Covalent protein modification by reactive drug metabolites using online electrochemistry/liquid chromatography/mass spectrometry

Analytical Chemistry

Volumn 80, Issue 24, 2008, Pages 9714-9719

  Lohmann, Wiebke ^a   Hayen, Heiko ^b   Karst, Uwe ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b LEIBNIZ INSTITUT FÜR ANALYTISCHE WISSENSCHAFTEN ISAS E V   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADDUCT FORMATIONS; ANALYSIS TIMES; CHROMATOGRAPHY/MASS SPECTROMETRIES; CLOZAPINE; CONVENIENT METHODS; DRUG METABOLITES; EC CELLS; HIGH PURITIES; HIGH YIELDS; HUMAN SERUM ALBUMINS; INJECTION SYSTEMS; LACTOGLOBULIN; ONLINE TIMES; OXIDATIVE METABOLISMS; PARACETAMOL; PROTEIN BINDINGS; PROTEIN MODIFICATIONS; REACTIVE METABOLITES; SET-UPS; SYNTHESIS OF;

ANIMAL CELL CULTURE; BIOCHEMISTRY; BIOMOLECULES; BLOOD VESSEL PROSTHESES; ELECTRIC CONDUCTIVITY MEASUREMENT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MASS SPECTROMETRY; METABOLITES; RISK ANALYSIS; RISK MANAGEMENT; SPECTROMETERS; SPECTROMETRY; SPECTRUM ANALYSIS;

RISK ASSESSMENT;

AMIODAQUINE QUINONEIMINE; AMODIAQUINE; BETA LACTOGLOBULIN; CLOZAPINE; DRUG METABOLITE; N ACETYL 1,4 BENZOQUINONE IMINE; PARACETAMOL; SERUM ALBUMIN; UNCLASSIFIED DRUG;

AEROBIC METABOLISM; ARTICLE; CONTROLLED STUDY; DRUG OXIDATION; DRUG PROTEIN BINDING; ELECTROCHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INFRARED SPECTROSCOPY; PROTEIN MODIFICATION; SIMULATION; TIME OF FLIGHT MASS SPECTROMETRY;

ACETAMINOPHEN; AMODIAQUINE; CHROMATOGRAPHY, LIQUID; CLOZAPINE; ELECTROCHEMISTRY; HUMANS; LACTOGLOBULINS; MASS SPECTROMETRY; SERUM ALBUMIN; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 58149134070     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac801699g     Document Type: Article

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