Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with β-amyloid anti-aggregation properties and beneficial effects on memory in vivo

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 10, 2015, Pages 2445-2457

  Więckowska, Anna ^a   Więckowski, Krzysztof ^a   Bajda, Marek ^a   Brus, Boris ^b   Sałat, Kinga ^a   Czerwińska, Paulina ^a   Gobec, Stanislav ^b   Filipek, Barbara ^a   Malawska, Barbara ^a  

^a JAGIELLONIAN UNIVERSITY   (Poland)

^b UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

Alzheimer's disease; Blood brain barrier permeability; Cholinesterase inhibitors; Indole; N benzylpiperidine; Passive avoidance; Phthalimide; Amyloid aggregation

Indexed keywords

ACETYLCHOLINESTERASE; AMYLOID BETA PROTEIN; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; DONEPEZIL; INDAN DERIVATIVE; INDOLE DERIVATIVE; NEUROPROTECTIVE AGENT; PHTHALIMIDE DERIVATIVE; PIPERIDINE DERIVATIVE; PROTEIN AGGREGATE; SCOPOLAMINE BROMIDE;

ALZHEIMER DISEASE; AMNESIA; ANIMAL; BLOOD BRAIN BARRIER; CHEMICAL STRUCTURE; CHEMICALLY INDUCED; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; HUMAN; MALE; MEMORY; METABOLISM; MOUSE; PATHOLOGY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; AMNESIA; AMYLOID BETA-PEPTIDES; ANIMALS; BLOOD-BRAIN BARRIER; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; DISEASE MODELS, ANIMAL; HUMANS; INDANS; INDOLES; MALE; MEMORY; MICE; MODELS, MOLECULAR; NEUROPROTECTIVE AGENTS; PHTHALIMIDES; PIPERIDINES; PROTEIN AGGREGATES; SCOPOLAMINE HYDROBROMIDE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84937758940     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.03.051     Document Type: Article

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