P16INK4a and its regulator miR-24 link senescence and chondrocyte terminal differentiation-associated matrix remodeling in osteoarthritis

Arthritis Research and Therapy

Volumn 16, Issue 1, 2014, Pages

  Philipot, Didier ^a,b   Guérit, David ^a,b   Platano, Daniela ^c   Chuchana, Paul ^a,b   Olivotto, Eleonora ^c   Espinoza, Francisco ^a,b   Dorandeu, Anne ^d   Pers, Yves Marie ^a,b,e   Piette, Jacques ^f   Borzi, Rosa M ^c   Jorgensen, Christian ^a,b,e   Noel, Danièle ^a,b   Brondello, Jean Marc ^a,b  

^a HÔPITAL SAINT ELOI   (France)

^b UNIV MONTPELLIER   (France)

^c RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

^d MONTPELLIER UNIVERSITY HOSPITAL   (France)

^e LAPEYRONIE HOSPITAL   (France)

^f Centre National de la Recherche Scientifique   (France)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGENASE 3; CYCLIN DEPENDENT KINASE INHIBITOR 2A; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; INTERSTITIAL COLLAGENASE; MICRORNA 24; PROTEIN; SENESCENCE ASSOCIATED SECRETORY PHENOTYPE PROTEIN; UNCLASSIFIED DRUG; MICRORNA; MIRN24 MICRORNA, HUMAN; MMP1 PROTEIN, HUMAN; MMP13 PROTEIN, HUMAN; INTERLEUKIN 16;

ADULT; ALTERNATIVE RNA SPLICING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTICULAR CARTILAGE; BONE DEVELOPMENT; CARTILAGE; CARTILAGE CELL; CELL CYCLE PROGRESSION; CELL CYCLE REGULATION; CELL DIFFERENTIATION; CHONDROGENESIS; DISEASE COURSE; DNA DAMAGE; ENCHONDRAL OSSIFICATION; GENE EXPRESSION; GENOME ANALYSIS; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; OSTEOARTHRITIS; PATHOGENESIS; PHENOTYPE; PROTEIN EXPRESSION; REGULATORY MECHANISM; SENESCENCE; TRANSIENT TRANSFECTION; ANIMAL; CELL AGING; CYTOLOGY; DNA MICROARRAY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPERIMENTAL ARTHRITIS; GENETIC TRANSFECTION; KNOCKOUT MOUSE; MESENCHYMAL STROMA CELL; METABOLISM; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING; CONTROLLED STUDY; GENE CONTROL; GENE OVEREXPRESSION; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; SENESCENCE ASSOCIATED SECRETORY PHENOTYPE;

ANIMALS; ARTHRITIS, EXPERIMENTAL; BLOTTING, WESTERN; CELL AGING; CELL DIFFERENTIATION; CHONDROCYTES; CHONDROGENESIS; CYCLIN-DEPENDENT KINASE INHIBITOR P16; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOHISTOCHEMISTRY; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 13; MESENCHYMAL STROMAL CELLS; MICE; MICE, KNOCKOUT; MICRORNAS; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OSTEOARTHRITIS; REAL-TIME POLYMERASE CHAIN REACTION; TRANSFECTION;

EID: 84899478665     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar4494     Document Type: Article

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