Fundus Autofluorescence and Progression of Age-related Macular Degeneration

Survey of Ophthalmology

Volumn 54, Issue 1, 2009, Pages 96-117

  Schmitz Valckenberg, Steffen ^a   Fleckenstein, Monika ^a   Scholl, Hendrik P N ^a   Holz, Frank G ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

age related macular degeneration; fundus autofluorescence; lipofuscin; retinal autofluorescence; retinal pigment epithelium; scanning laser ophthalmoscopy

Indexed keywords

LIPOFUSCIN;

ARTICLE; ATROPHY; AUTOFLUORESCENCE; CAMERA; CELL TRANSPLANTATION; DISEASE COURSE; FUNDUS AUTOFLUORESCENCE; HUMAN; IMAGING; METHODOLOGY; PATHOPHYSIOLOGY; PHENOTYPE; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROGNOSIS; RETINA DETACHMENT; RETINA MACULA AGE RELATED DEGENERATION; RETINA MACULOPATHY; RETINA TEAR; SCANNING LASER OPHTHALMOSCOPE; SPECTROPHOTOMETER; SUBRETINAL NEOVASCULARIZATION;

DIAGNOSTIC TECHNIQUES, OPHTHALMOLOGICAL; DISEASE PROGRESSION; FLUORESCEIN ANGIOGRAPHY; FLUORESCENCE; FUNDUS OCULI; HUMANS; LIPOFUSCIN; MACULAR DEGENERATION; RETINAL PIGMENT EPITHELIUM;

EID: 58449086657     PISSN: 00396257     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.survophthal.2008.10.004     Document Type: Article

References (105)

1. Institute ANS. American National Standard for the Safe Use of Lasers. ANSI Z136.1 (2000), Laser Institute of America, Orlando, FL
2. Ambati J., Ambati B.K., Yoo S.H., et al. Age-related macular degeneration: etiology, pathogenesis, and therapeutic strategies. Surv Ophthalmol 48 3 (2003) 257-293
3. Arnold J.J., Sarks S.H., Killingsworth M.C., and Sarks J.P. Reticular pseudodursen: a risk factor in age-related maculopathy. Retina 15 (1995) 183-191
4. Augood C.A., Vingerling J.R., de Jong P.T., et al. Prevalence of age-related maculopathy in older Europeans: the European Eye Study (EUREYE). Arch Ophthalmol 124 4 (2006) 529-535
5. Bellmann C., Holz F.G., Schapp O., et al. [Topography of fundus autofluorescence with a new confocal scanning laser ophthalmoscope]. Ophthalmologe 94 6 (1997) 385-391
6. Bellmann C., Jorzik J., Spital G., et al. Symmetry of bilateral lesions in geographic atrophy in patients with age-related macular degeneration. Arch Ophthalmol 120 5 (2002) 579-584
7. Bellmann C., Rubin G.S., Kabanarou S.A., et al. Fundus autofluorescence imaging compared with different confocal scanning laser ophthalmoscopes. Br J Ophthalmol 87 11 (2003) 1381-1386
8. Bergmann M., Schutt F., Holz F.G., and Kopitz J. Inhibition of the ATP-driven proton pump in RPE lysosomes by the major lipofuscin fluorophore A2-E may contribute to the pathogenesis of age-related macular degeneration. Faseb J 18 3 (2004) 562-564
9. Binder S., Stolba U., Krebs I., et al. Transplantation of autologous retinal pigment epithelium in eyes with foveal neovascularization resulting from age-related macular degeneration: a pilot study. Am J Ophthalmol 133 2 (2002) 215-225
10. Bindewald-Wittich A., Han M., Schmitz-Valckenberg S., et al. Two-photon-excited fluorescence imaging of human RPE cells with a femtosecond Ti:Sapphire laser. Invest Ophthalmol Vis Sci 47 10 (2006) 4553-4557
11. Bindewald A., Schmitz-Valckenberg S., Jorzik J.J., et al. Classification of abnormal fundus autofluorescence patterns in the junctional zone of geographic atrophy in patients with age related macular degeneration. Br J Ophthalmol 89 7 (2005) 874-878
12. Bindewald A., Bird A.C., Dandekar S.S., et al. Classification of fundus autofluorescence patterns in early age-related macular disease. Invest Ophthalmol Vis Sci 46 9 (2005) 3309-3314
13. Bird A. Age-related macular disease. Br J Ophthalmol 80 1 (1996) 2-3
14. Blair C.J. Geographic atrophy of the retinal pigment epithelium. A manifestation of senile macular degeneration. Arch Ophthalmol 93 1 (1975) 19-25
15. Boulton M., and Dayhaw-Barker P. The role of the retinal pigment epithelium: topographical variation and ageing changes. Eye 15 Pt 3 (2001) 384-389
16. Brunk U.T., Wihlmark U., Wrigstad A., et al. Accumulation of lipofuscin within retinal pigment epithelial cells results in enhanced sensitivity to photo-oxidation. Gerontology 41 Suppl 2 (1995) 201-212
17. Bui T.V., Han Y., Radu R.A., et al. Characterization of native retinal fluorophores involved in biosynthesis of A2E and lipofuscin-associated retinopathies. J Biol Chem 281 26 (2006) 18112-18119
18. Chakravarthy U., Augood C., Bentham G.C., et al. Cigarette Smoking and Age-Related Macular Degeneration in the EUREYE Study. Ophthalmology 114 6 (2007) 1157-1163
19. Dandekar S.S., Jenkins S.A., Peto T., et al. Autofluorescence imaging of choroidal neovascularization due to age-related macular degeneration. Arch Ophthalmol 123 11 (2005) 1507-1513
20. Deckert A., Schmitz-Valckenberg S., Jorzik J., et al. Automated analysis of digital fundus autofluorescence images of geographic atrophy in advanced age-related macular degeneration using confocal scanning laser ophthalmoscopy (cSLO). BMC Ophthalmol 5 1 (2005) 8
21. Delori F.C. Spectrophotometer for non-nvasive measurement of intrinsic fluorescence and reflectance of the ocular fundus. Appl Optics 33 (1994) 7429-7452
22. Delori F.C., Dorey C.K., Staurenghi G., et al. In vivo fluorescence of the ocular fundus exhibits retinal pigment epithelium lipofuscin characteristics. Invest Ophthalmol Vis Sci 36 3 (1995) 718-729
23. Delori F.C., Fleckner M.R., Goger D.G., et al. Autofluorescence distribution associated with drusen in age-related macular degeneration. Invest Ophthalmol Vis Sci 41 2 (2000) 496-504
24. Delori F.C., Goger D.G., and Dorey C.K. Age-related accumulation and spatial distribution of lipofuscin in RPE of normal subjects. Invest Ophthalmol Vis Sci 42 8 (2001) 1855-1866
25. Dorey C.K., Wu G., Ebenstein D., et al. Cell loss in the aging retina. Relationship to lipofuscin accumulation and macular degeneration. Invest Ophthalmol Vis Sci 30 8 (1989) 1691-1699
26. Dreyhaupt J., Mansmann U., Pritsch M., et al. Modelling the natural history of geographic atrophy in patients with age-related macular degeneration. Ophthalmic Epidemiol 12 6 (2005) 353-362
27. Einbock W., Moessner A., Schnurrbusch U.E., et al. Changes in fundus autofluorescence in patients with age-related maculopathy. Correlation to visual function: a prospective study. Graefes Arch Clin Exp Ophthalmol 243 4 (2005) 300-305
28. Eldred G.E. Questioning the nature of the fluorophores in age pigments. Adv Biosci 64 (1987) 23-26
29. Eldred G.E., and Katz M.L. Fluorophores of the human retinal pigment epithelium: separation and spectral characterization. Exp Eye Res 47 1 (1988) 71-86
30. Eldred G.E., and Lasky M.R. Retinal age-pigments generated by self-assembling lysosomotrophic detergents. Nature 361 (1993) 724-726
31. Feeney-Burns L., Berman E.R., and Rothmann H. Lipofuscin of human retinal pigment epithelium. Am J Ophthalmol 90 (1980) 783-791
32. Framme C., Bunse A., Sofroni R., et al. Fundus autofluorescence before and after photodynamic therapy for choroidal neovascularization secondary to age-related macular degeneration. Ophthalmic Surg Lasers Imaging 37 5 (2006) 406-414
33. Green W.R., and Engel C. Age-related macular degeneration: histopathologic studies: the 1992 Lorenz E. Zimmermann Lecture. Ophthalmology 100 (1992) 1519-1535
34. Hammer M., Richter S., Guehrs K.H., and Schweitzer D. Retinal pigment epithelium cell damage by A2-E and its photo-derivatives. Mol Vis 12 (2006) 1348-1354
35. Hashimoto T., and Harada T. Confocal scanning laser microscopic findings of excised choroidal neovascular membranes of age-related macular degeneration and their comparison with the clinical features. Jpn J Ophthalmol 43 5 (1999) 375-385
36. Hogan M. Role of the retinal pigment epithelium in macular disease. Am Acad Ophthalmol Otolaryngol 76 (1972) 64-80
37. Holz F.G., Bellmann C., Margaritidis M., et al. Patterns of increased in vivo fundus autofluorescence in the junctional zone of geographic atrophy of the retinal pigment epithelium associated with age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol 237 2 (1999) 145-152
38. Holz F.G., Schutt F., Kopitz J., et al. Inhibition of lysosomal degradative functions in RPE cells by a retinoid component of lipofuscin. Invest Ophthalmol Vis Sci 40 3 (1999) 737-743
39. Holz F.G., Bellman C., Staudt S., et al. Fundus autofluorescence and development of geographic atrophy in age-related macular degeneration. Invest Ophthalmol Vis Sci 42 5 (2001) 1051-1056
40. Holz F.G., Pauleikhoff D., Spaide R.F., and Bird A.C. Age-related Macular Degeneration (2004), Springer, Berlin Heidelberg New York
41. Holz F.G., Pauleikhoff D., Klein R., and Bird A.C. Pathogenesis of lesions in late age-related macular disease. Am J Ophthalmol 137 3 (2004) 504-510
42. Holz F.G., Bindewald-Wittich A., Fleckenstein M., et al. Progression of geographic atrophy and impact of fundus autofluorescence patterns in age-related macular degeneration. Am J Ophthalmol 143 (2007) 463-472
43. Hopkins J., Walsh A., and Chakravarthy U. Fundus autofluorescence in age-related macular degeneration: an epiphenomenon?. Invest Ophthalmol Vis Sci 47 6 (2006) 2269-2271
44. Hwang J.C., Chan J.W., Chang S., and Smith R.T. Predictive value of fundus autofluorescence for development of geographic atrophy in age-related macular degeneration. Invest Ophthalmol Vis Sci 47 6 (2006) 2655-2661
45. Jorzik J.J., Bindewald A., Dithmar S., and Holz F.G. Digital simultaneous fluorescein and indocyanine green angiography, autofluorescence, and red-free imaging with a solid-state laser-based confocal scanning laser ophthalmoscope. Retina 25 4 (2005) 405-416
46. Joussen A.M., Heussen F.M., Joeres S., et al. Autologous translocation of the choroid and retinal pigment epithelium in age-related macular degeneration. Am J Ophthalmol 142 1 (2006) 17-30
47. Karadimas P., and Bouzas E.A. Fundus autofluorescence imaging in serous and drusenoid pigment epithelial detachments associated with age-related macular degeneration. Am J Ophthalmol 140 6 (2005) 1163-1165
48. Karadimas P., Paleokastritis G.P., and Bouzas E.A. Fundus autofluorescence imaging findings in retinal pigment epithelial tear. Eur J Ophthalmol 16 5 (2006) 767-769
49. Katz M.L. Potential role of retinal pigment epithelial lipofuscin accumulation in age-related macular degeneration. Arch Gerontol Geriatr 34 (2002) 359-370
50. Keilhauer C.N., and Delori F.C. Near-infrared autofluorescence imaging of the fundus: visualization of ocular melanin. Invest Ophthalmol Vis Sci 47 8 (2006) 3556-3564
51. Kitagawa K., Nishida S., and Ogura Y. In vivo quantitation of autofluorescence in human retinal pigment epithelium. Ophthalmologica 199 2-3 (1989) 116-121
52. Klaver C.C., Wolfs R.C., Vingerling J.R., et al. Age-specific prevalence and causes of blindness and visual impairment in an older population: the Rotterdam Study. Arch Ophthalmol 116 5 (1998) 653-658
53. Klein R., Klein B.E., Knudtson M.D., et al. Fifteen-year cumulative incidence of age-related macular degeneration: the Beaver Dam Eye Study. Ophthalmology 114 2 (2007) 253-262
54. Kopitz J., Holz F.G., Kaemmerer E., and Schutt F. Lipids and lipid peroxidation products in the pathogenesis of age-related macular degeneration. Biochimie 86 11 (2004) 825-831
55. Lamb L.E., and Simon J.D. A2E: a component of ocular lipofuscin. Photochem Photobiol 79 2 (2004) 127-136
56. Lengyel I., Tufail A., Hosaini H.A., et al. Association of drusen deposition with choroidal intercapillary pillars in the aging human eye. Invest Ophthalmol Vis Sci 45 9 (2004) 2886-2892
57. Liu J., Itagaki Y., Ben-Shabat S., et al. The biosynthesis of A2E, a fluorophore of aging retina, involves the formation of the precursor, A2-PE, in the photoreceptor outer segment membrane. J Biol Chem 275 38 (2000) 29354-29360
58. Lois N., Halfyard A.S., Bunce C., et al. Reproducibility of fundus autofluorescence measurements obtained using a confocal scanning laser ophthalmoscope. Br J Ophthalmol 83 3 (1999) 276-279
59. Lois N., Halfyard A.S., Bird A.C., and Fitzke F.W. Quantitative evaluation of fundus autofluorescence imaged "in vivo" in eyes with retinal disease. Br J Ophthalmol 84 7 (2000) 741-745
60. Lois N., Owens S.L., Coco R., et al. Fundus autofluorescence in patients with age-related macular degeneration and high risk of visual loss. Am J Ophthalmol 133 3 (2002) 341-349
61. Machemer R., Norton E.W., Gass J.D., and Choromokos E. Pseudofluorescence-a problem in interpretation of fluorescein angiograms. Am J Ophthalmol 70 1 (1970) 1-10
62. MacLaren R.E., Bird A.C., Sathia P.J., and Aylward G.W. Long-term results of submacular surgery combined with macular translocation of the retinal pigment epithelium in neovascular age-related macular degeneration. Ophthalmology 112 12 (2005) 2081-2087
63. Maguire M.G., and Fine S.L. Reticular pseudodrusen. Retina 16 (1996) 167-168
64. Marmorstein A.D., Marmorstein L.Y., Sakaguchi H., and Hollyfield J.G. Spectral profiling of autofluorescence associated with lipofuscin, Bruch's Membrane, and sub-RPE deposits in normal and AMD eyes. Invest Ophthalmol Vis Sci 43 7 (2002) 2435-2441
65. McBain V.A., Townend J., and Lois N. Fundus autofluorescence in exudative age-related macular degeneration. Br J Ophthalmol 91 4 (2007) 491-496
66. Okubo A., Rosa Jr. R.H., Bunce C.V., et al. The relationships of age changes in retinal pigment epithelium and Bruch's membrane. Invest Ophthalmol Vis Sci 40 2 (1999) 443-449
67. Sarks J.P., Sarks S.H., and Killingsworth M.C. Evolution of geographic atrophy of the retinal pigment epithelium. Eye 2 5 (1988) 552-577
68. Sarks S.H. Ageing and degeneration in the macular region: a clinico-pathological study. Br J Ophthalmol 60 5 (1976) 324-341
69. Sarks S.H. Drusen patterns predisposing to geographic atrophy of the retinal pigment epithelium. Aust J Ophthalmol 10 2 (1982) 91-97
70. Sawa M., Ober M.D., and Spaide R.F. Autofluorescence and retinal pigment epithelial atrophy after subretinal hemorrhage. Retina 26 1 (2006) 119-120
71. Schatz H., and McDonald H.R. Atrophic macular degeneration. Rate of spread of geographic atrophy and visual loss. Ophthalmology 96 10 (1989) 1541-1551
72. Schmitz-Valckenberg S., Jorzik J., Unnebrink K., and Holz F.G. Analysis of digital scanning laser ophthalmoscopy fundus autofluorescence images of geographic atrophy in advanced age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol 240 2 (2002) 73-78
73. Schmitz-Valckenberg S., Bultmann S., Dreyhaupt J., et al. Fundus autofluorescence and fundus perimetry in the junctional zone of geographic atrophy in patients with age-related macular degeneration. Invest Ophthalmol Vis Sci 45 12 (2004) 4470-4476
74. Schmitz-Valckenberg S., Bindewald-Wittich A., Dolar-Szczasny J., et al. Correlation between the area of increased autofluorescence surrounding geographic atrophy and disease progression in patients with AMD. Invest Ophthalmol Vis Sci 47 6 (2006) 2648-2654
75. Schmitz-Valckenberg S., Holz F.G., and Fitzke F.W. Perspectives in imaging technologies. In: Holz F.G., Schmitz-Valckenberg S., Spaide R.F., and Bird A.C. (Eds). Atlas of Autofluorescence Imaging (2007), Springer, Berlin Heidelberg 331-339
76. Scholl H.P., Bellmann C., Dandekar S.S., et al. Photopic and scotopic fine matrix mapping of retinal areas of increased fundus autofluorescence in patients with age-related maculopathy. Invest Ophthalmol Vis Sci 45 2 (2004) 574-583
77. Schütt F., Davies S., Kopitz J., et al. Photodamage to human RPE cells by A2-E, a retinoid component of lipofuscin. Invest Ophthalmol Vis Sci 41 8 (2000) 2303-2308
78. Smith R.T., Chan J.K., Busuoic M., et al. Autofluorescence characteristics of early, atrophic, and high-risk fellow eyes in age-related macular degeneration. Invest Ophthalmol Vis Sci 47 12 (2006) 5495-5504
79. Solbach U., Keilhauer C., Knabben H., and Wolf S. Imaging of retinal autofluorescence in patients with age-related macular degeneration. Retina 17 5 (1997) 385-389
80. Spaide R.F. Fundus autofluorescence and age-related macular degeneration. Ophthalmology 110 2 (2003) 392-399
81. Spaide R.F., and Klancnik Jr. J.M. Fundus autofluorescence and central serous chorioretinopathy. Ophthalmology 112 5 (2005) 825-833
82. Spaide R.F. Autofluorescence Imaging with the fundus camera. In: Holz F.G., Schmitz-Valckenberg S., Spaide R.F., and Bird A.C. (Eds). Atlas of Autofluorescence Imaging (2007), Springer, Berlin Heidelberg 49-53
83. Sparrow J.R., and Boulton M. RPE lipofuscin and its role in retinal pathobiology. Exp Eye Res 80 5 (2005) 595-606
84. Spital G., Radermacher M., Muller C., et al. [Autofluorescence characteristics of lipofuscin components in different forms of late senile macular degeneration]. Klin Monatsbl Augenheilkd 213 1 (1998) 23-31
85. Stanga P.E., Kychenthal A., Fitzke F.W., et al. Retinal pigment epithelium translocation after choroidal neovascular membrane removal in age-related macular degeneration. Ophthalmology 109 8 (2002) 1492-1498
86. Sunness J.S., Gonzalez-Baron J., Applegate C.A., et al. Enlargement of atrophy and visual acuity loss in the geographic atrophy form of age-related macular degeneration. Ophthalmology 106 9 (1999) 1768-1779
87. Terman A., and Brunk U.T. Oxidative stress, accumulation of biological 'garbage', and aging. Antioxid Redox Signal 8 1-2 (2006) 197-204
88. Tomany S.C., Wang J.J., Van Leeuwen R., et al. Risk factors for incident age-related macular degeneration: pooled findings from 3 continents. Ophthalmology 111 7 (2004) 1280-1287
89. Treumer F., Bunse A., Klatt C., and Roider J. Autologous RPE-choroid sheet transplantation in AMD. Morphological and functional results. Br J Ophthalmol 91 3 (2007) 349-353
90. Vaclavik V., Vujosevic S., Dandekar S.S., et al. Autofluorescence Imaging in Age-Related Macular Degeneration Complicated by Choroidal Neovascularization A Prospective Study. Ophthalmology 115 2 (2008) 342-346
91. van Leeuwen R., Klaver C.C., Vingerling J.R., et al. Epidemiology of age-related maculopathy: a review. Eur J Epidemiol 18 9 (2003) 845-854
92. von Ruckmann A., Fitzke F.W., and Bird A.C. Distribution of fundus autofluorescence with a scanning laser ophthalmoscope. Br J Ophthalmol 79 5 (1995) 407-412
93. von Ruckmann A., Fitzke F.W., and Bird A.C. In vivo fundus autofluorescence in macular dystrophies. Arch Ophthalmol 115 5 (1997) 609-615
94. von Ruckmann A., Fitzke F.W., and Bird A.C. Fundus autofluorescence in age-related macular disease imaged with a laser scanning ophthalmoscope. Invest Ophthalmol Vis Sci 38 2 (1997) 478-486
95. von Ruckmann A., Schmidt K.G., Fitzke F.W., et al. [Fundus autofluorescence in patients with hereditary macular dystrophies, malattia leventinese, familial dominant and aged-related drusen]. Klin Monatsbl Augenheilkd 213 2 (1998) 81-86
96. von Ruckmann A., Schmidt K.G., Fitzke F.W., et al. [Studies of the distribution of lipofuscin in the retinal pigment epithelium using high-resolution TV laser scanning ophthalmoscopy]. Ophthalmologe 95 10 (1998) 699-705
97. von Ruckmann A., Schmidt K.G., Fitzke F.W., et al. [Dynamics of accumulation and degradation of lipofuscin in retinal pigment epithelium in senile macular degeneration]. Klin Monatsbl Augenheilkd 213 1 (1998) 32-37
98. von Ruckmann A., Fitzke F.W., and Bird A.C. Distribution of pigment epithelium autofluorescence in retinal disease state recorded in vivo and its change over time. Graefes Arch Clin Exp Ophthalmol 237 1 (1999) 1-9
99. Wabbels B., Demmler A., Paunescu K., et al. Fundus autofluorescence in children and teenagers with hereditary retinal diseases. Graefes Arch Clin Exp Ophthalmol 244 1 (2006) 36-45
100. Wang J.J., Rochtchina E., Lee A.J., et al. Ten-year incidence and progression of age-related maculopathy: the blue Mountains Eye Study. Ophthalmology 114 1 (2007) 92-98
101. Webb R.H., Hughes G.W., and Delori F.C. Confocal scanning laser ophthalmoscope. Appl Optics 26 (1987) 1492-1499
102. Weinberger A.W., Lappas A., Kirschkamp T., et al. Fundus near infrared fluorescence correlates with fundus near infrared reflectance. Invest Ophthalmol Vis Sci 47 7 (2006) 3098-3108
103. Weiter J.J., Delori F.C., Wing G.L., and Fitch K.A. Retinal pigment epithelial lipofuscin and melanin and choroidal melanin in human eyes. Invest Ophthalmol Vis Sci 27 2 (1986) 145-152
104. Wing G.L., Blanchard G.C., and Weiter J.J. The topography and age relationship of lipofuscin concentration in the retinal pigment epithelium. Invest Ophthalmol Vis Sci 17 7 (1978) 601-607
105. Zhou J., Jang Y.P., Kim S.R., and Sparrow J.R. Complement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epithelium. Proc Natl Acad Sci USA 103 44 (2006) 16182-16187