Age- and Light-Dependent Development of Localised Retinal Atrophy in CCL2-/-CX3CR1GFP/GFP Mice

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Chen, Mei ^a   Hombrebueno, Jose R ^a   Luo, Chang ^a   Penalva, Rosana ^a   Zhao, Jiawu ^a   Colhoun, Liza ^a   Pandi, Sudha Pirya Soundara ^a   Forrester, John V ^b   Xu, Heping ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CX3CR1; GREEN FLUORESCENT PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 12; INTERLEUKIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; RETINA S ANTIGEN; RHODOPSIN; SYNAPTOPHYSIN; TUMOR NECROSIS FACTOR ALPHA;

AGE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL HYPOXIA; CELL PHAGOCYTOSIS; CELL STIMULATION; CONTROLLED STUDY; DISEASE PREDISPOSITION; FLUORESCENCE ANGIOGRAPHY; GLIA CELL; IMMUNOPATHOGENESIS; LIGHT; MACROPHAGE; MICROGLIA; MOUSE; MUELLER CELL; NONHUMAN; PHOTORECEPTOR OUTER SEGMENT; PIGMENT EPITHELIUM; PROTEIN EXPRESSION; RETINA BIPOLAR GANGLION CELL; RETINA CONE; RETINA MACULA DEGENERATION;

ANIMALS; CHEMOKINE CCL2; GREEN FLUORESCENT PROTEINS; LIGHT; MACROPHAGES; MACULAR DEGENERATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHAGOCYTOSIS; RECEPTORS, CYTOKINE; RECEPTORS, HIV; RETINA; RETINAL DEGENERATION;

MUS;

EID: 84876339803     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0061381     Document Type: Article

References (54)

1. Coleman HR, Chan CC, Ferris FL 3rd, Chew EY, (2008) Age-related macular degeneration. Lancet 372(9652): 1835-1845.
2. Zweifel SA, Spaide RF, Curcio CA, Malek G, Imamura Y, (2010) Reticular pseudodrusen are subretinal drusenoid deposits. Ophthalmology 117(2): 303-12.e1.
3. Zweifel SA, Imamura Y, Spaide TC, Fujiwara T, Spaide RF, et al. (2010) Prevalence and significance of subretinal drusenoid deposits (reticular pseudodrusen) in age-related macular degeneration. Ophthalmology 117(9): 1775-1781.
4. Telander DG, (2011) Inflammation and Age-Related Macular Degeneration (AMD). Semin.Ophthalmol. 26(3): 192-197.
5. Penfold PL, Madigan MC, Gillies MC, Provis JM (2001) Immunological and aetiological aspects of macular degeneration. Prog.Retin.Eye Res. 20385-414.
6. Donoso LA, Kim D, Frost A, Callahan A, Hageman G, (2006) The role of inflammation in the pathogenesis of age-related macular degeneration. Surv.Ophthalmol. pp. 51137-152.
7. Klein RJ, Zeiss C, Chew EY, Tsai JY, Sackler RS, et al. (2005) Complement factor H polymorphism in age-related macular degeneration. Science 308(572): 385-389.
8. Hageman GS, Anderson DH, Johnson LV, Hancox LS, Taiber AJ, et al. (2005) From The Cover: A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. PNAS 102(2): 7227-7232.
9. Haines JL, Hauser MA, Schmidt S, Scott WK, Olson LM, et al. (2005) Complement factor H variant increases the risk of age-related macular degeneration. Science 308(572): 419-421.
10. Edwards AO, Ritter R III, Abel KJ, Manning A, Panhuysen C, et al. (2005) Complement factor H polymorphism and age-related macular degeneration. Science 308(572): 421-424.
11. Gold B, Merriam JE, Zernant J, Hancox LS, Taiber AJ, et al. (2006) Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration. Nat.Genet. pp. 38458-462.
12. Yates JR, Sepp T, Matharu BK, Khan JC, Thurlby DA, et al. (2007) Complement C3 variant and the risk of age-related macular degeneration. N.Engl.J.Med. 357(6): 553-561.
13. Spencer KL, Olson LM, Anderson BM, Schnetz-Boutaud N, Scott WK, et al. (2008) C3 R102G polymorphism increases risk of age-related macular degeneration. Hum.Mol.Genet. 17(12): 1821-1824.
14. Maller JB, Fagerness JA, Reynolds RC, Neale BM, Daly MJ, et al. (2007) Variation in complement factor 3 is associated with risk of age-related macular degeneration. Nat.Genet. 39(10): 1200-1201.
15. Yang Z, Stratton C, Francis PJ, Kleinman ME, Tan PL, et al. (2008) Toll-like receptor 3 and geographic atrophy in age-related macular degeneration. N.Engl.J.Med. 359(14): 1456-1463.
16. Combadiere C, Feumi C, Raoul W, Keller N, Rodero M, et al. (2007) CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration. J.Clin.Invest. 117(10): 2920-2928.
17. Tuo J, Smith BC, Bojanowski CM, Meleth AD, Gery I, et al. (2004) The involvement of sequence variation and expression of CX3CR1 in the pathogenesis of age-related macular degeneration. FASEB J. 18(11): 1297-1299.
18. Yang X, Hu J, Zhang J, Guan H, (2010) Polymorphisms in CFH, HTRA1 and CX3CR1 confer risk to exudative age-related macular degeneration in Han Chinese. Br.J.Ophthalmol. 94 (9):: 1211-1214.
19. Chan CC, Tuo J, Bojanowski CM, Csaky KG, Green WR, (2005) Detection of CX3CR1 single nucleotide polymorphism and expression on archived eyes with age-related macular degeneration. Histol.Histopathol. 20 (3):: 857-863.
20. Zerbib J, Puche N, Richard F, Leveziel N, Cohen SY, et al. (2011) No association between the T280M polymorphism of the CX3CR1 gene and exudative AMD. Exp.Eye Res. 93 (4):: 382-386.
21. Anderson DH, Mullins RF, Hageman GS, Johnson LV (2002) A role for local inflammation in the formation of drusen in the aging eye. Am.J.Ophthalmol. 134411-431.
22. Crabb JW, Miyagi M, Gu X, Shadrach K, West KA, et al. (2002) Drusen proteome analysis: an approach to the etiology of age-related macular degeneration. Proc.Natl.Acad.Sci.U.S.A. 99 (23):: 14682-14687.
23. Nussenblatt RB, Byrnes G, Nida H, Yeh S, Faia L, et al. (2010) A Randomized Pilot Study of Systemic Immunosuppression in the Treatment of Age-Related Macular Degeneration with Choroidal Neovascularization. Retina 30 (10):: 1579-1587.
24. Xu H, Chen M, Forrester JV, (2009) Para-inflammation in the aging retina. Prog.Retin.Eye Res. 28 (5):: 348-368.
25. Chen M, Muckersie E, Forrester JV, Xu H, (2010) Immune activation in Retinal Aging: A Gene Expression Study. Invest.Ophthalmol.Vis.Sci 51 (11):: 5888-5896.
26. Chen M, Muckersie E, Robertson M, Forrester JV, Xu H,. (2008) Up-regulation of complement factor B in retinal pigment epithelial cells is accompanied by complement activation in the aged retina. Exp.Eye Res. 87 (6):: 543-550.
27. Chen M, Zhao J, Luo C, Pandi SP, Penalva RG, et al. (2012) Para-inflammation-mediated retinal recruitment of bone marrow-derived myeloid cells following whole-body irradiation is CCL2 dependent. Glia 60 (5):: 833-842.
28. Chen M, Forrester JV, Xu H, (2011) Dysregulation in retinal para-inflammation and age-related retinal degeneration in CCL2 or CCR2 deficient mice. PLoS One 68:: e22818.
29. Ambati J, Anand A, Fernandez S, Sakurai E, Lynn BC, et al. (2003) An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice. Nat.Med. 9 (1):: 1390-1397.
30. Tuo J, Bojanowski CM, Zhou M, Shen D, Ross RJ, et al. (2007) Murine ccl2/cx3cr1 deficiency results in retinal lesions mimicking human age-related macular degeneration. Invest.Ophthalmol.Vis.Sci. 48 (8):: 3827-3836.
31. Mattapallil MJ, Wawrousek EF, Chan CC, Zhao H, Roychoudhury J, et al. (2012) The Rd8 mutation of the Crb1 gene is present in vendor lines of C57BL/6N mice and embryonic stem cells, and confounds ocular induced mutant phenotypes. Invest.Ophthalmol.Vis.Sci. 53 (6):: 2921-2927.
32. Luhmann UF, Lange CA, Robbie S, Munro PM, Cowing JA, et al. (2012) Differential modulation of retinal degeneration by Ccl2 and Cx3cr1 chemokine signalling. PLoS One 7 (4):: e35551.
33. Luhmann UF, Robbie S, Munro PM, Barker SE, Duran Y, et al. (2009) The drusenlike phenotype in aging Ccl2-knockout mice is caused by an accelerated accumulation of swollen autofluorescent subretinal macrophages. Invest.Ophthalmol.Vis.Sci. 50 (12):: 5934-5943.
34. Luhmann UF, Carvalho LS, Robbie SJ, Cowing JA, Duran Y, et al. (2013) Ccl2, Cx3cr1 and Ccl2/Cx3cr1 chemokine deficiencies are not sufficient to cause age-related retinal degeneration. Exp.Eye Res. pp. 10780-87.
35. Vessey KA, Greferath U, Jobling AI, Phipps JA, Ho T, et al. (2012) Ccl2/Cx3cr1 knock-out mice have inner retinal dysfunction but are not an accelerated model of age related macular degeneration. Invest.Ophthalmol.Vis.Sci. 53 (12):: 7833-7846.
36. Jung S, Aliberti J, Graemmel P, Sunshine MJ, Kreutzberg GW, et al. (2000) Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol.Cell.Biol. 20 (1):: 4106-4114.
37. Xu H, Koch P, Chen M, Lau A, Reid DM, et al. (2008) A clinical grading system for retinal inflammation in the chronic model of experimental autoimmune uveoretinitis using digital fundus images. Exp.Eye Res. 87 (4):: 319-326.
38. Paques M, Guyomard JL, Simonutti M, Roux MJ, Picaud S, et al. (2007) Panretinal, high-resolution color photography of the mouse fundus. Invest.Ophthalmol.Vis.Sci. 48 (6):: 2769-2774.
39. Chen M, Muckersie E, Robertson M, Fraczek M, Forrester JV, et al. (2008) Characterization of a spontaneous mouse retinal pigment epithelial cell line B6-RPE07. Invest.Ophthalmol.Vis.Sci. 49 (8):: 3699-3706.
40. Luo C, Chen M, Xu H, (2011) Complement gene expression and regulation in mouse retina and retinal pigment epithelium/choroid. Mol.Vis.pp. 171588-1597.
41. Xu H, Chen M, Reid DM, Forrester JV, (2007) LYVE positive macrophages are present in normal murine eyes. Invest.Ophthalmol.Vis.Sci. 48 (5):: 2162-2171.
42. Xu H, Chen M, Manivannan A, Lois N, Forrester JV, (2008) Age-dependent accumulation of lipofuscin in perivascular and subretinal microglia in experimental mice. Aging Cell. 7 (1);:: 58-68.
43. Fletcher AE, Bentham GC, Agnew M, Young IS, Augood C, et al. (2008) Sunlight exposure, antioxidants, and age-related macular degeneration. Arch.Ophthalmol. 126 (10);:: 1396-1403.
44. Hirakawa M, Tanaka M, Tanaka Y, Okubo A, Koriyama C, et al. (2008) Age-related maculopathy and sunlight exposure evaluated by objective measurement. Br.J.Ophthalmol. 92 (5);:: 630-634.
45. Yu DY, Cringle SJ, (2001) Oxygen distribution and consumption within the retina in vascularised and avascular retinas and in animal models of retinal disease. Prog.Retin.Eye Res 20 (2);:: 175-208.
46. Chan CC, Ross RJ, Shen D, Ding X, Majumdar Z, et al. (2008) Ccl2/Cx3cr1-deficient mice: an animal model for age-related macular degeneration. Ophthalmic Res. 40 (3-4);:: 124-128.
47. Medzhitov R, (2008) Origin and physiological roles of inflammation. Nature 454 (7203);:: 428-435.
48. Cardona AE, Pioro EP, Sasse ME, Kostenko V, Cardona SM, et al. (2006) Control of microglial neurotoxicity by the fractalkine receptor. Nat.Neurosci. 9 (7);:: 917-924.
49. Mizuno T, Kawanokuchi J, Numata K, Suzumura A, (2003) Production and neuroprotective functions of fractalkine in the central nervous system. Brain Res. 979 (1-2);:: 65-70.
50. Chen M, Luo C, Penalva R, Xu H, (2013) Paraquat-Induced Retinal Degeneration Is Exaggerated in CX3CR1-Deficient Mice and Is Associated with Increased Retinal Inflammation. Invest.Ophthalmol.Vis.Sci. 54 (1);:: 682-690.
51. Tarallo V, Hirano Y, Gelfand BD, Dridi S, Kerur N, et al. (2012) DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88. Cell 149 (4);:: 847-859.
52. Kauppinen A, Niskanen H, Suuronen T, Kinnunen K, Salminen A, et al. (2012) Oxidative stress activates NLRP3 inflammasomes in ARPE-19 cells-Implications for age-related macular degeneration (AMD). Immunol.Lett. 147 (1-2);:: 29-33.
53. Deangelis MM, Silveira AC, Carr EA, Kim IK, (2011) Genetics of age-related macular degeneration: current concepts, future directions. Semin.Ophthalmol. 26 (3);:: 77-93.
54. Zareparsi S, Buraczynska M, Branham KE, Shah S, Eng D, et al. (2005) Toll-like receptor 4 variant D299G is associated with susceptibility to age-related macular degeneration. Hum.Mol.Genet 14 (11);:: 1449-1455.