Dual exosite-binding inhibitors of insulin-degrading enzyme challenge its role as the primary mediator of insulin clearance in vivo

Journal of Biological Chemistry

Volumn 290, Issue 33, 2015, Pages 20044-20059

  Durham, Timothy B ^a   Toth, James L ^a   Klimkowski, Valentine J ^a   Cao, Julia X C ^a   Siesky, Angela M ^a   Alexander Chacko, Jesline ^a   Wu, Ginger Y ^a   Dixon, Jeffrey T ^a   McGee, James E ^a   Wang, Yong ^a   Guo, Sherry Y ^a   Cavitt, Rachel Nicole ^a   Schindler, John ^a   Thibodeaux, Stefan J ^a   Calvert, Nathan A ^a   Coghlan, Michael J ^a   Sindelar, Dana K ^a   Christe, Michael ^a   Kiselyov, Vladislav V ^a   Michael, M Dodson ^a   Sloop, Kyle W ^a   more..

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYMES; GLUCOSE; INTEGRODIFFERENTIAL EQUATIONS; MAMMALS; METABOLISM;

BINDING INHIBITORS; INSULIN SENSITIVITY; INSULIN-DEGRADING ENZYMES; ORAL GLUCOSE TOLERANCE TESTS; PEPTIDE INHIBITORS; PHARMACOKINETIC PROPERTIES; PLASMA INSULIN LEVELS; STRUCTURE-BASED DESIGNS;

INSULIN;

AMYLIN; INSULIN; INSULINASE; ENZYME INHIBITOR;

ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATABOLISM; CONTROLLED STUDY; CRYSTALLIZATION; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME METABOLISM; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INSULIN BLOOD LEVEL; INSULIN CLEARANCE; MALE; MOUSE; NONHUMAN; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DETERMINATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RAT; ANIMAL; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; HEK293 CELL LINE; METABOLISM; X RAY CRYSTALLOGRAPHY;

ANIMALIA; MUS; RODENTIA;

ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HEK293 CELLS; HUMANS; INSULIN; INSULYSIN; MODELS, MOLECULAR; PROTEOLYSIS;

EID: 84939620729     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.638205     Document Type: Article

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