Regulated intramembrane proteolysis of the frontotemporal lobar degeneration risk factor, TMEM106B, by signal peptide peptidase-like 2a (SPPL2a)

Journal of Biological Chemistry

Volumn 289, Issue 28, 2014, Pages 19670-19680

  Brady, Owen A ^a   Zhou, Xiaolai ^a   Hu, Fenghua ^a  

^a School of Integrative Plant Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; ENZYME ACTIVITY; PROTEOLYSIS;

ECTODOMAIN SHEDDING; INTRACELLULAR DOMAIN; INTRAMEMBRANE PROTEOLYSIS; MEMBRANE PROTEINS; SEQUENTIAL PROCESSING; SIGNALING PROCESS; SPECIFIC SUBSTRATES; TRANS-MEMBRANE PROTEINS;

PROTEINS;

ADAM PROTEIN; MEMBRANE PROTEIN; PROTEINASE; SIGNAL PEPTIDASE; SIGNAL PEPTIDASE LIKE 2A; SIGNAL PEPTIDASE LIKE 2B; TMEM106B PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME ACTIVITY; FRONTOTEMPORAL DEMENTIA; INTRACELLULAR SIGNALING; MOLECULAR PATHOLOGY; MOUSE; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN HOMEOSTASIS; PROTEIN LOCALIZATION; PROTEIN PROCESSING; RISK ASSESSMENT; RISK FACTOR;

FRONTOTEMPORAL LOBAR DEGENERATION; INTRAMEMBRANE PROTEOLYSIS; LYSOSOMAL GLYCOPROTEIN; LYSOSOME; NEURODEGENERATIVE DISEASE; SHEDDING; SPPL2A; TMEM106B;

ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; CELL MEMBRANE; FRONTOTEMPORAL LOBAR DEGENERATION; HEK293 CELLS; HUMANS; LYSOSOMES; MEMBRANE PROTEINS; MICE; NERVE TISSUE PROTEINS; PROTEIN STRUCTURE, TERTIARY; PROTEOLYSIS; RISK FACTORS;

EID: 84904215127     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.515700     Document Type: Article

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