Adenosine analogues as inhibitors of Trypanosoma brucei phosphoglycerate kinase: Elucidation of a novel binding mode for a 2-Amino-N6-substituted adenosine

Journal of Medicinal Chemistry

Volumn 43, Issue 22, 2000, Pages 4135-4150

  Bressi, J C ^a   Choe, J ^b   HoughHough, M T ^b   Buckner, F S ^a   Van Voorhis, W C ^a   Verlinde, C L M J ^c   Hol, W G J ^b,c,d   Gelb, M H ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c Howard Hughes Medical Institute ^*  (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [[2'' (4 HYDROXYPHENYL)ETHYL]AMINO]ADENOSINE; 2 AMINO N 6 [2'' (4 HYDROXYPHENYL)ETHYL]ADENOSINE; ADENOSINE DERIVATIVE; ENZYME INHIBITOR; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GLYCEROL 3 PHOSPHATE DEHYDROGENASE; N 6 (2'' PHENYLETHYL) 2 [(2'' PHENYLETHYL)AMINO]ADENOSINE; PHOSPHOGLYCERATE KINASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG ACTIVITY; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME STRUCTURE; NONHUMAN; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA BRUCEI; TRYPANOSOMIASIS;

ADENOSINE; ANIMALS; COMBINATORIAL CHEMISTRY TECHNIQUES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; GLYCEROLPHOSPHATE DEHYDROGENASE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PHOSPHOGLYCERATE KINASE; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMA CRUZI;

EID: 0034597543     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000287a     Document Type: Article

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