Acebutolol and alprenolol metabolism predictions: Comparative study of electrochemical and cytochrome P450-catalyzed reactions using liquid chromatography coupled to high-resolution mass spectrometry

Analytical and Bioanalytical Chemistry

Volumn 405, Issue 18, 2013, Pages 6077-6085

  Bussy, Ugo ^a   Delaforge, Marcel ^b   El Bekkali, Chaimaâ ^a   Ferchaud Roucher, Véronique ^a   Krempf, Michel ^a   Tea, Illa ^a   Galland, Nicolas ^a   Jacquemin, Denis ^a,c   Boujtita, Mohammed ^a  

^a UNIVERSITÉ DE NANTES   (France)

^b DIF   (France)

^c INSTITUT UNIVERSITAIRE DE FRANCE   (France)

Author keywords

Blockers; CYP450; Drug metabolism prediction; EC LC HRMS; EC MS

Indexed keywords

CYP450; DRUG METABOLISMS; EC-LC-HRMS; EC-MS; ELECTROCHEMICAL CONVERSION; HIGH RESOLUTION MASS SPECTROMETRY; HYDROXYLATION REACTIONS; THEORETICAL CALCULATIONS;

ANODIC OXIDATION; AROMATIC COMPOUNDS; AROMATIZATION; CATALYSIS; ELECTROCHEMICAL OXIDATION; ELECTROCHEMISTRY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; PHYSIOLOGY;

HYDROXYLATION;

ACEBUTOLOL; ALPRENOLOL; CYTOCHROME P450;

ANIMAL; CATALYSIS; COMPARATIVE STUDY; CONFERENCE PAPER; DEALKYLATION; ELECTROCHEMICAL ANALYSIS; HYDROXYLATION; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MASS SPECTROMETRY; METABOLISM; METHODOLOGY; OXIDATION REDUCTION REACTION; RAT; THEORETICAL MODEL;

ACEBUTOLOL; ALPRENOLOL; ANIMALS; CATALYSIS; CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; DEALKYLATION; ELECTROCHEMICAL TECHNIQUES; HYDROXYLATION; MASS SPECTROMETRY; MICROSOMES, LIVER; MODELS, THEORETICAL; OXIDATION-REDUCTION; RATS;

RATTUS;

EID: 84879799079     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-013-7050-7     Document Type: Conference Paper

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