Age- and gene-dosage-dependent Cre-induced abnormalities in the retinal pigment epithelium

American Journal of Pathology

Volumn 184, Issue 6, 2014, Pages 1660-1667

  He, Lizhi ^a,b   Marioutina, Mariya ^a,b   Dunaief, Joshua L ^c   Marneros, Alexander G ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CRE RECOMBINASE; PHALLOIDIN; INTEGRASE;

AGE; ANIMAL EXPERIMENT; ARTICLE; ATTENUATION; CELL LOSS; CELL NUCLEUS; CELL SIZE; CELL STRUCTURE; CONTROLLED STUDY; GENE DOSAGE; HETEROZYGOSITY; HOMOZYGOSITY; MOUSE; NONHUMAN; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; AGING; ANIMAL; BIOSYNTHESIS; GENETICS; METABOLISM; PATHOLOGY; TRANSGENIC MOUSE;

AGING; ANIMALS; GENE DOSAGE; INTEGRASES; MICE; MICE, TRANSGENIC; RETINAL PIGMENT EPITHELIUM;

EID: 84901044356     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2014.02.007     Document Type: Article

References (19)

1. P.D. Kiser, M. Golczak, A. Maeda, and K. Palczewski Key enzymes of the retinoid (visual) cycle in vertebrate retina Biochim Biophys Acta 1821 2012 137 151
2. J. Iacovelli, C. Zhao, N. Wolkow, P. Veldman, K. Gollomp, P. Ojha, N. Lukinova, A. King, L. Feiner, N. Esumi, D.J. Zack, E.A. Pierce, D. Vollrath, and J.L. Dunaief Generation of Cre transgenic mice with postnatal RPE-specific ocular expression Invest Ophthalmol Vis Sci 52 2011 1378 1383
3. M. Mori, D. Metzger, J.M. Garnier, P. Chambon, and M. Mark Site-specific somatic mutagenesis in the retinal pigment epithelium Invest Ophthalmol Vis Sci 43 2002 1384 1388
4. I.T. Aydin, and F. Beermann A mart-1::Cre transgenic line induces recombination in melanocytes and retinal pigment epithelium Genesis 49 2011 403 409
5. Y.Z. Le, W. Zheng, P.C. Rao, L. Zheng, R.E. Anderson, N. Esumi, D.J. Zack, and M. Zhu Inducible expression of cre recombinase in the retinal pigmented epithelium Invest Ophthalmol Vis Sci 49 2008 1248 1253
6. R. Longbottom, M. Fruttiger, R.H. Douglas, J.P. Martinez-Barbera, J. Greenwood, and S.E. Moss Genetic ablation of retinal pigment epithelial cells reveals the adaptive response of the epithelium and impact on photoreceptors Proc Natl Acad Sci U S A 106 2009 18728 18733
7. L. Guyonneau, A. Rossier, C. Richard, E. Hummler, and F. Beermann Expression of Cre recombinase in pigment cells Pigment Cell Res 15 2002 305 309
8. A. Thanos, Y. Morizane, Y. Murakami, A. Giani, D. Mantopoulos, M. Kayama, M.I. Roh, N. Michaud, B. Pawlyk, M. Sandberg, L.H. Young, J.W. Miller, and D.G. Vavvas Evidence for baseline retinal pigment epithelium pathology in the Trp1-Cre mouse Am J Pathol 180 2012 1917 1927
9. M. Schmidt-Supprian, and K. Rajewsky Vagaries of conditional gene targeting Nat Immunol 8 2007 665 668
10. E.L. Chan, B.E. Peace, K. Toney, S.A. Kader, P. Pathrose, M.H. Collins, and S.E. Waltz Homozygous K5Cre transgenic mice have wavy hair and accelerated malignant progression in a murine model of skin carcinogenesis Mol Carcinog 46 2007 49 59
11. A.Y. Higashi, T. Ikawa, M. Muramatsu, A.N. Economides, A. Niwa, T. Okuda, A.J. Murphy, J. Rojas, T. Heike, T. Nakahata, H. Kawamoto, T. Kita, and M. Yanagita Direct hematological toxicity and illegitimate chromosomal recombination caused by the systemic activation of CreERT2 J Immunol 182 2009 5633 5640
12. K. Rajewsky, H. Gu, R. Kuhn, U.A. Betz, W. Muller, J. Roes, and F. Schwenk Conditional gene targeting J Clin Invest 98 1996 600 603
13. D.L. Hamilton, and K. Abremski Site-specific recombination by the bacteriophage P1 lox-Cre system. Cre-mediated synapsis of two lox sites J Mol Biol 178 1984 481 486
14. A. Loonstra, M. Vooijs, H.B. Beverloo, B.A. Allak, E. van Drunen, R. Kanaar, A. Berns, and J. Jonkers Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells Proc Natl Acad Sci U S A 98 2001 9209 9214
15. E.E. Schmidt, D.S. Taylor, J.R. Prigge, S. Barnett, and M.R. Capecchi Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids Proc Natl Acad Sci U S A 97 2000 13702 13707
16. V.C. Janbandhu, D. Moik, and R. Fassler Cre recombinase induces DNA damage and tetraploidy in the absence of LoxP sites Cell Cycle 13 2013 462 470
17. D.P. Silver, and D.M. Livingston Self-excising retroviral vectors encoding the Cre recombinase overcome Cre-mediated cellular toxicity Mol Cell 8 2001 233 243
18. S. Semprini, T.J. Troup, N. Kotelevtseva, K. King, J.R. Davis, L.J. Mullins, K.E. Chapman, D.R. Dunbar, and J.J. Mullins Cryptic loxP sites in mammalian genomes: genome-wide distribution and relevance for the efficiency of BAC/PAC recombineering techniques Nucleic Acids Res 35 2007 1402 1410
19. Y. Baba, M. Nakano, Y. Yamada, I. Saito, and Y. Kanegae Practical range of effective dose for Cre recombinase-expressing recombinant adenovirus without cell toxicity in mammalian cells Microbiol Immunol 49 2005 559 570