α,β-Methylene-ADP (AOPCP) Derivatives and Analogues: Development of Potent and Selective ecto-5′-Nucleotidase (CD73) Inhibitors

Journal of Medicinal Chemistry

Volumn 58, Issue 15, 2015, Pages 6248-6263

  Bhattarai, Sanjay ^a   Freundlieb, Marianne ^a   Pippel, Jan ^b   Meyer, Anne ^a   Abdelrahman, Aliaa ^a   Fiene, Amelie ^a   Lee, Sang Yong ^a   Zimmermann, Herbert ^c   Yegutkin, Gennady G ^d   Sträter, Norbert ^b   El Tayeb, Ali ^a   Müller, Christa E ^a  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY OF LEIPZIG   (Germany)

^c GOETHE UNIVERSITY   (Germany)

^d UNIVERSITY OF TURKU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

6 N BENZYLADENOSINE; ALPHA,BETA METHYLENEADENOSINE DIPHOSPHATE; ECTO 5' NUCLEOTIDASE; 5' NUCLEOTIDASE; ADENOSINE 5'-METHYLENEDIPHOSPHATE; ADENOSINE DIPHOSPHATE; ENZYME INHIBITOR;

ANIMAL CELL; ARTICLE; BINDING SITE; DRUG DESIGN; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; LIVER MICROSOME; METABOLIC STABILITY; NONHUMAN; RAT; SERUM; SUBSTITUTION REACTION; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; SPODOPTERA;

5'-NUCLEOTIDASE; ADENOSINE DIPHOSPHATE; ANIMALS; CELL LINE; ENZYME INHIBITORS; HUMANS; MICROSOMES, LIVER; MODELS, MOLECULAR; RATS; SPODOPTERA;

EID: 84939182460     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b00802     Document Type: Article

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