B cell receptor-mediated Syk-independent activation of phosphatidylinositol 3-kinase, Ras, and mitogen-activated protein kinase pathways

Journal of Immunology

Volumn 171, Issue 3, 2003, Pages 1328-1335

  Yokozeki, Takeaki ^a   Adler, Kristin ^a   Lankar, Danielle ^a   Bonnerot, Christian ^a  

^a INSTITUT CURIE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; CALCIUM CHLORIDE; CD19 ANTIGEN; COMPLEMENTARY DNA; CYTOKINE; INOSITOL TRISPHOSPHATE; INTERLEUKIN 2; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE C; PROTEIN KINASE SYK; PROTEIN TYROSINE KINASE; RAS PROTEIN; RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; CALCIUM MOBILIZATION; CROSS LINKING; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; LYMPHOMA CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 0042346187     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.171.3.1328     Document Type: Article

References (59)

1. Lanzavecchia, A. 1987. Antigen uptake and accumulation in antigen-specific B cells. Immunol. Rev. 99:39.
2. Germain, R. N. 1994. MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. Cell 76:287.
3. Cresswell, P. 1994. Assembly, transport, and function of MHC class II molecules. Annu. Rev. Immunol. 12:259.
4. DeFranco, A. L. 1997. The complexity of signaling pathways activated by the BCR. Curr. Opin. Immunol. 9:296.
5. Kurosaki, T. 1997. Molecular mechanisms in B cell antigen receptor signaling. Curr. Opin. Immunol. 9:309.
6. Tamir, I., and J. C. Cambier. 1998. Antigen receptor signaling: integration of protein tyrosine kinase functions. Oncogene 17:1353.
7. 2+ mobilization through distinct pathways. EMBO J. 13:1341.
8. Fu, C., C. W. Turck, T. Kurosaki, and A. C. Chan. 1998. BLNK: a central linker protein in B cell activation. Immunity 9:93.
9. 2-terminal kinase, and p38 mitogen-activated protein kinase activation by the B cell antigen receptor. J. Exp. Med. 188:1287.
10. 2-terminal kinase, and p38 mitogen-activated protein kinase. J. Exp. Med. 188:1297.
11. Beitz, L. O., D. A. Fruman, T. Kurosaki, L. C. Cantley, and A. M. Scharenberg. 1999. SYK is upstream of phosphoinositide 3-kinase in B cell receptor signaling. J. Biol. Chem. 274:32662.
12. Craxton, A., A. Jiang, T. Kurosaki, and E. A. Clark. 1999. Syk and Bruton's tyrosine kinase are required for B cell antigen receptor-mediated activation of the kinase Akt. J. Biol. Chem. 274:30644.
13. Ishiai, M., M. Kurosaki, R. Pappu, K. Okawa, I. Ronko, C. Fu, M. Shibata, A. Iwamatsu, A. C. Chan, and T. Kurosaki. 1999. BLNK required for coupling Syk to PLCγ2 and Rac1-JNK in B cells, Immunity 10:117.
14. Okada, T., A. Maeda, A. Iwamatsu, K. Gotoh, and T. Kurosaki. 2000. BCAP: The tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation. Immunity 13:817.
15. Cheng, A. M., B. Rowley, W. Pao, A. Hayday, J. B. Bolen, and T. Pawson. 1995. Syk tyrosine kinase required for mouse viability and B-cell development. Nature 378:303.
16. Turner, M., P. J. Mee, P. S. Costello, O. Williams, A. A. Price, L. P. Duddy, M. T. Furlong, R. L. Geahlen, and V. L. J. Tybulewicz. 1995. Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature 378:298.
17. Turner. M., A. Gulbranson-Judge, M. E. Quinn, A. E. Walters, I. C. M. MacLennan, and V. L. J. Tybulewicz. 1997. Syk tyrosine kinase is required for the positive selection of immature B cells into the recirculating B cell pool. J. Exp. Med. 186:2013.
18. Cornall, R. J., A. M. Cheng, T. Pawson, and C. C. Goodnow. 2000. Role of Syk in B-cell development and antigen-receptor signaling. Proc. Natl. Acad. Sci. USA 97:1713.
19. Weil, R., C. Laurent-Winter, and A. Israël. 1997. Regulation of IκBβ degradation. J. Biol. Chem. 272:9942.
20. Fujimoto, M., J. C. Poe, A. B. Satterthwaite, M. I. Wahl, O. N. Witte, and T. F. Tedder. 2002. Complementary roles for CD19 and Bruton's tyrosine kinase in B lymphocyte signal transduction. J. Immunol. 168:5465.
21. Bruhns, P., P. Marchetti, W. H. Fridman, E. Vivier, and M. Daeron. 1999. Differential roles of N- and C-terminal immunoreceptor tyrosine-based inhibition motifs during inhibition of cell activation by killer cell inhibitory receptors. J. Immunol. 162:3168.
22. Keshvara, L. M., C. C. Isaacson, T. M. Yankee, R. Sarac, M. L. Harrison, and R. L. Geahlen. 1998. Syk- and Lyn-dependent phosphorylation of Syk on multiple tyrosines following B cell activation includes a site that negatively regulates signaling. J. Immunol. 161:5276.
23. Chan, V. W., F. Meng, P. Soriano, A. L. DeFranco, and C. A. Lowell. 1997. Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation. Immunity 7:69.
24. Hashimoto, S., A. Iwamatsu, M. Ishiai, K. Okawa, T. Yamadori, M. Matsushita, Y. Baba, T. Kishimoto, T. Kurosaki, and S. Tsukada. 1999. Identification of the SH2 domain binding protein of Bruton's tyrosine kinase as BLNK-functional significance of Btk-SH2 domain in B-cell antigen receptor-coupled calcium signaling. Blood 94:2357.
25. Ishiai, M., H. Sugawara, M. Kurosaki, and T. Kurosaki. 1999. Cutting edge: association of phospholipase C-γ2 Src homology 2 domains with BLNK is critical for B cell antigen receptor signaling. J. Immunol. 163:1746.
26. Su, Y. W., Y. Zhang, J. Schweikert, G. A. Koretzky, M. Reth, and J. Wienands. 1999. Interaction of SLP adaptors with the SH2 domain of Tec family kinases. Eur. J. Immunol. 29:3702.
27. Baba, Y., S. Hashimoto, M. Matsushita, D. Watanabe, T. Kishimoto, T. Kurosaki, and S. Tsukada. 2001. BLNK mediates Syk-dependent Btk activation. Proc. Natl. Acad. Sci. USA 98:2582.
28. Engels, N., B. Wollscheid, and J. Wienands. 2001. Association of SLP-65/BLNK with the B cell antigen receptor through a non-1TAM tyrosine of Ig-α. Eur. J. Immunol. 31:2126.
29. Kabak, S., B. J. Skaggs, M. R. Gold, M. Affolter, K. L. West, M. S. Foster, K. Siemasko, A. C. Chan, R. Aebersold, and M. R. Clark. 2002. The direct recruitment of BLNK to immunoglobulin α couples the B-cell antigen receptor to distal signaling pathways. Mol. Cell. Biol. 22:2524.
30. Tan, J. E.-L., S.-C. Wong, S. K.-E. Gan, S. Xu, and K.-P. Lam. 2001. The adaptor protein BLNK is required for B cell antigen receptor-induced activation of nuclear factor-κB and cell cycle entry and survival of B lymphocytes. J. Biol. Chem. 276:20055.
31. Tuveson, D. A., R. H. Carter, S. P. Soltoff, and D. T. Fearon. 1993. CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase. Science 260:986.
32. Chalupny, N. J., A. Aruffo. J. M. Esselstyn, P. Y. Chan, J. Bajorath, J. Blake, L. K. Gilliland, J. A. Ledbetter, and M. A. Tepper. 1995. Specific binding of Fyn and phosphatidylinositol 3-kinase to the B cell surface glycoprotein CD19 through their src homology 2 domains. Eur. J. Immunol. 25:2978.
33. Buhl, A. M., and J. C. Cambier. 1999. Phosphorylation of CD19 Y484 and Y515, and linked activation of phosphatidylinositol 3-kinase, are required for B cell antigen receptor-mediated activation of Bruton's tyrosine kinase. J. Immunol. 162:4438.
34. Brooks, S. R., X. Li, E. J. Volanakis, and R. H. Carter. 2000. Systematic analysis of the role of CD19 cytoplasmic tyrosines in enhancement of activation in Daudi human B cells: clustering of phospholipase C and Vav and of Grb2 and Sos with different CD19 tyrosines. J. Immunol. 164:3123.
35. Fujimoto, M., Y. Fujimoto, J. C. Poe, P. J. Jansen, C. A. Lowell, A. L. DeFranco, and T. F. Tedder. 2000. CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification. Immunity 13:47.
36. Petro, J. B., and W. N. Khan. 2001. Phospholipase C-γ2 couples Bruton's tyrosine kinase to the NF-κB signaling pathway in B lymphocytes. J. Biol. Chem. 276:1715.
37. Jacob, A., D. Cooney, M. Pradhan, and K. M. Coggeshall. 2002. Convergence of signaling pathways on the activation of ERK in B cells. J. Biol. Chem. 277:23420.
38. Trowbridge, I. S., J. F. Collawn, and C. R. Hopkins. 1993. Signal-dependent membrane protein trafficking in the endocytic pathway. Annu. Rev. Cell Biol. 9:129.
39. Knight, A. M., J. M. Lucocq, A. R. Prescott, S. Ponnambalam, and C. Watts. 1997. Antigen endocytosis and presentation mediated by human membrane IgG1 in the absence of the Igα/Igβ dimer. EMBO J. 16:3842.
40. Pogue, S. L., and C. C. Goodnow. 2000. Gene dose-dependent maturation and receptor editing of B cells expressing immunoglobulin (Ig)G1 of IgM/IgG1 tail antigen receptors. J. Exp. Med. 191:1031.
41. Takata, M., and T. Kurosaki. 1996. A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-γ2. J. Exp. Med. 184:31.
42. Lindsberg, M.-L., M. Brunswick, H. Yamada, A. Lees, J. Inman, C. H. June, and J. J. Mond. 1991. Biochemical analysis of the immune B cell defect in xid mice. J. Immunol. 147:3774.
43. Jumaa, H., B. Wollscheid, M. Mitterer, J. Wienands, M. Reth, and P. J. Nielsen. 1999. Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65. Immunity 11:547.
44. Pappu, R., A. M. Cheng, B. Li, Q. Gong, C. Chiu, N. Griffin, M. White, B. P. Sleckman, and A. C. Chan. 1999. Requirement for B cell linker protein (BLNK) in B cell development. Science 286:1949.
45. Burkhardt, A. L., M. Brunswick, J. B. Bolen, and J. J. Mond. 1991. Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases. Proc. Natl. Acad. Sci. USA 88:7410.
46. lck protein tyrosine kinase in response to antigen receptor cross-linking in B lymphocytes. J. Immunol. 153:2369.
47. fgr is expressed in murine splenic B cells and is activated in response to antigen receptor cross-linking. J. Immunol. 154:3234.
48. Pleiman, C. M., W. M. Hertz, and J. C. Cambier. 1994. Activation of phosphatidylinositol-3′ kinase by Src-family kinase SH3 binding to the p85 subunit. Science 263:1609.
49. Yamanashi, Y., Y. Fukui. B. Wongsasant, Y. Kinoshita, Y. Ichimori, K. Toyoshima, and T. Yamamoto. 1992. Activation of Src-like protein-tyrosine kinase Lyn and its association with phosphatidylinositol 3-kinase upon B-cell antigen receptor-mediated signaling. Proc. Natl. Acad. Sci. USA 89:1118.
50. Rodriguez-Viciana, P., P. H. Warne, B. Vanhaesebroeck, M. D. Waterfield, and J. Downward. 1996. Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation. EMBO J. 15:2442.
51. Rodriguez-Viciana, P., P. H. Warne. R. Dhand, B. Vanhaesebroeck, I. Gout, M. J. Fry, M. D. Waterfield, and J. Downward. 1994. Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature 370:527.
52. Kodaki, T., R. Woscholski, B. Hallberg, P. Rodriguez-Viciana, J. Downward, and P. J. Parker. 1994. The activation of phosphatidylinositol 3-kinase by Ras. Curr. Biol. 4:798.
53. Kerner, J. D., M. W. Appleby, R. N. Mohr, S. Chien, D. J. Rawlings, C. R. Maliszewski, O. N. Witte, and R. M. Perlmutter. 1995. Impaired expansion of mouse B cell progenitors lacking Btk. Immunity 3:301.
54. Khan, W. N., F. W. Alt, R. M. Gerstein, B. A. Malynn, I. Larsson, G. Rathbun, L. Davidson, S. Muller, A. B. Kantor, and L. A. Herzenberg. 1995. Defective B cell development and function in Btk-deficient mice. Immunity 3:283.
55. Grossmann, M., L. A. O'Reilly, R. Gugasyan, A. Strasser, J. M. Adams, and S. Gerondakis. 2000. The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression. EMBO J. 19:6351.
56. Hayashi, K., R. Nittono, N. Okamoto, S. Tsuji, Y. Hara, R. Goitsuka, and D. Kitamura. 2000. The B cell-restricted adaptor BASH is required for normal development and antigen receptor-mediated activation of B cells. Proc. Natl. Acad. Sci. USA 97:2755.
57. Wang, D., J. Feng, R. Wen, J.-C. Marine, M. Y. Sangster, E. Parganas. A. Hoffmeyer, C. W. Jackson, J. L. Cleveland, P. J. Murray, and J. N. Ihle. 2000. Phospholipase Cγ2 is essential in the functions of B cell and several Fc receptors. Immunity 13:25.
58. Kaisho, T., K. Takeda, T. Tsujimura, T. Kawai, F. Nomura, N. Terada, and S. Akira. 2001. IκB kinase α is essential for mature B cell development and function. J. Exp. Med. 193:417.
59. Ma, H., T. M. Yankee, J. Hu, D. J. Asai, M. L. Harrison, and R. L. Geahlen. 2001. Visualization of Syk-antigen receptor interactions using green fluorescent protein: differential roles for Syk and Lyn in the regulation of receptor capping and internalization. J. Immunol. 166:1507.