The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways

Nature

Volumn 411, Issue 6834, 2001, Pages 215-219

  Tarricone, C ^a,b   Xiao, B ^a   Justin, N ^a   Walker, P A ^a   Rittinger, K ^a   Gamblin, S J ^a   Smerdon, S J ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^b EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOLOGY; DIMERS; MOLECULAR BIOLOGY; X RAY ANALYSIS;

SIGNALLING PATHWAYS;

PROTEINS;

GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATE; RAC PROTEIN; RHO FACTOR;

ARTICLE; BINDING AFFINITY; CELL MOTILITY; GOLGI COMPLEX; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADP-RIBOSYLATION FACTOR 1; ADP-RIBOSYLATION FACTORS; AMINO ACID SEQUENCE; BINDING, COMPETITIVE; CALORIMETRY; CARRIER PROTEINS; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; FLUORESCENCE POLARIZATION; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; GUANYLYL IMIDODIPHOSPHATE; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; RAC GTP-BINDING PROTEINS; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; TEMPERATURE; TITRIMETRY;

EID: 0035837426     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35075620     Document Type: Article

References (26)

1. Macara, I. G., Lounsbury, K. M., Richards, S. A., McKiernan, C. & Bar-Sagi, D. The Ras superfamily of GTPases. FASEB J. 10, 625-630 (1996).
2. Bar-Sagi, D. & Hall, A. Ras and Rho GTPases: A family reunion. Cell 103, 227-238 (2000).
3. Fensome, A., Whatmore, J., Morgan, C., Jones, D. & Cockcroft, S. ADP-ribosylation factor and Rho proteins mediate fMLP-dependent activation of phospholipase D in human neutrophils. J. Biol. Chem. 273, 13157-13164 (1998).
4. Zhang, Q., Calafat, J., Janssen, H. & Greenberg, S. ARF6 is required for growth factor- and rac-mediated membrane ruffling in macrophages at a stage distal to rac membrane targeting. Mol. Cell. Biol. 19, 8158-8168 (1999).
5. Wu, W. J., Erickson, J. W., Lin, R. & Cerione, R. A. The γ-subunit of the coatomer complex binds Cdc42 to mediate transformation. Nature 405, 800-804 (2000).
6. Walker, S. J., Wu, W. J., Cerione, R. A. & Brown, H. A. Activation of phospholipase D1 by Cdc42 requires the Rho insert region. J. Biol. Chem. 275, 15665-15668 (2000).
7. Boshans, R. L., Szanto, S., van Aelst, L. & D'Souza-Schorey, C. ADP-ribosylation factor 6 regulates actin cytoskeleton remodeling in coordination with Rac1 and RhoA. Mol. Cell. Biol. 20, 3685-3694 (2000).
8. D'Souza-Schorey, C., Boshans, R. L., McDonough, M., Stahl, P. D. & Van Aelst, L. A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements. EMBO J. 16, 5445-5454 (1997).
9. Van Aelst, L., Joneson, T. & Bar-Sagi, D. Identification of a novel Rac1-interacting protein involved in membrane ruffling. EMBO J. 15, 3778-3786 (1996).
10. Kanoh, H., Williger, B. T. & Exton, J. H. Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes. J. Biol. Chem. 272, 5421-5429 (1997).
11. Williger, B. T., Ostermann, J. & Exton, J. H. Arfaptin 1, an ARF-binding protein, inhibits phospholipase D and endoplasmic reticulum/Golgi protein transport. FEBS Lett. 443, 197-200 (1999).
12. Joneson, T., McDonough, M., Bar-Sagi, D. & Van Aelst, L. RAC regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase. Science 274, 1374-1376 (1996).
13. Maesaki, R. et al. The structural basis of Rho effector recognition revealed by the crystal structure of human RhoA complexed with the effector domain of PKN/PRK1. Mol. Cell 4, 793-803 (1999).
14. pbox in complex with Rac-GTP. Mol. Cell 6, 1-20 (2000).
15. Geyer, M. & Wittinghofer, A. GEFs, GAPs, GDIs and effectors: taking a closer (3D) look at the regulation of Ras-related GTP-binding proteins. Curr. Opin. Struct. Biol. 7, 786-792 (1997).
16. Hoffman, G. R., Nassar, N. & Cerione, R. A. Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI. Cell 100, 345-356 (2000).
17. Scheffzek, K., Stephan, I., Jensen, O. N., Illenberger, D. & Gierschik, P. The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI. Nature Struct. Biol. 7, 122-126 (2000).
18. Wittinghofer, A. Signal transduction via Ras. Biol. Chem. 379, 933-937 (1998).
19. Pacold, M. E. et al. Crystal structure and functional analysis of ras binding to its effector phosphoinositide 3-kinase γ, Cell 103, 931-943 (2000).
20. Franco, M. et al. EFA6, a sec7 domain-containing exchange factor for ARF6, coordinates membrane recycling and actin cytoskeleton organization. EMBO J. 18, 1480-1491 (1999).
21. Otwinowski, Z. & Minor, W. in Data Collection and Processing (eds Sawyer, L., Isaacs, N. & Bailey, S.) 556-562 (Daresbury Laboratory, Warrington, UK, 1993).
22. Terwilliger, T. C. & Berendzen, J. Automated MAD and MIR structure solution. Acta Crystallogr. D 55, 849-861 (1999).
23. Jones, T. A., Zhou, J. Y., Cowan, S. W. & Kjeldgaard, M. Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr. A 47, 110-119 (1991).
24. Collaborative Computer Project No. 4. The CCP4 suite: programs for protein crystallography. Acta Crystallogr. D 50, 760-763 (1994).
25. Brunger, A. T. et al. Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr. D 54, 905-921 (1998).
26. Kraulis, P. J. MOLSCRIPT: A program to produce both detailed and schematic plots of protein structures. J. Appl. Crystallogr. 24, 946-950 (1991).