A proton-shuttle mechanism mediated by the porphyrin in benzene hydroxylation by cytochrome P450 enzymes

Journal of the American Chemical Society

Volumn 125, Issue 24, 2003, Pages 7413-7424

  De Visser, Sam P ^a   Shaik, Sason ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

BENZENE; CATALYSIS; CHEMICAL BONDS; COMPLEXATION; ELECTRON TRANSITIONS; ENZYME KINETICS; HYDROXYLATION; PROBABILITY DENSITY FUNCTION; PROTONS;

RADICALAR PATHWAYS;

PORPHYRINS;

ARENE OXIDE; BENZENE; BENZENE DERIVATIVE; BENZENE EPOXIDE; CARBON; CYTOCHROME P450; HYDROGEN; IRON; KETONE; OXIDE; PHENOL; PORPHYRIN; PROTON; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CALCULATION; CATALYSIS; CHEMICAL REACTION; ENZYME MECHANISM; EPOXIDATION; HYDROGEN BOND; HYDROXYLATION; OXIDATION; PROTON TRANSPORT; REACTION ANALYSIS; RING CLOSING METATHESIS;

EID: 0038110968     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja034142f     Document Type: Article

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