Structure-function based design of small molecule inhibitors targeting Rho family GTPases

Current Topics in Medicinal Chemistry

Volumn 6, Issue 11, 2006, Pages 1109-1116

  Nassar, Nicolas ^a,b   Cancelas, Jose ^a   Zheng, Jie ^c   Williams, David A ^a   Zheng, Yi ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

Cell Transformation; Genetic alterations; NSC23766; Prostate Epithelial Tumor Cell; Rac GEF interaction

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATE; HYDROLASE INHIBITOR; NSC 23766; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN CDC42; RAC PROTEIN; RAC1 PROTEIN; RAS PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; TRYPTOPHAN; UNCLASSIFIED DRUG;

CANCER CELL CULTURE; CARCINOGENESIS; CELL FUNCTION; CELL GROWTH; CELL INVASION; CELL PROLIFERATION; CELL TRANSFORMATION; CHEMICAL MODIFICATION; COMPUTER ANALYSIS; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SOLUBILITY; DRUG TARGETING; ENZYME DEGRADATION; ENZYME INHIBITION; FIBROBLAST CULTURE; GENE DISRUPTION; GENE TARGETING; GROWTH INHIBITION; HEMATOPOIETIC STEM CELL; HUMAN; IN VITRO STUDY; INHIBITION KINETICS; MALIGNANT NEOPLASTIC DISEASE; MEMBRANE PERMEABILITY; MOUSE; MUTAGENESIS; NONHUMAN; PROSTATE CANCER; PROTEIN BINDING; PROTEIN FAMILY; PROTEIN INTERACTION; PROTEIN STRUCTURE; REGULATORY MECHANISM; REVIEW; STEM CELL MOBILIZATION; STRUCTURE ACTIVITY RELATION;

ANIMALS; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RHO GTP-BINDING PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33746326517     PISSN: 15680266     EISSN: None     Source Type: Journal    
DOI: 10.2174/156802606777812095     Document Type: Review

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