Recovery of function in osteoarthritis chondrocytes induced by p16INK4a-specific siRNA in vitro

Rheumatology

Volumn 43, Issue 5, 2004, Pages 555-568

  Zhou, H W ^a   Lou, S Q ^a   Zhang, K ^a  

^a PEKING UNIVERSITY   (China)

Author keywords

Osteoarthritis; p16INK4a; Senescence; siRNA

Indexed keywords

AGGRECAN; BETA GALACTOSIDASE; COLLAGEN TYPE 1; COLLAGEN TYPE 2; CYTOKINE; INTERLEUKIN 1ALPHA; PROLINE; PROTEIN P14ARF; PROTEIN P16; PROTEIN P53; RETINOBLASTOMA PROTEIN; SMALL INTERFERING RNA; SULFATE; TRANSFORMING GROWTH FACTOR BETA1; TRITIUM; PROTEIN P16INK4A;

AGED; ARTICLE; CARTILAGE; CARTILAGE CELL; CELL AGING; CELL COUNT; CELL CULTURE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL FUNCTION; CELL PROLIFERATION; CELL REGENERATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DNA SYNTHESIS; DRUG TARGETING; FETUS; GENE EXPRESSION; HISTOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; STATISTICAL ANALYSIS; WESTERN BLOTTING; ARTICULAR CARTILAGE; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; KNEE OSTEOARTHRITIS; METABOLISM; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY;

AGED; AGED, 80 AND OVER; CARTILAGE, ARTICULAR; CELL AGING; CELLS, CULTURED; CHONDROCYTES; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYTOKINES; DISEASE PROGRESSION; GENE EXPRESSION REGULATION; HUMANS; MIDDLE AGED; OSTEOARTHRITIS, KNEE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P14ARF; TUMOR SUPPRESSOR PROTEIN P53;

EID: 3042723605     PISSN: 14620324     EISSN: None     Source Type: Journal    
DOI: 10.1093/rheumatology/keh127     Document Type: Article

References (63)

1. Loeser RF, Shanker G, Carlson CS et al. Reduction in the chondrocyte response to insulin-like growth factor 1 in ageing and osteoarthritis: studies in a non-human primate model of naturally occurring disease. Arthritis Rheum 2000;43:2110-20.
2. Ribault D, Habib M, Abdel-Majid K et al. Age-related decrease in the responsiveness of rat articular chondrocytes to EGF is associated with diminished number and affinity for the ligand of cell surface binding sites. Mech Ageing Dev 1998;100:25-40.
3. Guerne PA, Blanco F, Kaelin A et al. Growth factor responsiveness of human articular chondrocytes in aging and development. Arthritis Rheum 1995;38:960-8.
4. Evans CH, Georgescu HI. Observations on the senescence of cells derived from articular cartilage. Mech Ageing Dev 1983;22:179-91.
5. Vaziri H, Schachter F, Uchida I et al. Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes. Am J Hum Genet 1993;52:661-7.
6. Harley CB, Futcher AB, Greider CW. Telomeres shorten during ageing of human fibroblasts. Nature 1990;345:458-60.
7. Allsopp RC, Vaziri H, Patterson C et al. Telomere length predicts replicative capacity of human fibroblasts. Proc Natl Acad Sci USA 1992;89:10114-18.
8. Olovnikov AM. A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. J Theor Biol 1973; 41:181-90.
9. Martin JA, Buckwalter JA. Telomere erosion and senescence in human articular cartilage chondrocytes. J Gerontol A Biol Sci Med Sci 2001;56:B172-9.
10. Hastie ND, Dempster M, Dunlop MG et al. Telomere reduction in human colorectal carcinoma and with ageing. Nature 1990; 346:866-8.
11. Counter CM, Gupta J, Harley CB et al. Telomerase activity in normal leukocytes and in hematologic malignancies. Blood 1995;85:2315-20.
12. Klingelhutz AJ, Barber SA, Smith PP et al. Restoration of telomeres in human papillomavirus-immortalized human anogenital epithelial cells. Mol Cell Biol 1994;14:961-9.
13. Lansdorp PM, Verwoerd NP, van de Rijke FM et al. Heterogeneity in telomere length human chromosomes. Hum Mol Genet 1996;5: 685-91.
14. Martens UM, Chavez EA, Poon SS et al. Accumulation of short telomeres in human fibroblasts prior to replicative senescence. Exp Cell Res 2000;256:291-9.
15. Ouellette MM, Liao M, Herbert BS et al. Subsenescent telomere lengths in fibroblasts immortalized by limiting amounts of telomerase. J Biol Chem 2000;275:10072-6.
16. INK4a inactivation and telomerase activity are required to immortalize human epithelial cells. Nature 1998;396:84-8.
17. Dickson MA, Hahn WC, Ino Y et al. Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics. Mol Cell Biol 2000;20:1436-47.
18. 2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication. Biochem J 1998;332:43-50.
19. Di Leonardo A, Linke SP, Clarkin K et al. DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Genes Dev 1994;8:2540-51.
20. INK4a enrichment and the premature senescence of normal fibroblasts. Oncogene 1998;16:1113-23.
21. Ogryzko VV, Hirai TH, Russanova VR et al. Human fibroblast commitment to a senescence-like state in response to histone deacetylase inhibitors is cell cycle dependent. Mol Cell Biol 1996;16:5210-18.
22. INK4a. Cell 1997;88:593-602.
23. Zhu J, Woods D, McMahon M et al. Senescence of human fibroblasts induced by oncogenic Raf. Genes Dev 1998;12:2997-3007.
24. Sharpless NE, DePinho RA. The INK4A/ARF locus and its two gene products. Curr Opin Genet Dev 1999;9:22-30.
25. Carnero A, Hudson JD, Price CM et al. p16INK4A and p19ARF act in overlapping pathways in cellular immortalization. Nature Cell Biol 2000;2:148-55.
26. Munro J, Stott FJ, Vousden KH et al. Role of the alternative INK4A proteins in human keratinocyte senescence: evidence for the specific inactivation of p16INK4A upon immortalization. Cancer Res 1999;59:2516-21.
27. Stott FJ, Bates S, James MC et al. The alternative product from the human CDKN2A locus, p14 (ARF), participates in a regulatory feedback loop with p53 and MDM2. EMBO J 1998;17:5001-14.
28. Elbashir SM, Harborth J, Lendeckel W et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 2001;411:494-8.
29. Caplen NJ, Parrish S, Imani F et al. Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems. Proc Natl Acad Sci USA 2001;98:9742-7.
30. Cole AA, Kuettner KE. Molecular basis for differences between human joints. Cell Mol Life Sci 2002;59:19-26.
31. Moos V, Fickert S, Muller B et al. Immunohistological analysis of cytokine expression in human osteoarthritic and healthy cartilage. J Rheumatol 1999;26:870-9.
32. Serrano M, Hannon GJ, Beach D. A new regulatory motif in cell cycle control causing specific inhibition of cyclin D/CDK4. Nature 1993;366:704-7.
33. Cs-Szabo G, Melching LI, Roughley PJ, Glant TT. Changes in messenger RNA and protein levels of proteoglycans and link protein in human osteoarthritic cartilage samples. Arthritis Rheum 1997; 40:1037-45.
34. Merlo A, Herman JG, Mao L et al. 5′CpG island methylation is associated with transcriptional silencing of the tumor suppressor p16/CDKN2/MTS1 in human cancers. Nature Med 1995; 1:686-92.
35. Magdinier F, Wolffe AP. Selective association of the methyl-CpG binding protein MBD2 with the silent p14/p16 locus in human neoplasia. Proc Natl Acad Sci USA 2001;98:4990-5.
36. Kato S, Akagi T, Sugimura K et al. Evaluation of biological responses to polymeric biomaterials by RT-PCR analysis IV: study of c-myc, c-fos and p53 mRNA expression. Biomaterials 2000;21:521-7.
37. Piera-Velazquez S, Jimenez SA, Stokes D. Increased life span of human osteoarthritic chondrocytes by exogenous expression of telomerase. Arthritis Rheum 2002;46:683-93.
38. Konttinen YT, Ainola M, Valleala HJM et al. Analysis of 16 different matrix metalloproteinases (MMP-1 to MMP-20) in the synovial membrane: different profiles in trauma and rheumatoid arthritis. Ann Rheum Dis 1999;58:691-7.
39. Pfander D, Körtje D, Zimmermann R et al. Vascular endothelial growth factor in articular cartilage of healthy and osteoarthritic human knee joints. Ann Rheum Dis 2001;60:1070-3.
40. Chow G, Nietfeld JJ, Knudson CB et al. Antisense inhibition of chondrocyte CD44 expression leading to cartilage chondrolysis. Arthritis Rheum 1998;4:1411-19.
41. Khatib AM, Ribault D, Quintero M et al. The mechanism of inhibition of endothelin-1-induced stimulation of DNA synthesis in rat articular chondrocytes. Mol Cell Endocrinol 1997;132: 25-31.
42. Ciapetti G, Granchi D, Savarino L et al. In vitro testing of the potential for orthopedic bone cements to cause apoptosis of osteoblast-like cells. Biomaterials 2002;23:617-27.
43. Ribault D, Khatib AM, Panasyuk A et al. Mitogenic and metabolic actions of epidermal growth factor on rat articular chondrocytes: modulation by fetal calf serum, transforming growth factor-beta, and tyrphostin. Arch Biochem Biophys 1997;337:149-58.
44. Dimri GP, Lee X, Basile G et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 1995;92:9363-7.
45. Hohjoh H. RNA interference (RNA (i)) induction with various types of synthetic oligonucleotide duplexes in cultured human cells. FEBS Lett 2002;521:195-9.
46. Dobra K, Hjerpe A. Analysis of proteoglycan gene expression in connective tissues by semi-quantitative RT-PCR. J Musculoskelet Res 2001;5:79-88.
47. McKenna LA, Liu H, Sansom. PA et al. An N-terminal peptide from link protein stimulates proteoglycan biosynthesis in human articular cartilage in vitro. Arthritis Rheum 1998;41:157-62.
48. Davis MA, Ettinger WH, Neuhaus JM et al. The association of knee injury and obesity with unilateral and bilateral osteoarthritis of the knee. Am J Epidemiol 1989;130:278-88.
49. Gelber AC, Hochberg MC, Mead LA et al. Joint injury in young adults and risk for subsequent knee and hip osteoarthritis. Ann Intern Med 2000;133:321-8.
50. Roos H, Adalberth T, Dahlberg L et al. Osteoarthritis of the knee after injury to the anterior cruciate ligament or meniscus: the influence of time and age. Osteoarthritis Cartilage 1995;3:261-7.
51. Kannus P, Jarvinen M. Posttraumatic anterior cruciate ligament insufficiency as a cause of osteoarthritis in a knee joint. Clin Rheumatol 1989;8:251-60.
52. Felson DT, Lawrence RC, Dieppe PA et al. Osteoarthritis: new insights. Part 1: The disease and its risk factors. Ann Intern Med 2000;133:635-46.
53. Ramirez RD, Morales CP, Herbert BS et al. Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions. Genes Dev 2001;15:398-403.
54. Chen QM. Replicative senescence and oxidant-induced premature senescence: beyond the control of cell cycle checkpoints. Ann NY Acad Sci 2000;908:111-25.
55. Toussaint O, Medrano EE, von Zglinicki T. Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes. Exp Gerontol 2000;35:927-45.
56. Kuwabara PE, Coulson A. RNAi-prospects for a general technique for determining gene function. Parasitol Today 2000;16:347-9.
57. Livne E, Laufer D, Blumenfeld I. Differential response of articular cartilage from young growing and mature old mice to IL-1 and TGF-β. Arch Gerontol Geriat 1997;24:211-21.
58. Livne E, Laufer D, Blumenfeld I. Osteoarthritis in the temporomandibular joint (TMJ) of aged mice and the in vitro effect of TGF-β1 on cell proliferation, matrix synthesis, and alkaline phosphates activity. Micros Res Tech 1997;37:314-23.
59. Scharstuhl A, van Beuningen HM, Vitters EL et al. Loss of transforming growth factor counteraction on interleukin 1 mediated effects in cartilage of old mice. Ann Rheum Dis 2002;61:1095-8.
60. Dean DD, Schwartz Z, Muniz OE et al. Matrix vesicles are enriched in metalloproteinases that degrade proteoglycans. Calcif Tissue Int 1992;50:342-9.
61. Vivien D, Galera P, Lebrun E et al. Differential effects of transforming growth factor-beta and epidermal growth factor on the cell cycle of cultured rabbit articular chondrocytes. J Cell Physiol 1990;143:534-45.
62. INK4a. Exp Cell Res 1997;237:7-13.
63. Huschtscha LI, Reddel RR. p16 (INK4a) and the control of cellular proliferative life span. Carcinogenesis 1999;20:921-6.