AKT facilitates EGFR trafficking and degradation by phosphorylating and activating PIKfyve

Science Signaling

Volumn 6, Issue 279, 2013, Pages

  Er, Ekrem Emrah ^a   Mendoza, Michelle C ^a   Mackey, Ashley M ^b   Rameh, Lucia E ^b   Blenis, John ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BOSTON BIOMEDICAL RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 PHOSPHATE 5 KINASE; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN KINASE; PROTEIN KINASE B; S6 KINASE; UNCLASSIFIED DRUG; PHOSPHATIDYLINOSITOL 3 KINASE; PIKFYVE PROTEIN, HUMAN;

ARTICLE; CELL SURFACE; CELL VACUOLE; CONTROLLED STUDY; ENDOSOME; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FEEDBACK SYSTEM; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; INTRACELLULAR TRANSPORT; LYSOSOME; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN TRANSPORT; RECEPTOR OCCUPANCY; BIOLOGICAL MODEL; CELL LINE; CONFOCAL MICROSCOPY; DRUG EFFECTS; ENDOCYTOSIS; GENETICS; HEK293 CELL LINE; METABOLISM; PHOSPHORYLATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

BLOTTING, WESTERN; CELL LINE; ENDOCYTOSIS; ENDOSOMES; ENZYME ACTIVATION; EPIDERMAL GROWTH FACTOR; HEK293 CELLS; HUMANS; LYSOSOMES; MICROSCOPY, CONFOCAL; MODELS, BIOLOGICAL; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEIN TRANSPORT; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

EID: 84879987829     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2004015     Document Type: Article

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