Processing of CD74 by the intramembrane protease SPPL2a is critical for B cell receptor signaling in transitional B cells

Journal of Immunology

Volumn 195, Issue 4, 2015, Pages 1548-1563

  Hüttl, Susann ^a   Kläsener, Kathrin ^b,c   Schweizer, Michaela ^d   Schneppenheim, Janna ^a   Oberg, Hans Heinrich ^a   Kabelitz, Dieter ^a   Reth, Michael ^b,c   Saftig, Paul ^a   Schröder, Bernd ^a  

^a UNIVERSITY OF KIEL   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

^d UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; CD74 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN M; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE SYK; PROTEIN P100; SIGNAL PEPTIDASE II; SPPL2A PROTEASE; TRANSCRIPTION FACTOR FKHR; UNCLASSIFIED DRUG; ASPARTIC PROTEINASE; B LYMPHOCYTE ANTIGEN; FORKHEAD TRANSCRIPTION FACTOR; FOXO1 PROTEIN, MOUSE; HLA ANTIGEN CLASS 2; INVARIANT CHAIN; LYMPHOCYTE ANTIGEN RECEPTOR; MEMBRANE PROTEIN; PROTEIN BINDING; PROTEIN TYROSINE KINASE; SIGNAL PEPTIDE; SPPL2A PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL MATURATION; CELL SURFACE; CONTROLLED STUDY; ENDOCYTOSIS; ENZYME ACTIVATION; GENETIC TRANSCRIPTION; INTERNALIZATION; MOUSE; NONHUMAN; PRE B LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; ANIMAL; APOPTOSIS; B LYMPHOCYTE; CELL DIFFERENTIATION; CELL MEMBRANE; CHEMISTRY; CYTOLOGY; DEFICIENCY; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; LYMPHOCYTE ACTIVATION; METABOLISM; PHOSPHORYLATION; PROTEIN DOMAIN;

ANIMALS; ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; APOPTOSIS; ASPARTIC ACID ENDOPEPTIDASES; B-LYMPHOCYTES; CELL DIFFERENTIATION; CELL MEMBRANE; ENDOCYTOSIS; FORKHEAD TRANSCRIPTION FACTORS; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNOGLOBULIN M; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LYMPHOCYTE ACTIVATION; MAP KINASE SIGNALING SYSTEM; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; NF-KAPPA B; NF-KAPPA B P52 SUBUNIT; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PRECURSOR CELLS, B-LYMPHOID; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, ANTIGEN, B-CELL; SIGNAL TRANSDUCTION;

EID: 84938941245     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1403171     Document Type: Article

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