Deletion of Insulin-degrading enzyme elicits Antipodal, age-dependent effects on glucose and insulin tolerance

PLoS ONE

Volumn 6, Issue 6, 2011, Pages

  Abdul Hay, Samer O ^a   Kang, Dongcheul ^a   McBride, Melinda ^a   Li, Lilin ^b   Zhao, Ji ^b   Leissring, Malcolm A ^a,b  

^a MAYO CLINIC   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; INSULIN RECEPTOR; INSULINASE;

ADIPOCYTE; ADIPOSE TISSUE; AGE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY MASS; BODY WEIGHT; CONTROLLED STUDY; DIABETES MELLITUS; DIET RESTRICTION; ENZYME ACTIVITY; ENZYME DEFICIENCY; GENE DELETION; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; GLUCOSE TRANSPORT; GLYCEMIC CONTROL; HYPERINSULINEMIA; INSULIN BLOOD LEVEL; INSULIN CLEARANCE; INSULIN DEGRADING ENZYME GENE; INSULIN TOLERANCE TEST; KNOCKOUT MOUSE; LIVER LEVEL; MOUSE; MUSCLE LEVEL; NONHUMAN; PHENOTYPE; WEIGHT GAIN; WEIGHT REDUCTION; WILD TYPE; AGING; ANIMAL; BLOOD; DRUG EFFECT; EXPERIMENTAL DIABETES MELLITUS; GENETICS; HYPERINSULINISM; INSULIN RESISTANCE; METABOLISM; MOUSE MUTANT;

MUS;

AGING; ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; DIABETES MELLITUS, EXPERIMENTAL; GENE DELETION; HYPERINSULINISM; INSULIN; INSULIN RESISTANCE; INSULYSIN; MICE; MICE, KNOCKOUT; PHENOTYPE;

EID: 79958294798     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0020818     Document Type: Article

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