Development of an intein-mediated split-Cas9 system for gene therapy

Nucleic Acids Research

Volumn 43, Issue 13, 2015, Pages 6450-6458

  Truong, Dong Jiunn Jeffery ^a,b   Kühner, Karin ^a   Kühn, Ralf ^a,c   Werfel, Stanislas ^b   Engelhardt, Stefan ^b,d   Wurst, Wolfgang ^a,b,e,f   Ortiz, Oskar ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^d DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^e GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^f UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CAS9D10A NICKASE; ENDONUCLEASE; INTEIN; UNCLASSIFIED DRUG; VIRUS VECTOR; CRISPR ASSOCIATED PROTEIN; DEOXYRIBONUCLEASE;

ADENO ASSOCIATED VIRUS; ARTICLE; CONTROLLED STUDY; DNA END JOINING REPAIR; GENE EXPRESSION; GENE LOCUS; GENE TARGETING; GENE THERAPY; GENETIC CODE; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; INTEIN MEDIATED SPLIT CAS9 SYSTEM; NONVIRAL GENE DELIVERY SYSTEM; PLASMID; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROCESS DEVELOPMENT; VIRUS RECOMBINANT; CELL LINE; CRISPR CAS SYSTEM; DEPENDOPARVOVIRUS; ENZYMOLOGY; GENETIC TRANSFECTION; GENETICS; PROCEDURES; STREPTOCOCCUS PYOGENES;

ADENO-ASSOCIATED VIRUS;

CELL LINE; CRISPR-ASSOCIATED PROTEINS; CRISPR-CAS SYSTEMS; DEOXYRIBONUCLEASES; DEPENDOVIRUS; GENE TARGETING; GENETIC THERAPY; HUMANS; INTEINS; PLASMIDS; STREPTOCOCCUS PYOGENES; TRANSFECTION;

EID: 84939630169     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkv601     Document Type: Article

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