Insulin-like growth factor-1-induced phosphorylation of transcription factor FKHRL1 is mediated by phosphatidylinositol 3-kinase/Akt kinase and role of this pathway in insulin-like growth factor-1-induced survival of cultured hippocampal neurons

Molecular Pharmacology

Volumn 62, Issue 2, 2002, Pages 225-233

  Zheng, Wen Hua ^a   Kar, Satyabrata ^a   Quirion, Rémi ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; APROTININ; ENZYME INHIBITOR; LEUPEPTIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; PROTEIN P27; RAPAMYCIN; RECOMBINANT SOMATOMEDIN C; SOMATOMEDIN C DERIVATIVE; SOMATOMEDIN C INHIBITOR; SOMATOMEDIN C RECEPTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FKHRL1; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL CELL; ARTICLE; CELL CYCLE; CELL SURVIVAL; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME REGULATION; ENZYME SUBSTRATE COMPLEX; FETUS; FIBROBLAST; GENE MUTATION; GENE OVEREXPRESSION; GROWTH REGULATION; HIPPOCAMPUS; HUMAN; HUMAN CELL; INHIBITION KINETICS; INSULIN LIKE ACTIVITY; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; RAT; RECEPTOR BINDING; REGULATORY MECHANISM; TRANSCRIPTION REGULATION; WILD TYPE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; APOPTOSIS; CELL SURVIVAL; CELLS, CULTURED; CULTURE MEDIA, SERUM-FREE; DNA-BINDING PROTEINS; FAS LIGAND PROTEIN; FORKHEAD TRANSCRIPTION FACTORS; HIPPOCAMPUS; INSULIN-LIKE GROWTH FACTOR I; MEMBRANE GLYCOPROTEINS; NEURONS; NITROGEN; PC12 CELLS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RECEPTOR, IGF TYPE 1; SERINE; SIGNAL TRANSDUCTION; THREONINE; TIME FACTORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0036078618     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.62.2.225     Document Type: Article

References (40)

1. Mechanism of activation of protein kinase B by insulin and IGF-1
2. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
3. PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2
4. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
5. Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)
6. Insulin-like growth factor-I receptor signal transduction: At the interface between physiology and cell biology
7. Regulation of cell death protease caspase-9 by phosphorylation
8. Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases
9. Cellular survival: A play in three Akts
10. Interleukin-3-induced phosphorylation of BAD though the protein kinase Akt
11. Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase and protein kinase B/AKT by the integrin-linked kinase
12. Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1
13. Insulin-like growth factor I protects and hippocampal neurons against β-amyloid- and human amylin-induced toxicity
14. Regulation of neuronal survival by the serine-threonine protein kinase Akt
15. Akt phosphorylation site found in human caspase-9 is absent in mouse capase-9
16. Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence
17. Neurotrophin signal transduction in the nervous system
18. Requirement for activation of the serine-threonine kinase Akt (protein kinase B) in insulin stimulation of protein synthesis but not of glucose transport
19. Forkhead transcription factor: New insights into protein kinase B (c-akt) signaling
20. Direct control of the Forkhead transcription factor AFX by protein kinase B
21. Hepatocyte nuclear factor 3/fork head or "winged helix" proteins: A family of transcription factors of diverse biologic function
22. Molecular and cellular aspects of the insulin-like growth factor I receptor
23. Morphine treatment induced calcitonin gene-related peptide and substance P increases in cultured dorsal root ganglion neurons
24. Bcl-2-related protein expression in apoptosis: Oxidative stress versus serum deprivation in PC12 cells
25. Activation of Akt kinase inhibits apoptosis and changes in Bcl-2 and Bax expression induced by nitric oxide in primary hippocampal neurons
26. AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1
27. IRS-1 is a common element in insulin and insulin-like growth factor-1 signaling to the phosphatidylinositol 3′-kinase
28. Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a wortmannin-sensitive pathway
29. Insulin-like growth factor-I promotes neurogenesis and synaptogenesis in the hippocampal dentate gyrus during postnatal development
30. The proapoptotic BH3-only protein bim is expressed in hematopoietic, epithelial, neuronal and germ cells
31. Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1 and epidermal growth factor
32. Transforming growth factor β enhances epithelial cell survival via Akt-dependent regulation of FKHRL1
33. Negative regulation of the forkhead transcription factor FKHR by Akt
34. Circulating insulin-like growth factor I mediates exercise induced increases in the number of new neurons in the adult hippocampus
35. A specific inhibitor of phosphatidylinositul 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
36. Akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53
37. Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor
38. Insulin-like growth factor-1 (IGF-1): A neuroprotective trophic factor acting via the Akt kinase pathway
39. Insulin-like growth factor-1-induced phosphorylation of the forkhead family transcription factor FKHRL1 is mediated by akt kinase in PC12 cells
40. Stimulation of protein kinase C modulates insulin-like growth factor-1-induced akt activation in PC12 cells