Rapid and highly efficient inducible cardiac gene knockout in adult mice using AAV-mediated expression of Cre recombinase

Cardiovascular Research

Volumn 104, Issue 1, 2014, Pages 15-23

  Werfel, Stanislas ^a,b,c   Jungmann, Andreas ^a   Lehmann, Lorenz ^a,c   Ksienzyk, Jan ^a   Bekeredjian, Raffi ^a,c   Kaya, Ziya ^a,c   Leuchs, Barbara ^d   Nordheim, Alfred ^e   Backs, Johannes ^a,c   Engelhardt, Stefan ^b,c   Katus, Hugo A ^a,c   Müller, Oliver J ^a,c  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^d GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^e UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Adeno associated virus; Cardiomyopathy; Conditional transgenic mouse; Gene regulation; Serum response factor

Indexed keywords

ADENOVIRUS VECTOR; CALCIUM; CRE RECOMBINASE; MESSENGER RNA; SERUM RESPONSE FACTOR; TROPONIN T; GT(ROSA)26SOR NON-CODING RNA, MOUSE; INTEGRASE; UNTRANSLATED RNA;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DISEASE SEVERITY; FIBROSING ALVEOLITIS; GENE INACTIVATION; GENE SWITCHING; GENE TRANSFER; GENETIC RECOMBINATION; HEART DISEASE; HEART MUSCLE; HEART MUSCLE CELL; KNOCKOUT MOUSE; LOXP SITE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SEROTYPE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CARDIOMYOPATHY; DEPENDOPARVOVIRUS; DOWN REGULATION; ENZYMOLOGY; FIBROSIS; GENE SILENCING; GENETICS; GENOTYPE; HEART LEFT VENTRICLE FUNCTION; LACTOSE OPERON; MALE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHENOTYPE; PROMOTER REGION; TIME;

ANIMALS; CARDIOMYOPATHIES; DEPENDOVIRUS; DOWN-REGULATION; FIBROSIS; GENE KNOCKDOWN TECHNIQUES; GENOTYPE; INTEGRASES; LAC OPERON; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOCYTES, CARDIAC; PHENOTYPE; PROMOTER REGIONS, GENETIC; RNA, MESSENGER; RNA, UNTRANSLATED; SERUM RESPONSE FACTOR; TIME FACTORS; TROPONIN T; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR FUNCTION, LEFT;

EID: 84913570462     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvu174     Document Type: Article

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