Replicative aging of human articular chondrocytes during ex vivo expansion

Arthritis and Rheumatism

Volumn 46, Issue 11, 2002, Pages 2911-2916

  Parsch, Dominik ^a,c   Brümmendorf, Tim H ^b   Richter, Wiltrud ^a   Fellenberg, Jörg ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; AGING; ARTICLE; CARTILAGE CELL; CELL DIVISION; CELL ISOLATION; CELL POPULATION; CELL TRANSPLANTATION; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; INCIDENCE; MALE; MALIGNANT TRANSFORMATION; ONSET AGE; PRIORITY JOURNAL; TELOMERE;

ADULT; AGED; AGED, 80 AND OVER; CARTILAGE, ARTICULAR; CELL AGING; CELLS, CULTURED; CHONDROCYTES; FEMALE; HUMANS; MALE; MIDDLE AGED; TELOMERASE;

EID: 0036845282     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.10626     Document Type: Article

References (43)

1. Martin JA, Ellerbroek SM, Buckwalter JA. Age-related decline in chondrocyte response to insulin-like growth factor-I: The role of growth factor binding proteins. J Orthop Res 1997;15:491-8.
2. Guerne PA, Blanco F, Kaelin A, Desgeorges A, Lotz M. Growth factor responsiveness of human articular chondrocytes in aging and development. Arthritis Rheum 1995;38:960-8.
3. Buckwalter JA, Woo SL, Goldberg VM, Hadley EC, Booth F, Oegema TR, et al. Soft-tissue aging and musculoskeletal function. J Bone Joint Surg Am 1993;75:1533-48.
4. Brand HS, de Koning MH, van Kampen GP, van der Korst JK. Age related changes in the turnover of proteoglycans from explants of bovine articular cartilage. J Rheumatol 1991;18:599-605.
5. Adolphe M, Ronot X, Jaffray P, Hecquet C, Fontagne J, Lechat P. Effects of donor's age on growth kinetics of rabbit articular chondrocytes in culture. Mech Ageing Dev 1983;23:191-8.
6. Martin JA, Buckwalter JA. Telomere erosion and senescence in human articular cartilage chondrocytes. J Gerontol A Biol Sci Med Sci 2001;56:B172-9.
7. Watson JD. Origin of concatemeric T7 DNA. Nat New Biol 1972;239:197-201.
8. Olovnikov AM. A theory of marginotomy: The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. J Theor Biol 1973;41:181-90.
9. Counter CM, Avilion AA, LeFeuvre CE, Stewart NG, Greider CW, Harley CB, et al. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J 1992;11:1921-9.
10. Blasco MA, Lee HW, Hande MP, Samper E, Lansdorp PM, DePinho RA, et al. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 1997;91:25-34.
11. Harley CB. Telomere loss: Mitotic clock or genetic time bomb? Mutat Res 1991;256:271-82.
12. Harley CB, Vaziri H, Counter CM, Allsopp RC. The telomere hypothesis of cellular aging. Exp Gerontol 1992;27:375-82.
13. Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 1965;37:614-36.
14. Allsopp RC, Vaziri H, Patterson C, Goldstein S, Younglai EV, Futcher AB, et al. Telomere length predicts replicative capacity of human fibroblasts. Proc Natl Acad Sci U S A 1992;89:10114-8.
15. Blackburn EH. Telomerases. Annu Rev Biochem 1992;61:113-29.
16. Greider CW. Telomerase activity, cell proliferation, and cancer. Proc Natl Acad Sci U S A 1998;95:90-2.
17. Aue G, Muralidhar B, Schwartz HS, Butler MG. Telomerase activity in skeletal sarcomas. Ann Surg Oncol 1998;5:627-34.
18. Shay JW. Telomerase in human development and cancer. J Cell Physiol 1997;173:266-70.
19. Martin JA, Mitchell CJ, Klingelhutz AJ, Buckwalter JA. Effects of telomerase and viral oncogene expression on the in vitro growth of human chondrocytes. J Gerontol A Biol Sci Med Sci 2002;57: B48-53.
20. Piera-Velazquez S, Jimenez SA, Stokes D. Increased life span of human osteoarthritic chondrocytes by exogenous expression of telomerase. Arthritis Rheum 2002;46:683-93.
21. Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu CP, Morin GB, et al. Extension of life-span by introduction of telomerase into normal human cells. Science 1998;279:349-52.
22. Vaziri H, Benchimol S. Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span. Curr Biol 1998;8:279-82.
23. Hahn WC, Counter CM, Lundberg AS, Beijersbergen RL, Brooks MW, Weinberg RA. Creation of human tumour cells with defined genetic elements. Nature 1999;400:464-8.
24. Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med 1994;331:889-95.
25. Brittberg M, Nilsson A, Lindahl A, Ohlsson C, Peterson L. Rabbit articular cartilage defects treated with autologous cultured chondrocytes. Clin Orthop 1996;5:270-83.
26. Zeng W, Maciejewski JP, Chen G, Young NS. Limited heterogeneity of T cell receptor BV usage in aplastic anemia. J Clin Invest 2001;108:765-73.
27. Rufer N, Brummendorf TH, Kolvraa S, Bischoff C, Christensen K, Wadsworth L, et al. Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood. J Exp Med 1999;190:157-67.
28. Harley CB, Futcher AB, Greider CW. Telomeres shorten during ageing of human fibroblasts. Nature 1990;345:458-60.
29. Yudoh K, Matsuno H, Nakazawa F, Katayama R, Kimura T. Reconstituting telomerase activity using the telomerase catalytic subunit prevents the telomere shorting and replicative senescence in human osteoblasts. J Bone Miner Res 2001;16:1453-64.
30. Decary S, Mouly V, Hamida CB, Sautet A, Barbet JP, Butler-Browne GS. Replicative potential and telomere length in human skeletal muscle: Implications for satellite cell-mediated gene therapy. Hum Gene Ther 1997;8:1429-38.
31. Allsopp RC, Chang E, Kashefi-Aazam M, Rogaev EI, Piatyszek MA, Shay JW, et al. Telomere shortening is associated with cell division in vitro and in vivo. Exp Cell Res 1995;220:194-200.
32. Belair CD, Yeager TR, Lopez PM, Reznikoff CA. Telomerase activity: A biomarker of cell proliferation, not malignant transformation. Proc Natl Acad Sci U S A 1997;94:13677-82.
33. Harle-Bachor C, Boukamp P. Telomerase activity in the regenerative basal layer of the epidermis inhuman skin and in immortal and carcinoma-derived skin keratinocytes. Proc Natl Acad Sci U S A 1996;93:6476-81.
34. Engelhardt M, Kumar R, Albanell J, Pettengell R, Han W, Moore MA. Telomerase regulation, cell cycle, and telomere stability in primitive hematopoietic cells. Blood 1997;90:182-93.
35. Benya PD, Shaffer JD. Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels. Cell 1982;30:215-24.
36. Zhu J, Wang H, Bishop JM, Blackburn EH. Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening. Proc Natl Acad Sci U S A 1999;96:3723-8.
37. Chang E, Harley CB. Telomere length and replicative aging in human vascular tissues. Proc Natl Acad Sci U S A 1995;92:11190-4.
38. Hackett JA, Feldser DM, Greider CW. Telomere dysfunction increases mutation rate and genomic instability. Cell 2001;106:275-86.
39. Brummendorf TH, Maciejewski JP, Mak J, Young NS, Lansdorp PM. Telomere length in leukocyte subpopulations of patients with aplastic anemia. Blood 2001;97:895-900.
40. Vulliamy T, Marrone A, Goldman F, Dearlove A, Bessler M, Mason PJ, et al. The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita. Nature 2001;413:432-5.
41. Vaziri H, Schachter F, Uchida I, Wei L, Zhu X, Effros R, et al. Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes. Am J Hum Genet 1993;52:661-7.
42. Smilenov LB, Dhar S, Pandita TK. Altered telomere nuclear matrix interactions and nucleosomal periodicity in ataxia telangiectasia cells before and after ionizing radiation treatment. Mol Cell Biol 1999;19:6963-71.
43. Marciniak R, Guarente L. Human genetics: testing telomerase. Nature 2001;413:370-1, 373.