Signal-peptide-peptidase-like 2a is required for CD74 intramembrane proteolysis in human B cells

Biochemical and Biophysical Research Communications

Volumn 451, Issue 1, 2014, Pages 48-53

  Schneppenheim, Janna ^a   Hüttl, Susann ^a   Kruchen, Anne ^b   Fluhrer, Regina ^c,d   Müller, Ingo ^e   Saftig, Paul ^a   Schneppenheim, Reinhard ^e   Martin, Christa L ^f   Schröder, Bernd ^a  

^a UNIVERSITY OF KIEL   (Germany)

^b Research Institute Children's Cancer Center   (Germany)

^c UNIVERSITY OF MUNICH   (Germany)

^d GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^e UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^f GEISINGER HEALTH SYSTEM   (United States)

Author keywords

B cell maturation; CD74; Common variable immune deficiency; Intramembrane proteolysis; Invariant chain; Signal peptide peptidase like protease

Indexed keywords

CD74 ANTIGEN; SIGNAL PEPTIDE; SIGNAL PEPTIDE PEPTIDASE LIKE 2A; UNCLASSIFIED DRUG; ASPARTIC PROTEINASE; B LYMPHOCYTE ANTIGEN; HLA ANTIGEN CLASS 2; INVARIANT CHAIN; PEPTIDE FRAGMENT; SPPL2A PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; CHROMOSOME 15; CHROMOSOME 15Q; CHROMOSOME DELETION; CONTROLLED STUDY; ENZYME ACTIVITY; EXON; FLOW CYTOMETRY; GENE LOCUS; HOMEOSTASIS; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; LYMPHOBLASTOID CELL LINE; MODULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; SIBLING; TURNOVER TIME; CELL LINE; GENETICS; HOMOZYGOTE; IMMUNE DEFICIENCY; INTRACELLULAR MEMBRANE; METABOLISM; PATHOLOGY;

MUS;

ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; ASPARTIC ACID ENDOPEPTIDASES; B-LYMPHOCYTES; CELL LINE; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 15; HISTOCOMPATIBILITY ANTIGENS CLASS II; HOMOZYGOTE; HUMANS; IMMUNOLOGIC DEFICIENCY SYNDROMES; INTRACELLULAR MEMBRANES; PEPTIDE FRAGMENTS;

EID: 84906281734     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.07.051     Document Type: Article

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