Sirt1-deficient mice exhibit an altered cartilage phenotype

Joint Bone Spine

Volumn 80, Issue 6, 2013, Pages 613-620

  Gabay, Odile ^a   Zaal, Kristien J ^a   Sanchez, Christelle ^b   Dvir Ginzberg, Mona ^c   Gagarina, Viktoria ^a   Song, Yingjie ^d   He, Xiao Hong ^e   McBurney, Michael W ^e  

^a NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

^b UNIVERSITY OF LIÈGE   (Belgium)

^c HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^d Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center   (United States)

^e OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

Author keywords

Animal models; Cartilage; Osteoarthritis; Sirtuin 1

Indexed keywords

AGGRECAN; AGGRECANASE; AGGRECANASE 1; AGGRECANASE 2; ALCIAN BLUE; COLLAGEN TYPE 2; COLLAGENASE 3; GENOMIC DNA; GLYCOSAMINOGLYCAN; INTERSTITIAL COLLAGENASE; PROTEIN TYROSINE PHOSPHATASE 1B; SIRTUIN 1; STROMELYSIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ARTICULAR CARTILAGE; BONE DEVELOPMENT; BONE MINERALIZATION; CARTILAGE CELL; CARTILAGE DEGENERATION; CELL COUNT; CELL CULTURE; CONTROLLED STUDY; FLOW CYTOMETRY; GENOTYPE; HETEROZYGOTE; HINDLIMB; HISTOPATHOLOGY; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; OSTEOARTHRITIS; PHENOTYPE; SKULL; SPINE; STAINING; THORAX; WILD TYPE; ANIMAL; CHEMISTRY; CHONDROPATHY; DISEASE MODEL; GENETIC PREDISPOSITION; GENETICS; HOMEOSTASIS; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ANIMALS; APOPTOSIS; CARTILAGE DISEASES; CARTILAGE, ARTICULAR; CHONDROCYTES; DISEASE MODELS, ANIMAL; GENETIC PREDISPOSITION TO DISEASE; HOMEOSTASIS; MICE; MICE, KNOCKOUT; OSTEOARTHRITIS; PHENOTYPE;

EID: 84888432382     PISSN: 1297319X     EISSN: 17787254     Source Type: Journal    
DOI: 10.1016/j.jbspin.2013.01.001     Document Type: Article

References (26)

1. Goldring M.B. The role of cytokines as inflammatory mediators in osteoarthritis: lessons from animal models. Connect Tissue Res 1999, 40:1-11.
2. Zhang W.G., Bai X.J., Chen X.M. SIRT1 variants are associated with aging in a healthy Han Chinese population. Clin Chim Acta 2010, 411:1679-1683.
3. Loeser R.F. Age-related changes in the musculoskeletal system and the development of osteoarthritis. Clin Geriatr Med 2010, 26:371-386.
4. Lawrence R.C., Felson D.T., Helmick C.G., et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis Rheum 2008, 58:26-35.
5. Tissenbaum H.A., Guarente L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 2001, 410:227-230.
6. Michan S., Sinclair D. Sirtuins in mammals: insights into their biological function. Biochem J 2007, 404:1-13.
7. Backesjo C.M., Li Y., Lindgren U., et al. Activation of Sirt1 decreases adipocyte formation during osteoblast differentiation of mesenchymal stem cells. J Bone Miner Res 2006, 21:993-1002.
8. Zeng L., Chen R., Liang F., et al. Silent information regulator, Sirtuin 1, and age-related diseases. Geriatr Gerontol Int 2009, 9:7-15.
9. Dvir-Ginzberg M., Gagarina V., Lee E.J., et al. Regulation of cartilage-specific gene expression in human chondrocytes by SirT1 and nicotinamide phosphoribosyltransferase. J Biol Chem 2008, 283:36300-36310.
10. Gagarina V., Gabay O., Dvir-Ginzberg M., et al. SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor receptor pathway. Arthritis Rheum 2010, 62:1383-1392.
11. Takayama K., Ishida K., Matsushita T., et al. SIRT1 regulation of apoptosis of human chondrocytes. Arthritis Rheum 2009, 60:2731-2740.
12. Fujita N., Matsushita T., Ishida K., et al. Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions. J Orthop Res 2011, 29:511-515.
13. McBurney M.W., Yang X., Jardine K., et al. The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Mol Cell Biol 2003, 23:38-54.
14. McBurney M.W., Yang X., Jardine K., et al. The absence of SIR2alpha protein has no effect on global gene silencing in mouse embryonic stem cells. Mol Cancer Res 2003, 1:402-409.
15. Lemieux M.E., Yang X., Jardine K., et al. The Sirt1 deacetylase modulates the insulin-like growth factor signaling pathway in mammals. Mech Ageing Dev 2005, 126:1097-1105.
16. Gabay O., Oppenheimer H., Meir H., et al. Increased apoptotic chondrocytes in articular cartilage from adult heterozygous SirT1 mice. Ann Rheum Dis 2012, 71:613-616.
17. Gabay O., Gosset M., Levy A., et al. Stress-induced signaling pathways in hyalin chondrocytes: inhibition by Avocado-Soybean Unsaponifiables (ASU). Osteoarthritis Cartilage 2008, 16:373-384.
18. Glasson S.S., Chambers M.G., Van Den Berg W.B., et al. The OARSI histopathology initiative-recommendations for histological assessments of osteoarthritis in the mouse. Osteoarthritis Cartilage 2010, 18:S17-S23.
19. Depew M.J. Analysis of skeletal ontogenesis through differential staining of bone and cartilage. Methods Mol Biol 2008, 461:37-45.
20. Yasuda M., Yuki T., Tanimura T. Color atlas of fetal skeleton of the mouse, rat, and rabbit. Congenit Anom 1996, 36:263-265.
21. Lee J.H., Fitzgerald J.B., DiMicco M.A., et al. Co-culture of mechanically injured cartilage with joint capsule tissue alters chondrocyte expression patterns and increases ADAMTS5 production. Arch Biochem Biophys 2009, 489:118-126.
22. Verma P., Dalal K. ADAMTS-4 and ADAMTS-5: key enzymes in osteoarthritis. J Cell Biochem 2011, 112:3507-3514.
23. Dvir-Ginzberg M., Gagarina V., Lee E.J., et al. Tumor necrosis factor alpha-mediated cleavage and inactivation of SirT1 in human osteoarthritic chondrocytes. Arthritis Rheum 2011, 63:2363-2373.
24. Oppenheimer H., Gabay O., Meir H., et al. 75kDa SirT1 blocks TNFalpha-mediated apoptosis in human osteoarthritic chondrocytes. Arthritis Rheum 2012, 64:718-728.
25. Cheng H.L., Mostoslavsky R., Saito S., et al. Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A 2003, 100:10794-10799.
26. Peck B., Chen C.Y., Ho K.K., et al. SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2. Mol Cancer Ther 2010, 9:844-855.