Fundus autofluorescence in age-related macular disease imaged with a laser scanning ophthalmoscope

Investigative Ophthalmology and Visual Science

Volumn 38, Issue 2, 1997, Pages 478-486

  Von Rückmann, Andrea ^a   Fitzke, Fredrick W ^a   Bird, Alan C ^a  

^a MOORFIELDS EYE HOSPITAL   (United Kingdom)

Author keywords

age related macular degeneration; fundus autofluorescence; laser scanning ophthalmoscope; lipofuscin; retinal pigment epithelium

Indexed keywords

LIPOFUSCIN;

ADULT; AGED; AGING; ARTICLE; AUTOFLUORESCENCE; CHILD; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; OPHTHALMOSCOPY; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RETINA MACULA AGE RELATED DEGENERATION; SCANNING LASER OPHTHALMOSCOPY; VISUAL IMPAIRMENT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AGING; CHILD; FEMALE; FLUORESCENCE; FUNDUS OCULI; HUMANS; LIPOFUSCIN; MACULAR DEGENERATION; MALE; MICROSCOPY, CONFOCAL; MIDDLE AGED; OPHTHALMOSCOPES; PIGMENT EPITHELIUM OF EYE; RETINAL DRUSEN;

EID: 0344830731     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Gass JDM. Pathogenesis of disciform detachment of the neuro-epithelium. 3. Senile disciform macular degeneration. Am J Ophthalmol 1967;63:617-644.
2. Hogan MJ. Role of the retinal pigment epithelium in macular disease. Trans Am Acad Otolaryngol Ophthalmol. 1972;76:64-80.
3. Wing GL, Blanchard GC, Weiter JJ. The topography and age relationship of lipofuscin concentrations in the RPE. Invest Ophthalmol Vis Sci. 1978;17:600-607.
4. Feeney-Burns L, Berman ER, Rothman H. Lipofuscin of the human retinal pigment epithelium. Am J Ophthalmol. 1980;90:783-791.
5. Feeney-Burns L, Hildebrand ES, Eldridge S. Aging human RPE: Morphometric analysis of macular, equatorial, and peripheral cells. Invest Ophthalmol Vis Sci. 1984;25:195-200.
6. Weiter JJ, Delori FC, Wing GL, Fitch KA. Retinal pigment epithelial lipofuscin and melanin and choroidal melanin in human eyes. Invest Ophthalmol Vis Sci. 1986;27:145-152.
7. Boulton M, Docchio F, Dayhaw-Barker P, Ramponi R, Cubbedu R, Age-related changes in the morphology, absorption and fluorescence of melanosomes and lipofuscin granules of the retinal pigment epithelium. Vision Res. 1990;30:1291-1303.
8. Boulton M. Aging of the retinal pigment epithelium, In: Osborne NN, Chader GJ, eds. Progress in Retinal Research. Vol II Oxford: Pergamon; 1991;125-152.
9. Dorey CK, Wu G, Ebenstein D, Garsd A, Weiter JJ. Cell loss in the ageing retina: relationship to lipofuscin accumulation and macular degeneration. Invest Ophthalmol Vis Sci. 1989;30:1691-1699.
10. Dorey CK, Staurenghi G, Delori FC. Lipofuscin in aged and AMD eyes. In: Holyfield JG, et al, eds. Retinal Degeneration. New York: Plenum; 1993:3-14.
11. Kitagawa K, Nishida S, Ogura Y. In vivo quantitation of autofluorescence in human RPE. Ophthalmologica. 1989;199:116-121.
12. Delori FC, Dorey K, Staurenghi G, Arend O, Goger DG, Weiter JJ. In vivo fluorescence of the ocular fundus exibits retinal pigment epithelial lipofuscin characteristics. Invest Ophthalmol Vis Sci. 1995;36:718-729.
13. von Rückmann A, Fitzke FW, Bird AC. Distribution of fundus autofluorescence with a scanning laser ophthalmoscope. Br J Ophthalmol. 1995;119:543-562.
14. Farkas T, Sylvester V, Archer D, Altona M. The histochemistry of drusen. Am J Ophthalmol. 1971;71:1206-1215.
15. Ishibashi T, Sorgente N, Patterson R, Ryan SJ. Pathogenesis of drusen in the primate. Invest Ophthalmol Vis Sci. 1986;27:184-193.
16. Burns RP, Feeney-Burns L. Clinico-morphological correlations of drusen and Bruch's membrane. Trans Am Ophthalmol Soc. 1980;78:206-225.
17. Sarks SH, Sarks J, Killingsworth C. Evolution of geographic atrophy of the retinal pigment epithelium. Eye. 1988;2:552-577.
18. O'Gorman S, Flaherty WA, Fishman GA, Berson EL. Histopathologic findings in Best's vitelliform macular dystrophy. Arch Ophthalmol. 1988;106:1261-1268.
19. McFarland CB. Heredodegeneration of macula lutea; study of clinical and pathological aspects. Arch Ophthalmol. 1955;53:224-228.
20. Frangieh GT, Green R, Fine SL. A histopathological study of Best's macular dystrophy. Arch Ophthalmol. 1982;100:1115-1121.
21. Weingeist TA, Kobrin JL, Watzke RC. Histopathology of Best's macular dystrophy. Arch Ophthalmol. 1982; 100:1108-1114.
22. Gass JDM. Idiopathic senile macular hole. Its early stages and pathogenesis. Arch Ophthalmol. 1986; 102:172-175.
23. Eldred GE. Questioning the nature of the fluorophores in age pigments. Adv Biosci. 1987;64:23-36.
24. Eldred GE, Katz ML. Fluorophores of the human retinal pigment epithelium: Separation and spectral characterisation. Exp Eye Res. 1988;47:71-86.
25. Arendt OA, Weiter JJ, Goger DG, Delon FC. In vivo Fundus Fluoreszenz Messungen bei Patienten mit altersabhangiger Makuladegeneration. Ophthalmologe. 1995;92:647-653.
26. Delori FC, Arend O, Staurenghi G, Goger D, Dorey CK, Weiter JJ. Lipofuscin and drusen fluorescencece in aging and age-related macular degeneration. ARVO Abstracts. Invest Ophthalmol Vis Sci. 1994; 35:2145.
27. Pauleikhoff D, Harper CA, Marshall J, Bird AC. Aging changes in Bruch's membrane: a histochemical and morphological study. Ophthalmology. 1990;97:171-178.
28. Sheraidah G, Steinmetz R, Maguire J, Pauleikhoff D, Marshall J, Bird A. Correlation between lipids extracted from Bruch's membrane and age. Ophthalmology. 1993;100:47-51.
29. Holz FG, Sheriadah G, Pauleikhoff D, Bird AC. Analysis of lipid deposits extracted from macular and peripheral Bruch's membrane. Arch Ophthalmol. 1994; 112:402-406.
30. Rungger-Branche E, Englert U, Leuenberger PM. Exocytic clearing of degraded membrane material from pigment epithelial cells in frog retina. Invest Ophthalmol Vis Sci. 1988;28:2026-2037.
31. Feeney L. Lipofuscin and melanin of human retinal pigment epithelium: fluorescence, enzyme cytochemical and ultrastructural studies. Invest Ophthalmol Vis Sci. 1978;17:583-600.