The phosphatidylinositol (3,4,5)-trisphosphate-dependent Rac exchanger 1·Ras-related C3 botulinum toxin substrate 1 (P-Rex1·Rac1) complex reveals the basis of Rac1 activation in breast cancer cells

Journal of Biological Chemistry

Volumn 290, Issue 34, 2015, Pages 20827-20840

  Lucato, Christina M ^a   Halls, Michelle L ^a   Ooms, Lisa M ^a   Liu, Heng Jia ^a   Mitchell, Christina A ^a   Whisstock, James C ^a   Ellisdon, Andrew M ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BINDING SITES; CELL MEMBRANES; CRYSTAL STRUCTURE; DISEASES; PROTEINS;

BOTULINUM TOXINS; BREAST CANCER CELLS; C-TERMINAL DOMAINS; G PROTEIN COUPLED RECEPTORS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; MOLECULAR MECHANISM; PHOSPHATIDYLINOSITOL; RECEPTOR TYROSINE KINASE;

RHENIUM COMPOUNDS;

BETA ADRENERGIC RECEPTOR; CHEMOKINE RECEPTOR CXCR4; EPIDERMAL GROWTH FACTOR RECEPTOR; G PROTEIN BETA GAMMA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN; MULTIPROTEIN COMPLEX; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHATIDYLINOSITOL(3,4,5)TRISPHOSPHATE DEPENDENT RAC EXCHANGER 1; PHOSPHATIDYLINOSITOL(3,4,5)TRISPHOSPHATE DEPENDENT RAC EXCHANGER 1 RAS RELATED C3 BOTULINUM TOXIN SUBSTRATE 1 COMPLEX; RAC1 PROTEIN; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; UNCLASSIFIED DRUG; GUANINE NUCLEOTIDE EXCHANGE FACTOR; HYBRID PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5-TRIPHOSPHATE; POLYPHOSPHOINOSITIDE; PREX1 PROTEIN, HUMAN; PROTEIN BINDING; RAC1 PROTEIN, HUMAN;

ARTICLE; BINDING SITE; BREAST CANCER CELL LINE; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DH DOMAIN; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MUTAGENESIS; PH DOMAIN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; AMINO ACID SEQUENCE; ANIMAL; BACULOVIRIDAE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVE SITE; FEMALE; GENE EXPRESSION REGULATION; GENETICS; MCF 7 CELL LINE; METABOLISM; MOLECULAR GENETICS; MUTATION; SEQUENCE ALIGNMENT; SF9 CELL LINE; SPODOPTERA; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANIMALS; BACULOVIRIDAE; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; MCF-7 CELLS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHATIDYLINOSITOL PHOSPHATES; PROTEIN BINDING; RAC1 GTP-BINDING PROTEIN; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT; SF9 CELLS; SIGNAL TRANSDUCTION; SPODOPTERA;

EID: 84939796114     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.660456     Document Type: Article

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