Characterization of the insulin inhibition of the peptidolytic activities of the insulin-degrading enzyme-proteasome complex

Diabetes

Volumn 46, Issue 2, 1997, Pages 197-203

  Bennett, Robert G ^a   Hamel, Frederick G ^a   Duckworth, William C ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATRIAL NATRIURETIC FACTOR; CHYMOTRYPSIN; GLUCAGON; INSULIN; INSULINASE; PROINSULIN; PROTEASOME; RELAXIN; SOMATOMEDIN B; SOMATOMEDIN C; TRYPTASE;

ANIMAL TISSUE; ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SUBSTRATE COMPLEX; HYDROLYSIS; INSULIN DEGRADATION; INSULIN RESPONSE; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT;

EID: 0030953108     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.46.2.197     Document Type: Article

References (46)

1. Mirsky IA: Insulinase, insulinase inhibitors, and diabetes mellitus. Recent Prog Horm Res 13:429-471, 1957
2. Duckworth WC: Insulin degradation: mechanisms, products, and significance. Endocr Rev 9:319-345, 1988
3. Shii K, Yokono K, Baba S, Roth RA: Purification and characterization of insulin-degrading enzyme from human erythrocytes. Diabetes 35:675-683, 1986
4. Affholter JA, Fried VA, Roth RA: Human insulin-degrading enzyme shares structural and functional homologies with E. coli protease III. Science 242:1415-1418, 1988
5. Becker AB, Roth RA: An unusual active site identified in a family of zinc metalloendopeptidases. Proc Natl Acad Sci USA 89:3835-3839, 1992
6. Gehm BD, Kuo WL, Perlman RK, Rosner MR: Mutations in a zinc-binding domain of human insulin-degrading enzyme eliminate catalytic activity but not insulin binding. J Biol Chem 268:7943-7948, 1993
7. Ebrahim A, Hamel FG, Bennett RG, Duckworth WC: Identification of the metal associated with the insulin degrading enzyme. Biochem Biophys Res Commun 181:1398-1406, 1991
8. Garcia JV, Fenton BW, Rosner MR: Isolation and characterization of an insulin-degrading enzyme from Drosophila melanogaster. Biochemistry 27:4237-4244, 1988
9. Hamel FG, Posner BI, Bergeron JJM, Frank BH, Duckworth WC: Isolation of insulin degradation products from endosomes derived from intact rat liver. J Biol Chem 263:6703-6708, 1988
10. Hamel FG, Mahoney MJ, Duckworth WC: Degradation of intraendosomal insulin by insulin degrading enzyme without acidification. Diabetes 40:436-443, 1991
11. Gehm BD, Rosner MR: Regulation of insulin, epidermal growth factor, and transforming growth factor-α levels by growth factor degrading enzymes. Endocrinology 128:1603-1609, 1991
12. Fagan J, Waxman L: Purification of a protease in red blood cells that degrades oxidatively damaged haemoglobin. Biochem J 277:779-786, 1991
13. Stoppelli MP, Garcia JV, Decker SJ, Rosner MR: Developmental regulation of an insulin degrading enzyme from Drosophila melanogaster. Proc Natl Acad Sci USA 85:3469-3473, 1988
14. Kuo W, Montag A, Rosner M: Insulin-degrading enzyme is differentially expressed and developmentally regulated in various rat tissues. Endocrinology 132:604-611, 1993
15. Bennett R, Hamel F, Duckworth W: Identification and isolation of a cytosolic proteolytic complex containing insulin degrading enzyme and the multicatalytic proteinase. Biochem Biophys Res Commun 202:1047-1053, 1994
16. Duckworth W, Bennett R, Hamel F: A direct inhibitory effect of insulin on a cytosolic proteolytic complex containing insulin-degrading enzyme and multicatalytic proteinase. J Biol Chem 269:24575-24580, 1994
17. Draznin B, Trowbridge M: Inhibition of intracellular proteolysis by insulin in isolated rat hepatocytes: possible role of internalized hormone. J Biol Chem 257:11988-11993, 1982
18. Peavy DE, Edmondson JW, Duckworth WC: Selective effects of inhibitors of hormone processing on insulin action in isolated hepatocytes. Endocrinology 114:753-760, 1984
19. Garcia JV, Stopelli MP, Decker SJ, Rosner MR: An insulin epidermal growth factor-binding protein from Drosophila has insulin-degrading activity. J Cell Biol 108:177-182, 1989
20. Kupfer SR, Wilson EM, French FS: Androgen and glucocorticoid receptors interact with insulin degrading enzyme. J Biol Chem 269:20622-20628, 1994
21. Frank BH, Peavy DE, Hooker CS, Duckworth WC: Receptor binding properties of monoiodotyrosyl insulin isomers purified by high-performance liquid chromatography. Diabetes 32:705-711, 1983
22. Duckworth WC, Heinemann MA, Kitabchi AE: Purification of insulin specific protease by affinity chromatography. Proc Natl Acad Sci USA 69:3698-3702, 1972
23. Duckworth WC, Kitabchi AE: Insulin and glucagon degradation by the same enzyme. Diabetes 23:536-543, 1974
24. Rivett AJ: Proteasomes: multicatalytic proteinase complexes. Biochem J 291:1-10, 1993
25. Roth R, Mesirow M, Cassell D, Yokono K, Baba S: Characterization of an insulin degrading enzyme from cultured human lymphocytes. Diabetes Res Clin Pract 1:31-39, 1985
26. Affholter J, Casciere M, Bayne M, Brange J, Casaretto M, Roth R: Identification of residues in the insulin molecule important for binding to insulin-degrading enzyme. Biochemistry 29:7727-7733, 1990
27. Morgan DO, Ho L, Korn LJ, Roth RA; Insulin action is blocked by a monoclonal antibody that inhibits the insulin receptor kinase. Proc Natl Acad Sci USA 83:328-332, 1986
28. Ciechanover A: The ubiquitin-proteasome proteolytic pathway. Cell 79:13-21, 1994
29. Rechsteiner M, Hoffman L, Dubiel W: Minireview: the multicatalytic and 26S proteases. J Biol Chem 268:6065-6068, 1993
30. Rock KL, Gramm C, Rothstein L, Clark K, Stein R, Dick L, Hwang D, Goldberg AL: Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell 78:761-771, 1994
31. Arrigo AP, Tanaka K, Goldberg AL, Welch WJ: Identity of the 19S 'prosome' particle with the large multifunctional protease complex of mammalian cells (the proteasome). Nature 331:192-194, 1988
32. Frentzel S, Pesold-Hurt B, Seelig A, Kloetzel P-M: 20S proteasomes are assembled via distinct precursor complexes. J Mol Biol 236:975-981, 1994
33. Barrett E, Jahn L, Oliveras E, Fryburg D: Chloroquine does not exert insulin-like actions on human forearm muscle metabolism. Am J Physiol 268:E820-E824, 1995
34. Rabkin R, Birn H, Shi J, Roth R, Christensen E: Insulin-degrading enzyme (IDE) in renal proximal tubules (Abstract). Diabetes 41 (Suppl. 1):15A, 1992
35. Authier F, Bergeron JJM, Ou W-J, Rachubinski RA, Posner BI, Walton PA: Degradation of the cleaved leader peptide of thiolase by a peroxisomal proteinase. Proc Natl Acad Sci. USA 92:3859-3863, 1995
36. Kuo WL, Gehm BD, Rosner MR, Li W, Keller G: Inducible expression and cellular localization of insulin-degrading enzyme in a stable transfected cell line. J Biol Chem 269:22599-22606, 1994
37. 6 myoblasts inhibit insulin degradation by the endogenous insulin-degrading enzyme. J Biol Chem 264:8928-8934, 1989
38. 3H1 and primary skeletal muscle cells and the activity of their endogenous insulin-degrading enzyme are inhibited by the same metalloendoprotease inhibitors. J Cell Biochem 44:137-151, 1990
39. Harada S, Smith R, Smith J, Jarett L: Inhibition of insulin-degrading enzyme increases translocation of insulin to the nucleus in H35 rat hepatoma cells: evidence of a cytosolic pathway. Endocrinology 132:2293-2298, 1993
40. Garcia JV, Stoppelli MP, Thompson KL, Decker SJ, Rosner MR: Characterization of a Drosophila protein that binds both epidermal growth factor and insulin-related growth factors. J Biol Chem 105:449-456, 1987
41. Fajita A, Oka C, Arikana Y, Katagai T, Tonouchi A, Kuhara S, Misumi Y: A yeast gene necessary for bud-site selection oncodes a protein similar to insulin-degrading enzymes. Nature 372:567-570, 1994
42. Adames N, Blandell K, Ashby M, Boone C: Role of yeast insulin-degrading enzyme homologs in propheromone processing and bud site selection. Science 270:464-467, 1995
43. Kupfer SR, Marschke KB, Wilson EM, French FS: Receptor accessory factor enhances specific DNA binding of androgen and glucocorticoid receptors. J Biol Chem 268:17519-17527, 1993
44. Miller DS: Stimulation of RNA and protein synthesis by intracellular insulin. Science 240:506-509, 1988
45. Hofmann CA, Lotan RM, Ku WW, Oeltmann TN: Insulin-ricin B hybrid molecules mediate an insulin-associated effect on cells which do not bind insulin. J Biol Chem 258:11774-11779, 1983
46. 125I insulin with a cytosolic insulin-degrading enzyme: detection by covalent cross-linking and immunoprecipitation with a monoclonal antibody. Endocrinology 120:829-831, 1987