Oxidative stress induces senescence in chondrocytes

Journal of Orthopaedic Research

Volumn 29, Issue 7, 2011, Pages 1114-1120

  Brandl, Anita ^a   Hartmann, Andreas ^a   Bechmann, Volker ^a   Graf, Bernhard ^a   Nerlich, Michael ^a   Angele, Peter ^a  

^a UNIVERSITY HOSPITAL REGENSBURG   (Germany)

Author keywords

cellular senescence; DNA damage; human chondrocytes; oxidative stress; telomeres

Indexed keywords

BETA GALACTOSIDASE; HYDROGEN PEROXIDE; NUCLEIC ACID BINDING PROTEIN; NUCLEIC ACID BINDING PROTEIN XRCC5; PROTEIN P21; SIRTUIN 1; TELOMERIC REPEAT BINDING FACTOR 2; UNCLASSIFIED DRUG;

ADULT; AGED; AGING; ARTICLE; CARTILAGE CELL; CELL CYCLE ARREST; CELL PROLIFERATION; CELL STRUCTURE; CELLULAR STRESS RESPONSE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOLOGY; DNA DAMAGE; DNA REPAIR; GENE EXPRESSION; HUMAN; HUMAN CELL; OSTEOARTHRITIS; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENESCENCE; TELOMERE; UPREGULATION;

ADULT; AGED; CARTILAGE, ARTICULAR; CELL AGING; CELL DIVISION; CELLS, CULTURED; CHONDROCYTES; DNA DAMAGE; DNA REPAIR; HUMANS; HYDROGEN PEROXIDE; MIDDLE AGED; OXIDANTS; OXIDATIVE STRESS; TELOMERE;

EID: 79955893457     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.21348     Document Type: Article

References (39)

1. Blackburn EH., 2000. Telomere states and cell fates. Nature 408: 53-56.
2. Xin H, Liu D, Songyang Z., 2008. The telosome/shelterin complex and its functions. Genome Biol 9: 232.
3. Palm W, de Lange T., 2008. How shelterin protects mammalian telomeres. Annu Rev Genet 42: 301-334.
4. Thacker J, Zdzienicka MZ., 2003. The mammalian XRCC genes: their roles in DNA repair and genetic stability. DNA Repair (Amst) 2: 655-672. (Pubitemid 36588757)
5. Thacker J, Zdzienicka MZ., 2004. The XRCC genes: expanding roles in DNA double-strand break repair. DNA Repair (Amst) 3: 1081-1090. (Pubitemid 38997951)
6. Guarente L., 1999. Diverse and dynamic functions of the Sir silencing complex. Nat Genet 23: 281-285. (Pubitemid 29526424)
7. Herbig U, Jobling WA, Chen BP, et al. 2004. Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol Cell 14: 501-513. (Pubitemid 38648803)
8. Ben-Porath I, Weinberg RA., 2005. The signals and pathways activating cellular senescence. Int J Biochem Cell Biol 37: 961-976. (Pubitemid 40311739)
9. Samani NJ, Boultby R, Butler R, et al. 2001. Telomere shortening in atherosclerosis. Lancet 358: 472-473. (Pubitemid 32769858)
10. Brouilette S, Singh RK, Thompson JR, et al. 2003. White cell telomere length and risk of premature myocardial infarction. Arterioscler Thromb Vasc Biol 23: 842-846. (Pubitemid 36566175)
11. Martin JA, Klingelhutz AJ, Moussavi-Harami F, et al. 2004. Effects of oxidative damage and telomerase activity on human articular cartilage chondrocyte senescence. J Gerontol A Biol Sci Med Sci 59: 324-337. (Pubitemid 38478730)
12. von Zglinicki T., 2002. Oxidative stress shortens telomeres. Trends Biochem Sci 27: 339-344. (Pubitemid 34756516)
13. Jackson A, Gu W., 2009. Transport properties of cartilaginous tissues. Curr Rheumatol Rev 5: 40-50.
14. Altindag O, Erel O, Aksoy N, et al. 2007. Increased oxidative stress and its relation with collagen metabolism in knee osteoarthritis. Rheumatol Int 27: 339-344. (Pubitemid 46122276)
15. Dimri GP, Lee X, Basile G, et al. 1995. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 92: 9363-9367.
16. Benya PD, Shaffer JD., 1982. Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels. Cell 30: 215-224. (Pubitemid 13237099)
17. Darling EM, Athanasiou KA., 2005. Rapid phenotypic changes in passaged articular chondrocyte subpopulations. J Orthop Res 23: 425-432. (Pubitemid 40287871)
18. Brandl A, Angele P, Roll C, et al. 2010. Influence of the growth factors PDGF-BB, TGF-beta1 and bFGF on the replicative aging of human articular chondrocytes during in vitro expansion. J Orthop Res 28: 354-360.
19. Angele P, Fritz J., 2006. Navigation-guided transfer of cartilage defect geometry for arthroscopic autologous chondrocyte transplantation. Orthopedics 29: S100-S103. (Pubitemid 44680394)
20. Peterson L, Brittberg M, Kiviranta I, et al. 2002. Autologous chondrocyte transplantation. Biomechanics and long-term durability. Am J Sports Med 30: 2-12. (Pubitemid 34083708)
21. Ahmed N, Gan L, Nagy A, et al. 2009. Cartilage tissue formation using redifferentiated passaged chondrocytes in vitro. Tissue Eng Part A 15: 665-673.
22. Kang SW, Yoo SP, Kim BS., 2007. Effect of chondrocyte passage number on histological aspects of tissue-engineered cartilage. Biomed Mater Eng 17: 269-276. (Pubitemid 47357151)
23. 2 involves DNA-damage-and-repair genes and telomere shortening. Int J Biochem Cell Biol 37: 1407-1420.
24. Tchirkov A, Lansdorp PM., 2003. Role of oxidative stress in telomere shortening in cultured fibroblasts from normal individuals and patients with ataxia-telangiectasia. Hum Mol Genet 12: 227-232. (Pubitemid 36204420)
25. Toussaint O, Medrano EE, von Zglinicki T., 2000. Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes. Exp Gerontol 35: 927-945.
26. 2 stress triggers a release of transforming growth factor-beta 1, which induces biomarkers of cellular senescence of human diploid fibroblasts. J Biol Chem 276: 2531-2537.
27. Sklavounou E, Hay A, Ashraf N, et al. 2006. The use of telomere biology to identify and develop superior nitrone based anti-oxidants. Biochem Biophys Res Commun 347: 420-427. (Pubitemid 44041433)
28. Ramakrishnan P, Hecht BA, Pedersen DR, et al. 2010. Oxidant conditioning protects cartilage from mechanically induced damage. J Orthop Res 28: 914-920.
29. Hayflick L., 2000. The illusion of cell immortality. Br J Cancer 83: 841-846.
30. Saretzki G, Von Zglinicki T., 2002. Replicative aging, telomeres, and oxidative stress. Ann N Y Acad Sci 959: 24-29. (Pubitemid 34457548)
31. von Zglinicki T, Petrie J, Kirkwood TB., 2003. Telomere-driven replicative senescence is a stress response. Nat Biotechnol 21: 229-230. (Pubitemid 36314800)
32. Chen QM, Prowse KR, Tu VC, et al. 2001. Uncoupling the senescent phenotype from telomere shortening in hydrogen peroxide-treated fibroblasts. Exp Cell Res 265: 294-303. (Pubitemid 32980218)
33. Rubio MA, Davalos AR, Campisi J., 2004. Telomere length mediates the effects of telomerase on the cellular response to genotoxic stress. Exp Cell Res 298: 17-27. (Pubitemid 38887303)
34. Opresko PL, Fan J, Danzy S, et al. 2005. Oxidative damage in telomeric DNA disrupts recognition by TRF1 and TRF2. Nucleic Acids Res 33: 1230-1239. (Pubitemid 41439916)
35. d'Adda di Fagagna F, Reaper PM, Clay-Farrace L, et al. 2003. A DNA damage checkpoint response in telomere-initiated senescence. Nature 426: 194-198. (Pubitemid 37442589)
36. Oh H, Wang SC, Prahash A, et al. 2003. Telomere attrition and Chk2 activation in human heart failure. Proc Natl Acad Sci USA 100: 5378-5383. (Pubitemid 36542713)
37. Zhang Y, Cao EH, Qin JF., 2005. Up-regulation of telomere-binding TRF1, TRF2 related to reactive oxygen species induced by As(2)O(3) in MGC-803 cells. Eur J Pharmacol 516: 1-9. (Pubitemid 40780111)
38. Vaziri H, Dessain SK, Ng Eaton E, et al. 2001. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107: 149-159. (Pubitemid 33035942)
39. Shackelford DA, Tobaru T, Zhang S, et al. 1999. Changes in expression of the DNA repair protein complex DNA-dependent protein kinase after ischemia and reperfusion. J Neurosci 19: 4727-4738. (Pubitemid 29270108)