Intra-articular administration of gelatin hydrogels incorporating rapamycin-micelles reduces the development of experimental osteoarthritis in a murine model

Biomaterials

Volumn 35, Issue 37, 2014, Pages 9904-9911

  Matsuzaki, Tokio ^a   Matsushita, Takehiko ^a   Tabata, Yasuhiko ^b   Saito, Takashi ^b   Matsumoto, Tomoyuki ^a   Nagai, Kanto ^a   Kuroda, Ryosuke ^a   Kurosaka, Masahiro ^a  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Animal model; Arthritis; Biodegradation; Cartilage; Matrix metalloproteinase

Indexed keywords

BIODEGRADATION; CARTILAGE; CELL DEATH; HYDROGELS; MAMMALS; POLYMERASE CHAIN REACTION; SURGERY;

ANIMAL MODEL; ARTHRITIS; CELLULAR HOMEOSTASIS; GELATIN HYDROGELS; IMMUNOHISTOCHEMICAL ANALYSIS; MATRIX METALLOPROTEINASES; REAL TIME POLYMERASE CHAIN REACTIONS; THERAPEUTIC EFFECTS;

MICELLES;

CCAAT ENHANCER BINDING PROTEIN BETA; COLLAGEN TYPE 2; COLLAGENASE 3; GELATIN; GELATINASE B; INTERLEUKIN 1BETA; INTERLEUKIN 6; MAMMALIAN TARGET OF RAPAMYCIN; RAPAMYCIN; DRUG CARRIER; HYDROGEL; IMMUNOSUPPRESSIVE AGENT; MICELLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CARTILAGE CELL; CONTROLLED STUDY; DNA MICROARRAY; DOWN REGULATION; GENE EXPRESSION; HUMAN; HUMAN TISSUE; HYDROGEL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MICELLE; MOUSE; NONHUMAN; NORMAL HUMAN; OSTEOARTHRITIS; REAL TIME POLYMERASE CHAIN REACTION; SINGLE DRUG DOSE; SUSTAINED DRUG RELEASE; THERAPY EFFECT; UPREGULATION; ANIMAL; C57BL MOUSE; CHEMISTRY; DRUG EFFECTS; INTRAARTICULAR DRUG ADMINISTRATION; MALE; PATHOLOGY;

ANIMALS; AUTOPHAGY; CHONDROCYTES; DRUG CARRIERS; GELATIN; HYDROGELS; IMMUNOSUPPRESSIVE AGENTS; INJECTIONS, INTRA-ARTICULAR; MALE; MICE; MICE, INBRED C57BL; MICELLES; OSTEOARTHRITIS; SIROLIMUS;

EID: 84907266449     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2014.08.041     Document Type: Article

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