Creation of targeted genomic deletions using TALEN or CRISPR/Cas nuclease pairs in one-cell mouse embryos

FEBS Open Bio

Volumn 5, Issue , 2015, Pages 26-35

  Brandl, Christina ^a,b   Ortiz, Oskar ^a   Röttig, Bernhard ^a,b   Wefers, Benedikt ^a,c   Wurst, Wolfgang ^a,b,c,d,e   Kühn, Ralf ^a,b,f  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^d MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^e UNIVERSITY OF MUNICH   (Germany)

^f MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

Cas9; CRISPR; Disease model; Mouse mutant; One cell embryo; TALENs

Indexed keywords

NUCLEASE; RNA; SINGLE GUIDE RNA; TAL EFFECTOR NUCLEASE; UNCLASSIFIED DRUG;

ALLELE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CRISPR CAS SYSTEM; DNA SEQUENCE; EMBRYO; GENE; GENE DELETION; GENE TARGETING; GENE TRANSFER; GENOTYPE; MICROINJECTION; MOUSE; MOUSE EMBRYO; MUTANT; NONHUMAN; PROGENY; RAB38 GENE;

EID: 84917692795     PISSN: None     EISSN: 22115463     Source Type: Journal    
DOI: 10.1016/j.fob.2014.11.009     Document Type: Article

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