cell contractility and interferes with the formation of focal adhesions. Mol. Biol. Cell. 10, 3097-3112.
46. Hill, C. S., Wynne, J. and Treisman, R. (1995). The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF. Cell. 81, 1159-1170.
47. Hinz, B., Gabbiani, G. and Chaponnier, C. (2002). The NH2-terminal peptide of alpha-smooth muscle actin inhibits force generation by the myofibroblast in vitro and in vivo. J. Cell Biol. 157, 657-663.
48. Hirata, H., Tatsumi, H. and Sokabe, M. (2008). Mechanical forces facilitate actin polymerization at focal adhesions in a zyxin-dependent manner. J. Cell Sci. 121, 2795-2804.
49. Honda, K., Yamada, T., Endo, R., Ino, Y., Gotoh, M., Tsuda, H., Yamada, Y., Chiba, H. and Hirohashi, S. (1998). Actinin-4, a novel actin-bundling protein associated with cell motility and cancer invasion. J. Cell Biol. 140, 1383-1393.
50. Hossain, M. M., Hwang, D. Y., Huang, Q. Q., Sasaki, Y. and Jin, J. P. (2003). Developmentally regulated expression of calponin isoforms and the effect of h2- calponin on cell proliferation. Am. J. Physiol Cell Physiol. 284, C156-C167.
51. Hotulainen, P. and Lappalainen, P. (2006). Stress fibers are generated by two distinct actin assembly mechanisms in motile cells. J. Cell Biol. 173, 383-394.
52. Hou, X., Katahira, T., Kimura, J. and Nakamura, H. (2009). Expression of chick Coactosin in cells in morphogenetic movement. Dev. Growth Differ. 51, 833-840.
53. Hu, K., Ji, L., Applegate, K. T., Danuser, G. and Waterman-Storer, C. M. (2007). Differential transmission of actin motion within focal adhesions. Science. 315, 111-115.
54. Ishikawa, R., Yamashiro, S. and Matsumura, F. (1989a). Differential modulation of actin-severing activity of gelsolin by multiple isoforms of cultured rat cell tropomyosin. Potentiation of protective ability of tropomyosins by 83-kDa nonmuscle caldesmon. J. Biol. Chem. 264, 7490-7497.
55. Ishikawa, R., Yamashiro, S. and Matsumura, F. (1989b). Annealing of gelsolinsevered actin fragments by tropomyosin in the presence of Ca2+. Potentiation of the annealing process by caldesmon. J. Biol. Chem. 264, 16764-16770.
56. Jacinto, A., Wood, W., Woolner, S., Hiley, C., Turner, L., Wilson, C., Martinez-Arias, A. and Martin, P. (2002). Dynamic analysis of actin cable function during Drosophila dorsal closure. Curr. Biol. 12, 1245-1250.
57. Johnson, C. P., Tang, H.-Y., Carag, C., Speicher, D. W. and Discher, D. E. (2007). Forced unfolding of proteins within cells. Science 317, 663-666.
58. Joo, E., Surka, M. C. and Trimble, W. S. (2007). Mammalian SEPT2 is required for scaffolding nonmuscle myosin II and its kinases. Dev. Cell. 13, 677-690.
59. Jurmeister, S., Baumann, M., Balwierz, A., Keklikoglou, I., Ward, A., Uhlmann, S., Zhang, J. D., Wiemann, S. and Sahin, O. (2011). MicroRNA-200c represses migration and invasion of breast cancer cells by targeting actin-regulatory proteins FHOD1 and PPM1F. Mol. Cell Biol. 32, 633-651.
60. Kaksonen, M., Toret, C. P. and Drubin, D. G. (2006). Harnessing actin dynamics for clathrin-mediated endocytosis. Nat. Rev. Mol. Cell Biol. 7, 404-414.
61. Kashiwada, K., Nishida, W., Hayashi, K., Ozawa, K., Yamanaka, Y., Saga, H., Yamashita, T., Tohyama, M., Shimada, S., Sato, K. and Sobue, K. (1997). Coordinate expression of alpha-tropomyosin and caldesmon isoforms in association with phenotypic modulation of smooth muscle cells. J. Biol. Chem. 272, 15396-13404.
62. Katayama, E., Scott-Woo, G. and Ikebe, M. (1995). Effect of caldesmon on the assembly of smooth muscle myosin. J. Biol. Chem. 270, 3919-3925.
63. Katoh, K., Kano, Y., Amano, M., Onishi, H., Kaibuchi, K. and Fujiwara, K. (2001a). Rho-kinase-mediated contraction of isolated stress fibers. J. Cell Biol. 153, 569-584.
64. Katoh, K., Kano, Y., Amano, M., Kaibuchi, K. and Fujiwara, K. (2001b). Stress fiber organization regulated by MLCK and Rho-kinase in cultured human fibroblasts. Am J. Physiol Cell Physiol. 280, C1669-C1679.
65. Kawabata, S., Usukura, J., Morone, N., Ito, M., Iwamatsu, A., Kaibuchi, K. and Amano, M. (2004). Interaction of Rho-kinase with myosin II at stress fibres. Genes Cells 9, 653-660.
66. Khatau, S. B., Hale, C. M., Stewart-Hutchinson, P. J., Patel, M. S., Stewart, C. L., Searson, P. C., Hodzic, D. and Wirtz, D. (2009). A perinuclear actin cap regulates nuclear shape. Proc. Natl. Acad. Sci. USA 106, 19017-19022.
67. Kimura, K., Ito, M., Amano, M., Chihara, K., Fukata, Y., Nakafuku, M., Yamamori, B., Feng, J., Nakano, T., Okawa, K., Iwamatsu, A. and Kaibuchi, K. (1996). Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science 273, 245-248.
68. Kinoshita, M., Field, C. M., Coughlin, M. L., Straight, A. F. and Mitchison, T. J. (2002). Self- and actin-templated assembly of Mammalian septins. Dev. Cell. 3, 791-802.
69. Koga, Y. and Ikebe, M. (2005). p116Rip decreases myosin II phosphorylation by activating myosin light chain phosphatase and by inactivating RhoA. J. Biol. Chem. 280, 4983-4991.
70. Kordowska, J., Hetrick, T., Adam, L. P. and Wang, C. L. (2006). Phosphorylated lcaldesmon is involved in disassembly of actin stress fibers and postmitotic spreading. Exp. Cell Res. 312, 95-110.
71. Krcmery, J., Camarata, T., Kulisz, A. and Simon, H. G. (2010). Nucleocytoplasmic functions of the PDZ-LIM protein family: new insights into organ development. BioEssays 32, 100-108.
72. Kubow, K. E. and Horwitz, A. R. (2011). Reducing background fluorescence reveals adhesions in 3D matrices. Nat. Cell Biol. 13, 3-5.
73. Langanger, G., Moeremans, M., Daneels, G., Sobieszek, A., De Brabander, M. and De Mey, J. (1986). The molecular organization of myosin in stress fibers of cultured cells. J. Cell Biol. 102, 200-209.
74. Lazarides, E. (1975). Tropomyosin antibody: the specific localization of tropomyosin in nonmuscle cells. J. Cell Biol. 65, 549-561.
75. Lazarides, E. and Burridge, K. (1975). Alpha-actinin: immunofluorescent localization of a muscle structural protein in nonmuscle cells. Cell. 6, 289-298.
76. Leinweber, B. D., Leavis, P. C., Grabarek, Z., Wang, C. L. and Morgan, K. G. (1999a) Extracellular regulated kinase (ERK) interaction with actin and the calponin homology (CH) domain of actin-binding proteins. Biochem. J. 1, 117-123.
77. Leinweber, B., Tang, J. X., Stafford, W. F. and Chalovich, J. M. (1999b) Calponin interaction with alpha-actinin-actin: evidence for a structural role for calponin. Biophys. J. 77, 3208-3217.
78. Leung, T., Chen, X. Q., Manser, E. and Lim, L. (1996). The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton. Mol. Cell Biol. 16, 5313-5327.
79. Luxton, G. W., Gomes, E. R., Folker, E. S., Vintinner, E. and Gundersen, G. G. (2010). Linear arrays of nuclear envelope proteins harness retrograde actin flow for nuclear movement. Science 329, 956-959.
80. Maekawa, M., Ishizaki, T., Boku, S., Watanabe, N., Fujita, A., Iwamatsu, A., Obinata, T., Ohashi, K., Mizuno, K. and Narumiya, S. (1999). Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase. Science 285, 895-898.
81. Marston, S., Pinter, K. and Bennett, P. (1992). Caldesmon binds to smooth muscle myosin and myosin rod and crosslinks thick filaments to actin filaments. J. Muscle Res. Cell Motil. 13, 206-218.
82. Mayanagi, T. and Sobue, K. (2011). Diversification of caldesmon-linked actin cytoskeleton in cell motility. Cell Adh. Migr. 5, 150-159.
83. McKillop, D. F. and Geeves, M. A. (1993). Regulation of the interaction between actin and myosin subfragment 1: evidence for three states of the thin filament. Biophys J. 65, 693-701.
84. McMichael, B. K., Kotadiya, P., Singh, T., Holliday, L. S. and Lee, B. S. (2006). Tropomyosin isoforms localize to distinct microfilament populations in osteoclasts. Bone 39, 694-705
85. Michelot, A. and Drubin, D. G. (2011). Building distinct actin filament networks in a common cytoplasm. Curr. Biol. 21, R560-R569.
86. Millán, J., Cain, R. J., Reglero-Real, N., Bigarella, C., Marcos-Ramiro, B., Fernández-Martín, L., Correas, I. and Ridley, A. J. (2010). Adherens junctions connect stress fibres between adjacent endothelial cells. BMC Biol. 8, 11.
87. Miralles, F., Posern, G., Zaromytidou, A. I. and Treisman, R. (2003). Actin dynamics control SRF activity by regulation of its coactivator MAL. Cell 113, 329-342.
88. Mitchison, T. J. and Cramer, L. P. (1996). Actin-Based Cell Motility and Cell Locomotion. Cell 84, 371-379.
89. Mulder, J., Poland, M., Gebbink, M. F., Calafat, J., Moolenaar, W. H. and Kranenburg, O. (2003). p116Rip is a novel filamentous actin-binding protein. J. Biol. Chem. 278, 27216-27223.
90. Mykkänen, O. M., Grönholm, M., Rönty, M., Lalowski, M., Salmikangas, P., Suila, H. and Carpén, O. (2001). Characterization of human palladin, a microfilamentassociated protein. Mol. Biol. Cell. 12, 3060-3073.
91. Nagayama, K., Yahiro, Y. and Matsumoto, T. (2011). Stress fibers stabilize the position of intranuclear DNA through mechanical connection with the nucleus in vascular smooth muscle cells. FEBS Lett. 585, 3992-3997.
92. Naumanen, P., Lappalainen, P. and Hotulainen, P. (2008). Mechanisms of actin stress fibre assembly. J. Microsc. 231, 446-454. Review.
93. Nemethova, M., Auinger, S. and Small, J. V. (2008). Building the actin cytoskeleton: filopodia contribute to the construction of contractile bundles in the lamella. J. Cell Biol. 180, 1233-1244.
94. Ono, S. (2010). Dynamic regulation of sarcomeric actin filaments in striated muscle. Cytoskeleton (Hoboken). 67, 677-692.
95. Ono, S. and Ono, K. (2002). Tropomyosin inhibits ADF/cofilin-dependent actin filament dynamics. J. Cell Biol. 156, 1065-1076.
96. Papagrigoriou, E., Gingras, A. R., Barsukov, I. L., Bate, N., Fillingham, I. J., Patel, B., Frank, R., Ziegler, W. H., Roberts, G. C. K., Critchley, D. R. et al. (2004). Activation of a vinculin-binding site in the talin rod involves rearrangement of a fivehelix bundle. EMBO J. 23, 2942-2951.
97. Parast, M. M. and Otey, C. A. (2000). Characterization of palladin, a novel protein localized to stress fibers and cell adhesions. J. Cell Biol. 150, 643-656.
98. Parsons, J. T., Horwitz, A. R. and Schwartz, M. A. (2010). Cell adhesion: integrating cytoskeletal dynamics and cellular tension. Nat. Rev. Mol. Cell Biol. 11, 633-643.
99. Patil, S. B., Pawar, M. D. and Bitar, K. N. (2004). Direct association and translocation of PKC-alpha with calponin. Am. J. Physiol. Gastrointest. Liver Physiol. 286, G954- G963.
100. Pellegrin, S. P. and Mellor, H. (2007). Actin stress fibres. J. Cell Sci. 120, 3491-3499.
101. Peterson, L. J., Rajfur, Z., Maddox, A. S., Freel, C. D., Chen, Y., Edlund, M., Otey, C. and Burridge, K. (2004). Simultaneous stretching and contraction of stress fibers in vivo. Mol. Biol. Cell. 15, 3497-3508.
102. Pollard, T. D. (2007). Regulation of actin filament assembly by Arp2/3 complex and formins. Annu. Rev. Biophys Biomol. Struct. 36, 451-477.
103. Pollard, T. D. and Cooper, J. A. (2009). Actin, a central player in cell shape and movement. Science 326, 1208-1212.
104. Pollard, T. D. and Wu, J. Q. (2010). Understanding cytokinesis: lessons from fission yeast. Nat. Rev. Mol. Cell Biol. 11, 149-155.
105. Ponti, A., Machacek, M., Gupton, S. L., Waterman-Storer, C. M. and Danuser, G. (2004). Two Distinct Actin Networks Drive the Protrusion of Migrating Cells. Science 305, 1782-1786.
106. Prager-Khoutorsky, M., Lichtenstein, A., Krishnan, R., Rajendran, K., Mayo, A., Kam, Z., Geiger, B. and Bershadsky, A. D. (2011). Fibroblast polarization is a matrix rigidity-dependent process controlled by focal adhesion mechanosensing. Nat. Cell. Biol. 13, 1457-1465.
107. Puklin-Faucher, E., Gao, M., Schulten, K. and Vogel, V. (2006). How the headpiece hinge angle is opened: new insights into the dynamics of integrin activation. J. Cell Biol. 175, 349-360.
108. Ridley, A. J., Schwartz, M. A., Burridge, K., Firtel, R. A., Ginsberg, M. H., Borisy, G., Parsons, J. T. and Horwitz, A. R. (2003). Cell Migration: Integrating Signals from Front to Back. Science 302, 1704-1709.
109. Riveline, D., Zamir, E., Balaban, N. Q., Schwarz, U. S., Ishizaki, T., Narumiya, S., Kam, Z., Geiger, B. and Bershadsky, A. D. (2001). Focal Contacts as Mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism. J. Cell Biol. 153, 1175-1186.
110. Rozenblum, G. T. and Gimona, M. (2008). Calponins: adaptable modular regulators of the actin cytoskeleton. Int. J. Biochem Cell Biol. 40, 1990-1995.
111. Rubino, S., Fighetti, M., Unger, E. and Cappuccinelli, P. (1984). Location of actin, myosin, and microtubular structures during directed locomotion of Dictyostelium amebae. J. Cell Biol. 98, 382-390.
112. Sandbo, N. and Dulin, N. (2011). Actin cytoskeleton in myofibroblast differentiation: Ultrastructure defining form and driving function. Transl. Res. 158, 181-196.
113. Sanger, J. W., Kang, S., Siebrands, C. C., Freeman, N., Du, A., Wang, J., Stout, A. L. and Sanger, J. M. (2005). How to build a myofibril. J. Muscle Res. Cell Motil. 26, 343-354.
114. Sanger, J. W., Wang, J., Holloway, B., Du, A. and Sanger, J. M. (2009). Myofibrillogenesis in skeletal muscle cells in zebrafish. Cell Motil. Cytoskeleton 66, 556-566.
115. Sanger, J. W., Wang, J., Fan, Y., White, J. and Sanger, J. M. (2010). Assembly and dynamics of myofibrils. J. Biomed Biotechnol. 2010, 858606.
116. Sato, M. and Ohashi, T. (2005). Biorheological views of endothelial cell responses to mechanical stimuli. Biorheology 42, 421-441.
117. Sawada, Y., Tamada, M., Dubin-Thaler, B. J., Cherniavskaya, O., Sakai, R., Tanaka, S. and Sheetz, M. P. (2006). Force Sensing by Mechanical Extension of the Src Family Kinase Substrate p130Cas. Cell 127, 1015-1026.
118. Schaefer, A. W., Schoonderwoert, V. T., Ji, L., Mederios, N., Danuser, G. and Forscher, P. (2008). Coordination of actin filament and microtubule dynamics during neurite outgrowth. Dev. Cell. 15, 146-162.
119. Schmidt, K. and Nichols, B. J. (2004). Functional interdependence between septin and actin cytoskeleton. BMC Cell Biol. 5, 43-56.
120. Shemesh, T., Verkhovsky, A. B., Svitkina, T. M., Bershadsky, A. D. and Kozlov, M. M. (2009). Role of focal adhesions and mechanical stresses in the formation and progression of the lamellipodium-lamellum interface. Biophys. J. 97, 1254-6124.
121. Sjöblom, B., Salmazo, A. and Djinović-Carugo, K. (2008). Alpha-actinin structure and regulation. Cell Mol. Life Sci. 65, 2688-2701.
122. Small, J. V., Rottner, K., Kaverina, I. and Anderson, K. I. (1998). Assembling an actin cytoskeleton for cell attachment and movement. Biochim. Biophys. Acta. 1404, 271-281.
123. Smith, M. A., Blankman, E., Gardel, M. L., Luettjohann, L., Waterman, C. M. and Beckerle, M. C. (2010). A Zyxin-Mediated Mechanism for Actin Stress Fiber Maintenance and Repair. Dev. Cell. 19, 365-376.
124. Somlyo, A. P. and Somlyo, A. V. (2000). Signal transduction by G-proteins, rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II. J. Physiol. 2, 177-185.
125. Sparrow, J. C. and Schöck, F. (2009). The initial steps of myofibril assembly: integrins pave the way. Nat. Rev. Mol. Cell Biol.10, 293-298.
126. Stark, B. C., Sladewski, T. E., Pollard, L. W. and Lord, M. (2010). Tropomyosin and myosin-II cellular levels promote actomyosin ring assembly in fission yeast. Mol. Biol. Cell. 21, 989-1000.
127. Strasser, P., Gimona, M., Moessler, H., Herzog, M. and Small, J. V. (1993). Mammalian calponin. Identification and expression of genetic variants. FEBS Lett. 330, 13-18.
128. Surks, H. K., Riddick, N. and Ohtani, K. (2005). M-RIP targets myosin phosphatase to stress fibers to regulate myosin light chain phosphorylation in vascular smooth muscle cells. J. Biol. Chem. 280, 42543-42551.
129. Tojkander, S., Gateva, G., Schevzov, G., Hotulainen, P., Naumanen, P., Martin, C., Gunning, P. W. and Lappalainen, P. (2011): A molecular pathway for myosin II recruitment to stress fibers. Curr. Biol. 21, 539-550.
130. Tominaga, T., Sahai, E., Chardin, P., McCormick, F., Courtneidge, S. A. and Alberts, A. S. (2000). Diaphanous-related formins bridge Rho GTPase and Src tyrosine kinase signaling. Mol. Cell. 5, 13-25.
131. Totsukawa, G., Yamakita, Y., Yamashiro, S., Hartshorne, D. J., Sasaki, Y. and Matsumura, F. (2000). Distinct roles of ROCK (Rho-kinase) and MLCK in spatial regulation of MLC phosphorylation for assembly of stress fibers and focal adhesions in 3T3 fibroblasts. J. Cell Biol. 150, 797-806.
132. Tran, T. C., Singleton, C., Fraley, T. S. and Greenwood, J. A. (2005). Cysteine-rich protein 1 (CRP1) regulates actin filament bundling. BMC Cell Biol. 6, 45.
133. Valerius, N. H., Stendahl, O., Hartwig, J. H. and Stossel, T. P. (1981). Distribution of actin-binding protein and myosin in polymorphonuclear leukocytes during locomotion and phagocytosis. Cell 24, 195-202.
134. Vallenius, T., Luukko, K. and Mäkelä, T. P. (2000). CLP-36 PDZ-LIM protein associates with nonmuscle alpha-actinin-1 and alpha-actinin-4. J. Biol. Chem. 275, 11100-11105.
135. Vallenius, T. and Mäkelä, T. P. (2002). Clik1: a novel kinase targeted to actin stress fibers by the CLP-36 PDZ-LIM protein. J. Cell Sci. 115, 2067-2073.
136. Vallenius, T., Vaahtomeri, K., Kovac, B., Osiceanu, A. M., Viljanen, M. and Mäkelä, T. P. (2011). An association between NUAK2 and MRIP reveals a novel mechanism for regulation of actin stress fibers. J. Cell Sci. 124, 384-393.
137. Vallotton, P. and Small, J. V. (2009). Shifting views on the leading role of the lamellipodium in cell migration: speckle tracking revisited. J. Cell Sci. 122, 1955-1958.
138. Vicente-Manzanares, M., Ma, X., Adelstein, R. S. and Horwitz, A. R. (2009). Nonmuscle myosin II takes centre stage in cell adhesion and migration. Nat. Rev. Mol. Cell Biol. 10, 778-790.
139. Vlahovich, N., Schevzov, G., Nair-Shaliker, V., Ilkovski, B., Artap, S. T., Joya, J. E., Kee, A. J., North, K. N., Gunning, P. W. and Hardeman, E. C. (2008). Tropomyosin 4 defines novel filaments in skeletal muscle associated with muscle remodelling/regeneration in normal and diseased muscle. Cell Motil. Cytoskeleton 65, 73-85.
140. Vogel, V. (2006). Mechanotransduction involving multimodular proteins: Converting Force into Biochemical Signals. Annu. Rev. Biophys. Biomol. Struct. 35, 459-488.
141. Walcott, S. and Sun, S. X. (2010). A mechanical model of actin stress fiber formation and substrate elasticity sensing in adherent cells. Proc. Natl. Acad. Sci. USA 107, 7757-7762.
142. Wang, K., Ash, J. F. and Singer, S. J. (1975). Filamin, a new high-molecular-weight protein found in smooth muscle and non-muscle cells. Proc. Natl. Acad. Sci. USA 72, 4483-4486
143. Watanabe, N., Madaule, P., Reid, T., Ishizaki, T., Watanabe, G., Kakizuka, A., Saito, Y., Nakao, K., Jockusch, B. M. and Narumiya, S. (1997). p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin. EMBO J. 16, 3044-3056.
144. Weber, K. and Groeschel-Stewart, U. (1974). Antibody to myosin: the specific visualization of myosin-containing filaments in nonmuscle cells. Proc. Natl. Acad. Sci. USA 71, 4561-4564
145. Winder, S. J., Allen, B. G., Clément-Chomienne, O. and Walsh, M. P. (1998). Regulation of smooth muscle actin-myosin interaction and force by calponin. Acta. Physiol. Scand. 164, 415-426.
146. Wong, A. J., Pollard, T. D. and Herman, I. M. (1983). Actin filament stress fibers in vascular endothelial cells in vivo. Science 219, 867-869.
147. Yamashiro, S., Yamakita, Y., Yoshida, K., Takiguchi, K. and Matsumura, F. (1995). Characterization of the COOH terminus of non-muscle caldesmon mutants lacking mitosis-specific phosphorylation sites. J. Biol. Chem. 270, 4023-4030.
148. Yamashiro-Matsumura, S. and Matsumura, F. (1988). Characterization of 83- kilodalton nonmuscle caldesmon from cultured rat cells: stimulation of actin binding of nonmuscle tropomyosin and periodic localization along microfilaments like tropomyosin. J. Cell Biol. 106, 1973-1983.
149. Yamboliev, I. A. and Gerthoffer, W. T. (2001). Modulatory role of ERK MAPKcaldesmon pathway in PDGF-stimulated migration of cultured pulmonary artery SMCs. Am J. Physiol. Cell Physiol. 280, C1680-C1688.
150. Ydenberg, C. A., Smith, B. A., Breitsprecher, D., Gelles, J. and Goode, B. L.(2011). Cease-fire at the leading edge: New perspectives on actin filament branching, debranching, and cross-linking. Cytoskeleton (Hoboken), 68, 596-602.
151. Yi, J., Wu, X. S., Crites, T. and Hammer, J. A. (2012). Actin Retrograde Flow and Acto-Myosin II Arc Contraction Drive Receptor Cluster Dynamics at the Immunological Synapse in Jurkat T-Cells. Mol. Biol. Cell. 23, 834-852.
152. Zagórska, A., Deak, M., Campbell, D. G., Banerjee, S., Hirano, M., Aizawa, S., Prescott, A. R. and Alessi, D. R. (2010). New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion. Sci. Signal 3, ra25.
153. Zemel, A., Rehfeldt, F., Brown, A. E. X., Discher, D. E. and Safran, S. A. (2010). Optimal matrix rigidity for stress-fibre polarization in stem cells. Nat. Phys. 6, 468-473.
154. Zhang, X.-F., Schaefer, A. W., Burnette, D. T., Schoonderwoert, V. T. and Forscher, P. (2003). Rho-Dependent Contractile Responses in the Neuronal Growth Cone Are Independent of Classical Peripheral Retrograde Actin Flow. Neuron 40, 931-944.