Glucosamine activates autophagy in vitro and in vivo

Arthritis and Rheumatism

Volumn 65, Issue 7, 2013, Pages 1843-1852

  Caramés, Beatriz ^a,b   Kiosses, William B ^a   Akasaki, Yukio ^a   Brinson, Diana C ^a   Eap, William ^a   Koziol, James ^a   Lotz, Martin K ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b HOSPITAL JUAN CANALEJO   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSAMINE; GREEN FLUORESCENT PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE B; PROTEIN S6; TRANSCRIPTION FACTOR FKHRL1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTICULAR CARTILAGE; AUTOPHAGOSOME; AUTOPHAGY; CARTILAGE CELL; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DIET RESTRICTION; DRUG RESPONSE; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; KNEE; LIGHT CHAIN; LIVER; MOUSE; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; STARVATION; TURNOVER TIME; WESTERN BLOTTING;

ANIMALS; AUTOPHAGY; CARTILAGE, ARTICULAR; CHONDROCYTES; FORKHEAD TRANSCRIPTION FACTORS; GLUCOSAMINE; HUMANS; LIVER; MICE; MICE, TRANSGENIC; MICROSCOPY, CONFOCAL; MICROTUBULE-ASSOCIATED PROTEINS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RIBOSOMAL PROTEIN S6; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84879874726     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.37977     Document Type: Article

References (43)

1. Zhang Y, Jordan JM,. Epidemiology of osteoarthritis. Clin Geriatr Med 2010; 26: 355-69.
2. Loeser RF,. Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix. Osteoarthritis Cartilage 2009; 17: 971-9.
3. Zhang W, Nuki G, Moskowitz RW, Abramson S, Altman RD, Arden NK, et al. OARSI recommendations for the management of hip and knee osteoarthritis: part III: Changes in evidence following systematic cumulative update of research published through January 2009. Osteoarthritis Cartilage 2010; 18: 476-99.
4. Lapane KL, Sands MR, Yang S, McAlindon TE, Eaton CB,. Use of complementary and alternative medicine among patients with radiographic- confirmed knee osteoarthritis. Osteoarthritis Cartilage 2012; 20: 22-8.
5. Henrotin Y, Mobasheri A, Marty M,. Is there any scientific evidence for the use of glucosamine in the management of human osteoarthritis? Arthritis Res Ther 2012; 14: 201.
6. Goldring MB, Goldring SR,. Osteoarthritis. J Cell Physiol 2007; 213: 626-34.
7. Wang M, Shen J, Jin H, Im HJ, Sandy J, Chen D,. Recent progress in understanding molecular mechanisms of cartilage degeneration during osteoarthritis. Ann N Y Acad Sci 2011; 1240: 61-9.
8. Hellio Le Graverand-Gastineau MP,. OA clinical trials: current targets and trials for OA. Choosing molecular targets: what have we learned and where we are headed? Osteoarthritis Cartilage 2009; 17: 1393-401.
9. Hunter DJ,. Pharmacologic therapy for osteoarthritis: the era of disease modification. Nat Rev Rheumatol 2011; 7: 13-22.
10. Lotz MK, Carames B,. Autophagy and cartilage homeostasis mechanisms in joint health, aging and OA. Nat Rev Rheumatol 2011; 7: 579-87.
11. Mizushima N,. Physiological functions of autophagy. Curr Top Microbiol Immunol 2009; 335: 71-84.
12. Zhou H, Huang S,. The complexes of mammalian target of rapamycin. Curr Protein Pept Sci 2010; 11: 409-24.
13. Fenton TR, Gout IT,. Functions and regulation of the 70kDa ribosomal S6 kinases. Int J Biochem Cell Biol 2011; 43: 47-59.
14. Rubinsztein DC, Marino G, Kroemer G,. Autophagy and aging. Cell 2011; 146: 682-95.
15. Carames B, Taniguchi N, Otsuki S, Blanco FJ, Lotz M,. Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis. Arthritis Rheum 2010; 62: 791-801.
16. Carames B, Taniguchi N, Seino D, Blanco FJ, D'Lima D, Lotz M,. Mechanical injury suppresses autophagy regulators and its pharmacologic activation results in chondroprotection. Arthritis Rheum 2012; 64: 1182-92.
17. Carames B, Hasegawa A, Taniguchi N, Miyaki S, Blanco FJ, Lotz M,. Autophagy activation by rapamycin reduces severity of experimental osteoarthritis. Ann Rheum Dis 2012; 71: 575-81.
18. Klumpen HJ, Beijnen JH, Gurney H, Schellens JH,. Inhibitors of mTOR. Oncologist 2010; 15: 1262-9.
19. Anderson JW, Nicolosi RJ, Borzelleca JF,. Glucosamine effects in humans: a review of effects on glucose metabolism, side effects, safety considerations and efficacy. Food Chem Toxicol 2005; 43: 187-201.
20. Towheed TE, Maxwell L, Anastassiades TP, Shea B, Houpt J, Robinson V, et al. Glucosamine therapy for treating osteoarthritis. Cochrane Database Syst Rev 2005:CD002946.
21. Simon RR, Marks V, Leeds AR, Anderson JW,. A comprehensive review of oral glucosamine use and effects on glucose metabolism in normal and diabetic individuals. Diabetes Metab Res Rev 2011; 27: 14-27.
22. Altman RD,. Glucosamine therapy for knee osteoarthritis: pharmacokinetic considerations. Expert Rev Clin Pharmacol 2009; 2: 359-71.
23. Tiraloche G, Girard C, Chouinard L, Sampalis J, Moquin L, Ionescu M, et al. Effect of oral glucosamine on cartilage degradation in a rabbit model of osteoarthritis. Arthritis Rheum 2005; 52: 1118-28.
24. Wen ZH, Tang CC, Chang YC, Huang SY, Hsieh SP, Lee CH, et al. Glucosamine sulfate reduces experimental osteoarthritis and nociception in rats: association with changes of mitogen-activated protein kinase in chondrocytes. Osteoarthritis Cartilage 2010; 18: 1192-202.
25. Chiusaroli R, Piepoli T, Zanelli T, Ballanti P, Lanza M, Rovati LC, et al. Experimental pharmacology of glucosamine sulfate. Int J Rheumatol 2011; 2011: 939265.
26. Gouze JN, Gouze E, Popp MP, Bush ML, Dacanay EA, Kay JD, et al. Exogenous glucosamine globally protects chondrocytes from the arthritogenic effects of IL-1β. Arthritis Res Ther 2006; 8: R173.
27. Imagawa K, de Andres MC, Hashimoto K, Pitt D, Itoi E, Goldring MB, et al. The epigenetic effect of glucosamine and a nuclear factor-κB (NF-κB) inhibitor on primary human chondrocytes: implications for osteoarthritis. Biochem Biophys Res Commun 2011; 405: 362-7.
28. Largo R, Alvarez-Soria MA, Diez-Ortego I, Calvo E, Sanchez-Pernaute O, Egido J, et al. Glucosamine inhibits IL-1β-induced NFκB activation in human osteoarthritic chondrocytes. Osteoarthritis Cartilage 2003; 11: 290-8.
29. Mizushima N, Yamamoto A, Matsui M, Yoshimori T, Ohsumi Y,. In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell 2004; 15: 1101-11.
30. Alirezaei M, Kemball CC, Flynn CT, Wood MR, Whitton JL, Kiosses WB,. Short-term fasting induces profound neuronal autophagy. Autophagy 2010; 6: 702-10.
31. Mizushima N, Yoshimori T, Levine B,. Methods in mammalian autophagy research. Cell 2010; 140: 313-26.
32. Green DR, Galluzzi L, Kroemer G,. Mitochondria and the autophagy-inflammation-cell death axis in organismal aging. Science 2011; 333: 1109-12.
33. Blanco FJ, Rego I, Ruiz-Romero C,. The role of mitochondria in osteoarthritis. Nat Rev Rheumatol 2011; 7: 161-9.
34. Lotz M, Loeser RF,. Effects of aging on articular cartilage homeostasis. Bone 2012; 51: 241-8.
35. Sofroniadou S, Goldsmith D,. Mammalian target of rapamycin (mTOR) inhibitors: potential uses and a review of haematological adverse effects. Drug Saf 2011; 34: 97-115.
36. Shintani T, Yamazaki F, Katoh T, Umekawa M, Matahira Y, Hori S, et al. Glucosamine induces autophagy via an mTOR-independent pathway. Biochem Biophys Res Commun 2010; 391: 1775-9.
37. Block JA, Oegema TR, Sandy JD, Plaas A,. The effects of oral glucosamine on joint health: is a change in research approach needed? Osteoarthritis Cartilage 2010; 18: 5-11.
38. Taniguchi S, Ryu J, Seki M, Sumino T, Tokuhashi Y, Esumi M,. Long-term oral administration of glucosamine or chondroitin sulfate reduces destruction of cartilage and up-regulation of MMP-3 mRNA in a model of spontaneous osteoarthritis in Hartley guinea pigs. J Orthop Res 2012; 30: 673-8.
39. Jackson CG, Plaas AH, Sandy JD, Hua C, Kim-Rolands S, Barnhill JG, et al. The human pharmacokinetics of oral ingestion of glucosamine and chondroitin sulfate taken separately or in combination. Osteoarthritis Cartilage 2010; 18: 297-302.
40. Shigemitsu K, Tsujishita Y, Hara K, Nanahoshi M, Avruch J, Yonezawa K,. Regulation of translational effectors by amino acid and mammalian target of rapamycin signaling pathways: possible involvement of autophagy in cultured hepatoma cells. J Biol Chem 1999; 274: 1058-65.
41. Sabers CJ, Martin MM, Brunn GJ, Williams JM, Dumont FJ, Wiederrecht G, et al. Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells. J Biol Chem 1995; 270: 815-22.
42. Mammucari C, Milan G, Romanello V, Masiero E, Rudolf R, Del Piccolo P, et al. FoxO3 controls autophagy in skeletal muscle in vivo. Cell Metab 2007; 6: 458-71.
43. Jia K, Chen D, Riddle DL,. The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. Development 2004; 131: 3897-906.