Resveratrol inhibits interleukin 1β-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear factor-κB activity

European Journal of Pharmacology

Volumn 674, Issue 2-3, 2012, Pages 73-79

  Lei, Ming ^a,e   Wang, Ji Guo ^b   Xiao, De Ming ^c   Fan, Meng ^d   Wang, Da Ping ^e   Xiong, Jian Yi ^e   Chen, Yang ^e   Ding, Yue ^a   Liu, Shang Li ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b SOUTHERN MEDICAL UNIVERSITY   (China)

^c PEKING UNIVERSITY SHENZHEN HOSPITAL   (China)

^d TIANJIN FIRST CENTRAL HOSPITAL   (China)

^e THE FIRST AFFILIATED HOSPITAL OF SHENZHEN UNIVERSITY   (China)

Author keywords

Articular chondrocytes; Inducible nitric oxide synthase; Nuclear factor B; Resveratrol; SIRT1

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; RESVERATROL; SIRTUIN 1; SYNAPTOTAGMIN I;

ACETYLATION; ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARTILAGE CELL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DEACETYLATION; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE TRANSLOCATION; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RAT; SIGNAL TRANSDUCTION; TRANSACTIVATION;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; CELL NUCLEUS; CHONDROCYTES; DNA; GENE EXPRESSION REGULATION, ENZYMOLOGIC; INTERLEUKIN-1BETA; JOINTS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; OSTEOARTHRITIS; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; SIRTUIN 1; STILBENES; TRANSCRIPTION FACTOR RELA; TRANSCRIPTIONAL ACTIVATION;

EID: 84855559736     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.10.015     Document Type: Article

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