-
1
-
-
0035138098
-
Knee pain and osteoarthritis in older adults: A review of community burden and current use of primary health care
-
Peat G, McCarney R, Croft P. Knee pain and osteoarthritis in older adults: a review of community burden and current use of primary health care. Ann Rheum Dis 2001; 60: 91-7
-
(2001)
Ann Rheum Dis
, vol.60
, pp. 91-97
-
-
Peat, G.1
McCarney, R.2
Croft, P.3
-
3
-
-
0031857481
-
An update on the epidemiology of knee and hip osteoarthritis with a view to prevention
-
Felson DT, Zhang Y. An update on the epidemiology of knee and hip osteoarthritis with a view to prevention. Arthritis Rheum 1998; 41: 1343-55
-
(1998)
Arthritis Rheum
, vol.41
, pp. 1343-1355
-
-
Felson, D.T.1
Zhang, Y.2
-
4
-
-
33749177293
-
The burden of musculoskeletal disease--a global perspective
-
Brooks PM. The burden of musculoskeletal disease--a global perspective. Clin Rheumatol 2006; 25(6): 778-81
-
(2006)
Clin Rheumatol
, vol.25
, Issue.6
, pp. 778-781
-
-
Brooks, P.M.1
-
6
-
-
84887406073
-
Diagnosis and treatment of osteoarthritis
-
Taruc-Uy RL, Lynch SA. Diagnosis and treatment of osteoarthritis. Primary Care 2013; 40: 821-36
-
(2013)
Primary Care
, vol.40
, pp. 821-836
-
-
Taruc-Uy, R.L.1
Lynch, S.A.2
-
7
-
-
84927643255
-
Pain trajectory groups in persons with, or at high risk of, knee osteoarthritis: Findings from the knee clinical assessment study and the osteoarthritis initiative
-
Nicholls E, Thomas E, Van der Windt DA, Croft PR, Peat G. Pain trajectory groups in persons with, or at high risk of, knee osteoarthritis: findings from the knee clinical assessment study and the osteoarthritis initiative. Osteoarthr Cartil 2014; 22(12): 2041-50
-
(2014)
Osteoarthr Cartil
, vol.22
, Issue.12
, pp. 2041-2050
-
-
Nicholls, E.1
Thomas, E.2
Van Der Windt, D.A.3
Croft, P.R.4
Peat, G.5
-
9
-
-
38149052992
-
Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II
-
Lawrence RC, Felson DT, Helmick CG, et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis Rheum 2008; 58: 26-35
-
(2008)
Arthritis Rheum
, vol.58
, pp. 26-35
-
-
Lawrence, R.C.1
Felson, D.T.2
Helmick, C.G.3
-
10
-
-
33846263084
-
Prevalence of knee symptoms and radiographic and symptomatic knee osteoarthritis in African Americans and Caucasians: The Johnston County Osteoarthritis Project
-
Jordan JM, Helmick CG, Renner JB, et al. Prevalence of knee symptoms and radiographic and symptomatic knee osteoarthritis in African Americans and Caucasians: the Johnston County Osteoarthritis Project. J Rheumatol 2007; 34: 172-80
-
(2007)
J Rheumatol
, vol.34
, pp. 172-180
-
-
Jordan, J.M.1
Helmick, C.G.2
Renner, J.B.3
-
11
-
-
84903706776
-
Metalloproteinases and metalloproteinase inhibitors in age-related diseases
-
Gargiulo S, Gamba P, Poli G, Leonarduzzi G. Metalloproteinases and metalloproteinase inhibitors in age-related diseases. Curr Pharm Des 2014; 20: 2993-3018
-
(2014)
Curr Pharm Des
, vol.20
, pp. 2993-3018
-
-
Gargiulo, S.1
Gamba, P.2
Poli, G.3
Leonarduzzi, G.4
-
12
-
-
73249137617
-
Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development
-
Little CB, Barai A, Burkhardt D, et al. Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development. Arthritis Rheum 2009; 60: 3723-33
-
(2009)
Arthritis Rheum
, vol.60
, pp. 3723-3733
-
-
Little, C.B.1
Barai, A.2
Burkhardt, D.3
-
13
-
-
15844384854
-
ADAMTS5 is the major aggrecanase in mouse cartilage In vivo and in vitro
-
Stanton H, Rogerson FM, East CJ, et al. ADAMTS5 is the major aggrecanase in mouse cartilage In vivo and in vitro. Nature 2005; 434: 648-52
-
(2005)
Nature
, vol.434
, pp. 648-652
-
-
Stanton, H.1
Rogerson, F.M.2
East, C.J.3
-
14
-
-
15844413814
-
Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis
-
Glasson SS, Askew R, Sheppard B, et al. Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis. Nature 2005; 434: 644-8
-
(2005)
Nature
, vol.434
, pp. 644-648
-
-
Glasson, S.S.1
Askew, R.2
Sheppard, B.3
-
15
-
-
84863727443
-
Oxidative stress in secondary osteoarthritis: From cartilage destruction to clinical presentation?
-
Ziskoven C, Jager M, Zilkens C, Bloch W, Brixius K, Krauspe R. Oxidative stress in secondary osteoarthritis: from cartilage destruction to clinical presentation? Orthop Rev 2010; 2: e23
-
(2010)
Orthop Rev
, vol.2
-
-
Ziskoven, C.1
Jager, M.2
Zilkens, C.3
Bloch, W.4
Brixius, K.5
Krauspe, R.6
-
16
-
-
66249096001
-
Cartilage homeostasis in health and rheumatic diseases
-
Goldring MB, Marcu KB. Cartilage homeostasis in health and rheumatic diseases. Arthritis Res Ther 2009; 11: 224
-
(2009)
Arthritis Res Ther
, vol.11
-
-
Goldring, M.B.1
Marcu, K.B.2
-
18
-
-
0021200576
-
Cellular aspects of the aging of articular cartilage. I. Condylar cartilage with a normal surface sampled from normal knees
-
Quintero M, Mitrovic DR, Stankovic A, de Seze S, Miravet L, Ryckewaert A. Cellular aspects of the aging of articular cartilage. I. Condylar cartilage with a normal surface sampled from normal knees. Rev Rhum Mal Osteoartic 1984; 51: 375-9
-
(1984)
Rev Rhum Mal Osteoartic
, vol.51
, pp. 375-379
-
-
Quintero, M.1
Mitrovic, D.R.2
Stankovic, A.3
De Seze, S.4
Miravet, L.5
Ryckewaert, A.6
-
19
-
-
84863008132
-
Histopathology of naturally occurring and surgically induced osteoarthritis in mice
-
McNulty MA, Loeser RF, Davey C, Callahan MF, Ferguson CM, Carlson CS. Histopathology of naturally occurring and surgically induced osteoarthritis in mice. Osteoarthr Cartil 2012; 20: 949-56
-
(2012)
Osteoarthr Cartil
, vol.20
, pp. 949-956
-
-
McNulty, M.A.1
Loeser, R.F.2
Davey, C.3
Callahan, M.F.4
Ferguson, C.M.5
Carlson, C.S.6
-
20
-
-
0031915678
-
Chondrocyte apoptosis increases with age in the articular cartilage of adult animals
-
Adams CS, Horton WE Jr. Chondrocyte apoptosis increases with age in the articular cartilage of adult animals. Anat Rec 1998; 250: 418-25
-
(1998)
Anat Rec
, vol.250
, pp. 418-425
-
-
Adams, C.S.1
Horton, W.E.2
-
21
-
-
7744229575
-
Characterization of mature vs aged rabbit articular cartilage: Analysis of cell density, apoptosis-related gene expression and mechanisms controlling chondrocyte apoptosis
-
Todd AR, Robertson CM, Harwood FL, et al. Characterization of mature vs aged rabbit articular cartilage: analysis of cell density, apoptosis-related gene expression and mechanisms controlling chondrocyte apoptosis. Osteoarthr Cartil 2004; 12: 917-23
-
(2004)
Osteoarthr Cartil
, vol.12
, pp. 917-923
-
-
Todd, A.R.1
Robertson, C.M.2
Harwood, F.L.3
-
23
-
-
84905046428
-
Aging and oxidative stress reduce the response of human articular chondrocytes to insulin-like growth factor 1 and osteogenic protein 1
-
Loeser RF, Gandhi U, Long DL, Yin W, Chubinskaya S. Aging and oxidative stress reduce the response of human articular chondrocytes to insulin-like growth factor 1 and osteogenic protein 1. Arthritis Rheumatol 2014; 66: 2201-9
-
(2014)
Arthritis Rheumatol
, vol.66
, pp. 2201-2209
-
-
Loeser, R.F.1
Gandhi, U.2
Long, D.L.3
Yin, W.4
Chubinskaya, S.5
-
24
-
-
0033680154
-
Reduction in the chondrocyte response to insulin-like growth factor 1 in aging and osteoarthritis: Studies in a non-human primate model of naturally occurring disease
-
Loeser RF, Shanker G, Carlson CS, Gardin JF, Shelton BJ, Sonntag WE. Reduction in the chondrocyte response to insulin-like growth factor 1 in aging and osteoarthritis: studies in a non-human primate model of naturally occurring disease. Arthritis Rheum 2000; 43: 2110-20
-
(2000)
Arthritis Rheum
, vol.43
, pp. 2110-2120
-
-
Loeser, R.F.1
Shanker, G.2
Carlson, C.S.3
Gardin, J.F.4
Shelton, B.J.5
Sonntag, W.E.6
-
25
-
-
0031193785
-
Age-related decline in chondrocyte response to insulin-like growth factor-I: The role of growth factor binding proteins
-
Martin JA, Ellerbroek SM, Buckwalter JA. Age-related decline in chondrocyte response to insulin-like growth factor-I: the role of growth factor binding proteins. J Orthop Res 1997; 15: 491-8
-
(1997)
J Orthop Res
, vol.15
, pp. 491-498
-
-
Martin, J.A.1
Ellerbroek, S.M.2
Buckwalter, J.A.3
-
26
-
-
0034679059
-
Articular chondrocytes from aging rats respond poorly to insulinlike growth factor-1: An altered signaling pathway
-
Messai H, Duchossoy Y, Khatib AM, Panasyuk A, Mitrovic DR. Articular chondrocytes from aging rats respond poorly to insulinlike growth factor-1: an altered signaling pathway. Mech Ageing Dev 2000; 115: 21-37
-
(2000)
Mech Ageing Dev
, vol.115
, pp. 21-37
-
-
Messai, H.1
Duchossoy, Y.2
Khatib, A.M.3
Panasyuk, A.4
Mitrovic, D.R.5
-
27
-
-
33746956085
-
Signaling through the small G-protein Cdc42 is involved in insulin-like growth factor-I resistance in aging articular chondrocytes
-
Fortier LA, Miller BJ. Signaling through the small G-protein Cdc42 is involved in insulin-like growth factor-I resistance in aging articular chondrocytes. J Orthop Res 2006; 24: 1765-72
-
(2006)
J Orthop Res
, vol.24
, pp. 1765-1772
-
-
Fortier, L.A.1
Miller, B.J.2
-
28
-
-
34547451736
-
Hsp90 mediates insulin-like growth factor 1 and interleukin-1beta signaling in an agedependent manner in equine articular chondrocytes
-
Boehm AK, Seth M, Mayr KG, Fortier LA. Hsp90 mediates insulin-like growth factor 1 and interleukin-1beta signaling in an agedependent manner in equine articular chondrocytes. Arthritis Rheum 2007; 56: 2335-43
-
(2007)
Arthritis Rheum
, vol.56
, pp. 2335-2343
-
-
Boehm, A.K.1
Seth, M.2
Mayr, K.G.3
Fortier, L.A.4
-
29
-
-
0141453478
-
Expression of bone morphogenetic protein 6 in healthy and osteoarthritic human articular chondrocytes and stimulation of matrix synthesis in vitro
-
Bobacz K, Gruber R, Soleiman A, Erlacher L, Smolen JS, Graninger WB. Expression of bone morphogenetic protein 6 in healthy and osteoarthritic human articular chondrocytes and stimulation of matrix synthesis in vitro. Arthritis Rheum 2003; 48: 2501-8
-
(2003)
Arthritis Rheum
, vol.48
, pp. 2501-2508
-
-
Bobacz, K.1
Gruber, R.2
Soleiman, A.3
Erlacher, L.4
Smolen, J.S.5
Graninger, W.B.6
-
30
-
-
24344459586
-
Aged bovine chondrocytes display a diminished capacity to produce a collagen-rich, mechanically functional cartilage extracellular matrix
-
Tran-Khanh N, Hoemann CD, McKee MD, Henderson JE, Buschmann MD. Aged bovine chondrocytes display a diminished capacity to produce a collagen-rich, mechanically functional cartilage extracellular matrix. J Orthop Res 2005; 23: 1354-62
-
(2005)
J Orthop Res
, vol.23
, pp. 1354-1362
-
-
Tran-Khanh, N.1
Hoemann, C.D.2
McKee, M.D.3
Henderson, J.E.4
Buschmann, M.D.5
-
31
-
-
33144481368
-
Reduced transforming growth factor-beta signaling in cartilage of old mice: Role in impaired repair capacity
-
Blaney Davidson EN, Scharstuhl A, Vitters EL, Van der Kraan PM, Van den Berg WB. Reduced transforming growth factor-beta signaling in cartilage of old mice: role in impaired repair capacity. Arthritis Res Ther 2005; 7: R1338-47
-
(2005)
Arthritis Res Ther
, vol.7
, pp. 338
-
-
Blaney Davidson, E.N.1
Scharstuhl, A.2
Vitters, E.L.3
Van Der Kraan, P.M.4
Van Den Berg, W.B.5
-
32
-
-
0036893256
-
Loss of transforming growth factor counteraction on interleukin 1 mediated effects in cartilage of old mice
-
Scharstuhl A, Van Beuningen HM, Vitters EL, van der Kraan PM, van den Berg WB. Loss of transforming growth factor counteraction on interleukin 1 mediated effects in cartilage of old mice. Ann Rheum Dis 2002; 61: 1095-8
-
(2002)
Ann Rheum Dis
, vol.61
, pp. 1095-1098
-
-
Scharstuhl, A.1
Van Beuningen, H.M.2
Vitters, E.L.3
Van Der Kraan, P.M.4
Van Den Berg, W.B.5
-
33
-
-
70450274965
-
Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways
-
Yin W, Park JI, Loeser RF. Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways. J Biol Chem 2009; 284: 31972-81
-
(2009)
J Biol Chem
, vol.284
, pp. 31972-31981
-
-
Yin, W.1
Park, J.I.2
Loeser, R.F.3
-
35
-
-
0028040115
-
Human osteoarthritic chondrocytes possess an increased number of insulin-like growth factor 1 binding sites but are unresponsive to its stimulation. Possible role of IGF-1-binding proteins
-
Dore S, Pelletier JP, DiBattista JA, Tardif G, Brazeau P, Martel-Pelletier J. Human osteoarthritic chondrocytes possess an increased number of insulin-like growth factor 1 binding sites but are unresponsive to its stimulation. Possible role of IGF-1-binding proteins. Arthritis Rheum 1994; 37: 253-63
-
(1994)
Arthritis Rheum
, vol.37
, pp. 253-263
-
-
Dore, S.1
Pelletier, J.P.2
Dibattista, J.A.3
Tardif, G.4
Brazeau, P.5
Martel-Pelletier, J.6
-
36
-
-
0344622606
-
The serial cultivation of human diploid cell strains
-
Hayflick L, Moorhead PS. The serial cultivation of human diploid cell strains. Exp Cell Res 1961; 25: 585-621
-
(1961)
Exp Cell Res
, vol.25
, pp. 585-621
-
-
Hayflick, L.1
Moorhead, P.S.2
-
37
-
-
79951912532
-
Four faces of cellular senescence
-
Rodier F, Campisi J. Four faces of cellular senescence. J Cell Biol 2011; 192: 547-56
-
(2011)
J Cell Biol
, vol.192
, pp. 547-556
-
-
Rodier, F.1
Campisi, J.2
-
38
-
-
84873638532
-
Aging, cellular senescence, and cancer
-
Campisi J. Aging, cellular senescence, and cancer. Annu Rev Physiol 2013; 75: 685-705
-
(2013)
Annu Rev Physiol
, vol.75
, pp. 685-705
-
-
Campisi, J.1
-
39
-
-
84874603171
-
Cellular senescence and the senescent secretory phenotype: Therapeutic opportunities
-
Tchkonia T, Zhu Y, Van Deursen J, Campisi J, Kirkland JL. Cellular senescence and the senescent secretory phenotype: therapeutic opportunities. J Clin Invest 2013; 123: 966-72
-
(2013)
J Clin Invest
, vol.123
, pp. 966-972
-
-
Tchkonia, T.1
Zhu, Y.2
Van Deursen, J.3
Campisi, J.4
Kirkland, J.L.5
-
40
-
-
0036674028
-
Sites of collagenase cleavage and denaturation of type II collagen in aging and osteoarthritic articular cartilage and their relationship to the distribution of matrix metalloproteinase 1 and matrix metalloproteinase 13
-
Wu W, Billinghurst RC, Pidoux I, et al. Sites of collagenase cleavage and denaturation of type II collagen in aging and osteoarthritic articular cartilage and their relationship to the distribution of matrix metalloproteinase 1 and matrix metalloproteinase 13. Arthritis Rheum 2002; 46: 2087-94
-
(2002)
Arthritis Rheum
, vol.46
, pp. 2087-2094
-
-
Wu, W.1
Billinghurst, R.C.2
Pidoux, I.3
-
41
-
-
0028839263
-
Collagen in aging and osteoarthritis starts at the articular surface, originates around chondrocytes, and extends into the cartilage with progressive degeneration
-
Hollander AP, Pidoux I, Reiner A, Rorabeck C, Bourne R, Poole AR. Damage to type II collagen in aging and osteoarthritis starts at the articular surface, originates around chondrocytes, and extends into the cartilage with progressive degeneration. J Clin Invest 1995; 96: 2859-69
-
(1995)
J Clin Invest
, vol.96
, pp. 2859-2869
-
-
Hollander, A.P.1
Pidoux, I.2
Reiner, A.3
Rorabeck, C.4
Bourne, R.5
Poole, A.R.6
Damage To Type, I.I.7
-
42
-
-
0036846971
-
Matrix homeostasis in aging normal human ankle cartilage
-
Aurich M, Poole AR, Reiner A, et al. Matrix homeostasis in aging normal human ankle cartilage. Arthritis Rheum 2002; 46: 2903-10.
-
(2002)
Arthritis Rheum
, vol.46
, pp. 2903-2910
-
-
Aurich, M.1
Poole, A.R.2
Reiner, A.3
-
43
-
-
84860802481
-
Increased type II collagen cleavage by cathepsin K and collagenase activities with aging and osteoarthritis in human articular cartilage
-
Dejica VM, Mort JS, Laverty S, et al. Increased type II collagen cleavage by cathepsin K and collagenase activities with aging and osteoarthritis in human articular cartilage. Arthritis Res Ther 2012; 14: R113.
-
(2012)
Arthritis Res Ther
, vol.14
-
-
Dejica, V.M.1
Mort, J.S.2
Laverty, S.3
-
44
-
-
25644437811
-
Increased matrix metalloproteinase-13 production with aging by human articular chondrocytes in response to catabolic stimuli
-
Forsyth CB, Cole A, Murphy G, Bienias JL, Im HJ, Loeser RF Jr. Increased matrix metalloproteinase-13 production with aging by human articular chondrocytes in response to catabolic stimuli. J Gerontol A Biol Sci Med Sci 2005; 60: 1118-24.
-
(2005)
J Gerontol a Biol Sci Med Sci
, vol.60
, pp. 1118-1124
-
-
Forsyth, C.B.1
Cole, A.2
Murphy, G.3
Bienias, J.L.4
Im, H.J.5
Loeser, R.F.6
-
45
-
-
0036701572
-
Response of young, aged and osteoarthritic human articular chondrocytes to inflammatory cytokines: Molecular and cellular aspects
-
Dozin B, Malpeli M, Camardella L, Cancedda R, Pietrangelo A. Response of young, aged and osteoarthritic human articular chondrocytes to inflammatory cytokines: molecular and cellular aspects. Matrix Biol 2002; 21: 449-59.
-
(2002)
Matrix Biol
, vol.21
, pp. 449-459
-
-
Dozin, B.1
Malpeli, M.2
Camardella, L.3
Cancedda, R.4
Pietrangelo, A.5
-
46
-
-
84857742047
-
Microarray analysis reveals age-related differences in gene expression during the development of osteoarthritis in mice
-
Loeser RF, Olex AL, McNulty MA, et al. Microarray analysis reveals age-related differences in gene expression during the development of osteoarthritis in mice. Arthritis Rheum 2012; 64: 705-17.
-
(2012)
Arthritis Rheum
, vol.64
, pp. 705-717
-
-
Loeser, R.F.1
Olex, A.L.2
McNulty, M.A.3
-
48
-
-
77952208407
-
Age-related differences in prostaglandin E2 synthesis by equine cartilage explants and synoviocytes
-
Briston L, Dudhia J, Lees P. Age-related differences in prostaglandin E2 synthesis by equine cartilage explants and synoviocytes. J Vet Pharmacol Ther 2010; 33: 268-76.
-
(2010)
J Vet Pharmacol Ther
, vol.33
, pp. 268-276
-
-
Briston, L.1
Dudhia, J.2
Lees, P.3
-
49
-
-
33644899652
-
Catabolic stress induces features of chondrocyte senescence through overexpression of caveolin 1: Possible involvement of caveolin 1-induced down-regulation of articular chondrocytes in the pathogenesis of osteoarthritis
-
Dai SM, Shan ZZ et al. Catabolic stress induces features of chondrocyte senescence through overexpression of caveolin 1: possible involvement of caveolin 1-induced down-regulation of articular chondrocytes in the pathogenesis of osteoarthritis. Arthritis Rheum 2006; 54: 818-31.
-
(2006)
Arthritis Rheum
, vol.54
, pp. 818-831
-
-
Dai, S.M.1
Shan, Z.Z.2
-
50
-
-
0036745073
-
Detection of nitrotyrosine in aging and osteoarthritic cartilage: Correlation of oxidative damage with the presence of interleukin-1beta and with chondrocyte resistance to insulin-like growth factor 1
-
Loeser RF, Carlson CS, Del Carlo M, Cole A. Detection of nitrotyrosine in aging and osteoarthritic cartilage: Correlation of oxidative damage with the presence of interleukin-1beta and with chondrocyte resistance to insulin-like growth factor 1. Arthritis Rheum 2002; 46: 2349-57.
-
(2002)
Arthritis Rheum
, vol.46
, pp. 2349-2357
-
-
Loeser, R.F.1
Carlson, C.S.2
Del Carlo, M.3
Cole, A.4
-
51
-
-
0347481187
-
Increased oxidative stress with aging reduces chondrocyte survival: Correlation with intracellular glutathione levels
-
Carlo MD Jr., Loeser RF. Increased oxidative stress with aging reduces chondrocyte survival: correlation with intracellular glutathione levels. Arthritis Rheum 2003; 48: 3419-30.
-
(2003)
Arthritis Rheum
, vol.48
, pp. 3419-3430
-
-
Carlo, M.D.1
Loeser, R.F.2
-
52
-
-
20944433514
-
Vulnerability to ROS-induced cell death in ageing articular cartilage: The role of antioxidant enzyme activity
-
Jallali N, Ridha H, Thrasivoulou C, Underwood C, Butler PE, Cowen T. Vulnerability to ROS-induced cell death in ageing articular cartilage: the role of antioxidant enzyme activity. Osteoarthr Cartil 2005; 13: 614-22.
-
(2005)
Osteoarthr Cartil
, vol.13
, pp. 614-622
-
-
Jallali, N.1
Ridha, H.2
Thrasivoulou, C.3
Underwood, C.4
Butler, P.E.5
Cowen, T.6
-
53
-
-
23844482134
-
Proteomic characterization of human normal articular chondrocytes: A novel tool for the study of osteoarthritis and other rheumatic diseases
-
Ruiz-Romero C, Lopez-Armada MJ, Blanco FJ. Proteomic characterization of human normal articular chondrocytes: a novel tool for the study of osteoarthritis and other rheumatic diseases. Proteomics 2005; 5: 3048-59.
-
(2005)
Proteomics
, vol.5
, pp. 3048-3059
-
-
Ruiz-Romero, C.1
Lopez-Armada, M.J.2
Blanco, F.J.3
-
54
-
-
0025740098
-
Superoxide dismutase and catalase activities in the growth cartilage: Relationship between oxidoreductase activity and chondrocyte maturation
-
Matsumoto H, Silverton SF, Debolt K, Shapiro IM. Superoxide dismutase and catalase activities in the growth cartilage: relationship between oxidoreductase activity and chondrocyte maturation. J Bone Miner Res 1991; 6: 569-74.
-
(1991)
J Bone Miner Res
, vol.6
, pp. 569-574
-
-
Matsumoto, H.1
Silverton, S.F.2
Debolt, K.3
Shapiro, I.M.4
-
55
-
-
84874611617
-
Telomeres and age-related disease: How telomere biology informs clinical paradigms
-
Armanios M. Telomeres and age-related disease: how telomere biology informs clinical paradigms. J Clin Invest 2013; 123: 996-1002.
-
(2013)
J Clin Invest
, vol.123
, pp. 996-1002
-
-
Armanios, M.1
-
57
-
-
0035071327
-
Telomere erosion and senescence in human articular cartilage chondrocytes
-
Martin JA, Buckwalter JA. Telomere erosion and senescence in human articular cartilage chondrocytes. J Gerontol A Biol Sci Med Sci 2001; 56: B172-9.
-
(2001)
J Gerontol a Biol Sci Med Sci
, vol.56
, pp. 172
-
-
Martin, J.A.1
Buckwalter, J.A.2
-
58
-
-
0036187950
-
Increased life span of human osteoarthritic chondrocytes by exogenous expression of telomerase
-
Piera-Velazquez S, Jimenez SA, Stokes D. Increased life span of human osteoarthritic chondrocytes by exogenous expression of telomerase. Arthritis Rheum 2002; 46: 683-93.
-
(2002)
Arthritis Rheum
, vol.46
, pp. 683-693
-
-
Piera-Velazquez, S.1
Jimenez, S.A.2
Stokes, D.3
-
59
-
-
84864823834
-
Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer
-
Bernardes de Jesus B, Vera E, Schneeberger K, et al. Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer. EMBO Mol Med 2012; 4: 691-704.
-
(2012)
EMBO Mol Med
, vol.4
, pp. 691-704
-
-
De Bernardes Jesus, B.1
Vera, E.2
Schneeberger, K.3
-
60
-
-
0037369651
-
Differential roles of hydrogen peroxide and superoxide in mediating IL-1-induced NF-kappa B activation and iNOS expression in bovine articular chondrocytes
-
Mendes AF, Caramona MM, Carvalho AP, Lopes MC. Differential roles of hydrogen peroxide and superoxide in mediating IL-1-induced NF-kappa B activation and iNOS expression in bovine articular chondrocytes. J Cell Biochem. 2003; 88: 783-93.
-
(2003)
J Cell Biochem
, vol.88
, pp. 783-793
-
-
Mendes, A.F.1
Caramona, M.M.2
Carvalho, A.P.3
Lopes, M.C.4
-
61
-
-
38449110162
-
Antioxidants block cyclic loading induced chondrocyte death
-
Beecher BR, Martin JA, Pedersen DR, Heiner AD, Buckwalter JA. Antioxidants block cyclic loading induced chondrocyte death. Iowa Orthop J 2007; 27: 1-8.
-
(2007)
Iowa Orthop J
, vol.27
, pp. 1-8
-
-
Beecher, B.R.1
Martin, J.A.2
Pedersen, D.R.3
Heiner, A.D.4
Buckwalter, J.A.5
-
62
-
-
84871609424
-
Mechanical stress and ATP synthesis are coupled by mitochondrial oxidants in articular cartilage
-
Wolff KJ, Ramakrishnan PS, Brouillette MJ, et al. Mechanical stress and ATP synthesis are coupled by mitochondrial oxidants in articular cartilage. J Orthop Res 2013; 31: 191-6.
-
(2013)
J Orthop Res
, vol.31
, pp. 191-196
-
-
Wolff, K.J.1
Ramakrishnan, P.S.2
Brouillette, M.J.3
-
63
-
-
0029127226
-
Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: A model for senescence?
-
Von Zglinicki T, Saretzki G, Docke W, Lotze C. Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence? Exp Cell Res 1995; 220: 186-93.
-
(1995)
Exp Cell Res
, vol.220
, pp. 186-193
-
-
Von Zglinicki, T.1
Saretzki, G.2
Docke, W.3
Lotze, C.4
-
64
-
-
0028345161
-
Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells
-
Chen Q, Ames BN. Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells. Proc Natl Acad Sci USA 1994; 91: 4130-4.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 4130-4134
-
-
Chen, Q.1
Ames, B.N.2
-
65
-
-
0032524563
-
Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts: P53 and Rb control G1 arrest but not cell replication
-
Chen QM, Bartholomew JC, Campisi J, Acosta M, Reagan JD, Ames BN. Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication. Biochem J 1998; 332(Pt 1): 43-50.
-
(1998)
Biochem J
, vol.332
, pp. 43-50
-
-
Chen, Q.M.1
Bartholomew, J.C.2
Campisi, J.3
Acosta, M.4
Reagan, J.D.5
Ames, B.N.6
-
66
-
-
0034655373
-
Apoptosis or senescence-like growth arrest: Influence of cell-cycle position, p53, p21 and bax in H2O2 response of normal human fibroblasts
-
Chen QM, Liu J, Merrett JB. Apoptosis or senescence-like growth arrest: influence of cell-cycle position, p53, p21 and bax in H2O2 response of normal human fibroblasts. Biochem J 2000; 347: 543-51.
-
(2000)
Biochem J
, vol.347
, pp. 543-551
-
-
Chen, Q.M.1
Liu, J.2
Merrett, J.B.3
-
67
-
-
24944488049
-
Heterogeneity in premature senescence by oxidative stress correlates with differential DNA damage during the cell cycle
-
Chen JH, Ozanne SE, Hales CN. Heterogeneity in premature senescence by oxidative stress correlates with differential DNA damage during the cell cycle. DNA Repair 2005; 4: 1140-8.
-
(2005)
DNA Repair
, vol.4
, pp. 1140-1148
-
-
Chen, J.H.1
Ozanne, S.E.2
Hales, C.N.3
-
68
-
-
10344260912
-
Loss of proliferative capacity and induction of senescence in oxidatively stressed human fibroblasts
-
Chen JH, Stoeber K, Kingsbury S, Ozanne SE, Williams GH, Hales CN. Loss of proliferative capacity and induction of senescence in oxidatively stressed human fibroblasts. J Biol Chem 2004; 279: 49439-46.
-
(2004)
J Biol Chem
, vol.279
, pp. 49439-49446
-
-
Chen, J.H.1
Stoeber, K.2
Kingsbury, S.3
Ozanne, S.E.4
Williams, G.H.5
Hales, C.N.6
-
69
-
-
0042195820
-
Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts
-
Parrinello S, Samper E, Krtolica A, Goldstein J, Melov S, Campisi J. Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nat Cell Biol 2003; 5: 741-7.
-
(2003)
Nat Cell Biol
, vol.5
, pp. 741-747
-
-
Parrinello, S.1
Samper, E.2
Krtolica, A.3
Goldstein, J.4
Melov, S.5
Campisi, J.6
-
70
-
-
2942570699
-
Oxygen accelerates the accumulation of mutations during the senescence and immortalization of murine cells in culture
-
Busuttil RA, Rubio M, Dolle ME, Campisi J, Vijg J. Oxygen accelerates the accumulation of mutations during the senescence and immortalization of murine cells in culture. Aging cell 2003; 2: 287-94.
-
(2003)
Aging Cell
, vol.2
, pp. 287-294
-
-
Busuttil, R.A.1
Rubio, M.2
Dolle, M.E.3
Campisi, J.4
Vijg, J.5
-
71
-
-
0029051426
-
Oxidative DNA damage and senescence of human diploid fibroblast cells
-
Chen Q, Fischer A, Reagan JD, Yan LJ, Ames BN. Oxidative DNA damage and senescence of human diploid fibroblast cells. Proc Natl Acad Sci USA 1995; 92: 4337-41.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 4337-4341
-
-
Chen, Q.1
Fischer, A.2
Reagan, J.D.3
Yan, L.J.4
Ames, B.N.5
-
72
-
-
0033952417
-
Peroxide accumulation without major mitochondrial alteration in replicative senescence
-
Pfeuty A, Gueride M. Peroxide accumulation without major mitochondrial alteration in replicative senescence. FEBS Lett 2000; 468: 43-7.
-
(2000)
FEBS Lett
, vol.468
, pp. 43-47
-
-
Pfeuty, A.1
Gueride, M.2
-
74
-
-
79955893457
-
Oxidative stress induces senescence in chondrocytes
-
Brandl A, Hartmann A, Bechmann V, Graf B, Nerlich M, Angele P. Oxidative stress induces senescence in chondrocytes. J Orthop Res 2011; 29: 1114-20.
-
(2011)
J Orthop Res
, vol.29
, pp. 1114-1120
-
-
Brandl, A.1
Hartmann, A.2
Bechmann, V.3
Graf, B.4
Nerlich, M.5
Angele, P.6
-
75
-
-
0038389113
-
Peroxisome proliferatoractivated receptor gamma (PPARgamma) expression is decreased in pulmonary hypertension and affects endothelial cell growth
-
Ameshima S, Golpon H, Cool CD, et al. Peroxisome proliferatoractivated receptor gamma (PPARgamma) expression is decreased in pulmonary hypertension and affects endothelial cell growth. Circ Res 2003; 92: 1162-9.
-
(2003)
Circ Res
, vol.92
, pp. 1162-1169
-
-
Ameshima, S.1
Golpon, H.2
Cool, C.D.3
-
76
-
-
26444473434
-
Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: Oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function
-
Yudoh K, Nguyen VT, Nakamura H, Hongo-Masuko K, Kato T, Nishioka K. Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function. Arthritis Res Ther 2005; 7: R380-91.
-
(2005)
Arthritis Res Ther
, vol.7
-
-
Yudoh, K.1
Nguyen, V.T.2
Nakamura, H.3
Hongo-Masuko, K.4
Kato, T.5
Nishioka, K.6
-
77
-
-
46249125488
-
How shelterin protects mammalian telomeres
-
Palm W, De Lange T. How shelterin protects mammalian telomeres. Annu Rev Genet 2008; 42: 301-34.
-
(2008)
Annu Rev Genet
, vol.42
, pp. 301-334
-
-
Palm, W.1
De Lange, T.2
-
78
-
-
3242881692
-
The XRCC genes: Expanding roles in DNA double-strand break repair
-
Thacker J, Zdzienicka MZ. The XRCC genes: expanding roles in DNA double-strand break repair. DNA Repair 2004; 3: 1081-90.
-
(2004)
DNA Repair
, vol.3
, pp. 1081-1090
-
-
Thacker, J.1
Zdzienicka, M.Z.2
-
79
-
-
84900310861
-
SIRT1 Is Necessary for Proficient Telomere Elongation and Genomic Stability of Induced Pluripotent Stem Cells
-
De Bonis ML, Ortega S, Blasco MA. SIRT1 Is Necessary for Proficient Telomere Elongation and Genomic Stability of Induced Pluripotent Stem Cells. Stem Cell Reports 2014; 2: 690-706.
-
(2014)
Stem Cell Reports
, vol.2
, pp. 690-706
-
-
De Bonis, M.L.1
Ortega, S.2
Blasco, M.A.3
-
80
-
-
78649482634
-
SIRT1: Recent lessons from mouse models
-
Herranz D, Serrano M. SIRT1: recent lessons from mouse models. Nat Rev Cancer 2010; 10: 819-23.
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 819-823
-
-
Herranz, D.1
Serrano, M.2
-
81
-
-
84855893320
-
Caveolin-1, cellular senescence and age-related diseases
-
Zou H, Stoppani E, Volonte D, Galbiati F. Caveolin-1, cellular senescence and age-related diseases. Mech Ageing Dev 2011; 132: 533-42.
-
(2011)
Mech Ageing Dev
, vol.132
, pp. 533-542
-
-
Zou, H.1
Stoppani, E.2
Volonte, D.3
Galbiati, F.4
-
82
-
-
16244421738
-
Inactivation of p38 kinase delays the onset of senescence in rabbit articular chondrocytes
-
Kang S, Jung M, Kim CW, Shin DY. Inactivation of p38 kinase delays the onset of senescence in rabbit articular chondrocytes. Mech Ageing Dev 2005; 126: 591-7.
-
(2005)
Mech Ageing Dev
, vol.126
, pp. 591-597
-
-
Kang, S.1
Jung, M.2
Kim, C.W.3
Shin, D.Y.4
-
83
-
-
4344688108
-
Post-traumatic osteoarthritis: The role of accelerated chondrocyte senescence
-
Martin JA, Brown T, Heiner A, Buckwalter JA. Post-traumatic osteoarthritis: the role of accelerated chondrocyte senescence. Biorheology 2004; 41: 479-91.
-
(2004)
Biorheology
, vol.41
, pp. 479-491
-
-
Martin, J.A.1
Brown, T.2
Heiner, A.3
Buckwalter, J.A.4
-
84
-
-
0036746119
-
Lectin-like oxidized low-density lipoprotein receptor 1 mediates leukocyte infiltration and articular cartilage destruction in rat zymosan-induced arthritis
-
Nakagawa T, Akagi M, Hoshikawa H, et al. Lectin-like oxidized low-density lipoprotein receptor 1 mediates leukocyte infiltration and articular cartilage destruction in rat zymosan-induced arthritis. Arthritis Rheum 2002; 46: 2486-94.
-
(2002)
Arthritis Rheum
, vol.46
, pp. 2486-2494
-
-
Nakagawa, T.1
Akagi, M.2
Hoshikawa, H.3
-
85
-
-
8444244889
-
Lectin-like oxidized low-density lipoprotein receptor 1 mediates matrix metalloproteinase 3 synthesis enhanced by oxidized low-density lipoprotein in rheumatoid arthritis cartilage
-
Kakinuma T, Yasuda T, Nakagawa T, et al. Lectin-like oxidized low-density lipoprotein receptor 1 mediates matrix metalloproteinase 3 synthesis enhanced by oxidized low-density lipoprotein in rheumatoid arthritis cartilage. Arthritis Rheum 2004; 50: 3495-503.
-
(2004)
Arthritis Rheum
, vol.50
, pp. 3495-3503
-
-
Kakinuma, T.1
Yasuda, T.2
Nakagawa, T.3
-
86
-
-
70349758283
-
Induction of bovine articular chondrocyte senescence with oxidized low-density lipoprotein through lectin-like oxidized low-density lipoprotein receptor 1
-
Zushi S, Akagi M, Kishimoto H, Teramura T, Sawamura T, Hamanishi C. Induction of bovine articular chondrocyte senescence with oxidized low-density lipoprotein through lectin-like oxidized low-density lipoprotein receptor 1. Arthritis Rheum 2009; 60: 3007-16.
-
(2009)
Arthritis Rheum
, vol.60
, pp. 3007-3016
-
-
Zushi, S.1
Akagi, M.2
Kishimoto, H.3
Teramura, T.4
Sawamura, T.5
Hamanishi, C.6
-
87
-
-
84866741381
-
D'Adda di Fagagna F. Crosstalk between chromatin state and DNA damage response in cellular senescence and cancer
-
Sulli G, Di Micco R, d'Adda di Fagagna F. Crosstalk between chromatin state and DNA damage response in cellular senescence and cancer. Nat Rev Cancer 2012; 12: 709-20.
-
(2012)
Nat Rev Cancer
, vol.12
, pp. 709-720
-
-
Sulli, G.1
Di Micco, R.2
-
88
-
-
84864392869
-
DNA damage, discoordinated gene expression and cellular senescence in osteoarthritic chondrocytes
-
Rose J, Soder S, Skhirtladze C, et al. DNA damage, discoordinated gene expression and cellular senescence in osteoarthritic chondrocytes. Osteoarthr Cartil 2012; 20: 1020-8.
-
(2012)
Osteoarthr Cartil
, vol.20
, pp. 1020-1028
-
-
Rose, J.1
Soder, S.2
Skhirtladze, C.3
-
89
-
-
54049092479
-
Damage in osteoarthritic porcine articular cartilage
-
Chen AF, Davies CM, De Lin M, Fermor B. Oxidative DNA damage in osteoarthritic porcine articular cartilage. J Cell Physiol 2008; 217: 828-33.
-
(2008)
J Cell Physiol
, vol.217
, pp. 828-833
-
-
Chen, A.F.1
Davies, C.M.2
De Lin, M.3
Fermor, B.4
Oxidative, D.5
-
90
-
-
0037123638
-
Premature aging in mice deficient in DNA repair and transcription
-
de Boer J, Andressoo JO, De Wit J, et al. Premature aging in mice deficient in DNA repair and transcription. Science 2002; 296: 1276-9.
-
(2002)
Science
, vol.296
, pp. 1276-1279
-
-
De Boer, J.1
Ressoo, J.O.2
De Wit, J.3
-
91
-
-
84906265329
-
Involvement of ERCC1 in the pathogenesis of osteoarthritis through the modulation of apoptosis and cellular senescence
-
Takayama K, Kawakami Y, Lee S, et al. Involvement of ERCC1 in the pathogenesis of osteoarthritis through the modulation of apoptosis and cellular senescence. J Orthop Res 2014; 32: 1326-32.
-
(2014)
J Orthop Res
, vol.32
, pp. 1326-1332
-
-
Takayama, K.1
Kawakami, Y.2
Lee, S.3
-
92
-
-
3042723605
-
Recovery of function in osteoarthritic chondrocytes induced by p16INK4a-specific siRNA in vitro
-
Zhou HW, Lou SQ, Zhang K. Recovery of function in osteoarthritic chondrocytes induced by p16INK4a-specific siRNA in vitro. Rheumatology. 2004; 43: 555-68.
-
(2004)
Rheumatology
, vol.43
, pp. 555-568
-
-
Zhou, H.W.1
Lou, S.Q.2
Zhang, K.3
-
93
-
-
84899478665
-
P16INK4a and its regulator miR-24 link senescence and chondrocyte terminal differentiationassociated matrix remodeling in osteoarthritis
-
Philipot D, Guerit D, Platano D, et al. P16INK4a and its regulator miR-24 link senescence and chondrocyte terminal differentiationassociated matrix remodeling in osteoarthritis. Arthritis Res Ther 2014; 16: R58.
-
(2014)
Arthritis Res Ther
, vol.16
-
-
Philipot, D.1
Guerit, D.2
Platano, D.3
-
94
-
-
79955143892
-
Senescence of chondrocytes in aging articular cartilage: GADD45beta mediates p21 expression in association with C/EBPbeta in senescenceaccelerated mice
-
Shimada H, Sakakima H, Tsuchimochi K, et al. Senescence of chondrocytes in aging articular cartilage: GADD45beta mediates p21 expression in association with C/EBPbeta in senescenceaccelerated mice. Pathol Res Pract. 2011; 207: 225-31.
-
(2011)
Pathol Res Pract
, vol.207
, pp. 225-231
-
-
Shimada, H.1
Sakakima, H.2
Tsuchimochi, K.3
-
97
-
-
61349159991
-
Regulation of cartilage-specific gene expression in human chondrocytes by SirT1 and nicotinamide phosphoribosyltransferase
-
Dvir-Ginzberg M, Gagarina V, Lee EJ, Hall DJ. Regulation of cartilage-specific gene expression in human chondrocytes by SirT1 and nicotinamide phosphoribosyltransferase. J Biol Chem 2008; 283: 36300-10.
-
(2008)
J Biol Chem
, vol.283
, pp. 36300-36310
-
-
Dvir-Ginzberg, M.1
Gagarina, V.2
Lee, E.J.3
Hall, D.J.4
-
98
-
-
84902267233
-
Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice
-
Matsuzaki T, Matsushita T, Takayama K, et al. Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice. Ann Rheum Dis 2014; 73: 1397-404.
-
(2014)
Ann Rheum Dis
, vol.73
, pp. 1397-1404
-
-
Matsuzaki, T.1
Matsushita, T.2
Takayama, K.3
-
99
-
-
78650978303
-
Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions
-
Fujita N, Matsushita T, Ishida K, et al. Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions. J Orthop Res 2011; 29: 511-5.
-
(2011)
J Orthop Res
, vol.29
, pp. 511-515
-
-
Fujita, N.1
Matsushita, T.2
Ishida, K.3
-
100
-
-
77951717549
-
SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor receptor pathway
-
Gagarina V, Gabay O, Dvir-Ginzberg M, et al. SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor receptor pathway. Arthritis Rheum 2010; 62: 1383-92.
-
(2010)
Arthritis Rheum
, vol.62
, pp. 1383-1392
-
-
Gagarina, V.1
Gabay, O.2
Dvir-Ginzberg, M.3
-
101
-
-
69449107308
-
SIRT1 regulation of apoptosis of human chondrocytes
-
Takayama K, Ishida K, Matsushita T, et al. SIRT1 regulation of apoptosis of human chondrocytes. Arthritis Rheum 2009; 60: 2731-40.
-
(2009)
Arthritis Rheum
, vol.60
, pp. 2731-2740
-
-
Takayama, K.1
Ishida, K.2
Matsushita, T.3
-
102
-
-
85027953113
-
Increased apoptotic chondrocytes in articular cartilage from adult heterozygous SirT1 mice
-
Gabay O, Oppenhiemer H, Meir H, Zaal K, Sanchez C, Dvir-Ginzberg M. Increased apoptotic chondrocytes in articular cartilage from adult heterozygous SirT1 mice. Ann Rheum Dis 2012; 71: 613-6.
-
(2012)
Ann Rheum Dis
, vol.71
, pp. 613-616
-
-
Gabay, O.1
Oppenhiemer, H.2
Meir, H.3
Zaal, K.4
Sanchez, C.5
Dvir-Ginzberg, M.6
-
103
-
-
84888432382
-
Sirt1-deficient mice exhibit an altered cartilage phenotype
-
Gabay O, Zaal KJ, Sanchez C, et al. Sirt1-deficient mice exhibit an altered cartilage phenotype. Joint Bone Spine 2013; 80: 613-20.
-
(2013)
Joint Bone Spine
, vol.80
, pp. 613-620
-
-
Gabay, O.1
Zaal, K.J.2
Sanchez, C.3
-
104
-
-
84855559736
-
Resveratrol inhibits interleukin 1beta-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear factor-kappaB activity
-
Lei M, Wang JG, Xiao DM, et al. Resveratrol inhibits interleukin 1beta-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear factor-kappaB activity. Eur J Pharmacol 2012; 674: 73-9.
-
(2012)
Eur J Pharmacol
, vol.674
, pp. 73-79
-
-
Lei, M.1
Wang, J.G.2
Xiao, D.M.3
-
107
-
-
84891738225
-
Autophagy and human diseases
-
Jiang P, Mizushima N. Autophagy and human diseases. Cell Res 2014; 24: 69-79.
-
(2014)
Cell Res
, vol.24
, pp. 69-79
-
-
Jiang, P.1
Mizushima, N.2
-
109
-
-
84893675756
-
Autophagy: A critical regulator of cellular metabolism and homeostasis
-
Ryter SW, Cloonan SM, Choi AM. Autophagy: a critical regulator of cellular metabolism and homeostasis. Mol Cells 2013; 36: 7-16.
-
(2013)
Mol Cells
, vol.36
, pp. 7-16
-
-
Ryter, S.W.1
Cloonan, S.M.2
Choi, A.M.3
-
110
-
-
77649128750
-
Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis
-
Carames B, Taniguchi N, Otsuki S, Blanco FJ, Lotz M. Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis. Arthritis Rheum 2010; 62: 791-801.
-
(2010)
Arthritis Rheum
, vol.62
, pp. 791-801
-
-
Carames, B.1
Taniguchi, N.2
Otsuki, S.3
Blanco, F.J.4
Lotz, M.5
-
111
-
-
84935036182
-
Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis
-
Zhang Y, Vasheghani F, Li YH, et al. Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis. Ann Rheum Dis 2015; 74(7): 1432-40.
-
(2015)
Ann Rheum Dis
, vol.74
, Issue.7
, pp. 1432-1440
-
-
Zhang, Y.1
Vasheghani, F.2
Li, Y.H.3
-
112
-
-
84861830188
-
Autophagy modulates osteoarthritis-related gene expression in human chondrocytes
-
Sasaki H, Takayama K, Matsushita T, et al. Autophagy modulates osteoarthritis-related gene expression in human chondrocytes. Arthritis Rheum 2012; 64: 1920-8.
-
(2012)
Arthritis Rheum
, vol.64
, pp. 1920-1928
-
-
Sasaki, H.1
Takayama, K.2
Matsushita, T.3
-
113
-
-
66049155861
-
Regulation of autophagy in human and murine cartilage: Hypoxia-inducible factor 2 suppresses chondrocyte autophagy
-
Bohensky J, Terkhorn SP, Freeman TA, et al. Regulation of autophagy in human and murine cartilage: hypoxia-inducible factor 2 suppresses chondrocyte autophagy. Arthritis Rheum 2009; 60: 1406-15.
-
(2009)
Arthritis Rheum
, vol.60
, pp. 1406-1415
-
-
Bohensky, J.1
Terkhorn, S.P.2
Freeman, T.A.3
-
114
-
-
84861981732
-
Mechanical injury suppresses autophagy regulators and pharmacologic activation of autophagy results in chondroprotection
-
Carames B, Taniguchi N, Seino D, Blanco FJ, D'Lima D, Lotz M. Mechanical injury suppresses autophagy regulators and pharmacologic activation of autophagy results in chondroprotection. Arthritis Rheum 2012; 64: 1182-92.
-
(2012)
Arthritis Rheum
, vol.64
, pp. 1182-1192
-
-
Carames, B.1
Taniguchi, N.2
Seino, D.3
Blanco, F.J.4
D'lima, D.5
Lotz, M.6
-
115
-
-
84902681901
-
What is the current status of chondroitin sulfate and glucosamine for the treatment of knee osteoarthritis?
-
Henrotin Y, Marty M, Mobasheri A. What is the current status of chondroitin sulfate and glucosamine for the treatment of knee osteoarthritis? Maturitas 2014; 78: 184-7.
-
(2014)
Maturitas
, vol.78
, pp. 184-187
-
-
Henrotin, Y.1
Marty, M.2
Mobasheri, A.3
-
116
-
-
84879874726
-
Glucosamine activates autophagy In vitro and In vivo
-
Carames B, Kiosses WB, Akasaki Y, et al. Glucosamine activates autophagy In vitro and In vivo. Arthritis Rheum 2013; 65: 1843-52.
-
(2013)
Arthritis Rheum
, vol.65
, pp. 1843-1852
-
-
Carames, B.1
Kiosses, W.B.2
Akasaki, Y.3
-
117
-
-
0642367846
-
Genetics: Influence of TOR kinase on lifespan in C. Elegans
-
Vellai T, Takacs-Vellai K, Zhang Y, Kovacs AL, Orosz L, Muller F. Genetics: influence of TOR kinase on lifespan in C. elegans. Nature 2003; 426: 620.
-
(2003)
Nature
, vol.426
-
-
Vellai, T.1
Takacs-Vellai, K.2
Zhang, Y.3
Kovacs, A.L.4
Orosz, L.5
Muller, F.6
-
118
-
-
67650944993
-
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
-
Harrison DE, Strong R, Sharp ZD, et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 2009; 460: 392-5.
-
(2009)
Nature
, vol.460
, pp. 392-395
-
-
Harrison, D.E.1
Strong, R.2
Sharp, Z.D.3
-
119
-
-
84857910484
-
Autophagy activation by rapamycin reduces severity of experimental osteoarthritis
-
Carames B, Hasegawa A, Taniguchi N, Miyaki S, Blanco FJ, Lotz M. Autophagy activation by rapamycin reduces severity of experimental osteoarthritis. Ann Rheum Dis 2012; 71: 575-81.
-
(2012)
Ann Rheum Dis
, vol.71
, pp. 575-581
-
-
Carames, B.1
Hasegawa, A.2
Taniguchi, N.3
Miyaki, S.4
Blanco, F.J.5
Lotz, M.6
-
120
-
-
64049111999
-
Sirolimus to replace calcineurin inhibitors? Too early yet
-
Cravedi P, Ruggenenti P, Remuzzi G. Sirolimus to replace calcineurin inhibitors? Too early yet. Lancet 2009; 373: 1235-6.
-
(2009)
Lancet
, vol.373
, pp. 1235-1236
-
-
Cravedi, P.1
Ruggenenti, P.2
Remuzzi, G.3
-
121
-
-
84907266449
-
Intra-articular administration of gelatin hydrogels incorporating rapamycin-micelles reduces the development of experimental osteoarthritis in a murine model
-
Matsuzaki T, Matsushita T, Tabata Y, et al. Intra-articular administration of gelatin hydrogels incorporating rapamycin-micelles reduces the development of experimental osteoarthritis in a murine model. Biomaterials 2014; 35: 9904-11.
-
(2014)
Biomaterials
, vol.35
, pp. 9904-9911
-
-
Matsuzaki, T.1
Matsushita, T.2
Tabata, Y.3
-
122
-
-
84924287483
-
Local intraarticular injection of rapamycin delays articular cartilage degeneration in a murine model of osteoarthritis
-
Takayama K, Kawakami Y, Kobayashi M, et al. Local intraarticular injection of rapamycin delays articular cartilage degeneration in a murine model of osteoarthritis. Arthritis Res Ther 2014; 16: 482.
-
(2014)
Arthritis Res Ther
, vol.16
-
-
Takayama, K.1
Kawakami, Y.2
Kobayashi, M.3
-
123
-
-
84922356976
-
PPARgamma deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage
-
Vasheghani F, Zhang Y, Li YH, et al. PPARgamma deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage. Ann Rheum Dis 2015; 74: 569-78.
-
(2015)
Ann Rheum Dis
, vol.74
, pp. 569-578
-
-
Vasheghani, F.1
Zhang, Y.2
Li, Y.H.3
|