Autofluorescence distribution associated with drusen in age-related macular degeneration

Investigative Ophthalmology and Visual Science

Volumn 41, Issue 2, 2000, Pages 496-504

  Delori, François C ^a,b   Fleckner, Mark R ^a   Goger, Douglas G ^a   Weiter, John J ^a,b   Dorey, C Kathleen ^a,b  

^a SCHEPENS EYE RESEARCH INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIPOFUSCIN;

ADULT; AGED; ARTICLE; AUTOFLUORESCENCE; CLINICAL ARTICLE; DRUSEN; EYE FUNDUS; HUMAN; IMAGE ANALYSIS; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RETINA MACULA AGE RELATED DEGENERATION;

ADULT; AGED; AGED, 80 AND OVER; FLUORESCENCE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; LIPOFUSCIN; MACULAR DEGENERATION; MIDDLE AGED; PIGMENT EPITHELIUM OF EYE; RETINAL DRUSEN;

EID: 0033950594     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Bressler NM, Silva JC, Bressler SB, Fine SL, Green WR. Clinicopathologic correlation of drusen and retinal pigment epithelial abnormalities in age-related macular degeneration. Retina. 1994;14: 130-142.
2. Feeney-Burns L, Ellersieck MR. Age-related changes in the ultra-structure of Bruch's membrane. Am J Ophthalmol. 1985;100:686-697.
3. Green WR, Enger C. Age-related macular degeneration histopathologic studies [The 1992 Lorenz E. Zimmerman Lecture]. Ophthalmology. 1993;100:1519-1535.
4. Sarks JP, Sarks SH, Killingsworth MC. Evolution of soft drusen in age-related macular degeneration. Eye. 1994;8:269-283.
5. Sarks SH, Arnold JJ, Killingsworth MC, Sarks JP. Early drusen formation in the normal and aging eye and their relation to age related maculopathy: a clinical pathological study. Br J Ophthalmol. 1999;83:358-368.
6. Holz FG, Sheraidah G, Pauleikhoff D, Bird AC. Analysis of lipid deposits extracted from human macular and peripheral Bruch's membrane. Arch Ophthamol. 1994;112:402-406.
7. Feeney-Burns L, Hilderbrand ES, Eldridge S. Aging human RPE: morphometric analysis of macular, equatorial, and peripheral cells. Invest Ophthalmol Vis Sci. 1984;25:195-200.
8. Weiter JJ, Delori FC, Wing G, Fitch KA. Retinal pigment epithelial lipofuscin and melanin and choroidal melanin in human eyes. Invest Ophthalmol Vis Sci. 1986;27:145-152.
9. Wing GL, Blanchard GC, Weiter JJ. The topography and age relationship of lipofuscin concentration in the retinal pigment epithelium. Invest Ophthalmol Vis Sci. 1978;17:601-607.
10. Eldred GE, Katz ML. Fluorophores of the human retinal pigment epithelium: separation and spectral characterization. Exp Eye Res. 1988;47:71-86.
11. Reinboth JJ, Gautschi K, Munz K, Eldred GE, Reme CE. Lipofuscin in the retina: quantitative assay for an unprecedented autofluorescent compound (pyridinium bis-retinoid, A2-E) of ocular age pigment. Exp Eye Res. 1997;65:639-643.
12. Holz FG, Schutt F, Kopitz J, et al. Inhibition of lysosomal degradative functions in RPE cells by a retinoid component of lipofuscin. Invest Ophthalmol Vis Sci. 1999;40:737-743.
13. Delori FC, Spectrophotometer for noninvasive measurement of intrinsic fluorescence and reflectance of the ocular fundus. Appl Optics. 1994;33:7439-7452.
14. Delori FC, Arend O. Staurenghi G, Goger D, Dorey CK, Weiter JJ. Lipofuscin and drusen fluorescence in aging and age-related macular degeneration [ARVO Abstract]. Invest Ophthalmol Vis Sci. 1994;35(3):S2145. Abstract nr 4127.
15. Delori FC, Dorey CK, Staurenghi G, Arend O, Goger DG, Weiter JJ. In vivo fluorescence of the ocular fundus exhibits retinal pigment epithelium lipofuscin characteristics. Invest Ophthalmol Vis Sci. 1995;36:718-729.
16. Dorey CK, Staurenghi G, Delori FC, Lipofuscin in aged and AMD eyes. In: Holyfield JG, Anderson RE, La Vail MM, eds. Retinal Degeneration. New York: Plenum Press: 1993;3-14.
17. Arend OA, Weiter JJ, Goger DG, Delori FC. In-vivo fundus-fluoreszenz-messungen bei patienten mit alterabhangiger makularde-generation. Ophthalmologie. 1995;92:647-653.
18. von Ruckmann A, Fitzke FW, Bird AC. Distribution of fundus autofluorescence with a scanning laser ophthalmoscope. Br J Ophthalmol. 1995;119:543-562.
19. Holz FG, Bellmann C, Margaritidis M, Schutt F, Otto TP, Volcker HE. Patterns of increased in vivo fundus autofluorescence in the junctional zone of geographic atrophy of the retinal pigment epithelium associated with age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol 1999;237: 145-52.
20. Solbach U, Keilhauer C, Knabben H, Wolf S. Imaging of retinal autofluorescence in patients with age related macular degeneration. Retina. 1997;17:385-389.
21. Spital G, Radermacher M, Muller C, Brumm G, Lommatzsch A, Pauleikhoff D. Autofluorescence characteristics of lipofuscin components in different forms of late senile macular degeneration (German). Klin Monatsbl Augenbeilkd. 1998;213:23-31 [Ophthalmoscopy Pigment Epithelium of Eye/pathology Prospective Studies 9743935.]
22. von Ruckmann A, Fitzke FW, Bird AC. Fundus autofluorescence in age-related macular disease imaged with a laser scanning ophthalmoscope. Invest Ophthalmol Vis Sci. 1997;38:478-486.
23. von Ruckmann A, Schmidt KG, Fitzke FW, Bird AC, Jacobi KW. Dynamics of accumulation and degradation of lipofuscin in retinal pigment epithelium in senile macular degeneration (German). Klin Monatsbl Augenheilkd. 1998;213:32-37.
24. Delori FC, Goger DG, Fleckner MR, Burns SA. Multispectral imaging of fundus autofluorescence in normal subjects and AMD patients [ARVO Abstract]. Invest Ophthalmol Vis Sci. 1998;39(4): S591. Abstract nr 2733.
25. Bird AC, Bressler NM, Bressler SB, et al. An international classification and grading system for age-related maculopathy and agerelated macular degeneration (The International ARM Epidemiological Study Group). Surv Ophthamol. 1995;39:367-374.
26. Delori FC, Gragoudas ES, Francisco R, Pruett RC. Monochromatic ophthalmoscopy and fundus photography, the normal fundus. Arch Ophthalmol. 1977;95:861-868.
27. ANSI. American National Standard for Safe Use of Lasers. ANSI 136.1-1993 (Revision of ANSI 136.1-1986), 1993.
28. Elsner AE, Burns SA, Weiter JJ, Delori FC. Infrared imaging of sub-retinal structures in the human ocular fundus. Vision Res. 1996;36:191-205.
29. Manivannan A, Kirkpatrick JN, Sharp PF, Forrester JV. Clinical investigation of an infrared digital scanning laser ophthalmoscope. Br J Ophthalmol. 1994;78:84-90.