Generation and identification of reactive metabolites by electrochemistry and immobilized enzymes coupled on-line to liquid chromatography/mass spectrometry

Analytical Chemistry

Volumn 79, Issue 17, 2007, Pages 6831-6839

  Lohmann, Wiebke ^a   Karst, Uwe ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELLULAR MACROMOLECULES; ELECTROCHEMICAL REACTORS; ON-LINE COUPLING;

COVALENT BONDS; ELECTROCHEMISTRY; ENZYME IMMOBILIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; REACTION KINETICS;

METABOLITES;

ALDEHYDE DERIVATIVE; AMODIAQUINE; AMSACRINE; CYTOCHROME P450; DRUG METABOLITE; GLUTATHIONE; HORSERADISH PEROXIDASE; MITOXANTRONE; QUININE; QUINONE DIIMINE; QUINONE IMINE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CATALYSIS; CONTROLLED STUDY; DEALKYLATION; DRUG DETERMINATION; DRUG IDENTIFICATION; DRUG METABOLISM; ELECTROCHEMICAL ANALYSIS; ELECTROCHEMISTRY; ENZYME IMMOBILIZATION; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MASS SPECTROMETRY; MICROPARTICLE ENZYME IMMUNOASSAY; NONHUMAN; OXIDATION; RAT; REACTOR; SIMULATION;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ELECTROCHEMISTRY; ENZYMES, IMMOBILIZED; HORSERADISH PEROXIDASE; MASS SPECTROMETRY; MICROSOMES, LIVER; MOLECULAR STRUCTURE; ONLINE SYSTEMS; RATS;

EID: 34548577031     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac071100r     Document Type: Article

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