Virtual screening identifies novel sulfonamide inhibitors of ecto -5′-nucleotidase

Journal of Medicinal Chemistry

Volumn 55, Issue 14, 2012, Pages 6576-6581

  Ripphausen, Peter ^a   Freundlieb, Marianne ^a   Brunschweiger, Andreas ^a,c   Zimmermann, Herbert ^b   Müller, Christa E ^a   Bajorath, Jürgen ^a  

^a UNIVERSITY OF BONN   (Germany)

^b GOETHE UNIVERSITY   (Germany)

^c ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

6 CHLORO 2 OXO N (4 SULFAMOYLPHENYL) 2H CHROMENE 3 CARBOXYLIC ACID AMIDE; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ALPHA,BETA METHYLENEADENOSINE DIPHOSPHATE; AMIDE; ANTHRAQUINONE DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; CHLORINE DERIVATIVE; CHROMENE DERIVATIVE; ECTO 5' NUCLEOTIDASE; ECTO 5' NUCLEOTIDASE INHIBITOR; METALLOPHOSPHOESTERASE; NUCLEOTIDE; PURINERGIC RECEPTOR; SULFONAMIDE; UNCLASSIFIED DRUG;

ARTICLE; BINDING COMPETITION; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG SCREENING; ENZYME INHIBITION; IC 50; PH; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; VIRTUAL SCREENING;

5'-NUCLEOTIDASE; ANIMALS; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; PROTEIN CONFORMATION; RATS; SULFONAMIDES; USER-COMPUTER INTERFACE;

EID: 84864258002     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300658n     Document Type: Article

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