Spare the rods, save the cones in aging and age-related maculopathy

Investigative Ophthalmology and Visual Science

Volumn 41, Issue 8, 2000, Pages 2015-2018

  Curcio, Christine A ^a   Owsley, Cynthia ^a   Jackson, Gregory R ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGING; DARK ADAPTATION; HISTOPATHOLOGY; NIGHT VISION; PHOTOPIC VISION; PRIORITY JOURNAL; RECEPTOR DENSITY; RETINA CONE; RETINA MACULA AGE RELATED DEGENERATION; RETINA ROD; RETINOL DEFICIENCY; REVIEW; VISUAL IMPAIRMENT;

AGING; CONES (RETINA); DARK ADAPTATION; HUMANS; MACULAR DEGENERATION; RODS (RETINA);

EID: 0033924382     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (70)

1. Klein R, Klein BEK, Linton KLP. Prevalence of age-related maculopathy. Ophthalmology. 1992;99:933-943.
2. Mitchell P, Smith W, Attebo K, Wang JJ. Prevalence of age-related maculopathy in Australia. The Blue Mountains Eye Study. Ophthalmology. 1995;102:1450-1460.
3. Vingerling JR, Dielemans I, Hofman A, et al. The prevalence of age-related maculopathy in the Rotterdam study. Ophthalmology. 1995;102:205-210.
4. Sarks SH. Ageing and degeneration in the macular region: a clinicopathological study. Br J Ophthalmol. 1976;60:324-341.
5. Green WR, Enger C. Age-related macular degeneration histopathologic studies: the 1992 Lorenz E. Zimmerman Lecture. Ophthalmology. 1993;100:1519-1535.
6. Ciulla TA, Danis RP, Harris A. Age-related macular degeneration: a review of experimental treatments. Surv Ophthalmol. 1998;43: 134-146.
7. Guymer R, Luthert P, Bird A. Changes in Bruch's membrane and related structures with age. Prog Retinal Eye Res. 1999;18:59-90.
8. Abdelsalam A, Del Priore L, Zarbin MA. Drusen in age-related macular degeneration: pathogenesis, natural course, and laser photocoagulation-induced regression. Surv Ophthalmol. 1999;44:1-29.
9. Klein R, Klein BE, Cruickshanks KJ. The prevalence of age-related maculopathy by geographic region and ethnicity. Prog Retinal Eye Res. 1999;18:371-389.
10. Shroyer NF, Lewis RA, Allikmets R, et al. The rod photoreceptor ATP-binding cassette transporter gene, ABCR, and retinal disease: from monogenic to multifactorial. Vision Res. 1999;39:2537-2544.
11. van Driel MA, Maugeri A, Klevering BJ, Hoyng CB, Cremers FP. ABCR unites what ophthalmologists divide(s). Ophthalmic Genet. 1998;19:117-122.
12. Zarbin MA. Age-related macular degeneration: review of pathogenesis. Eu. J Ophthalmol. 1998:199-206.
13. Jackson GR, Owsley C, Cordle EP, Finley CD. Aging and scotopic sensitivity. Vision Res. 1998;38:3655-5662.
14. Jackson GR, Owsley C, McGwin G. Aging and dark adaptation. Vision Res 1999;39:3975-3982.
15. Jackson GR, Edwards DJ, McGwin GJ, Owsley C. Changes in dark adaptation in early AMD [ARVO Abstract]. Invest Ophthalmol Vis Sci. 1999(4);40:S739. Abstract nr 3911.
16. Jackson GR, Owsley C. Scotopic sensitivity during adulthood. Vision Res. (In press).
17. Owsley C, Jackson GR, Cideciyan AV, et al. Psychophysical evidence for rod vulnerability in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2000;41:267-273.
18. Curcio CA, Millican CL, Allen KA, Kalina RE. Aging of the human photoreceptor mosaic: evidence for selective vulnerability of rods in central retina. Invest Ophthalmol Vis Sci. 1993;34:3278-3296.
19. Curcio CA, Medeiros NE, Millican CL. Photoreceptor loss in age-related macular degeneration. Invest Ophthalmol Vis Sci. 1996; 37:1236-1249.
20. Klein R, Davis MD, Magli YL, Segal P, Klein BEK, Hubbard L. The Wisconsin Age-Related Maculopathy Grading System. Ophthalmology. 1991;98:1128-1134.
21. Bird AC, Bressler NM, Chisholm IH, et al. An international classification and grading system for age-related maculopathy and age-related macular degeneration. Surv Ophthalmol. 1995;39:367-374.
22. Curcio CA, Medeiros NE, Millican CL. The Alabama Age-Related Macular Degeneration Grading System for donor eyes. Invest Ophthalmol Vis Sci. 1998;39:1085-1096.
23. Leibrock CS, Reuter T, Lamb TD. Molecular basis of dark adaptation in rod photoreceptors. Eye. 1998;12:511-520.
24. Lamb TD, Cideciyan AV, Jacobson SG, Pugh EN. Towards a molecular description of human dark adaptation. J Physiol. 1998;506: 88P.
25. Curcio CA, Sloan KR, Kalina RE, Hendrickson AE. Human photoreceptor topography. J Comp Neurol. 1990;292:497-523.
26. Brown B, Adams AJ, Coletta NJ, Haegerstrom-Portnoy G. Dark adaptation in age-related maculopathy. Ophthalmol Physiol Opt. 1985;6:81-84.
27. Steinmetz RL, Haimovici R, Jubb C, Fitzke FW, Bird AC. Symptomatic abnormalities of dark adaptation in patients with age-related Bruch's membrane change. Br J Ophthalmol. 1993;77:549-554.
28. Barlow H. Dark and light adaptation: psychophysics. In: Jameson D, Hurvich L, eds. Handbook of Sensory Physiology. New York: Springer; 1972:1-28.
29. Inglehearn C. Molecular genetics of human retinal dystrophies. Eye. 1998;12:571-579.
30. Lamb TD. Spontaneous quantal events induced in toad rods by pigment bleaching. Nature. 1980;287:349-351.
31. Lamb TD. The involvement of rod photoreceptors in dark adaptation. Vision Res. 1981;21:1773-1782.
32. Saari JC. Biochemistry of visual pigment regeneration. The Friedenwald Lecture. Invest Ophthalmol Vis Sci. 2000;41:337-348.
33. Dowling J, Wald G. Vitamin A deficiency and night blindness. Proc Natl Acad Sci USA. 1958;44:648-661.
34. Katz M, Gao C, Stientjes H. Regulation of the interphotoreceptor retinoid-binding protein content of the retina by vitamin A. Exp Eye Res. 1993;57:393-401.
35. Katz M, Kutryb M, Norberg M, Gao C, White R, Stark W. Maintenance of opsin density in photoreceptor outer segments of retinoid-deprived rats. Invest Ophthalmol Vis Sci. 1991;32:1968-1980.
36. Li T, Sandberg MA, Pawlyk BS, et al. Effect of vitamin A supplementation on rhodopsin mutants threonine-17→methionine and proline-347→serine in transgenic mice and in cell cultures. Proc Natl Acad Sci USA.. 1998;95:11933-11938.
37. Carter-Dawson L, Kuwabara T, O'Brien P, Bien J. Structural and biochemical changes in vitamin A-deficient rat retinas. Invest Ophthalmol Vis Sci. 1979;18:437-446.
38. Kemp C, Jacobson S, Faulkner D, Walt R. Visual function and rhodopsin levels in humans with vitamin A deficiency. Exp Eye Res. 1988;46:185-197.
39. Kemp C, Jacobson S, Borruat F, Chaitin M. Rhodopsin levels and retinal function in cats during recovery from vitamin A deficiency. Exp Eye Res. 1989;49:49-65.
40. Redmond TM, Yu S, Lee E, et al. Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle. Nat Genet. 1998;20: 344-351.
41. Haig C, Hecht S, Patek AJ. Vitamin A and rod-cone adaptation in cirrhosis of the liver. Science. 1938;87:534.
42. Seeliger MW, Biesalski HK, Wissinger B, et al. Phenotype in retinol deficiency due to a hereditary defect in retinol binding protein synthesis. Invest Ophthalmol Vis Sci. 1999;40:3-11.
43. Bridges C, Alvarez R, Fong S. Vitamin A in human eyes: amount, distribution, and composition. Invest Ophthalmol Vis Sci. 1982; 22:706-714.
44. Crabtree D, Snodderly D, Adler A. Retinyl palmitate in macaque retina-retinal pigment epithelium-choroid: distribution and correlation with age and vitamin E. Exp Eye Res. 1997;64:455-463
45. Katz M, Drea C, Robison W Jr. Age-related alterations in vitamin A metabolism in the rat retina. Exp Eye Res. 1987;44:939-949.
46. Feeney-Burns L, Ellersieck MR. Age-related changes in the ultrastructure of Bruch's membrane. Am J Ophthalmol. 1985;100:686-697.
47. Karwatowski W, Jeffried T, Duance V, Albon J, Bailey A, Easty D. Preparation of Bruch's membrane and analysis of the age-related changes in the structural collagens. Br J Ophthalmol. 1995;79: 944-952.
48. Pauleikhoff D, Harper CA, Marshall J, Bird AC. Aging changes in Bruch's membrane: a histochemical and morphological study. Ophthalmology. 1990;97:171-178.
49. Spraul CW, Grossniklaus HE. Characteristics of drusen and Bruch's membrane in postmortem eyes with age-related macular degeneration. Arch Ophthalmol. 1997;115:267-273.
50. Curcio CA, Millican CL. Basal linear deposit and large drusen are specific for early age-related maculopathy. Arch. Ophthalmol. 1999;117:329-339.
51. Marshall J, Hussain AA, Starita C, Moore DJ, Patmore AL. Aging and Bruch's membrane. In: Marmor MF, Wolfensberger TJ, eds. The Retinal Pigment Epithelium: Function and Disease. New York: Oxford University Press; 1998:669-692.
52. Jacobson SG, Cideciyan AV, Regunath G, et al. Night blindness in Sorsby's fundus dystrophy reversed by vitamin A. Nat Genet. 1995;11:27-32.
53. Kim RY, Faktorovich EG, Kuo CY, Olson JL. Retinal function abnormalities in membranoproliferative glomerulonephritis type II. Am J Ophthalmol. 1997;123:619-628.
54. Kuntz CA, Jacobson SG, Cideciyan AV, et al. Sub-retinal pigment epithelial deposits in a dominant late-onset retinal degeneration. Invest Ophthalmol Vis Sci. 1996;37:1772-1782.
55. Curcio CA, Saunders PL, Younger PW, Malek G. Peripapillary chorioretinal atrophy: Bruch's membrane changes and photoreceptor loss. Ophthalmology. 2000;107:334-343.
56. Sun H, Molday RS, Nathans J. Retinal stimulates ATP hydrolysis by purified and reconstituted ABCR, the photoreceptor-specific ATP-binding cassette transporter responsible for Stargardt disease. J Biol Chem. 1999;274:8269-8281.
57. Weng J, Mata N, Azarian S, Tzekov R, Birch D, Travis G. Insights into the function of Rim protein in photoreceptors and etiology of Stargardt's disease from the phenotype in ABCR knockout mice. Cell. 1999;98:13-23.
58. Seddon JM, Ajani UA, Sperduto RD, et al. Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. J Am Med Assoc. 1994;272:1413-1420.
59. Seddon JM, Willett WC, Speizer FE, Hankinson SE. A prospective study of cigarette smoking and age-related macular degeneration in women. J Am Med Assoc. 1996;276:1141-1146.
60. Seddon J, Ajani U, Mitchell B. Familial aggregation of age-related maculopathy. Am J Ophthalmol. 1997;123:199-206.
61. Christen WG, Glynn RJ, Manson JE, Ajani UA, Buring JE. A prospective study of cigarette smoking and risk of age-related macular degeneration in men. Am J Med Assoc. 1996;276:1147-1151.
62. Souied EH, Benlian P, Amouyel P, et al. The ∈4 allele of the apolipoprotein E gene as a potential protective factor for exudative age-related macular degeneration. Am J Ophthalmol. 1998; 125:353-359.
63. Delcourt C, Cristol J-P, Tessier F, Léger CL, Descomps B, Papoz L. Age-related macular degeneration and antioxidant status in the POLA Study. Arch Ophthalmol. 1999;117:1384-1390.
64. Weber BHF, Vogt G, Pruett RC, Stöhr H, Felbor U. Mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) in patients with Sorsby's fundus dystrophy. Nat Genet. 1994;8:352-365.
65. Allikmets R, Singh N, Sun H, et al. A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy. Nat Genet. 1997;15:236-246.
66. Petruhkin K, Koisti MJ, Bakall B, et al. Identification of the gene responsible for Best macular dystrophy. Nat Genet. 1998:19:241-247.
67. Stone E, Lotery A, Munier F, et al. A single EFEMPI mutation associated with both Malattia Leventinese and Doyne honeycomb retinal dystrophy. Nat Genet. 1999;22:199-202.
68. Kosnik W, Winslow L, Kline D, Rasinski K, Sekuler R. Visual changes in daily life throughout adulthood. J Gerontol. 1988; 43:P63-P70.
69. Mangione CM, Gutierrez PR, Lowe G, Orav EJ, Seddon JM. Influence of age-related maculopathy on visual functioning and health-related quality of life. Am J Ophthalmol. 1999;128:45-53.
70. Hicks D, Sahel J. The implications of rod-dependent cone survival for basic and clinical research. Invest Ophthalmol Vis Sci. 1999;40:3071-3074.