Metabolic activation of the antibacterial agent triclocarban by cytochrome P450 1A1 yielding glutathione adducts

Drug Metabolism and Disposition

Volumn 42, Issue 7, 2014, Pages 1098-1102

  Schebb, Nils Helge ^a   Muvvala, Jaya B ^b   Morin, Dexter ^b   Buckpitt, Alan R ^b   Hammock, Bruce D ^b   Rice, Robert H ^b  

^a UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DICHLORO 39 GLUTATHIONYL 49 HYDROXYCARBANILIDE; CARBANILIDE DERIVATIVE; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; GLUTATHIONE TRANSFERASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TRICLOCARBAN; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; GLUTATHIONE;

ARTICLE; CONTROLLED STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; INCUBATION TIME; KERATINOCYTE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLIC ACTIVATION; OXIDATION; PRIORITY JOURNAL; PROTEIN MODIFICATION; SOLID PHASE EXTRACTION; METABOLISM; TRANSFORMED CELL LINE;

ACTIVATION, METABOLIC; ANTI-BACTERIAL AGENTS; CARBANILIDES; CELL LINE, TRANSFORMED; CYTOCHROME P-450 CYP1A1; GLUTATHIONE; HUMANS;

EID: 84903124002     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.114.058206     Document Type: Article

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