Electrochemistry-mass spectrometry to study reactive drug metabolites and CYP450 simulations

TrAC - Trends in Analytical Chemistry

Volumn 70, Issue , 2015, Pages 67-73

  Bussy, Ugo ^a   Boisseau, Renaud ^b   Thobie Gautier, Christine ^b   Boujtita, Mohammed ^b  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b UNIVERSITÉ DE NANTES   (France)

Author keywords

CYP450 modified electrode; Cytochrome P450; Drug metabolism; EC MS; Electrochemistry mass spectrometry; Glutathione adduct; Inhibition; Metabolite identification; Reactive metabolite; Surface modified electrode

Indexed keywords

BIOMOLECULES; ELECTRODES; ENZYME INHIBITION; MASS SPECTROMETRY; METABOLISM; METABOLITES; NITROGEN OXIDES; PHYSIOLOGY;

CYTOCHROME P450; DRUG METABOLISMS; EC-MS; GLUTATHIONES; METABOLITE IDENTIFICATION; MODIFIED ELECTRODES; REACTIVE METABOLITES; SURFACE MODIFIED ELECTRODES;

ELECTROCHEMISTRY;

AROMATIC COMPOUND; CATION; CYTOCHROME P450; DRUG METABOLITE; EPOXIDE; GLUTATHIONE; IMINIUM REACTIVE METABOLITE; NITROGEN OXIDE; NITROSO DERIVATIVE; NITROSO REACTIVE METABOLITE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; PYRIDINIUM REACTIVE METABOLITE; REACTIVE NITROGEN SPECIES; UNCLASSIFIED DRUG;

CHEMICAL MODIFICATION; CHEMICAL REACTION; DRUG METABOLISM; DRUG STRUCTURE; ELECTROCHEMISTRY; ELECTRODE; ELECTRON TRANSPORT; ELECTROPHILICITY; ENZYME MECHANISM; HIGH THROUGHPUT SCREENING; MASS SPECTROMETRY; PRIORITY JOURNAL; REVIEW; SIMULATION;

EID: 84937977442     PISSN: 01659936     EISSN: 18793142     Source Type: Journal    
DOI: 10.1016/j.trac.2015.02.017     Document Type: Review

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