Activation of IGF-1 and Insulin Signaling Pathways Ameliorate Mitochondrial Function and Energy Metabolism in Huntington’s Disease Human Lymphoblasts

Molecular Neurobiology

Volumn 51, Issue 1, 2015, Pages 331-348

  Naia, Luana ^a,b   Ferreira, I Luísa ^a,c   Cunha Oliveira, Teresa ^a,c   Duarte, Ana I ^a,c   Ribeiro, Márcio ^a   Rosenstock, Tatiana R ^a,c   Laço, Mário N ^a,b,c   Ribeiro, Maria J ^a   Oliveira, Catarina R ^a,b,c   Saudou, Frédéric ^d   Humbert, Sandrine ^d   Rego, A Cristina ^a,b,c  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c UNIVERSITY OF COIMBRA   (Portugal)

^d INSTITUT CURIE   (France)

Author keywords

Energy metabolism; Huntington s disease; IGF 1; Insulin; Intracellular signaling; Mitochondria

Indexed keywords

CALCIUM; CYTOCHROME C; HTT PROTEIN, HUMAN; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE; NERVE PROTEIN; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR;

ANIMAL; CELL LINE; DRUG EFFECTS; ELECTRON TRANSPORT; ENERGY METABOLISM; FEMALE; HUMAN; HUNTINGTON CHOREA; LYMPHOCYTE; MALE; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; OXYGEN CONSUMPTION; PATHOLOGY; PHOSPHORYLATION; PIG; SIGNAL TRANSDUCTION;

ANIMALS; CALCIUM; CELL LINE; CYTOCHROMES C; ELECTRON TRANSPORT; ENERGY METABOLISM; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; HUMANS; HUNTINGTON DISEASE; INSULIN; INSULIN-LIKE GROWTH FACTOR I; LYMPHOCYTES; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NERVE TISSUE PROTEINS; OXYGEN CONSUMPTION; PHOSPHORYLATION; RECEPTOR, IGF TYPE 1; SIGNAL TRANSDUCTION; SUS SCROFA;

EID: 84938698507     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-014-8735-4     Document Type: Article

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