Electrochemistry meets enzymes: Instrumental on-line simulation of oxidative and conjugative metabolism reactions of toremifene

Analytical and Bioanalytical Chemistry

Volumn 394, Issue 5, 2009, Pages 1341-1348

  Lohmann, Wiebke ^a   Karst, Uwe ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Detoxification; Drug metabolism; Electrochemistry; Glutathione S transferase; Liquid chromatography; Mass spectrometry; Toremifene

Indexed keywords

CHLORINE ATOM; CHROMATOGRAPHY/MASS SPECTROMETRY; CONTINUOUS FLOWS; CONVERSION RATES; DETOXIFICATION MECHANISM; DRUG METABOLISM; FLOW-THROUGH CELLS; GLUTATHIONE; GLUTATHIONE-S-TRANSFERASE; MAGNETIC MICROPARTICLES; METABOLIC PATHWAYS; ONLINE SIMULATION; PHASE I; PHASE II; QUINOID COMPOUNDS; QUINOID SPECIES; SELECTIVE ESTROGEN RECEPTOR MODULATORS; TOREMIFENE;

BIOCHEMISTRY; CHLORINE; CHROMATOGRAPHIC ANALYSIS; DETOXIFICATION; ELECTROCHEMISTRY; ELECTROLYSIS; ENZYMES; LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETERS; MASS SPECTROMETRY; SPECTRUM ANALYSIS; SYSTEM THEORY;

METABOLISM;

GLUTATHIONE TRANSFERASE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TOREMIFENE;

CHEMICAL STRUCTURE; CHEMISTRY; CONFERENCE PAPER; ELECTROCHEMICAL ANALYSIS; INSTRUMENTATION; MASS SPECTROMETRY; METABOLISM; METHODOLOGY; ONLINE SYSTEM; OXIDATION REDUCTION REACTION;

ELECTROCHEMICAL TECHNIQUES; GLUTATHIONE TRANSFERASE; MASS SPECTROMETRY; MOLECULAR STRUCTURE; ONLINE SYSTEMS; OXIDATION-REDUCTION; SELECTIVE ESTROGEN RECEPTOR MODULATORS; TOREMIFENE;

EID: 67449133537     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-008-2586-7     Document Type: Conference Paper

References (42)

1. Grossman SJ (2008) Overview: drug metabolism in the modern pharmaceutical industry. In: Zhang D, Zhu M, Humphreys WG (eds) Drug metabolism in drug design and development. Wiley, Hoboken
2. WG Humphreys SE Unger 2006 Chem Res Toxicol 19 1564
3. KL Davis-Bruno A Atrakchi 2006 Chem Res Toxicol 19 1561
4. DC Evans AP Watt DA Nicoll-Griffith TA Baillie 2004 Chem Res Toxicol 17 3
5. FP Guengerich 2006 Chem Res Toxicol 19 1559
6. FP Guengerich JS MacDonald 2007 Chem Res Toxicol 20 344
7. KR Iyer MW Sinz 1999 Chem Biol Interact 118 151
8. PD Josephy FP Guengerich JO Miners 2005 Drug Metab Rev 37 575
9. DC Lamb MR Waterman SL Kelly FP Guengerich 2007 Curr Opin Biotechnol 18 504
10. FP Guengerich 2008 Chem Res Toxicol 21 70
11. Remmel R, Nagar S, Argikar U (2008) Conjugative metabolism of drugs. In: Zhang D, Zhu M, Humphreys WG (eds) Drug metabolism in drug design and development. Wiley, Hoboken
12. EFA Brandon CD Raap I Meijerman JH Beijnen JHM Schellens 2003 Toxicol Appl Pharmacol 189 233
13. O Pelkonen M Turpeinen J Uusitalo A Rautio H Raunio 2005 Basic Clin Pharmacol Toxicol 96 167
14. N Plant 2004 Drug Discovery Today 9 328
15. PH Marathe WC Shyu WG Humphreys 2004 Curr Pharm Des 10 2991
16. D Dalvie 2000 Curr Pharm Des 6 1009
17. SA Kulkarni J Zhu S Blechinger 2005 Xenobiotica 25 955
18. VK Gombar JJ Alberts KC Cassidy BE Mattioni MA Mohutsky 2006 Curr Comput-Aided Drug Des 2 177
19. B Meunier J Bernadou 2004 Adv Synth Catal 346 171
20. MC Feiters AE Rowan RJM Nolte 2000 Chem Soc Rev 29 375
21. B Meunier 1992 Chem Rev 92 1411
22. W Lohmann U Karst 2008 Anal Bioanal Chem 391 79
23. U Karst 2004 Angew Chem Int Ed 43 2476
24. HP Permentier AP Bruins R Bischoff 2008 Mini-Rev Med Chem 8 46
25. TA Getek WA Korfmacher TA McRae JA Hinson 1989 J Chromatogr A 474 245
26. U Jurva HV Wikström AP Bruins 2000 Rapid Commun Mass Spectrom 14 529
27. U Jurva HV Wikström L Weidolf AP Bruins 2003 Rapid Commun Mass Spectrom 17 800
28. SM Van Leeuwen B Blankert JM Kauffmann U Karst 2005 Anal Bioanal Chem 382 742
29. W Lohmann U Karst 2006 Anal Bioanal Chem 386 1701
30. KG Madsen J Olsen C Skonberg SH Hansen Jurva 2007 Chem Res Toxicol 20 821
31. W Lohmann U Karst 2007 Anal Chem 79 6831
32. T Johansson L Weidolf U Jurva 2007 Rapid Commun Mass Spectrom 21 2323
33. U Jurva A Holmen G Groenberg C Masimirembwa L Weidolf 2008 Chem Res Toxicol 21 928
34. KG Madsen C Skonberg U Jurva C Cornett SH Hansen TH Johansen 2008 Chem Res Toxicol 21 1107
35. Lohmann W, Dötzer R, Gütter G, Van Leeuwen SM, Karst U (2008) J Am Soc Mass Spectrom doi: 10.1016/j.jasms.2008.09.003
36. M Thevis W Lohmann Y Schrader M Kohler W Bornatsch U Karst W Schänzer 2008 Eur J Mass Spectrom 14 163
37. R Valavaara S Pyrrhonen M Meikkinen P Rissanan G Blanco E Tholix E Nordmann P Taskinen L Holsti Hajba 1988 Eur J Cancer Clin Oncol 24 785
38. GM Williams PM Ross AM Jeffry S Karlsson 1998 Drug Chem Toxicol 21 449
39. PW Fan F Zhang JL Bolton 2000 Chem Res Toxicol 13 45
40. D Yao F Zhang L Yu Y Yang RB van Breemen JL Bolton 2001 Chem Res Toxicol 14 1643
41. PW Fan JL Bolton 2001 Drug Metab Dispos 29 891
42. RM Jones CK Lim 2002 Biomed Chromatogr 16 361